Pole4 (polymerase (DNA-directed), epsilon 4 (p12 subunit))

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Gene: Pole4 (polymerase (DNA-directed), epsilon 4 (p12 subunit)) Mus musculus

Analyze

Symbol:

Pole4

Name:

polymerase (DNA-directed), epsilon 4 (p12 subunit)

RGD ID:

1317191

MGI Page

MGI

Description:

Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Orthologous to human POLE4 (DNA polymerase epsilon 4, accessory subunit); PARTICIPATES IN nucleotide excision repair pathway; base excision repair pathway; DNA replication pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3',4,4',5-Pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

2400007P05Rik; 5830430F06Rik; DNA polymerase epsilon subunit 4; DNA polymerase epsilon subunit p12; DNA polymerase II subunit 4

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	82,593,513 - 82,629,985 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	6	82,595,973 - 82,682,346 (-)	Ensembl
GRCm38	6	82,616,532 - 82,653,043 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	82,618,992 - 82,705,365 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	82,596,706 - 82,602,859 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	6	82,612,370 - 82,618,523 (-)	NCBI			mm8
Celera	6	84,622,456 - 84,628,609 (-)	NCBI		Celera
Cytogenetic Map	6	C3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,3,5-trinitro-1,3,5-triazinane (ISO)

17alpha-ethynylestradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3',4,4',5-Pentachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4-hydroxyphenyl retinamide (EXP)

4-phenylbutyric acid (ISO)

6-propyl-2-thiouracil (ISO)

aflatoxin B1 (ISO)

Aroclor 1254 (EXP)

arsenous acid (ISO)

benzo[a]pyrene (EXP)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

carbamazepine (ISO)

carbon nanotube (EXP)

chromium(6+) (EXP)

clofibric acid (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

diclofenac (ISO)

dicrotophos (ISO)

doxorubicin (EXP)

entinostat (ISO)

enzyme inhibitor (ISO)

ethanol (EXP)

finasteride (ISO)

flutamide (ISO)

folic acid (EXP)

gentamycin (ISO)

hydralazine (ISO)

lead diacetate (EXP)

Methylazoxymethanol acetate (ISO)

N-nitrosodiethylamine (ISO)

nefazodone (ISO)

nimesulide (ISO)

paracetamol (EXP,ISO)

pirinixic acid (EXP)

pregnenolone 16alpha-carbonitrile (EXP)

progesterone (ISO)

propiconazole (EXP)

sulindac (ISO)

tetrachloromethane (EXP)

thimerosal (ISO)

troglitazone (EXP)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

Ada2/Gcn5/Ada3 transcription activator complex (ISO)

epsilon DNA polymerase complex (IBA,ISO)

nucleus (IBA)

Molecular Function

DNA binding (IEA)

protein binding (ISO)

protein heterodimerization activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

base excision repair pathway (IEA)

DNA replication pathway (IEA)

nucleotide excision repair pathway (IEA,ISO)

purine metabolic pathway (IEA)

pyrimidine metabolic pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal B cell differentiation (IAGP)

abnormal cell cycle (IAGP)

abnormal craniofacial morphology (IAGP)

abnormal DNA replication (IAGP)

abnormal embryo development (IAGP)

abnormal fourth ventricle morphology (IAGP)

abnormal gait (IAGP)

abnormal mesenteric lymph node morphology (IAGP)

abnormal pelvic girdle bone morphology (IAGP)

abnormal roof plate morphology (IAGP)

abnormal spleen B cell follicle morphology (IAGP)

abnormal T cell differentiation (IAGP)

abnormal thymus morphology (IAGP)

absent thymus cortex (IAGP)

anemia (IAGP)

arrested B cell differentiation (IAGP)

ataxia (IAGP)

athymia (IAGP)

belly spot (IAGP)

caudal vertebral fusion (IAGP)

chromosomal instability (IAGP)

curly tail (IAGP)

decreased B cell number (IAGP)

decreased body length (IAGP)

decreased body weight (IAGP)

decreased brain weight (IAGP)

decreased embryo size (IAGP)

decreased embryo weight (IAGP)

decreased fetal size (IAGP)

decreased fetal weight (IAGP)

decreased fibroblast proliferation (IAGP)

decreased hematopoietic stem cell number (IAGP)

decreased leukocyte cell number (IAGP)

decreased litter size (IAGP)

decreased lymphocyte cell number (IAGP)

decreased male germ cell number (IAGP)

decreased single-positive T cell number (IAGP)

decreased spleen weight (IAGP)

decreased tumor latency (IAGP)

embryonic lethality during organogenesis, incomplete penetrance (IAGP)

impaired coordination (IAGP)

increased cellular sensitivity to hydroxyurea (IAGP)

increased double-negative T cell number (IAGP)

increased embryonic tissue cell apoptosis (IAGP)

increased forebrain apoptosis (IAGP)

increased granulocyte number (IAGP)

increased hematopoietic stem cell number (IAGP)

increased lymphoma incidence (IAGP)

increased monocyte cell number (IAGP)

increased T cell derived lymphoma incidence (IAGP)

induced chromosome breakage (IAGP)

kinked tail (IAGP)

lethality throughout fetal growth and development, incomplete penetrance (IAGP)

postnatal growth retardation (IAGP)

prenatal growth retardation (IAGP)

prenatal lethality, incomplete penetrance (IAGP)

prominent forehead (IAGP)

reduced cerebellar foliation (IAGP)

reduced fertility (IAGP)

short mandible (IAGP)

short tibia (IAGP)

small cerebellum (IAGP)

small spleen (IAGP)

thrombocytosis (IAGP)

References

References - curated


1.	Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3.	MGD and Homologene mouse data transfer
4.	MGD data from the GO Consortium
5.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6.	Pipeline to import KEGG annotations from KEGG into RGD
7.	Pospiech H and Syvaoja JE, ScientificWorldJournal. 2003 Mar 24;3:87-104.
8.	RGD automated import pipeline for gene-chemical interactions
9.	Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.

Additional References at PubMed

PMID:8889548	PMID:10349636	PMID:10922068	PMID:11042159	PMID:11076861	PMID:12477932	PMID:12904583	PMID:14610273	PMID:14681479	PMID:15489334	PMID:15782199	PMID:16141072
PMID:16141073	PMID:16602821	PMID:17967808	PMID:18287559	PMID:18799693	PMID:19538749	PMID:20412781	PMID:21267068	PMID:21677750	PMID:21731673	PMID:21873635	PMID:24154525
PMID:29754823	PMID:30217558	PMID:32460026

Genomics

Comparative Map Data

Pole4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	82,593,513 - 82,629,985 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	6	82,595,973 - 82,682,346 (-)	Ensembl
GRCm38	6	82,616,532 - 82,653,043 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	82,618,992 - 82,705,365 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	82,596,706 - 82,602,859 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	6	82,612,370 - 82,618,523 (-)	NCBI			mm8
Celera	6	84,622,456 - 84,628,609 (-)	NCBI		Celera
Cytogenetic Map	6	C3	NCBI

POLE4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	74,958,643 - 74,970,128 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	74,958,643 - 74,970,128 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	75,185,770 - 75,197,255 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	75,039,283 - 75,050,367 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	75,097,429 - 75,108,514	NCBI
Celera	2	75,017,063 - 75,028,146 (+)	NCBI
Cytogenetic Map	2	p12	NCBI
HuRef	2	74,922,607 - 74,933,690 (+)	NCBI		HuRef
CHM1_1	2	75,115,083 - 75,126,167 (+)	NCBI		CHM1_1

Pole4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	115,165,285 - 115,171,097 (-)	NCBI
Rnor_6.0 Ensembl	4	113,491,644 - 113,497,455 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	4	113,491,644 - 113,497,455 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	4	178,170,534 - 178,176,366 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	116,856,445 - 116,862,256 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	4	117,101,557 - 117,106,737 (-)	NCBI
Celera	4	104,161,837 - 104,167,648 (-)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

Pole4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	10,839,639 - 10,844,985 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	10,839,639 - 10,844,985 (-)	NCBI	ChiLan1.0	ChiLan1.0

POLE4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2A	76,526,385 - 76,537,463 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	76,526,385 - 76,537,463 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2A	75,023,087 - 75,034,178 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

POLE4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	48,241,641 - 48,251,679 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Pole4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936556	1,161,359 - 1,167,283 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

POLE4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	68,033,787 - 68,117,289 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	68,103,028 - 68,117,308 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	71,280,587 - 71,294,748 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

POLE4
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	32,313,399 - 32,320,084 (-)	NCBI
ChlSab1.1 Ensembl	14	32,312,893 - 32,320,016 (-)	Ensembl

Pole4
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624749	28,538,347 - 28,547,722 (-)	NCBI

Position Markers

Pole4

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	6	D1	UniSTS

Pole4

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	6	D1	UniSTS
cM Map	6	35.94	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
25440480	Moaq2_m	modifier of alien QTL 2 (mouse)					6	1	117500000	Mouse
26884414	Bzwq12_m	bi-zygomatic width QTL 12, 16 week (mouse)					6	3400000	139100000	Mouse
1300556	Cia6_m	collagen induced arthritis QTL 6 (mouse)			Not determined		6	4464884	87426034	Mouse
4142126	W3q3_m	weight 3 weeks QTL 3 (mouse)			Not determined			4503823	96656149	Mouse
4142361	W10q11_m	weight 10 weeks QTL 11 (mouse)			Not determined			4503823	96656149	Mouse
4142271	Egq8_m	early growth QTL 8 (mouse)			Not determined			4503823	96656149	Mouse
4142232	W6q4_m	weight 6 weeks QTL 4 (mouse)			Not determined			4503823	96656149	Mouse
1558984	Cplaq9_m	circadian period of locomotor activity 9 (mouse)			Not determined		6	38669625	92607450	Mouse
1300618	Pgia19_m	proteoglycan induced arthritis 19 (mouse)			Not determined		6	45314059	87426034	Mouse
10412157	Fl1n_m	fatty liver 1 in NSY (mouse)			Not determined		6	45314059	128835032	Mouse
4142259	Tabw2_m	tally ho associated body weight 2 (mouse)			Not determined			46935985	136423692	Mouse
25314319	Histh6_m	histamine hypersensitivity 6 (mouse)					6	48720000	125360000	Mouse
25314320	Histh5_m	histamine hypersensitivity 5 (mouse)					6	48720000	148450000	Mouse
1301962	Eila2_m	ethanol induced locomotor activity 2 (mouse)			Not determined		6	48726556	125356785	Mouse
1301254	Skts11_m	skin tumor susceptibility 11 (mouse)			Not determined		6	51179150	85179300	Mouse
1357683	Igf1sl1_m	IGF-1 serum levels 1 (mouse)			Not determined		6	52161713	116155267	Mouse
4141028	Mclr_m	methylcholanthrene lymphoma resistance (mouse)			Not determined			54373427	88379171	Mouse
15039373	Adip28_m	adiposity 28 (mouse)					6	56308211	90308211	Mouse
15039375	Bw41_m	body weight QTL 41 (mouse)					6	56308211	90308211	Mouse
1558977	Skmw10_m	skeletal muscle weight 10 (mouse)			Not determined		6	58447583	92447710	Mouse
10043972	Obq28_m	obesity QTL 28 (mouse)			Not determined		6	58540433	92540433	Mouse
1301740	Bwq2_m	body weight QTL 2 (mouse)			Not determined		6	60057680	94057799	Mouse
1301369	Im4_m	immunoregulatory 4 (mouse)			Not determined		6	63484738	97484905	Mouse
1300650	Bw18_m	body weight QTL 18 (mouse)			Not determined		6	66713869	100714031	Mouse
1301876	Bits2_m	bitterness sensitivity 2 (mouse)			Not determined		6	70425898	104426034	Mouse
1301813	Skl3_m	skeletal size (tail length) 3 (mouse)			Not determined		6	70425898	104426034	Mouse
1301034	Egrm2_m	early growth rate (mouse)			Not determined		6	70425898	104426034	Mouse
4141990	Etax6_m	ethanol induced ataxia 6 (mouse)			Not determined			71322621	86275719	Mouse
1302020	Bbaa20_m	B.burgdorferi-associated arthritis 20 (mouse)			Not determined		6	71322621	93464093	Mouse
1300869	Stheal5_m	soft tissue heal 5 (mouse)			Not determined		6	71575060	105575178	Mouse
1300954	Fcsa1_m	femoral cross-sectional area 1 (mouse)			Not determined		6	71981024	105981170	Mouse
1301521	Pas1c_m	pulmonary adenoma susceptibility 1c (mouse)			Not determined		6	71981024	105981170	Mouse
13506930	Recrq9_m	recombination rate in male meiosis QTL 9 (mouse)					6	73500000	134700000	Mouse
1301320	Ots1_m	ovarian teratoma susceptibility 1 (mouse)			Not determined		6	75447583	104503555	Mouse
1301571	Arrd1_m	age-related retinal degeneration 1 (mouse)			Not determined		6	75544356	92607450	Mouse
1300674	Nidd3n_m	non-insulin-dependent diabetes mellitus 3 in NSY (mouse)			Not determined		6	75544356	94225955	Mouse
10412195	Efw_m	epididymal fat weight (mouse)			Not determined		6	75544356	94225955	Mouse
10043901	Pfat5_m	predicted fat percentage 5 (mouse)			Not determined		6	75607306	109607450	Mouse
10412208	Cypr4_m	cytokine production 4 (mouse)			Not determined		6	75716503	109716697	Mouse
1357875	Pfat2_m	predicted fat percentage 2 (mouse)			Not determined		6	76463949	110464093	Mouse
14697704	Stsl4_m	Salmonella typhimurium susceptibility locus 4 (mouse)					6	77100000	90000000	Mouse
13824985	Alh1_m	amplitude of lateral head displacement 1 (mouse)					6	78000000	97000000	Mouse
4141376	Dbm1_m	diabetes modifier 1 (mouse)			Not determined		6	78629504	121115387	Mouse
14696731	Pairq1_m	P. aeruginosa infection resistance QTL 1 (mouse)					6	81500000	102200000	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1658
Count of miRNA genes:	655
Interacting mature miRNAs:	811
Transcripts:	ENSMUST00000095786, ENSMUST00000140281, ENSMUST00000141138, ENSMUST00000160281, ENSMUST00000161309
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001370295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_025882	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_003956251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC159655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK010135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK010300	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK011595	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK017956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK145365	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK160582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK167631	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK182530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK207330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK207634	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC023189	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466523	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000095786 ⟹ ENSMUSP00000093462

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	6	82,646,701 - 82,652,929 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000140281

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	6	82,647,843 - 82,652,518 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000141138

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	6	82,647,316 - 82,652,520 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000160281 ⟹ ENSMUSP00000124357

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	6	82,621,852 - 82,652,870 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000161309

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	6	82,618,992 - 82,705,365 (-)	Ensembl

RefSeq Acc Id:

NM_001370295 ⟹ NP_001357224

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	6	82,595,335 - 82,629,855 (-)	NCBI
GRCm38	6	82,618,354 - 82,652,874 (-)	NCBI

Sequence:

show sequence

AGTCAGCGACCGCGCGCCACACGTTTCGGGAGGGGATGGCGGCAGCGGCGGCTGCTGGGAGCGG
GACGCCCAGAGAGGAAGAGGCTCCCGGAGGGGAGGCAGCGGCTTCGCAGGCCCAAGCCCCGACG
AGTGCACCCGGGGGAGTTCGCCTCTCGAGGCTGCCTCTGGCGAGAGTAAAGGCCTTGGTGAAGG
CAGACCCTGACGTAACGCTGGCGGGACAGGAAGCCATCTTTATCCTGGCGCGTGCCGCGGAACT
GTTCGTGGAGACTATCGCAAAAGATGCCTACTGCTGTGCTCAACAAGGAAAGAGGAAAACTCTC
CAGAGGAGAGATTTGGATAATGCAATAGAAGCTGTGGATGAATTCGCTTTTCTAGAAGGACTAT
TTAACAAACTGCAATCAACAGCAATCAACAGCTATGAACCAGCAACCTACCCTGCCTCTTGGGA
CCCTAGCATTTATATACCCTCTGAAGAGTTCCCAGAATTCCAGATGTCACACTATCACAGAAAC
TATCCTCAGCTGGCAAAAAATCATACCCCTGCTAGAGCATGAGGCAAATCATAGTCAGCTGCTG
TGGACAGACTGAACCAGCCCCATACCACACCTGGGATTAAAACAAAAACATGTTCTTATATTTC
TGTTTTTCTTTTTCTTTTTTTGTAGAACATGATTTTAATATTTTCAACTGTTAATATTCAACAA
ACAGAATAATTATTTAAGATATATTTCATTGTTATGTCTCCCTTTTCATTTCTGATTTTATTAA
TAAGGACACTGTCTTTGTGCCCTTTGGTTAGTCTGGCTAAGGGTTTATCTATCTTGTTGATTTT
CTCAAAGAACCAGCTCCTGGTTTTGTTGATTCTTTGTATAGTTCTTTTTGTATCTGTTTGGTTG
ATTCAAGCCAAACAGATAAAAAAAGAACTATACAAATTCAAGGCCTGAGTTTGATTATTTCCGG
TGGTCTACTCCTCTTGGATGTATTTGCGTCTTTTTGTTCTAGAGCTTTCAGGTGTGCTGTCAAA
CTGCTAGTGTAAGCTCTCTTCAGTTTCTTTTTGGAGGCACTCAGAGCTATGAGTTTTCTTCTTA
CCACTGCTTTCTTGTATCCCATAAGTTTTGATATGATGTGTCTTCATTTTCATTAAATTCTAAA
AAGCCTTTAAA

hide sequence

RefSeq Acc Id:

NM_025882 ⟹ NP_080158

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	6	82,623,693 - 82,629,846 (-)	NCBI
GRCm38	6	82,646,712 - 82,652,865 (-)	NCBI
MGSCv37	6	82,596,706 - 82,602,859 (-)	RGD
Celera	6	84,622,456 - 84,628,609 (-)	RGD
cM Map	6		ENTREZGENE

Sequence:

show sequence

CCGCGCGCCACACGTTTCGGGAGGGGATGGCGGCAGCGGCGGCTGCTGGGAGCGGGACGCCCAG
AGAGGAAGAGGCTCCCGGAGGGGAGGCAGCGGCTTCGCAGGCCCAAGCCCCGACGAGTGCACCC
GGGGGAGTTCGCCTCTCGAGGCTGCCTCTGGCGAGAGTAAAGGCCTTGGTGAAGGCAGACCCTG
ACGTAACGCTGGCGGGACAGGAAGCCATCTTTATCCTGGCGCGTGCCGCGGAACTGTTCGTGGA
GACTATCGCAAAAGATGCCTACTGCTGTGCTCAACAAGGAAAGAGGAAAACTCTCCAGAGGAGA
GATTTGGATAATGCAATAGAAGCTGTGGATGAATTCGCTTTTCTAGAAGGCACTTTGGATTAAT
TGTGGAGCTGGATGGTCTGAGCCTTGGCTGCATCTGTCACCTTTCCCCTCTGTAAGCCTCAGCT
TTGGAGAAAGTCTGCGCATGTACACAATCTTCTTACTCTTTTTACCCAAGATAGAAGAAGCAGA
GAGCTCTTGGATAACGTTCTCCACCAAGTCTTCCATTACTTGAGTCTGTCTTCCAATTCAAGCC
TGGATGTAGCTGATGCTGTTTGGGGCAGAGATGAAAGGACTGTTCTGCATAGCTGGCTTAATGA
GCACAGACTAGAATAAAAGGTCTTTGTTCAGCTTCTTTCCTGTGTTTTATATTGCCTTTGCTCT
TGCCCTGTGACTGGGAACCCATGTGATCAGGCACAGACTTTCCTCATCTTTCTACCAACCACTC
CAAGTCAGTCTTTTTATTAAATTTGTTCTTTCTCAGCATGTCATTGGAATGTGGATCGATAATA
TATGGGATACCTCTTCTCCTTAGAAGTCAAATCGATGTGGTCCCAACAGTTTTATTCAAGTATA
ATTCATGTGTCATATTCAATTCAAACTGTAACATTCGGTGGTTTTTAAAAAAATATTCATAGAT
ATATGTAGTGAGATTTTGAACATTTTCCTGTGAATGGATTCACATGAGTCTTGTGTATGGCAAA
ATTTAGATAATGTTATTTAAAGTTAATCTATGCTATGATATGTATTTATACCCTTTAAGTTGTG
AAATATATGTGATATAAAATTTCCCATTTTAACTGCTTTTCAGTGTGTTGCTCAGTGAGATTGA
ATATTTTCAGAGTGTTGCACAACCTTCACCATCATTGGCCTCCAGAACTTTGTAACAGTGTTCT
CAGCCTGGAACATTGTGCACATGGAACAGTATCTTCCTTTCCTTTTCTCATCTCACGTTAGGCT
AAATTAATTTTGTTGTTGTTGTTATTTTGTGAAGTGTGGGCAGTGCACTTTTAGTACCTAGAAT
GTAGTGCTTCAGGAAAGCAGCAGAAAGCTGTGGCTAGGGCTTCCTACAGTGTTCTGCAGTGTAG
ATCTCTTAGGATAGAGTCTGCAGGATCTTCTCCCTAGAATGATACATTCAGTCCTGTAATACGT
TAAAAATAAACTTTCAGAAAAATACTACATTTGTAGAAAAGTGTTTTTAGGTCTTGCTTACTAA
GTCCACCCAAAACTGACATTTCAGGGTTACCAGAAACTGACTGACATTTATGGCTTATTATTTA
TTGAGTTCAGTTTTTATTTGAGTTCAGTATTTTTTTCCATTAATATCCTTTGTTTTGAGATCTA
ATCGAGATTATTAAATTGTTTTTGCTTCTT

hide sequence

RefSeq Acc Id:

XR_003956251

RefSeq Status:

Type:

NON-CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	6	82,593,513 - 82,629,985 (-)	NCBI
GRCm38	6	82,616,532 - 82,653,043 (-)	NCBI

Sequence:

show sequence

ACGCCCGGCCGCTTCCAGGCTGTGGCCGCCCGGAAGAGTACATCAGACCCCGGAGTCAGAGGGG
GCGGTTCTGGCGCGCCACGCCTAGTGAGGGTGGGGCCACGCCCACACGGAGAGGCGTGGTCTCT
ACCCGGCGCGGGAAAGGGGCCGAAATCGCGTGCGCGCGCTCAGTCAGCGACCGCGCGCCACACG
TTTCGGGAGGGGATGGCGGCAGCGGCGGCTGCTGGGAGCGGGACGCCCAGAGAGGAAGAGGCTC
CCGGAGGGGAGGCAGCGGCTTCGCAGGCCCAAGCCCCGACGAGTGCACCCGGGGGAGTTCGCCT
CTCGAGGCTGCCTCTGGCGAGAGTAAAGGCCTTGGTGAAGGCAGACCCTGACGTAACGCTGGCG
GGACAGGAAGCCATCTTTATCCTGGCGCGTGCCGCGGAACTGTTCGTGGAGACTATCGCAAAAG
ATGCCTACTGCTGTGCTCAACAAGGAAAGAGGAAAACTCTCCAGAGGAGAGATTTGGATAATGC
AATAGAAGCTGTGGATGAATTCGCTTTTCTAGAAGGACTATTTAACAAACTGCAATCAACAGCA
ATCAACAGCTATGAACCAGCAACCTACCCTGCCTCTTGGGACCCTAGCATTTATATACCCTCTG
AAGAGTTCCCAGAATTCCAGATGTCACACTATCACAGAAACTATCCTCAGCTGGCAAAAAATCA
TACCCCTGCTAGAGCATGAGGCAAATCATAGTCAGCTGCTGTGGACAGACTGAACCAGCCCCAT
ACCACACCTGGGATTAAAACAAAAACATGTTCTTATATTTCTGTTTTTCTTTTTCTTTTTTTGT
AGAACATGATTTTAATATTTTCAACTGTTAATATTCAACAAACAGAATAATTATTTAAGATATA
TTTCATTGTTATGTCTCCCTTTTCATTTCTGATTTTATTAATAAGGACACTGTCTTTGTGCCCT
TTGGTTAGTCTGGCTAAGGGTTTATCTATCTTGTTGATTTTCTCAAAGAACCAGCTCCTGGTTT
TGTTGATTCTTTGTATAGTTCTTTTTGTATCTGTTTGGTTGATTCAAGCCAAACAGATAAAAAA
AGAACTATACAAATTCAAGGCCTGAGTTTGATTATTTCCGGTGGTCTACTCCTCTTGGATGTAT
TTGCGTCTTTTTGTTCTAGAGCTTTCAGGTGTGCTGTCAAACTGCTAGTGTAAGCTCTCTTCAG
TTTCTTTTTGGAGGCACTCAGAGCTATGAGTTTTCTTCTTACCACTGCTTTCTTGTATCCCATA
AGTTTTGATATGATGTGTCTTCATTTTCATTAAATTCTAAAAAGCCTTTAAATTTCTTTCTTTA
TTTCTTCCTTGACTAAATTATCATTGAGTAGAGTGTTGTTCGGCTTCCATGTGTATGTGTGTTT
TCCATGTTTTTGTTGGTATTCAAGACCAGCCTTAGTCCATGGTGATCTGATAGGGTGCATGGGA
TTATTTCAATCTTCTTGTATCTGTTGAGGCCTGTTTTGTGACCAATTATGTGGTAATTGGAGAA
GGTGCCTTGAGGTGCTGAGAAGAAGGTATATTCTTTTGCTTTAGTATGAAATGTACTATAAATC
TCTCTTAGATCCATTTGGTTCATTACTTGTGTTAGTTTCACTGTGTCTCTGTTTAGTTTCTGTT
TCTATGATCTATCTATTGCTGAGAGTGGGGTGTTGAAGTCTCCCACCATTATTGTGTGCTTTGA
GCTTTAGTAAAGTTTCTTTTATGAATGTGGATGCCCCTGCATTTGGAGCATAGATGTTCAGAAT
TGAGAGTTCATCTTGGTAGATTTTTTTCCTTAGACCAGTATGAAGTGTCCTTCCTTATCTTTTT
TTGATAACTTTTGGTTGAAAGTTGATTTTGTTTGATATTAGAATGGCTACTCCAGCTTGTTTCT
TGGGACCATTTGCTTGGAAAATTGATTTCCAGCCTTTTACCCTGAGGTAGTGTCTGCCTTTGTC
ACTGAGGTGTGTTTCCTGTATGCAGAAAATGCTGGGTCCTGATTACATATCCAGTCTGTTAGTC
TATGTCTTTTGGGGGGAATTGAGTCCACTGATGTTAAGGGATATTAAGGAAAAGTGATTGTTAC
TCCCTGTTATTTTTGGTGTTAGAGGTGGAATTATGTTTGTGTGGCTATCTTTGTTTGGGTTTGT
TGAAAGATTACTTTCTTGCTTTTGCTAGGGTGTAGTTTCCCTCCTTGTGTTGGTGTTTTCTACC
TATTATCCTTTGTAGGGCTGGATTTATGGAAAGATATTGTGTAAATTTGGTTTTGTCATGGAAT
ATCTTGGTTTCTCCATCTATGGTAATTGAGTTTTGTTGGGTATAGTAGCCTGGGCTGGCATTTG
TGTTCTCATAGGGTCTGTATGATATCTGCCTAGGATCTTCTAGCTTTCATAGTCTCTGGTGAGA
AGTCTGGTGTAATTATGATAGATCTGCCTTTATATGTTACTTGACCTTTTTCCCTACTGCTTTT
AATAATCTTTCTTTGTTTACTGCATTTGGTATTTTGATTGTTATGTGCTGGGAGGAATTTCTTT
TCTGGTCCAGTCTATTTGGAGTTCTACAGGCTTCTTGTATGTTCCTGGGCATCTTTTTCTTTAG
GTTAGTGAAGTTTTCTTCTATAATTTTGTTGGAGATATTTACGGGCCCTTTAAGTTGGGAATCT
TCACTCTCTTCTATTCTTTTTATCCTTAGGTTTGTCTTCCCATTGTGTCCTGGATTTCCTGGAT
GTTTTAGTGAAGATCAGCAGAAATGAAGACTCAAGACCAATGAAGCTCGCCCCTCCCCCACTGA
TACCCTGTCACTGTCCATATTTATACATTTATACTCCCCCCAAACAGCACGTGAGTCTGTCTTA
GCAAAACTCCACGTGAGTCTCTATCAGTTGACAGCACTCTGCCAATTCATCAACAAGCTGCCAG
AGCACCACCAGAAGTTCTTTGGTGAATTTCTGTCTATGGAGACACCACAAATGATGACCAATAA
ACAATGGTAAGACATACCAATACCATCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001357224	(Get FASTA)	NCBI Sequence Viewer
	NP_080158	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH23189	(Get FASTA)	NCBI Sequence Viewer
	BAB26722	(Get FASTA)	NCBI Sequence Viewer
	BAB26833	(Get FASTA)	NCBI Sequence Viewer
	BAB27723	(Get FASTA)	NCBI Sequence Viewer
	BAE35889	(Get FASTA)	NCBI Sequence Viewer
	BAE39682	(Get FASTA)	NCBI Sequence Viewer
	EDK99034	(Get FASTA)	NCBI Sequence Viewer
	Q9CQ36	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_080158 ⟸ NM_025882
- Peptide Label:	isoform 1
- UniProtKB:	Q9CQ36 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAAAAAAGSGTPREEEAPGGEAAASQAQAPTSAPGGVRLSRLPLARVKALVKADPDVTLAGQEA IFILARAAELFVETIAKDAYCCAQQGKRKTLQRRDLDNAIEAVDEFAFLEGTLD hide sequence

RefSeq Acc Id:	NP_001357224 ⟸ NM_001370295
- Peptide Label:	isoform 2

RefSeq Acc Id:

ENSMUSP00000124357 ⟸ ENSMUST00000160281

RefSeq Acc Id:

ENSMUSP00000093462 ⟸ ENSMUST00000095786

Protein Domains

CBFD_NFYB_HMF

Promoters

RGD ID:

6839768

Promoter ID:

MM_KWN:46551

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

OTTMUST00000055746, OTTMUST00000055747, OTTMUST00000055748, UC009CLJ.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	6	82,602,401 - 82,603,772 (-)	MPROMDB

RGD ID:

6890096

Promoter ID:

EPDNEW_M8497

Type:

multiple initiation site

Name:

Pole4_1

Description:

Mus musculus polymerase (DNA-directed), epsilon 4 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	6	82,652,874 - 82,652,934	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1914229	AgrOrtholog
Ensembl Genes	ENSMUSG00000030042	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000093462	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUSP00000124357	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000095786	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUST00000160281	UniProtKB/TrEMBL
Gene3D-CATH	1.10.20.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	CBFA_NFYB_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Histone-fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:66979	UniProtKB/Swiss-Prot
MGD	MGI:1914229	ENTREZGENE
NCBI Gene	66979	ENTREZGENE
Pfam	CBFD_NFYB_HMF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pole4	PhenoGen
Superfamily-SCOP	SSF47113	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	DPOE4_MOUSE	UniProtKB/Swiss-Prot
	E0CYA9_MOUSE	UniProtKB/TrEMBL
	Q9CQ36	ENTREZGENE
UniProt Secondary	Q3TJ13	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)