Ccnk (cyclin K) - Rat Genome Database

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Gene: Ccnk (cyclin K) Mus musculus
Analyze
Symbol: Ccnk
Name: cyclin K
RGD ID: 1317545
MGI Page MGI
Description: Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity; protein kinase binding activity; and protein serine/threonine kinase activity. Acts upstream of or within in utero embryonic development and negative regulation of stem cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of cyclin K-CDK12 complex; cyclin K-CDK13 complex; and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; olfactory epithelium; and retina nuclear layer. Orthologous to human CCNK (cyclin K).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW123198; AW413594; CP; CPR4; CycK; cyclin-K
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,145,543 - 108,170,252 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,145,838 - 108,169,618 (+)EnsemblGRCm39 Ensembl
GRCm3812108,179,308 - 108,203,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,179,579 - 108,203,359 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712109,417,948 - 109,441,569 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612108,627,650 - 108,651,164 (+)NCBIMGSCv36mm8
Celera12109,416,780 - 109,443,587 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Novel complexes of cyclin-dependent kinases and a cyclin-like protein from Arabidopsis thaliana with a function unrelated to cell division. Barroco RM, etal., Cell Mol Life Sci 2003 Feb;60(2):401-12.
2. Control of transcriptional elongation. Kwak H and Lis JT, Annu Rev Genet. 2013;47:483-508. doi: 10.1146/annurev-genet-110711-155440. Epub 2013 Sep 11.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9632813   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12904583   PMID:14610273   PMID:14697215   PMID:15226823  
PMID:15489334   PMID:16141072   PMID:16141073   PMID:17250610   PMID:17938200   PMID:18799693   PMID:20059953   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22012619   PMID:22071476  
PMID:22547058   PMID:25004108   PMID:26658019   PMID:27073218   PMID:30196744   PMID:32325033   PMID:37597256  


Genomics

Comparative Map Data
Ccnk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,145,543 - 108,170,252 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,145,838 - 108,169,618 (+)EnsemblGRCm39 Ensembl
GRCm3812108,179,308 - 108,203,359 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,179,579 - 108,203,359 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712109,417,948 - 109,441,569 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612108,627,650 - 108,651,164 (+)NCBIMGSCv36mm8
Celera12109,416,780 - 109,443,587 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.23NCBI
CCNK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381499,481,409 - 99,512,440 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1499,481,169 - 99,535,044 (+)EnsemblGRCh38hg38GRCh38
GRCh371499,947,746 - 99,978,777 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,017,492 - 99,047,605 (+)NCBINCBI36Build 36hg18NCBI36
Build 341499,017,491 - 99,047,604NCBI
Celera1480,002,624 - 80,032,734 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1480,131,153 - 80,161,252 (+)NCBIHuRef
CHM1_11499,885,503 - 99,915,610 (+)NCBICHM1_1
T2T-CHM13v2.01493,712,952 - 93,744,005 (+)NCBIT2T-CHM13v2.0
Ccnk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86132,854,428 - 132,877,604 (+)NCBIGRCr8
mRatBN7.26127,090,115 - 127,113,195 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,090,569 - 127,113,191 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6127,214,939 - 127,237,557 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06127,509,983 - 127,532,601 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06126,868,198 - 126,890,820 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,090,235 - 132,113,560 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,090,218 - 132,113,557 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06141,260,560 - 141,283,940 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46132,547,058 - 132,569,679 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6124,649,851 - 124,672,436 (+)NCBICelera
Cytogenetic Map6q32NCBI
Ccnk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543820,835,825 - 20,849,999 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543820,826,818 - 20,850,496 (+)NCBIChiLan1.0ChiLan1.0
CCNK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215100,635,564 - 100,666,123 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11499,852,060 - 99,882,619 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01480,105,372 - 80,136,511 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11499,427,200 - 99,457,678 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1499,438,814 - 99,480,842 (+)Ensemblpanpan1.1panPan2
CCNK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1867,910,772 - 67,927,216 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl867,901,426 - 67,945,214 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha867,424,492 - 67,450,284 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0868,188,098 - 68,213,958 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl868,188,164 - 68,231,870 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1867,849,135 - 67,874,925 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0867,915,647 - 67,941,422 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0868,312,735 - 68,338,539 (+)NCBIUU_Cfam_GSD_1.0
Ccnk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086406,765,952 - 6,798,802 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366043,283,715 - 3,319,572 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366043,283,996 - 3,316,516 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7120,487,206 - 120,514,014 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17120,487,140 - 120,514,223 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27128,108,566 - 128,124,064 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCNK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12477,436,569 - 77,466,703 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2477,436,479 - 77,467,322 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605364,572,606 - 64,605,678 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccnk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247344,367,396 - 4,383,419 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247344,366,884 - 4,392,934 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccnk
663 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:220
Interacting mature miRNAs:242
Transcripts:ENSMUST00000101055
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse
25823169Hrsq8_mhost response to SARS QTL 8, log titer (mouse)1281696245108495368Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
12910790Pwgrq7_mpre-weaning growth rate QTL 7 (mouse)1290937367108645308Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
11039526Ccc1_mcolitis susceptibility in the Collaborative Cross 1 (mouse)1293528334111028223Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse

Markers in Region
AW123198  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812108,203,038 - 108,203,149UniSTSGRCm38
MGSCv3712109,441,248 - 109,441,359UniSTSGRCm37
Celera12109,443,266 - 109,443,377UniSTS
Cytogenetic Map12F1UniSTS
cM Map1252.0UniSTS
Whitehead/MRC_RH121023.9UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000101055   ⟹   ENSMUSP00000098616
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12108,145,997 - 108,169,618 (+)Ensembl
GRCm38.p6 Ensembl12108,179,738 - 108,203,359 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221167   ⟹   ENSMUSP00000152784
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12108,145,838 - 108,169,616 (+)Ensembl
GRCm38.p6 Ensembl12108,179,579 - 108,203,357 (+)Ensembl
RefSeq Acc Id: ENSMUST00000223363
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12108,165,344 - 108,168,405 (+)Ensembl
GRCm38.p6 Ensembl12108,199,085 - 108,202,146 (+)Ensembl
RefSeq Acc Id: NM_001421681   ⟹   NP_001408610
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,145,543 - 108,170,252 (+)NCBI
RefSeq Acc Id: NM_001421682   ⟹   NP_001408611
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,145,543 - 108,170,252 (+)NCBI
RefSeq Acc Id: NM_001421683   ⟹   NP_001408612
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,145,808 - 108,170,252 (+)NCBI
RefSeq Acc Id: NM_009832   ⟹   NP_033962
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912108,146,059 - 108,170,252 (+)NCBI
GRCm3812108,179,738 - 108,203,359 (+)NCBI
MGSCv3712109,417,948 - 109,441,569 (+)RGD
Celera12109,416,780 - 109,443,587 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033962   ⟸   NM_009832
- UniProtKB: Q8R068 (UniProtKB/Swiss-Prot),   O88874 (UniProtKB/Swiss-Prot),   E9QKT7 (UniProtKB/Swiss-Prot),   Q3U3M5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000098616   ⟸   ENSMUST00000101055
RefSeq Acc Id: ENSMUSP00000152784   ⟸   ENSMUST00000221167
RefSeq Acc Id: NP_001408610   ⟸   NM_001421681
- UniProtKB: Q8R068 (UniProtKB/Swiss-Prot),   O88874 (UniProtKB/Swiss-Prot),   E9QKT7 (UniProtKB/Swiss-Prot),   Q3U3M5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001408611   ⟸   NM_001421682
- UniProtKB: Q8R068 (UniProtKB/Swiss-Prot),   O88874 (UniProtKB/Swiss-Prot),   E9QKT7 (UniProtKB/Swiss-Prot),   Q3U3M5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001408612   ⟸   NM_001421683
- UniProtKB: Q8R068 (UniProtKB/Swiss-Prot),   O88874 (UniProtKB/Swiss-Prot),   E9QKT7 (UniProtKB/Swiss-Prot),   Q3U3M5 (UniProtKB/TrEMBL)
Protein Domains
Cyclin C-terminal   Cyclin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88874-F1-model_v2 AlphaFold O88874 1-554 view protein structure

Promoters
RGD ID:8679190
Promoter ID:EPDNEW_M17626
Type:multiple initiation site
Name:Ccnk_1
Description:Mus musculus cyclin K , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812108,179,813 - 108,179,873EPDNEW
RGD ID:6822797
Promoter ID:MM_KWN:12677
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000021683,   ENSMUST00000085012,   ENSMUST00000101055,   ENSMUST00000109879,   NM_009832,   OTTMUST00000046524,   OTTMUST00000046526,   OTTMUST00000046528,   UC007OZK.1,   UC007OZM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612109,416,711 - 109,418,107 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1276106 AgrOrtholog
Ensembl Genes ENSMUSG00000021258 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000101055.5 UniProtKB/TrEMBL
  ENSMUST00000221167 ENTREZGENE
  ENSMUST00000221167.2 UniProtKB/TrEMBL
Gene3D-CATH Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin/Ssn8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1276106 ENTREZGENE
NCBI Gene 12454 ENTREZGENE
PANTHER CYCLIN-K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10026 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CycT2-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccnk PhenoGen
SMART CYCLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CCNK_MOUSE UniProtKB/Swiss-Prot
  E9QKT7 ENTREZGENE
  O88874 ENTREZGENE
  Q3TV37_MOUSE UniProtKB/TrEMBL
  Q3U3H2_MOUSE UniProtKB/TrEMBL
  Q3U3M5 ENTREZGENE, UniProtKB/TrEMBL
  Q8R068 ENTREZGENE
UniProt Secondary E9QKT7 UniProtKB/Swiss-Prot
  Q8R068 UniProtKB/Swiss-Prot