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Gene: BCR (BCR activator of RhoGEF and GTPase) Homo sapiens
Symbol: BCR
Name: BCR activator of RhoGEF and GTPase
Description: Exhibits GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. Involved in several processes, including activation of GTPase activity; focal adhesion assembly; and keratinocyte differentiation. Localizes to protein-containing complex. Implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALL; BCR/FGFR1 chimera protein; BCR1; breakpoint cluster region; CML; D22S11; D22S662; FGFR1/BCR chimera protein; FLJ16453; PHL; renal carcinoma antigen NY-REN-26
Mus musculus (house mouse) : Bcr (BCR activator of RhoGEF and GTPase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bcr (BCR activator of RhoGEF and GTPase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bcr (BCR activator of RhoGEF and GTPase)
Pan paniscus (bonobo/pygmy chimpanzee) : BCR (BCR activator of RhoGEF and GTPase)
Canis lupus familiaris (dog) : BCR (BCR activator of RhoGEF and GTPase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bcr (BCR activator of RhoGEF and GTPase)
Sus scrofa (pig) : BCR (BCR activator of RhoGEF and GTPase)
Heterocephalus glaber (naked mole-rat) : Bcr (BCR activator of RhoGEF and GTPase)
more info ...
Related Pseudogenes: BCRP1   BCRP2   BCRP3   BCRP4   BCRP5   BCRP6   BCRP7   BCRP8   BCRP9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2223,179,704 - 23,318,037 (+)EnsemblGRCh38hg38GRCh38
GRCh382223,180,509 - 23,318,037 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372223,522,402 - 23,660,224 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362221,852,552 - 21,990,224 (+)NCBINCBI36hg18NCBI36
Build 342221,847,105 - 21,982,690NCBI
Celera227,337,083 - 7,474,738 (+)NCBI
Cytogenetic Map22q11.23ENTREZGENE
HuRef226,461,675 - 6,627,574 (+)NCBIHuRef
CHM1_12223,534,806 - 23,672,427 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on BCR
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317506
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.