Tmem168 (transmembrane protein 168) - Rat Genome Database

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Gene: Tmem168 (transmembrane protein 168) Mus musculus
Analyze
Symbol: Tmem168
Name: transmembrane protein 168
RGD ID: 1317167
MGI Page MGI
Description: Predicted to enable sodium channel regulator activity. Acts upstream of or within regulation of ubiquitin-dependent protein catabolic process. Located in nuclear membrane. Is expressed in cerebral cortex ventricular layer and heart ventricle. Orthologous to human TMEM168 (transmembrane protein 168).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5730526F17Rik; 8430437G11Rik; AI462344; AI504145
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39613,580,688 - 13,608,097 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl613,580,686 - 13,608,099 (-)EnsemblGRCm39 Ensembl
GRCm38613,580,689 - 13,608,098 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl613,580,687 - 13,608,100 (-)EnsemblGRCm38mm10GRCm38
MGSCv37613,530,689 - 13,558,063 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36613,530,687 - 13,558,063 (-)NCBIMGSCv36mm8
Celera613,672,708 - 13,700,081 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map65.68NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:18799693   PMID:19521500  
PMID:21267068   PMID:21873635   PMID:32175648   PMID:34086898  


Genomics

Comparative Map Data
Tmem168
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39613,580,688 - 13,608,097 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl613,580,686 - 13,608,099 (-)EnsemblGRCm39 Ensembl
GRCm38613,580,689 - 13,608,098 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl613,580,687 - 13,608,100 (-)EnsemblGRCm38mm10GRCm38
MGSCv37613,530,689 - 13,558,063 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36613,530,687 - 13,558,063 (-)NCBIMGSCv36mm8
Celera613,672,708 - 13,700,081 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map65.68NCBI
TMEM168
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387112,762,377 - 112,790,393 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7112,762,377 - 112,790,423 (-)EnsemblGRCh38hg38GRCh38
GRCh377112,402,432 - 112,430,448 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367112,193,023 - 112,217,714 (-)NCBINCBI36Build 36hg18NCBI36
Celera7107,217,551 - 107,242,217 (-)NCBICelera
Cytogenetic Map7q31.1NCBI
HuRef7106,773,091 - 106,797,770 (-)NCBIHuRef
CHM1_17112,339,671 - 112,364,332 (-)NCBICHM1_1
T2T-CHM13v2.07114,080,668 - 114,108,691 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27111,774,269 - 111,798,936 (-)NCBI
Tmem168
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8442,796,714 - 42,824,854 (-)NCBIGRCr8
mRatBN7.2441,830,623 - 41,858,763 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl441,830,624 - 41,858,776 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx446,807,390 - 46,834,480 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0442,728,393 - 42,755,484 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0441,137,097 - 41,164,187 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0440,006,362 - 40,041,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl440,007,844 - 40,036,563 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0439,840,355 - 39,868,490 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4439,012,323 - 39,039,671 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1439,130,864 - 39,158,211 (-)NCBI
Celera437,179,920 - 37,207,841 (-)NCBICelera
Cytogenetic Map4q21NCBI
Tmem168
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543219,002,083 - 19,032,432 (-)NCBIChiLan1.0ChiLan1.0
TMEM168
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26149,596,308 - 149,620,903 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan171,606,567 - 1,632,890 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07104,729,362 - 104,756,299 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17117,433,384 - 117,457,999 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7117,433,384 - 117,458,000 (-)Ensemblpanpan1.1panPan2
TMEM168
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11452,312,109 - 52,340,151 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1452,314,856 - 52,338,214 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1451,771,324 - 51,801,797 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01452,341,015 - 52,371,609 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1452,341,352 - 52,374,455 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11452,381,313 - 52,411,795 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01452,055,666 - 52,086,114 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01452,438,340 - 52,468,897 (-)NCBIUU_Cfam_GSD_1.0
Tmem168
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511840,990,152 - 41,018,604 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365895,671,182 - 5,699,714 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM168
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1832,927,748 - 32,957,960 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11832,928,104 - 32,960,884 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21835,535,714 - 35,603,519 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM168
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12181,567,647 - 81,594,451 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604222,209,045 - 22,235,420 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem168
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248276,526,073 - 6,557,851 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248276,522,145 - 6,557,543 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem168
938 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:829
Count of miRNA genes:563
Interacting mature miRNAs:642
Transcripts:ENSMUST00000031554, ENSMUST00000127050, ENSMUST00000138637, ENSMUST00000140750, ENSMUST00000146139, ENSMUST00000149123, ENSMUST00000155179
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14746985Manh59_mmandible shape 59 (mouse)6120847193Mouse
1301178Lith10_mlithogenic gene 10 (mouse)Not determined6121465015Mouse
10043884Bhr8_mbronchial hyperresponsiveness 8 (mouse)Not determined6121465015Mouse
10044000Mobq9_mmultigenetic obesity QTL 9 (mouse)Not determined6121465015Mouse
1357503Nhdlq5_mnon-HDL QTL 5 (mouse)Not determined6121465015Mouse
12904934Edlmmq4_mextensor digitorum longus muscle mass QTL 4 (mouse)6125514064Mouse
12904942Tammq3_mtibialis anterior muscle mass QTL 3 (mouse)6125514064Mouse
12904955Gmmq3_mgastrocnemius muscle mass QTL 3 (mouse)6125514064Mouse
1301131Chol2_mcholesterol 2 (mouse)Not determined6132144495Mouse
5491191Mobq2_mmultigenic obesity QTL 2 (mouse)Not determined6132144495Mouse
1302024Skull7_mskull morphology 7 (mouse)Not determined6132144495Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633435476334Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920638249325Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
11353836Bmiq1_mbody mass index QTL 1 (mouse)6450382329751333Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse

Markers in Region
AI504145  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38613,581,849 - 13,581,970UniSTSGRCm38
MGSCv37613,531,849 - 13,531,970UniSTSGRCm37
Celera613,673,868 - 13,673,989UniSTS
Cytogenetic Map6A2UniSTS
AI462344  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38613,581,525 - 13,581,679UniSTSGRCm38
MGSCv37613,531,525 - 13,531,679UniSTSGRCm37
Celera613,673,544 - 13,673,698UniSTS
Cytogenetic Map6A2UniSTS
UniSTS:235388  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38613,581,662 - 13,581,875UniSTSGRCm38
MGSCv37613,531,662 - 13,531,875UniSTSGRCm37
Celera613,673,681 - 13,673,894UniSTS
Cytogenetic Map6A2UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000031554   ⟹   ENSMUSP00000031554
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl613,580,686 - 13,608,099 (-)Ensembl
GRCm38.p6 Ensembl613,580,687 - 13,608,100 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127050
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl613,603,381 - 13,607,747 (-)Ensembl
GRCm38.p6 Ensembl613,603,382 - 13,607,748 (-)Ensembl
RefSeq Acc Id: ENSMUST00000138637
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl613,607,287 - 13,608,026 (-)Ensembl
GRCm38.p6 Ensembl613,607,288 - 13,608,027 (-)Ensembl
RefSeq Acc Id: ENSMUST00000140750
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl613,603,397 - 13,608,004 (-)Ensembl
GRCm38.p6 Ensembl613,603,398 - 13,608,005 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146139
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl613,606,598 - 13,608,018 (-)Ensembl
GRCm38.p6 Ensembl613,606,599 - 13,608,019 (-)Ensembl
RefSeq Acc Id: ENSMUST00000149123   ⟹   ENSMUSP00000145372
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl613,580,686 - 13,608,099 (-)Ensembl
GRCm38.p6 Ensembl613,580,687 - 13,608,100 (-)Ensembl
RefSeq Acc Id: ENSMUST00000155179
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl613,605,934 - 13,608,043 (-)Ensembl
GRCm38.p6 Ensembl613,605,935 - 13,608,044 (-)Ensembl
RefSeq Acc Id: NM_028990   ⟹   NP_083266
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39613,580,688 - 13,608,097 (-)NCBI
GRCm38613,580,689 - 13,608,098 (-)NCBI
MGSCv37613,530,689 - 13,558,063 (-)RGD
Celera613,672,708 - 13,700,081 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_155435
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39613,580,688 - 13,608,097 (-)NCBI
GRCm38613,580,689 - 13,608,098 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006504952   ⟹   XP_006505015
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39613,581,293 - 13,608,025 (-)NCBI
GRCm38613,581,294 - 13,607,915 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006504953   ⟹   XP_006505016
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39613,581,293 - 13,608,029 (-)NCBI
GRCm38613,581,294 - 13,607,911 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_083266   ⟸   NM_028990
- UniProtKB: Q3TDA5 (UniProtKB/Swiss-Prot),   Q91VX9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006505016   ⟸   XM_006504953
- Peptide Label: isoform X1
- UniProtKB: Q3TDA5 (UniProtKB/Swiss-Prot),   Q91VX9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006505015   ⟸   XM_006504952
- Peptide Label: isoform X1
- UniProtKB: Q3TDA5 (UniProtKB/Swiss-Prot),   Q91VX9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000031554   ⟸   ENSMUST00000031554
RefSeq Acc Id: ENSMUSP00000145372   ⟸   ENSMUST00000149123

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91VX9-F1-model_v2 AlphaFold Q91VX9 1-697 view protein structure

Promoters
RGD ID:6840081
Promoter ID:MM_KWN:45194
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000058284,   OTTMUST00000058285,   OTTMUST00000058286,   OTTMUST00000058287,   OTTMUST00000058288,   OTTMUST00000058289,   OTTMUST00000058295
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36613,557,566 - 13,558,697 (-)MPROMDB
RGD ID:6889022
Promoter ID:EPDNEW_M7962
Type:multiple initiation site
Name:Tmem168_1
Description:Mus musculus transmembrane protein 168 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38613,608,019 - 13,608,079EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921794 AgrOrtholog
Ensembl Genes ENSMUSG00000029569 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031554 ENTREZGENE
  ENSMUST00000031554.9 UniProtKB/Swiss-Prot
  ENSMUST00000149123 ENTREZGENE
  ENSMUST00000149123.3 UniProtKB/TrEMBL
InterPro TMEM168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:101118 UniProtKB/Swiss-Prot
MGD MGI:1921794 ENTREZGENE
NCBI Gene 101118 ENTREZGENE
PANTHER PTHR14437 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmem168 PhenoGen
UniProt A0A0N4SW50_MOUSE UniProtKB/TrEMBL
  Q3TDA5 ENTREZGENE
  Q91VX9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3TDA5 UniProtKB/Swiss-Prot