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Gene: Lhx4 (LIM homeobox protein 4) Mus musculus
Symbol: Lhx4
Name: LIM homeobox protein 4
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Involved in animal organ development; negative regulation of apoptotic process; and neuron differentiation. Localizes to intracellular. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in panhypopituitarism. Orthologous to human LHX4 (LIM homeobox 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A330062J17Rik; Gsh-4; Gsh4; LIM homeo box protein 4; LIM/homeobox protein Lhx4; RIKEN cDNA A330062J17 gene
Homo sapiens (human) : LHX4 (LIM homeobox 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lhx4 (LIM homeobox 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lhx4 (LIM homeobox 4)
Pan paniscus (bonobo/pygmy chimpanzee) : LHX4 (LIM homeobox 4)
Canis lupus familiaris (dog) : LHX4 (LIM homeobox 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lhx4 (LIM homeobox 4)
Sus scrofa (pig) : LHX4 (LIM homeobox 4)
Chlorocebus sabaeus (African green monkey) : LHX4 (LIM homeobox 4)
Heterocephalus glaber (naked mole-rat) : Lhx4 (LIM homeobox 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1155,698,031 - 155,751,684 (-)EnsemblGRCm38mm10GRCm38
GRCm381155,698,031 - 155,751,726 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371157,548,822 - 157,589,157 (-)NCBIGRCm37mm9NCBIm37
MGSCv361157,463,939 - 157,499,824 (-)NCBImm8
Celera1158,134,947 - 158,175,740 (-)NCBICelera
Cytogenetic Map1G3NCBI
cM Map167.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Lhx4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317586
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.