Sh2d4a (SH2 domain containing 4A)

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Gene: Sh2d4a (SH2 domain containing 4A) Mus musculus

Analyze

Symbol:

Sh2d4a

Name:

SH2 domain containing 4A

RGD ID:

1317503

MGI Page

MGI

Description:

Predicted to have phosphatase binding activity. Predicted to be involved in negative regulation of phosphatase activity. Localizes to cytoplasm. Is expressed in medulla oblongata floor plate; metencephalon floor plate; and spinal cord floor plate. Orthologous to human SH2D4A (SH2 domain containing 4A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; Benzo[k]fluoranthene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

2210402M20Rik; SH; SH2 domain-containing protein 4A; SH2A

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SH2D4A (SH2 domain containing 4A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Sh2d4a (SH2 domain containing 4A)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Sh2d4a (SH2 domain containing 4A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SH2D4A (SH2 domain containing 4A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SH2D4A (SH2 domain containing 4A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sh2d4a (SH2 domain containing 4A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC100518097 (SH2 domain-containing protein 4A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	SH2D4A (SH2 domain containing 4A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sh2d4a (SH2 domain containing 4A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Sh2d4a (SH2 domain containing 4A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	SH2D4A (SH2 domain containing 4A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	sh2d4a (SH2 domain containing 4A)	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|Roundup\|TreeFam\|ZFIN)
Caenorhabditis elegans (roundworm):	F13B12.6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup)

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	68,729,180 - 68,800,356 (+)	NCBI	GRCm39		mm39
GRCm38	8	68,276,528 - 68,347,704 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	68,276,567 - 68,347,699 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	70,800,427 - 70,871,603 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	71,205,517 - 71,277,048 (+)	NCBI			mm8
Celera	8	70,819,013 - 70,892,695 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,3-dinitrobenzene (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,5-hexanedione (ISO)

2-hydroxypropanoic acid (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3H-1,2-dithiole-3-thione (ISO)

acrylamide (ISO)

benomyl (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

Benzo[k]fluoranthene (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

bromobenzene (ISO)

calcitriol (ISO)

chloroprene (EXP)

chromium(6+) (EXP)

cobalt dichloride (ISO)

cyclosporin A (ISO)

DDE (ISO)

dexamethasone (ISO)

dibutyl phthalate (ISO)

dorsomorphin (ISO)

flutamide (ISO)

indometacin (ISO)

leflunomide (ISO)

mercury dibromide (ISO)

N-ethyl-N-nitrosourea (EXP)

nefazodone (ISO)

nimesulide (ISO)

oxaliplatin (ISO)

paracetamol (ISO)

phenobarbital (EXP)

phenylmercury acetate (ISO)

pirinixic acid (EXP)

potassium chromate (ISO)

rac-lactic acid (ISO)

rotenone (ISO)

SB 431542 (ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

topotecan (ISO)

trichostatin A (ISO)

trimellitic anhydride (EXP)

troglitazone (EXP)

valproic acid (EXP,ISO)

vinclozolin (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of phosphatase activity (IBA,ISO)

Cellular Component

cytoplasm (IBA,IDA)

cytosol (ISO)

Molecular Function

phosphatase binding (IBA,ISO)

protein binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

no abnormal phenotype detected (IAGP)

References

References - curated


1.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	MGD and Homologene mouse data transfer
3.	MGD data from the GO Consortium
4.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5.	RGD automated import pipeline
6.	RGD automated import pipeline for gene-chemical interactions
7.	Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.

Additional References at PubMed

PMID:10349636	PMID:10922068	PMID:11042159	PMID:11076861	PMID:12477932	PMID:16141072	PMID:16141073	PMID:17251388	PMID:18641339	PMID:21267068	PMID:21677750	PMID:21873635

Genomics

Comparative Map Data

Sh2d4a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	68,729,180 - 68,800,356 (+)	NCBI	GRCm39		mm39
GRCm38	8	68,276,528 - 68,347,704 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	68,276,567 - 68,347,699 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	70,800,427 - 70,871,603 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	71,205,517 - 71,277,048 (+)	NCBI			mm8
Celera	8	70,819,013 - 70,892,695 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI

SH2D4A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	8	19,313,693 - 19,396,218 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	8	19,313,693 - 19,396,218 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	8	19,171,081 - 19,253,729 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	19,215,483 - 19,297,596 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	8	19,215,486 - 19,297,594	NCBI
Celera	8	18,134,620 - 18,217,068 (+)	NCBI
Cytogenetic Map	8	p21.3	NCBI
HuRef	8	17,711,708 - 17,794,051 (+)	NCBI		HuRef
CHM1_1	8	19,372,569 - 19,455,187 (+)	NCBI		CHM1_1

Sh2d4a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	16	23,084,247 - 23,156,825 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	23,083,954 - 23,156,962 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	22,972,707 - 23,044,750 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	22,957,569 - 23,027,864 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	16	22,957,570 - 23,027,862 (-)	NCBI
Celera	16	21,499,092 - 21,568,252 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

Sh2d4a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	43,111,804 - 43,170,397 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	43,111,804 - 43,170,344 (+)	NCBI	ChiLan1.0	ChiLan1.0

SH2D4A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	8	15,486,658 - 15,568,497 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	15,486,659 - 15,568,497 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	8	18,536,774 - 18,619,073 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

SH2D4A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	16	22,143,602 - 22,209,341 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	16	22,138,555 - 22,209,326 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Sh2d4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936555	3,572,723 - 3,634,484 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC100518097
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	17	12,506,451 - 12,588,526 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	10,284,074 - 10,325,874 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SH2D4A
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	17,401,254 - 17,484,141 (+)	NCBI
ChlSab1.1 Ensembl	8	17,406,951 - 17,484,839 (+)	Ensembl

Sh2d4a
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624758	15,132,580 - 15,195,063 (+)	NCBI

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1558870	Eae36_m	experimental allergic encephalomyelitis susceptibility 36 (mouse)			Not determined		8	14723160	71045600	Mouse
1357811	Orq3_m	ovulation rate QTL 3 (mouse)			Not determined		8	32016544	71287993	Mouse
4141437	W10q14_m	weight 10 weeks QTL 14 (mouse)			Not determined			32016544	71287993	Mouse
4141172	W6q9_m	weight 6 weeks QTL 9 (mouse)			Not determined			32016544	71287993	Mouse
4140966	Egq12_m	early growth QTL 12 (mouse)			Not determined			32016544	71287993	Mouse
4140967	Bmd39_m	bone mineral density 39 (mouse)			Not determined		8	32016544	117238700	Mouse
1558875	Eae31_m	experimental allergic encephalomyelitis susceptibility 31 (mouse)			Not determined		8	34642776	114837007	Mouse
1301013	Capsq4_m	capsaicin sensitivity related QTL 4 (mouse)			Not determined		8	36163000	92728652	Mouse
27226754	Femd6_m	femur midshaft diameter 6, 10 week (mouse)					8	37400000	109600000	Mouse
12904744	Carcdq1_m	cardiac collagen deposition QTL 1 (mouse)					8	39709256	94689598	Mouse
1301544	Iba3_m	induction of brown adipocytes 3 (mouse)			Not determined		8	44294880	78295025	Mouse
1301717	Adip4_m	adiposity 4 (mouse)			Not determined		8	47637030	81637146	Mouse
10766453	Char11_m	P. chabaudi malaria resistance QTL 11 (mouse)					8	47637030	81637146	Mouse
1301441	Skull11_m	skull morphology 11 (mouse)			Not determined		8	47737134	81737254	Mouse
1357715	Alaa3_m	alopecia areata 3 (mouse)			Not determined		8	48792939	82793021	Mouse
14746987	Manh64_m	mandible shape 64 (mouse)					8	50053306	84053306	Mouse
14747005	Mancz7_m	mandible centroid size 7 (mouse)					8	50053306	84053306	Mouse
14700686	Civq3_m	cerebral infarct volume QTL 3 (mouse)					8	51882191	85882191	Mouse
1301506	Aevm1_m	autoimmune extremity vasculitis in MRL mice 1 (mouse)			Not determined		8	54287817	88287993	Mouse
1301952	Im3_m	immunoregulatory 3 (mouse)			Not determined		8	54706614	88706763	Mouse
10412287	Carg3_m	Candida albicans resistance gene 3 (mouse)			Not determined		8	55545028	89545028	Mouse
11353828	Gf7_m	gonadal fat pad weight 7 (mouse)					8	58201479	92201479	Mouse
10043975	Obq31_m	obesity QTL 31 (mouse)			Not determined		8	58409776	92409776	Mouse
1301688	Orch6_m	autoimmune orchitis resistance 6 (mouse)			Not determined		8	60786850	94786976	Mouse
4141285	Tgq18_m	triglyceride QTL 18 (mouse)			Not determined			63460107	97460107	Mouse
4141797	Skmw16_m	skeletal muscle weight 16 (mouse)			Not determined		8	63939547	97939696	Mouse
1357787	Vtbt5_m	vertebral trabecular bone trait 5 (mouse)			Not determined		8	65357768	99357920	Mouse
10043992	Hbnr11_m	Heligmosomoides bakeri nematode resistance 11 (mouse)			Not determined		8	65600207	99600347	Mouse
10766466	Char12_m	P. chabaudi malaria resistance QTL 12 (mouse)					8	68269827	82600347	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	346
Count of miRNA genes:	249
Interacting mature miRNAs:	289
Transcripts:	ENSMUST00000066594
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_028182	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006509751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC117740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC117792	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK008803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK157396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AX776203	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC023784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC116682	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000066594 ⟹ ENSMUSP00000070825

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	68,276,567 - 68,347,694 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000212166 ⟹ ENSMUSP00000148702

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	68,282,307 - 68,347,699 (+)	Ensembl

RefSeq Acc Id:

NM_028182 ⟹ NP_082458

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	68,729,180 - 68,800,356 (+)	NCBI
GRCm38	8	68,276,528 - 68,347,704 (+)	ENTREZGENE
MGSCv37	8	70,800,427 - 70,871,603 (+)	RGD
Celera	8	70,819,013 - 70,892,695 (+)	RGD
cM Map	8		ENTREZGENE

Sequence:

show sequence

ACTGTAGACAGCGCTCTAGATTAACCAAGGACTAGTGGCCTTGCTGTCACTGGACCAAGGCAGC
CAAGCTTGCCTACTGGCCCTGGAGCGCCTCCAGCACCCGGGTGGGGCCTTGAGGGAGCGCCCAG
TCAGTCACCCCAGCATGTGGGCGCGGCGGGGCGGGCCAGGGCTGCGATCTGGACGCTGAGTGTC
CTTCTGGTCCCGAGTGTTTGTCCAGACAGCCCGCGCGGCTGGGTCTCTGGGAGGCTGGGTCTCT
GCTTGTCCTCCCTTCTCTTCCCGGACAGTTGCTGTAGGCAATCTGGAGGTGGCAGGTGCTTGGG
TCACCTTGCTCCGGGTACTGAGCAGGTTTGTCCATATTTACCGAGCAGCATTTACTACAGATAC
AGCTCTGCTGAATTCCTGCAGTGAGAGTCATCATTTCTGGGCTGGTCAAGTCTCTGCAAAGGTG
CAGCAGTGCCCGAGCTCCTGGCTGCTGGTAGCAAACCGGCAAGTGGTTTCCAAGAACTTCTGCT
GTAGGTGGAGAAGTTCCTGTGAGCAGCAAAGATGCTGAGGCAGATACTGTCAGATATGTTCATA
GACCCTGACCTGCTGGCAGAGCTCAGCGAAGAGCAGAAACAGATCTTGTTCTACAAGATGAGAG
AGGAACAGATCCGACGATGGAAAGAAAGAGAAGCGGCCATGGAAAGAAAGGAGTCCTTGCCAGT
GAAATCCAGGCCAAAAAAAGAGAATGGCAAGTCTGTCCATTGGAAGCTGGGCGCCGATAAGCAG
GTGTGGGTTTGGGTAATGGGCGAGCACCATCTGGACAAACCCTATGATGTGCTGTGTGATGAGA
TCCTTGCGGAGAGGGAGCATCTGAGAGCAGCGAAGGATTCAGAGCTCAGGAAAACTCAGTCTCT
AGAACTCGCCAATAGCTTAAAAATAAAGTCACAGAACTGTGATCTGCAAGCAATGAAGAAGACA
GAGCCTCAGAATGTCACCAGGAAAGCAGCTTCAGAAGAGGCATCAGGTCAAGGACCCAGAGCAA
TACCAACCAGGAAGGATGACAAAGCCCAAACTAAACCCGTCAAGGAAAAAGACCACGAGGAAAT
GAAGCAGACAGAGGATGAGAAAACCAAGCAGATATACAAGAGCTGGAAAGAAGACTCAGAATGG
CAAGCATCTCTGCGAAAATCTAAGGCGGCTGATGAGAAGAGACGCTCTTTAGCTAAACAAGCAC
GGGAAGACTACAAGAGGCTATCCCAAAGGGGGAGGAGTGGGGACGGACTGCAGAACCCACTGAC
AGGTCCACAGAAGCCCAGAAGACCTCCTCTTCCTCCGAAGCCCCAGTTCCTACAGCCGCTGGGA
ATCCCTCCAAAGTCTTTAGGGAATCAGGGGGTGATAAGGACCGAGATCAGCTCCGCCCAGATGG
ACACCATTCGATGGTTCAAAGAGGAACAGTTGCCATTCCGTGCAGGTTACCAGAAAAACTCAGA
CACCATTGCTCCTTGGTTCCATGGGATTCTCACACTGAAGAAAGCAAATGAACTTCTGAGCACA
GGTGTGCCGGGAAGTTTTTTGATTCGAGTCAGTGAAAAGATCAAGGGCTATGCCCTGTCCTACC
TGTCTGAGGAAGGCTGCAAACATTTCCTTATAGATGCATCTGCCAACTCTTACAGCTTCCTGGG
TGTGGACCAGCTGCAGCATGCTACACTGGCAGATTTGGTGGAATATCACAAGGAGGAGCCCATA
ACCTCTCTGGGGAAGGAACTCCTTCTGTACCCCTGTGGTCAACAAGACAAGCTGCCCGACTACC
TGGAGCTCTTCCAGTGACAACTCTCATCCAGATCAGCCTCCAACTTCCAGCTGGTTTCCCCTCT
GGACAGACACCTCTGAGATGGACATTTGTGTGTGATGCCAAAATCTCTCTGTGACAGAGCCAAC
AGTGAACAACGTCTGAGGTCTTCATTGAAACCTCTCTTCTGCATAAATGCTGGATTCAGTTTAA
GGGGGTGTTACCTCTCTCTCATCCTCATTCTGAAAGGAAAAGGGGGAAGGTACCCACATTTGCA
ACATCCTAATATGAAGGATAGGACCTTGAAGGATATGACCATGATGATGTATATAAGATAAAAA
GGACAAGGGTACACTGAAATCTTTTTAGCAATTAAGATGTTATTTTAAAAGAACAAGTGAACAA
TTTCATGATCTACACACTCCCTTTTTGTTATTCACTCAAAGGTCTCAGTATTCTGTGTGTATAA
ATTTTTATCTTGCTTTTAGAATGGTGGAAAAATGTCCCCACTGAGGGATGAGATTATCTTCAAA
AGACCACCCTTTCTGTGTCTGTTGGAGTGAGGTTATAGAAGACAGAAGAGAAAGACCCAAGTGT
AAATTGAAAGACAAGTTTCAAAACTTGAGATGAGAGACTTACCACATATGAAAAAAACCAACCA
ACCAACCAAAGGTTTTATTGTGACAGTAACCCTGAGTGTGATGGTTTGAATATGCTTGGCCCAC
AGGGAGTGGTAGTATTAGGAGGTGTGGCCTTGTTGGAGGAGGTGTGGCTTTGTTGGAAGAAGTG
TGTCACTGTGGGGGTGGGCTTTGAGACCCTCCTCCTAGCTGCCTGAGAGATTCAGTCTTCTGGT
TCCCTTCGGAAGAAGATGCAGAACTCTCAGCTCCTCCTCTGCCATTCCTGTCTGGAAAATGCCG
CGCTCCTGCCTTGATTATAAAGGACTGAAACTCTGAAGCTGTAAGCCAGCCCCAATTAAATGTT
TTTCTTTAAAGAGTT

hide sequence

RefSeq Acc Id:

XM_006509751 ⟹ XP_006509814

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	68,729,532 - 68,800,356 (+)	NCBI
GRCm38	8	68,276,886 - 68,347,704 (+)	NCBI

Sequence:

show sequence

TCGGGTAAAACGCTGGAGCATGGAGCCAGGCAGAAGGGTGAGCGAGGAGTGGGAACCAGCAGGT
TTGTCCATATTTACCGAGCAGCATTTACTACAGATACAGCTCTGCTGAATTCCTGCAGTGAGAG
TCATCATTTCTGGGCTGGTCAAGTCTCTGCAAAGGTGCAGCAGTGCCCGAGCTCCTGGCTGCTG
GTAGCAAACCGGCAAGTGGTTTCCAAGAACTTCTGCTGTAGGTGGAGAAGTTCCTGTGAGCAGC
AAAGATGCTGAGGCAGATACTGTCAGATATGTTCATAGACCCTGACCTGCTGGCAGAGCTCAGC
GAAGAGCAGAAACAGATCTTGTTCTACAAGATGAGAGAGGAACAGATCCGACGATGGAAAGAAA
GAGAAGCGGCCATGGAAAGAAAGGAGTCCTTGCCAGTGAAATCCAGGCCAAAAAAAGAGAATGG
CAAGTCTGTCCATTGGAAGCTGGGCGCCGATAAGCAGGTGTGGGTTTGGGTAATGGGCGAGCAC
CATCTGGACAAACCCTATGATGTGCTGTGTGATGAGATCCTTGCGGAGAGGGAGCATCTGAGAG
CAGCGAAGGATTCAGAGCTCAGGAAAACTCAGTCTCTAGAACTCGCCAATAGCTTAAAAATAAA
GTCACAGAACTGTGATCTGCAAGCAATGAAGAAGACAGAGCCTCAGAATGTCACCAGGAAAGCA
GCTTCAGAAGAGGCATCAGGTCAAGGACCCAGAGCAATACCAACCAGGAAGGATGACAAAGCCC
AAACTAAACCCGTCAAGGAAAAAGACCACGAGGAAATGAAGCAGACAGAGGATGAGAAAACCAA
GCAGATATACAAGAGCTGGAAAGAAGACTCAGAATGGCAAGCATCTCTGCGAAAATCTAAGGCG
GCTGATGAGAAGAGACGCTCTTTAGCTAAACAAGCACGGGAAGACTACAAGAGGCTATCCCAAA
GGGGGAGGAGTGGGGACGGACTGCAGAACCCACTGACAGGTCCACAGAAGCCCAGAAGACCTCC
TCTTCCTCCGAAGCCCCAGTTCCTACAGCCGCTGGGAATCCCTCCAAAGTCTTTAGGGAATCAG
GGGGTGATAAGGACCGAGATCAGCTCCGCCCAGATGGACACCATTCGATGGTTCAAAGAGGAAC
AGTTGCCATTCCGTGCAGGTTACCAGAAAAACTCAGACACCATTGCTCCTTGGTTCCATGGGAT
TCTCACACTGAAGAAAGCAAATGAACTTCTGAGCACAGGTGTGCCGGGAAGTTTTTTGATTCGA
GTCAGTGAAAAGATCAAGGGCTATGCCCTGTCCTACCTGTCTGAGGAAGGCTGCAAACATTTCC
TTATAGATGCATCTGCCAACTCTTACAGCTTCCTGGGTGTGGACCAGCTGCAGCATGCTACACT
GGCAGATTTGGTGGAATATCACAAGGAGGAGCCCATAACCTCTCTGGGGAAGGAACTCCTTCTG
TACCCCTGTGGTCAACAAGACAAGCTGCCCGACTACCTGGAGCTCTTCCAGTGACAACTCTCAT
CCAGATCAGCCTCCAACTTCCAGCTGGTTTCCCCTCTGGACAGACACCTCTGAGATGGACATTT
GTGTGTGATGCCAAAATCTCTCTGTGACAGAGCCAACAGTGAACAACGTCTGAGGTCTTCATTG
AAACCTCTCTTCTGCATAAATGCTGGATTCAGTTTAAGGGGGTGTTACCTCTCTCTCATCCTCA
TTCTGAAAGGAAAAGGGGGAAGGTACCCACATTTGCAACATCCTAATATGAAGGATAGGACCTT
GAAGGATATGACCATGATGATGTATATAAGATAAAAAGGACAAGGGTACACTGAAATCTTTTTA
GCAATTAAGATGTTATTTTAAAAGAACAAGTGAACAATTTCATGATCTACACACTCCCTTTTTG
TTATTCACTCAAAGGTCTCAGTATTCTGTGTGTATAAATTTTTATCTTGCTTTTAGAATGGTGG
AAAAATGTCCCCACTGAGGGATGAGATTATCTTCAAAAGACCACCCTTTCTGTGTCTGTTGGAG
TGAGGTTATAGAAGACAGAAGAGAAAGACCCAAGTGTAAATTGAAAGACAAGTTTCAAAACTTG
AGATGAGAGACTTACCACATATGAAAAAAACCAACCAACCAACCAAAGGTTTTATTGTGACAGT
AACCCTGAGTGTGATGGTTTGAATATGCTTGGCCCACAGGGAGTGGTAGTATTAGGAGGTGTGG
CCTTGTTGGAGGAGGTGTGGCTTTGTTGGAAGAAGTGTGTCACTGTGGGGGTGGGCTTTGAGAC
CCTCCTCCTAGCTGCCTGAGAGATTCAGTCTTCTGGTTCCCTTCGGAAGAAGATGCAGAACTCT
CAGCTCCTCCTCTGCCATTCCTGTCTGGAAAATGCCGCGCTCCTGCCTTGATTATAAAGGACTG
AAACTCTGAAGCTGTAAGCCAGCCCCAATTAAATGTTTTTCTTTAAAGAGTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_082458	(Get FASTA)	NCBI Sequence Viewer
	XP_006509814	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI16683	(Get FASTA)	NCBI Sequence Viewer
	BAB25905	(Get FASTA)	NCBI Sequence Viewer
	CAE11720	(Get FASTA)	NCBI Sequence Viewer
	Q9D7V1	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_082458 ⟸ NM_028182

- UniProtKB:

Q9D7V1 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MLRQILSDMFIDPDLLAELSEEQKQILFYKMREEQIRRWKEREAAMERKESLPVKSRPKKENGK
SVHWKLGADKQVWVWVMGEHHLDKPYDVLCDEILAEREHLRAAKDSELRKTQSLELANSLKIKS
QNCDLQAMKKTEPQNVTRKAASEEASGQGPRAIPTRKDDKAQTKPVKEKDHEEMKQTEDEKTKQ
IYKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSQRGRSGDGLQNPLTGPQKPRRPPL
PPKPQFLQPLGIPPKSLGNQGVIRTEISSAQMDTIRWFKEEQLPFRAGYQKNSDTIAPWFHGIL
TLKKANELLSTGVPGSFLIRVSEKIKGYALSYLSEEGCKHFLIDASANSYSFLGVDQLQHATLA
DLVEYHKEEPITSLGKELLLYPCGQQDKLPDYLELFQ

hide sequence

RefSeq Acc Id:	XP_006509814 ⟸ XM_006509751
- Peptide Label:	isoform X1
- UniProtKB:	Q9D7V1 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLRQILSDMFIDPDLLAELSEEQKQILFYKMREEQIRRWKEREAAMERKESLPVKSRPKKENGK SVHWKLGADKQVWVWVMGEHHLDKPYDVLCDEILAEREHLRAAKDSELRKTQSLELANSLKIKS QNCDLQAMKKTEPQNVTRKAASEEASGQGPRAIPTRKDDKAQTKPVKEKDHEEMKQTEDEKTKQ IYKSWKEDSEWQASLRKSKAADEKRRSLAKQAREDYKRLSQRGRSGDGLQNPLTGPQKPRRPPL PPKPQFLQPLGIPPKSLGNQGVIRTEISSAQMDTIRWFKEEQLPFRAGYQKNSDTIAPWFHGIL TLKKANELLSTGVPGSFLIRVSEKIKGYALSYLSEEGCKHFLIDASANSYSFLGVDQLQHATLA DLVEYHKEEPITSLGKELLLYPCGQQDKLPDYLELFQ hide sequence

RefSeq Acc Id:

ENSMUSP00000070825 ⟸ ENSMUST00000066594

RefSeq Acc Id:

ENSMUSP00000148702 ⟸ ENSMUST00000212166

Protein Domains

SH2

Promoters

RGD ID:

8667205

Promoter ID:

EPDNEW_M11633

Type:

initiation region

Name:

Sh2d4a_2

Description:

Mus musculus SH2 domain containing 4A , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M11634

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	8	68,276,575 - 68,276,635	EPDNEW

RGD ID:

8667207

Promoter ID:

EPDNEW_M11634

Type:

multiple initiation site

Name:

Sh2d4a_1

Description:

Mus musculus SH2 domain containing 4A , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M11633

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	8	68,276,731 - 68,276,791	EPDNEW

RGD ID:

6843709

Promoter ID:

MM_KWN:54584

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Kidney, Liver, Lung

Transcripts:

NM_028182

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	8	70,800,356 - 70,800,856 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1919531	AgrOrtholog
Ensembl Genes	ENSMUSG00000053886	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000070825	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUSP00000148702	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000066594	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUST00000212166	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:72281	UniProtKB/Swiss-Prot
MGD	MGI:1919531	ENTREZGENE
NCBI Gene	72281	ENTREZGENE
Pfam	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Sh2d4a	PhenoGen
PRINTS	SH2DOMAIN	UniProtKB/Swiss-Prot
PROSITE	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF55550	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene	Mm.40974	ENTREZGENE
UniProt	A0A1D5RMA9_MOUSE	UniProtKB/TrEMBL
	Q9D7V1	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q14AV2	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)