Shpk (sedoheptulokinase) - Rat Genome Database
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Gene: Shpk (sedoheptulokinase) Mus musculus
Analyze
Symbol: Shpk
Name: sedoheptulokinase
RGD ID: 1317525
MGI Page MGI
Description: Exhibits sedoheptulokinase activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and pentose-phosphate shunt, non-oxidative branch. Localizes to cytoplasm. Is expressed in trigeminal ganglion. Orthologous to human SHPK (sedoheptulokinase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; choline; folic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4930431K22Rik; AI194947; AW260459; Ca; carbohydrate kinase-like protein; Carkl; SHK
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391173,090,153 - 73,115,337 (+)NCBIGRCm39mm39
GRCm381173,199,132 - 73,224,511 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1173,199,460 - 73,224,511 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,012,984 - 73,038,008 (+)NCBIGRCm37mm9NCBIm37
MGSCv361173,015,677 - 73,040,701 (+)NCBImm8
Celera1180,736,568 - 80,761,767 (+)NCBICelera
Cytogenetic Map11B4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
cytosol  (IBA)

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18775706   PMID:19413330   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:22682222  


Genomics

Comparative Map Data
Shpk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391173,090,153 - 73,115,337 (+)NCBIGRCm39mm39
GRCm381173,199,132 - 73,224,511 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1173,199,460 - 73,224,511 (+)EnsemblGRCm38mm10GRCm38
MGSCv371173,012,984 - 73,038,008 (+)NCBIGRCm37mm9NCBIm37
MGSCv361173,015,677 - 73,040,701 (+)NCBImm8
Celera1180,736,568 - 80,761,767 (+)NCBICelera
Cytogenetic Map11B4NCBI
SHPK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl173,585,149 - 3,636,249 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl173,608,253 - 3,636,250 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl173,608,240 - 3,636,250 (-)EnsemblGRCh38hg38GRCh38
GRCh38173,608,240 - 3,636,250 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37173,511,556 - 3,539,616 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37173,511,534 - 3,539,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36173,458,305 - 3,486,365 (-)NCBINCBI36hg18NCBI36
Build 34173,458,304 - 3,486,365NCBI
Celera173,525,274 - 3,553,357 (-)NCBI
Cytogenetic Map17p13.2NCBI
HuRef173,403,309 - 3,431,324 (-)NCBIHuRef
CHM1_1173,522,339 - 3,550,373 (-)NCBICHM1_1
Shpk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21057,817,551 - 57,841,981 (+)NCBI
Rnor_6.0 Ensembl1059,765,258 - 59,789,678 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01059,765,328 - 59,789,676 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01059,504,502 - 59,528,849 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41060,075,861 - 60,100,209 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11060,089,463 - 60,112,512 (+)NCBI
Celera1056,940,488 - 56,964,835 (+)NCBICelera
Cytogenetic Map10q24NCBI
Shpk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546713,169,072 - 13,209,585 (+)NCBIChiLan1.0ChiLan1.0
SHPK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1173,654,237 - 3,683,422 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0173,657,764 - 3,686,791 (-)NCBIMhudiblu_PPA_v0panPan3
SHPK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1947,445,969 - 47,486,756 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Shpk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936677314,328 - 342,892 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHPK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11249,713,224 - 49,732,319 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21251,572,902 - 51,592,034 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SHPK
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,104,139 - 3,138,545 (-)NCBI
Shpk
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247866,271,636 - 6,296,872 (-)NCBI

Position Markers
AW260459  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381173,224,228 - 73,224,321UniSTSGRCm38
MGSCv371173,037,730 - 73,037,823UniSTSGRCm37
Celera1180,761,489 - 80,761,582UniSTS
Cytogenetic Map11B4UniSTS
Whitehead/MRC_RH11930.19UniSTS
AI194947  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381173,224,228 - 73,224,455UniSTSGRCm38
MGSCv371173,037,730 - 73,037,957UniSTSGRCm37
Celera1180,761,489 - 80,761,716UniSTS
Cytogenetic Map11B4UniSTS
Whitehead/MRC_RH11931.14UniSTS
UniSTS:236632  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381173,224,264 - 73,224,470UniSTSGRCm38
MGSCv371173,037,766 - 73,037,972UniSTSGRCm37
Celera1180,761,525 - 80,761,731UniSTS
Cytogenetic Map11B4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116718736579923086Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170800372104800540Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170800372104800540Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170800372104800540Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170800372104800540Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172128823106128908Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117231897084840636Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172835299106835463Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172927789106927907Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172927789106927907Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1621
Count of miRNA genes:535
Interacting mature miRNAs:682
Transcripts:ENSMUST00000006105, ENSMUST00000131927
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000006105   ⟹   ENSMUSP00000006105
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1173,199,460 - 73,224,511 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131927   ⟹   ENSMUSP00000123639
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1173,199,460 - 73,224,502 (+)Ensembl
RefSeq Acc Id: NM_029031   ⟹   NP_083307
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391173,090,308 - 73,115,332 (+)NCBI
GRCm381173,199,482 - 73,224,506 (+)NCBI
MGSCv371173,012,984 - 73,038,008 (+)RGD
Celera1180,736,568 - 80,761,767 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_003949525
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391173,090,153 - 73,115,337 (+)NCBI
GRCm381173,199,132 - 73,224,511 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_083307   ⟸   NM_029031
- UniProtKB: Q9D5J6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000006105   ⟸   ENSMUST00000006105
RefSeq Acc Id: ENSMUSP00000123639   ⟸   ENSMUST00000131927
Protein Domains
FGGY_N

Promoters
RGD ID:6822096
Promoter ID:MM_KWN:8362
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000013846,   OTTMUST00000013848,   OTTMUST00000013849,   OTTMUST00000013856,   OTTMUST00000013857,   UC007KAF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361173,012,441 - 73,013,167 (+)MPROMDB
RGD ID:8675484
Promoter ID:EPDNEW_M15773
Type:initiation region
Name:Shpk_1
Description:Mus musculus sedoheptulokinase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381173,199,460 - 73,199,520EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921887 AgrOrtholog
Ensembl Genes ENSMUSG00000005951 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000006105 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000123639 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000006105 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000131927 UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carb_kinase_FGGY_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHK UniProtKB/Swiss-Prot
KEGG Report mmu:74637 UniProtKB/Swiss-Prot
MGD MGI:1921887 ENTREZGENE
NCBI Gene 74637 ENTREZGENE
Pfam FGGY_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Shpk PhenoGen
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D6RJM2_MOUSE UniProtKB/TrEMBL
  Q9D5J6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5SSE0 UniProtKB/Swiss-Prot