Paip2b (poly(A) binding protein interacting protein 2B) - Rat Genome Database
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Gene: Paip2b (poly(A) binding protein interacting protein 2B) Mus musculus
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Symbol: Paip2b
Name: poly(A) binding protein interacting protein 2B
RGD ID: 1317410
MGI Page MGI
Description: Predicted to have poly(A) binding activity and translation repressor activity, mRNA regulatory element binding. Predicted to be involved in negative regulation of translational initiation. Predicted to localize to cytoplasm. Is expressed in embryo. Orthologous to human PAIP2B (poly(A) binding protein interacting protein 2B); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC27648; MGC49717; PABP-interacting protein 2B; PAIP-2B; poly(A)-binding protein-interacting protein 2B; polyadenylate-binding protein-interacting protein 2B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm12604  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,783,040 - 83,808,723 (-)NCBIGRCm39mm39
GRCm38683,806,058 - 83,831,741 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,805,401 - 83,831,741 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,756,052 - 83,781,735 (-)NCBIGRCm37mm9NCBIm37
MGSCv36683,771,721 - 83,797,322 (-)NCBImm8
Celera685,789,017 - 85,814,725 (-)NCBICelera
Cytogenetic Map6C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

References - curated
1. RGD automated import pipeline
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15368895   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:16804161   PMID:18799693   PMID:20739757   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22190698   PMID:23622065  


Genomics

Comparative Map Data
Paip2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,783,040 - 83,808,723 (-)NCBIGRCm39mm39
GRCm38683,806,058 - 83,831,741 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,805,401 - 83,831,741 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,756,052 - 83,781,735 (-)NCBIGRCm37mm9NCBIm37
MGSCv36683,771,721 - 83,797,322 (-)NCBImm8
Celera685,789,017 - 85,814,725 (-)NCBICelera
Cytogenetic Map6C3NCBI
PAIP2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl271,182,738 - 71,227,103 (-)EnsemblGRCh38hg38GRCh38
GRCh38271,182,738 - 71,227,110 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37271,409,868 - 71,454,233 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36271,263,376 - 71,307,741 (-)NCBINCBI36hg18NCBI36
Celera271,260,574 - 71,304,932 (-)NCBI
Cytogenetic Map2p13.3NCBI
HuRef271,146,532 - 71,191,204 (-)NCBIHuRef
CHM1_1271,339,205 - 71,383,545 (-)NCBICHM1_1
Paip2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24116,291,376 - 116,323,422 (-)NCBI
Rnor_6.0 Ensembl4115,487,313 - 115,516,296 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04115,484,676 - 115,516,307 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04180,073,880 - 180,105,043 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44118,003,247 - 118,032,312 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14118,247,727 - 118,276,790 (-)NCBI
Celera4105,284,575 - 105,315,731 (-)NCBICelera
Cytogenetic Map4q34NCBI
Paip2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542414,156,768 - 14,190,865 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542414,157,358 - 14,190,865 (+)NCBIChiLan1.0ChiLan1.0
PAIP2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A72,728,012 - 72,772,036 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A72,733,750 - 72,772,036 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A71,227,562 - 71,271,642 (-)NCBIMhudiblu_PPA_v0panPan3
PAIP2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1751,385,194 - 51,413,360 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11751,381,891 - 51,388,964 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Paip2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649115,197,028 - 15,233,652 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAIP2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1371,452,753 - 71,500,176 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2374,881,371 - 74,940,494 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAIP2B
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11435,930,797 - 35,967,398 (+)NCBI
ChlSab1.1 Ensembl1435,930,819 - 35,972,073 (+)Ensembl
Paip2b
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247622,335,522 - 2,379,674 (+)NCBI

Position Markers
UniSTS:234959  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38487,581,741 - 87,581,974UniSTSGRCm38
GRCm38683,808,420 - 83,808,652UniSTSGRCm38
MGSCv37683,758,414 - 83,758,646UniSTSGRCm37
MGSCv37487,227,645 - 87,227,878UniSTSGRCm37
Celera685,791,379 - 85,791,611UniSTS
Celera486,106,724 - 86,106,957UniSTS
Cytogenetic Map6C3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1615
Count of miRNA genes:700
Interacting mature miRNAs:910
Transcripts:ENSMUST00000058383, ENSMUST00000125493, ENSMUST00000142806, ENSMUST00000145593
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_146169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC156283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK173114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC147239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC147240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY262990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK381272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000058383   ⟹   ENSMUSP00000050404
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,805,401 - 83,831,741 (-)Ensembl
RefSeq Acc Id: ENSMUST00000125493
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,808,656 - 83,810,198 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142806
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,812,857 - 83,831,713 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145593
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,809,712 - 83,831,713 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205421
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,831,457 - 83,831,700 (-)Ensembl
RefSeq Acc Id: NM_146169   ⟹   NP_666281
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,783,040 - 83,808,723 (-)NCBI
GRCm38683,806,058 - 83,831,741 (-)NCBI
MGSCv37683,756,052 - 83,781,735 (-)RGD
Celera685,789,017 - 85,814,725 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_666281   ⟸   NM_146169
- UniProtKB: Q91W45 (UniProtKB/Swiss-Prot),   A0A158RFV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000050404   ⟸   ENSMUST00000058383
Protein Domains
PAM2

Promoters
RGD ID:6839721
Promoter ID:MM_KWN:46636
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000057012
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36683,759,461 - 83,759,961 (-)MPROMDB
RGD ID:6839720
Promoter ID:MM_KWN:46637
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000057009,   OTTMUST00000057010,   OTTMUST00000057011
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36683,781,616 - 83,782,142 (-)MPROMDB
RGD ID:6890194
Promoter ID:EPDNEW_M8548
Type:initiation region
Name:Paip2b_1
Description:Mus musculus poly binding protein interacting protein 2B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38683,831,713 - 83,831,773EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2386865 AgrOrtholog
Ensembl Genes ENSMUSG00000045896 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000050404 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000058383 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Ataxin-2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAIP2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:232164 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2386865 ENTREZGENE
NCBI Gene 232164 ENTREZGENE
PANTHER PTHR13154 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PAM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KIAA1155 RGD
PhenoGen Paip2b PhenoGen
UniProt A0A158RFV3 ENTREZGENE, UniProtKB/TrEMBL
  PAI2B_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B9EJI7 UniProtKB/Swiss-Prot
  Q69ZQ4 UniProtKB/Swiss-Prot
  Q8BL93 UniProtKB/Swiss-Prot