GLRX2 (glutaredoxin 2) - Rat Genome Database
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Gene: GLRX2 (glutaredoxin 2) Homo sapiens
Analyze
Symbol: GLRX2
Name: glutaredoxin 2
RGD ID: 1317443
HGNC Page HGNC
Description: Predicted to have arsenate reductase (glutaredoxin) activity; glutathione disulfide oxidoreductase activity; and protein disulfide isomerase activity. Involved in response to hydrogen peroxide and response to organic substance. Localizes to mitochondrion and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bA101E13.1; bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2); CGI-133; glutaredoxin (thioltransferase) 2; glutaredoxin-2, mitochondrial; GRX2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1193,090,866 - 193,106,114 (-)EnsemblGRCh38hg38GRCh38
GRCh381193,096,465 - 193,106,114 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371193,065,595 - 193,075,659 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361191,332,223 - 191,341,867 (-)NCBINCBI36hg18NCBI36
Build 341189,797,256 - 189,806,213NCBI
Celera1166,175,205 - 166,184,851 (-)NCBI
Cytogenetic Map1q31.2NCBI
HuRef1164,301,400 - 164,311,051 (-)NCBIHuRef
CHM1_11194,487,507 - 194,497,577 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889549   PMID:9325327   PMID:10810093   PMID:11297543   PMID:11329013   PMID:11397793   PMID:12477932   PMID:14503974   PMID:14676218   PMID:14713336   PMID:15146197   PMID:15184054  
PMID:15297967   PMID:15328416   PMID:15489334   PMID:15649413   PMID:15917333   PMID:16112873   PMID:16246122   PMID:16710414   PMID:16712839   PMID:17065220   PMID:17115894   PMID:17121859  
PMID:17355958   PMID:17546662   PMID:17680760   PMID:17961515   PMID:18029348   PMID:18092940   PMID:18816065   PMID:19038292   PMID:19119916   PMID:19184988   PMID:19216714   PMID:19290777  
PMID:19292455   PMID:19383853   PMID:19723146   PMID:20064440   PMID:20547138   PMID:20829229   PMID:20877624   PMID:20929858   PMID:21029046   PMID:21437321   PMID:21586322   PMID:21735102  
PMID:22139372   PMID:23824909   PMID:24295294   PMID:25735211   PMID:26344197   PMID:27503909   PMID:28618115   PMID:29101900   PMID:29568061   PMID:31168542   PMID:32296183  


Genomics

Comparative Map Data
GLRX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1193,090,866 - 193,106,114 (-)EnsemblGRCh38hg38GRCh38
GRCh381193,096,465 - 193,106,114 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371193,065,595 - 193,075,659 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361191,332,223 - 191,341,867 (-)NCBINCBI36hg18NCBI36
Build 341189,797,256 - 189,806,213NCBI
Celera1166,175,205 - 166,184,851 (-)NCBI
Cytogenetic Map1q31.2NCBI
HuRef1164,301,400 - 164,311,051 (-)NCBIHuRef
CHM1_11194,487,507 - 194,497,577 (-)NCBICHM1_1
Glrx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,614,787 - 143,625,416 (+)NCBIGRCm39mm39
GRCm381143,739,224 - 143,749,678 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,716,338 - 143,749,676 (+)EnsemblGRCm38mm10GRCm38
MGSCv371145,586,479 - 145,596,808 (+)NCBIGRCm37mm9NCBIm37
MGSCv361145,501,567 - 145,511,896 (+)NCBImm8
Celera1146,314,372 - 146,324,701 (+)NCBICelera
Cytogenetic Map1FNCBI
cM Map162.53NCBI
Glrx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01360,529,057 - 60,552,115 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,529,932 - 60,537,916 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01365,517,621 - 65,540,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41357,567,017 - 57,589,873 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11357,581,096 - 57,603,951 (+)NCBI
Celera1355,569,577 - 55,592,422 (+)NCBICelera
Cytogenetic Map13q21NCBI
Glrx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540630,497,562 - 30,509,340 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540630,497,562 - 30,506,463 (-)NCBIChiLan1.0ChiLan1.0
GLRX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11172,848,858 - 172,859,970 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,849,013 - 172,859,062 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01168,555,858 - 168,565,949 (-)NCBIMhudiblu_PPA_v0panPan3
GLRX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl385,964,039 - 5,971,676 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1385,963,800 - 5,971,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Glrx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366381,325,076 - 1,333,994 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLRX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.110679,305 - 689,890 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GLRX2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12536,318,894 - 36,328,567 (+)NCBI
ChlSab1.1 Ensembl2536,319,637 - 36,328,417 (+)Ensembl
Glrx2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624814481,981 - 505,052 (+)NCBI

Position Markers
SHGC-32745  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371193,066,754 - 193,066,888UniSTSGRCh37
Build 361191,333,377 - 191,333,511RGDNCBI36
Celera1166,176,359 - 166,176,493RGD
Cytogenetic Map1q31.2UniSTS
HuRef1164,302,559 - 164,302,693UniSTS
TNG Radiation Hybrid Map193296.0UniSTS
GeneMap99-GB4 RH Map1648.58UniSTS
Whitehead-RH Map1809.2UniSTS
NCBI RH Map11596.8UniSTS
GeneMap99-G3 RH Map17508.0UniSTS
SHGC-146669  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371193,074,777 - 193,075,048UniSTSGRCh37
Build 361191,341,400 - 191,341,671RGDNCBI36
Celera1166,184,382 - 166,184,653RGD
Cytogenetic Map1q31.2UniSTS
HuRef1164,310,582 - 164,310,853UniSTS
TNG Radiation Hybrid Map193284.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:60
Interacting mature miRNAs:60
Transcripts:ENST00000367439, ENST00000367440, ENST00000472197
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1130 1259 519 255 662 234 2244 1272 1267 205 968 588 35 658 1459 2
Low 1302 1710 1204 367 1274 230 2111 917 2441 212 482 1020 136 546 1329 2
Below cutoff 15 1 11 4 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001243399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_197962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA056513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AA887118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF132495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF151891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF290514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY038988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG182176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM887926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ432881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU157087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN362908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ194815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB874295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB874309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB874850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB874864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB881206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB881220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB882353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB882367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB890952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB890966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB892776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB892790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB894074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB894088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB895424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB895438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB903255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB903269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC931704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC931718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC932259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC932273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC938615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC938629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC939762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC939776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC948361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC948375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC950185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC950199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC951483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC951497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC952833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC952847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC960664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC960678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000367439   ⟹   ENSP00000356409
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1193,096,468 - 193,105,431 (-)Ensembl
RefSeq Acc Id: ENST00000367440   ⟹   ENSP00000356410
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1193,096,468 - 193,106,114 (-)Ensembl
RefSeq Acc Id: ENST00000472197
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1193,096,667 - 193,106,057 (-)Ensembl
RefSeq Acc Id: ENST00000608166   ⟹   ENSP00000494652
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1193,090,866 - 193,105,433 (-)Ensembl
RefSeq Acc Id: NM_001243399   ⟹   NP_001230328
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381193,096,470 - 193,106,057 (-)NCBI
GRCh371193,065,595 - 193,075,659 (-)NCBI
HuRef1164,301,400 - 164,311,051 (-)NCBI
CHM1_11194,487,507 - 194,497,099 (-)NCBI
Sequence:
RefSeq Acc Id: NM_016066   ⟹   NP_057150
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381193,096,465 - 193,106,114 (-)NCBI
GRCh371193,065,595 - 193,075,659 (-)NCBI
Build 361191,332,224 - 191,341,867 (-)NCBI Archive
HuRef1164,301,400 - 164,311,051 (-)NCBI
CHM1_11194,487,507 - 194,497,156 (-)NCBI
Sequence:
RefSeq Acc Id: NM_197962   ⟹   NP_932066
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381193,096,470 - 193,105,414 (-)NCBI
GRCh371193,065,595 - 193,075,659 (-)NCBI
Build 361191,332,223 - 191,341,179 (-)NCBI Archive
HuRef1164,301,400 - 164,311,051 (-)NCBI
CHM1_11194,487,507 - 194,496,520 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001230328 (Get FASTA)   NCBI Sequence Viewer  
  NP_057150 (Get FASTA)   NCBI Sequence Viewer  
  NP_932066 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD34128 (Get FASTA)   NCBI Sequence Viewer  
  AAF37320 (Get FASTA)   NCBI Sequence Viewer  
  AAH09669 (Get FASTA)   NCBI Sequence Viewer  
  AAH28113 (Get FASTA)   NCBI Sequence Viewer  
  AAK72499 (Get FASTA)   NCBI Sequence Viewer  
  AAK83089 (Get FASTA)   NCBI Sequence Viewer  
  ABA03170 (Get FASTA)   NCBI Sequence Viewer  
  CBF61391 (Get FASTA)   NCBI Sequence Viewer  
  CBF61398 (Get FASTA)   NCBI Sequence Viewer  
  CBF61800 (Get FASTA)   NCBI Sequence Viewer  
  CBF61807 (Get FASTA)   NCBI Sequence Viewer  
  CBF64885 (Get FASTA)   NCBI Sequence Viewer  
  CBF64892 (Get FASTA)   NCBI Sequence Viewer  
  CBF65449 (Get FASTA)   NCBI Sequence Viewer  
  CBF65456 (Get FASTA)   NCBI Sequence Viewer  
  CBF69768 (Get FASTA)   NCBI Sequence Viewer  
  CBF69783 (Get FASTA)   NCBI Sequence Viewer  
  CBF71621 (Get FASTA)   NCBI Sequence Viewer  
  CBF71635 (Get FASTA)   NCBI Sequence Viewer  
  CBF72937 (Get FASTA)   NCBI Sequence Viewer  
  CBF72952 (Get FASTA)   NCBI Sequence Viewer  
  CBF74264 (Get FASTA)   NCBI Sequence Viewer  
  CBF74280 (Get FASTA)   NCBI Sequence Viewer  
  CBF82314 (Get FASTA)   NCBI Sequence Viewer  
  CBF82330 (Get FASTA)   NCBI Sequence Viewer  
  CBU86419 (Get FASTA)   NCBI Sequence Viewer  
  CBU86426 (Get FASTA)   NCBI Sequence Viewer  
  CBU86676 (Get FASTA)   NCBI Sequence Viewer  
  CBU86683 (Get FASTA)   NCBI Sequence Viewer  
  CBU89756 (Get FASTA)   NCBI Sequence Viewer  
  CBU89763 (Get FASTA)   NCBI Sequence Viewer  
  CBU90320 (Get FASTA)   NCBI Sequence Viewer  
  CBU90327 (Get FASTA)   NCBI Sequence Viewer  
  CBU94419 (Get FASTA)   NCBI Sequence Viewer  
  CBU94426 (Get FASTA)   NCBI Sequence Viewer  
  CBU95298 (Get FASTA)   NCBI Sequence Viewer  
  CBU95305 (Get FASTA)   NCBI Sequence Viewer  
  CBU95927 (Get FASTA)   NCBI Sequence Viewer  
  CBU95934 (Get FASTA)   NCBI Sequence Viewer  
  CBU96576 (Get FASTA)   NCBI Sequence Viewer  
  CBU96583 (Get FASTA)   NCBI Sequence Viewer  
  CBV00324 (Get FASTA)   NCBI Sequence Viewer  
  CBV00331 (Get FASTA)   NCBI Sequence Viewer  
  EAW91248 (Get FASTA)   NCBI Sequence Viewer  
  EAW91249 (Get FASTA)   NCBI Sequence Viewer  
  Q9NS18 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_932066   ⟸   NM_197962
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9NS18 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_057150   ⟸   NM_016066
- Peptide Label: isoform 1
- UniProtKB: Q9NS18 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001230328   ⟸   NM_001243399
- Peptide Label: isoform 3
- UniProtKB: Q9NS18 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000356410   ⟸   ENST00000367440
RefSeq Acc Id: ENSP00000356409   ⟸   ENST00000367439
RefSeq Acc Id: ENSP00000494652   ⟸   ENST00000608166
Protein Domains
Glutaredoxin

Promoters
RGD ID:6785647
Promoter ID:HG_KWN:6633
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000086699,   OTTHUMT00000086700,   OTTHUMT00000086701
Position:
Human AssemblyChrPosition (strand)Source
Build 361191,340,921 - 191,341,421 (-)MPROMDB
RGD ID:6858440
Promoter ID:EPDNEW_H2385
Type:initiation region
Name:GLRX2_1
Description:glutaredoxin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2386  EPDNEW_H2387  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381193,105,414 - 193,105,474EPDNEW
RGD ID:6858442
Promoter ID:EPDNEW_H2386
Type:multiple initiation site
Name:GLRX2_2
Description:glutaredoxin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2385  EPDNEW_H2387  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381193,106,052 - 193,106,112EPDNEW
RGD ID:6858444
Promoter ID:EPDNEW_H2387
Type:initiation region
Name:GLRX2_3
Description:glutaredoxin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2385  EPDNEW_H2386  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381193,115,708 - 193,115,768EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11
pathogenic
GRCh38/hg38 1q25.2-32.1(chr1:179032905-199724897)x1 copy number loss See cases [RCV000053948] Chr1:179032905..199724897 [GRCh38]
Chr1:179002040..199694025 [GRCh37]
Chr1:177268663..197960648 [NCBI36]
Chr1:1q25.2-32.1
pathogenic
GRCh38/hg38 1q31.2(chr1:192567876-193180049)x1 copy number loss See cases [RCV000053950] Chr1:192567876..193180049 [GRCh38]
Chr1:192537006..193149179 [GRCh37]
Chr1:190803629..191415802 [NCBI36]
Chr1:1q31.2
pathogenic
GRCh38/hg38 1q25.2-31.3(chr1:176595962-196301688)x1 copy number loss See cases [RCV000134144] Chr1:176595962..196301688 [GRCh38]
Chr1:176565098..196270818 [GRCh37]
Chr1:174831721..194537441 [NCBI36]
Chr1:1q25.2-31.3
pathogenic
GRCh38/hg38 1q31.1-32.1(chr1:189034483-199615866)x1 copy number loss See cases [RCV000135590] Chr1:189034483..199615866 [GRCh38]
Chr1:189003614..199584994 [GRCh37]
Chr1:187270237..197851617 [NCBI36]
Chr1:1q31.1-32.1
pathogenic
Single allele deletion Hyperparathyroidism 1 [RCV000677958] Chr1:191919194..194615758 [GRCh38]
Chr1:191888324..194584888 [GRCh37]
Chr1:1q31.2-31.3
pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179413479-201764737)x1 copy number loss See cases [RCV000445748] Chr1:179413479..201764737 [GRCh37]
Chr1:1q25.2-32.1
pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179073386-200192265)x1 copy number loss See cases [RCV000448809] Chr1:179073386..200192265 [GRCh37]
Chr1:1q25.2-32.1
pathogenic
GRCh37/hg19 1q24.3-31.3(chr1:171990029-195086758)x1 copy number loss See cases [RCV000448686] Chr1:171990029..195086758 [GRCh37]
Chr1:1q24.3-31.3
pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179011314-199022759)x1 copy number loss See cases [RCV000512128] Chr1:179011314..199022759 [GRCh37]
Chr1:1q25.2-32.1
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41
pathogenic
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44
pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:177551193-199599056)x1 copy number loss not provided [RCV001005157] Chr1:177551193..199599056 [GRCh37]
Chr1:1q25.2-32.1
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16065 AgrOrtholog
COSMIC GLRX2 COSMIC
Ensembl Genes ENSG00000023572 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000356409 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000356410 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000494652 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000367439 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000367440 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000608166 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000023572 GTEx
HGNC ID HGNC:16065 ENTREZGENE
Human Proteome Map GLRX2 Human Proteome Map
InterPro Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin_euk/vir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin_subgr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:51022 UniProtKB/Swiss-Prot
NCBI Gene 51022 ENTREZGENE
OMIM 606820 OMIM
Pfam Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28732 PharmGKB
PRINTS GLUTAREDOXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUTAREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs GRX_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.458283 ENTREZGENE
UniProt A0JLT0_HUMAN UniProtKB/TrEMBL
  GLRX2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3LR69 UniProtKB/Swiss-Prot
  Q7L1N7 UniProtKB/Swiss-Prot
  Q96JC0 UniProtKB/Swiss-Prot
  Q9Y3D4 UniProtKB/Swiss-Prot