Sat2 (spermidine/spermine N1-acetyl transferase 2) - Rat Genome Database
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Gene: Sat2 (spermidine/spermine N1-acetyl transferase 2) Mus musculus
Analyze
Symbol: Sat2
Name: spermidine/spermine N1-acetyl transferase 2
RGD ID: 1317313
MGI Page MGI
Description: Predicted to have diamine N-acetyltransferase activity; identical protein binding activity; and spermidine binding activity. Predicted to be involved in polyamine metabolic process. Predicted to localize to cytoplasm. Orthologous to human SAT2 (spermidine/spermine N1-acetyltransferase family member 2); PARTICIPATES IN hypoxia inducible factor pathway; arginine and proline metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; busulfan; cerium trichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2610016A03Rik; diamine acetyltransferase 2; MGC74376; polyamine N-acetyltransferase 2; spermidine/spermine N(1)-acetyltransferase 2; SS; SSA; SSAT-2; SSAT2; thialysine N-epsilon-acetyltransferase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,512,824 - 69,514,857 (+)NCBIGRCm39mm39
GRCm381169,621,996 - 69,624,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,622,024 - 69,623,870 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,435,611 - 69,437,371 (+)NCBIGRCm37mm9NCBIm37
MGSCv361169,438,219 - 69,440,480 (+)NCBImm8
MGSCv361170,206,131 - 70,208,392 (+)NCBImm8
Cytogenetic Map11B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11752298   PMID:12477932   PMID:12803540   PMID:14610273   PMID:14681479   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:17371273   PMID:19164485   PMID:21267068   PMID:21677750   PMID:21873635   PMID:28578006   PMID:31253191   PMID:32325033  


Genomics

Comparative Map Data
Sat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,512,824 - 69,514,857 (+)NCBIGRCm39mm39
GRCm381169,621,996 - 69,624,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,622,024 - 69,623,870 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,435,611 - 69,437,371 (+)NCBIGRCm37mm9NCBIm37
MGSCv361169,438,219 - 69,440,480 (+)NCBImm8
MGSCv361170,206,131 - 70,208,392 (+)NCBImm8
Cytogenetic Map11B3NCBI
SAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl177,626,234 - 7,627,876 (-)EnsemblGRCh38hg38GRCh38
GRCh38177,626,234 - 7,627,878 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37177,529,552 - 7,531,194 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,470,281 - 7,471,889 (-)NCBINCBI36hg18NCBI36
Build 34177,470,280 - 7,471,889NCBI
Celera177,555,972 - 7,557,610 (-)NCBI
Cytogenetic Map17p13.1NCBI
HuRef177,423,586 - 7,425,224 (-)NCBIHuRef
CHM1_1177,538,732 - 7,540,374 (-)NCBICHM1_1
Sat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21054,340,756 - 54,343,507 (+)NCBI
Rnor_6.0 Ensembl1056,227,692 - 56,229,850 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01056,227,703 - 56,229,796 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01055,973,151 - 55,975,434 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,440,651 - 56,442,403 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11056,454,206 - 56,456,015 (+)NCBI
Celera1053,495,543 - 53,497,295 (+)NCBICelera
Cytogenetic Map10q24NCBI
Sat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,305,746 - 9,308,668 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,306,210 - 9,308,668 (+)NCBIChiLan1.0ChiLan1.0
SAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1177,643,490 - 7,645,127 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,643,490 - 7,645,127 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0177,657,166 - 7,658,773 (-)NCBIMhudiblu_PPA_v0panPan3
SAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl532,534,310 - 32,535,846 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1532,534,302 - 32,536,022 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Sat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936595891,380 - 892,937 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,911,723 - 52,913,363 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,911,725 - 52,913,314 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,261,007 - 55,262,600 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SAT2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,001,087 - 7,003,538 (-)NCBI
ChlSab1.1 Ensembl167,001,259 - 7,002,270 (-)Ensembl
Sat2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478610,232,078 - 10,233,602 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111231863769794121Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113568778969794161Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116718736579923086Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116910000072600000Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116910000072600000Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116910000072600000Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116910000072600000Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116910000072600000Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116910000072600000Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116910000072600000Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116910000072600000Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116910000072600000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:452
Count of miRNA genes:241
Interacting mature miRNAs:262
Transcripts:ENSMUST00000092969, ENSMUST00000108656, ENSMUST00000151255
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000092969   ⟹   ENSMUSP00000090647
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,622,052 - 69,623,870 (+)Ensembl
RefSeq Acc Id: ENSMUST00000108656   ⟹   ENSMUSP00000104296
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,622,024 - 69,623,870 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151255
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,622,052 - 69,623,458 (+)Ensembl
RefSeq Acc Id: NM_001356468   ⟹   NP_001343397
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,512,878 - 69,514,704 (+)NCBI
GRCm381169,622,052 - 69,623,878 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001356469   ⟹   NP_001343398
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,512,878 - 69,514,277 (+)NCBI
GRCm381169,622,052 - 69,623,451 (+)NCBI
Sequence:
RefSeq Acc Id: NM_026991   ⟹   NP_081267
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,512,878 - 69,514,704 (+)NCBI
GRCm381169,622,052 - 69,623,878 (+)NCBI
MGSCv371169,435,611 - 69,437,371 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006534110   ⟹   XP_006534173
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,512,826 - 69,514,857 (+)NCBI
GRCm381169,621,998 - 69,624,032 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006534111   ⟹   XP_006534174
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,512,824 - 69,514,857 (+)NCBI
GRCm381169,621,996 - 69,624,032 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_081267   ⟸   NM_026991
- Peptide Label: isoform 1
- UniProtKB: Q6P8J2 (UniProtKB/Swiss-Prot),   A0A158SIT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006534174   ⟸   XM_006534111
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006534173   ⟸   XM_006534110
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001343397   ⟸   NM_001356468
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001343398   ⟸   NM_001356469
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000090647   ⟸   ENSMUST00000092969
RefSeq Acc Id: ENSMUSP00000104296   ⟸   ENSMUST00000108656
Protein Domains
N-acetyltransferase

Promoters
RGD ID:6822027
Promoter ID:MM_KWN:8085
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   MEF_B4
Transcripts:ENSMUST00000092969,   OTTMUST00000013450,   OTTMUST00000062238
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,435,279 - 69,435,779 (+)MPROMDB
RGD ID:8675190
Promoter ID:EPDNEW_M15626
Type:initiation region
Name:Sat2_1
Description:Mus musculus spermidine/spermine N1-acetyl transferase 2 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381169,622,052 - 69,622,112EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916465 AgrOrtholog
Ensembl Genes ENSMUSG00000069835 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000090647 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000104296 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000092969 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000108656 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000151255 ENTREZGENE
InterPro Acyl_CoA_acyltransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GNAT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAT2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:69215 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1916465 ENTREZGENE
NCBI Gene 69215 ENTREZGENE
PANTHER PTHR10545:SF51 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Acetyltransf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sat2 PhenoGen
PROSITE GNAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55729 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A158SIT0 ENTREZGENE, UniProtKB/TrEMBL
  Q3TTS0_MOUSE UniProtKB/TrEMBL
  Q6P8J2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5F299 UniProtKB/Swiss-Prot