Gan (giant axonal neuropathy) - Rat Genome Database

Name: Gan
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Gan (giant axonal neuropathy) Mus musculus

Analyze

Symbol:

Gan

Name:

giant axonal neuropathy

RGD ID:

1317148

MGI Page

MGI

Description:

Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within cytoskeleton organization. Predicted to be located in cytoplasm. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Used to study giant axonal neuropathy 1. Human ortholog(s) of this gene implicated in giant axonal neuropathy 1. Orthologous to human GAN (gigaxonin).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

A330045G18; gig; gigaxonin

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GAN (gigaxonin)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, Panther, PhylomeDB
Rattus norvegicus (Norway rat):	Gan (gigaxonin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gan (gigaxonin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GAN (gigaxonin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GAN (gigaxonin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gan (gigaxonin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GAN (gigaxonin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GAN (gigaxonin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gan (gigaxonin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Gan (gigaxonin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	GAN (gigaxonin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gan (gigaxonin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Xenopus tropicalis (tropical clawed frog):	gan	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	117,884,720 - 117,932,573 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	117,884,874 - 117,942,736 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	117,157,981 - 117,205,834 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	117,158,135 - 117,215,997 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	119,682,035 - 119,729,086 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	120,044,112 - 120,091,163 (+)	NCBI		MGSCv36	mm8
Celera	8	121,377,818 - 121,424,875 (+)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	63.71	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease (ISO)

genetic disease (ISO)

Giant Axonal Neuropathy (ISO)

giant axonal neuropathy 1 (IAGP,ISO)

intellectual disability (ISO)

Muscle Hypotonia (ISO)

neuropathy (ISO)

peripheral nervous system disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

3,4-methylenedioxymethamphetamine (EXP)

acetamide (ISO)

aflatoxin B1 (EXP,ISO)

arsenite(3-) (ISO)

Benoxacor (EXP)

bisphenol A (EXP,ISO)

carbon nanotube (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

doxorubicin (ISO)

ethanol (EXP)

gentamycin (ISO)

maneb (EXP)

methoxychlor (ISO)

nickel sulfate (ISO)

paracetamol (ISO)

paraquat (EXP)

perfluorooctanoic acid (ISO)

phenobarbital (EXP)

pirinixic acid (EXP)

potassium chromate (ISO)

quercetin (ISO)

resorcinol (ISO)

silicon dioxide (EXP)

silver atom (EXP)

silver(0) (EXP)

sodium arsenite (ISO)

stavudine (EXP)

sunitinib (ISO)

T-2 toxin (ISO)

thioacetamide (ISO)

triptonide (EXP)

trovafloxacin (EXP)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytoskeleton organization (ISO)

protein ubiquitination (ISO)

Cellular Component

Cul3-RING ubiquitin ligase complex (ISO)

cytoplasm (ISO)

cytoskeleton (IEA)

Molecular Function

protein binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal axon morphology (IAGP)

abnormal axonal transport (IAGP)

abnormal cell morphology (IAGP)

abnormal gait (IAGP)

abnormal locomotor activation (IAGP)

abnormal motor neuron innervation pattern (IAGP)

abnormal myelin sheath morphology (IAGP)

abnormal nervous system morphology (IAGP)

abnormal posture (IAGP)

abnormal ventral spinal root morphology (IAGP)

muscle spasm (IAGP)

muscular atrophy (IAGP)

premature death (IAGP)

progressive muscle weakness (IAGP)

seizures (IAGP)

weakness (IAGP)

weight loss (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	MGDs mouse GO annotations	MGD data from the GO Consortium
2.	MGD IEA	MGD IEA
3.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:11042159	PMID:11062483	PMID:11076861	PMID:11217851	PMID:12147674	PMID:12477932	PMID:12520002	PMID:14610273	PMID:14681479	PMID:16141072	PMID:16141073
PMID:16227972	PMID:16303566	PMID:16565160	PMID:16602821	PMID:18680552	PMID:19782434	PMID:21486449	PMID:21677750	PMID:23585478	PMID:27000625	PMID:30770803	PMID:32325033
PMID:37137704

Genomics

Comparative Map Data

Gan
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	117,884,720 - 117,932,573 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	117,884,874 - 117,942,736 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	117,157,981 - 117,205,834 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	117,158,135 - 117,215,997 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	119,682,035 - 119,729,086 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	120,044,112 - 120,091,163 (+)	NCBI		MGSCv36	mm8
Celera	8	121,377,818 - 121,424,875 (+)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	63.71	NCBI

GAN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	81,314,962 - 81,390,809 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	81,314,944 - 81,390,809 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	81,348,567 - 81,424,414 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	79,906,076 - 79,971,441 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	79,906,075 - 79,971,441	NCBI
Celera	16	65,645,867 - 65,711,100 (+)	NCBI		Celera
Cytogenetic Map	16	q23.2	NCBI
HuRef	16	67,103,386 - 67,168,596 (+)	NCBI		HuRef
CHM1_1	16	82,759,876 - 82,825,083 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	87,375,728 - 87,451,557 (+)	NCBI		T2T-CHM13v2.0

Gan
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	62,116,600 - 62,173,879 (+)	NCBI		GRCr8
mRatBN7.2	19	45,207,783 - 45,265,066 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	45,207,184 - 45,254,107 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	52,017,893 - 52,064,198 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	52,670,909 - 52,717,223 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	54,915,137 - 54,961,451 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	49,692,790 - 49,746,178 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	49,695,579 - 49,741,965 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	60,480,642 - 60,533,157 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	47,263,532 - 47,310,683 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	47,268,492 - 47,315,557 (+)	NCBI
Celera	19	44,479,857 - 44,526,017 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

Gan
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955522	4,035,672 - 4,090,630 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955522	4,035,672 - 4,096,845 (+)	NCBI	ChiLan1.0	ChiLan1.0

GAN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	91,056,924 - 91,140,629 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	96,976,406 - 97,060,039 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	61,919,004 - 61,994,811 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	81,347,221 - 81,410,363 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	81,347,215 - 81,410,363 (+)	Ensembl	panpan1.1		panPan2

GAN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	70,518,667 - 70,579,398 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	70,530,396 - 70,579,567 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	70,488,907 - 70,528,607 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	70,823,382 - 70,884,349 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	70,827,374 - 70,884,517 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	70,766,100 - 70,826,821 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	70,601,294 - 70,662,010 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	71,079,113 - 71,139,854 (-)	NCBI		UU_Cfam_GSD_1.0

Gan
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	30,609,452 - 30,661,047 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	28,945,908 - 28,967,653 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	28,913,132 - 28,979,656 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GAN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	6,933,503 - 6,989,653 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	6,921,446 - 6,989,670 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	7,466,847 - 7,524,943 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GAN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	66,754,752 - 66,820,933 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	66,754,893 - 66,816,761 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	9,017,449 - 9,081,670 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gan
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	6,081,033 - 6,126,858 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	6,070,680 - 6,126,949 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gan
1762 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	796
Count of miRNA genes:	357
Interacting mature miRNAs:	410
Transcripts:	ENSMUST00000064488, ENSMUST00000162997
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4140967	Bmd39_m	bone mineral density 39 (mouse)			Not determined		8	32506572	117965439	Mouse
1357708	Orq1_m	ovulation rate QTL 1 (mouse)			Not determined		8	71740461	124622354	Mouse
4142023	W3q5_m	weight 3 weeks QTL 5 (mouse)			Not determined			71740461	124622354	Mouse
27095912	Pglq14_m	pelvic girdle length QTL 14, 16 week (mouse)					8	74126628	126826739	Mouse
1301766	Desp1_m	despair 1 (mouse)			Not determined		8	85486208	119486373	Mouse
1302049	Heal1_m	wound healing/regeneration 1 (mouse)			Not determined		8	86443553	120443701	Mouse
1301253	Skmw2_m	skeletal muscle weight 2 (mouse)			Not determined		8	86443553	120443701	Mouse
10045619	Heal14_m	wound healing/regeneration 14 (mouse)			Not determined		8	86443553	120443701	Mouse
27226796	Scvln16_m	sacral vertebrae length 2, 16 week (mouse)					8	89726628	130027694	Mouse
1357494	Obsty2_m	obesity 2 (mouse)			Not determined		8	96245241	129745061	Mouse
12880431	Fgf23lq2_m	FGF23 serum level QTL 2 (mouse)					8	97626632	130127694	Mouse
11252141	Fdr2_m	fat response to dietary restriction 2 (mouse)					8	98390634	130127694	Mouse
1301481	Lith11_m	lithogenic gene 11 (mouse)			Not determined		8	98563635	130127694	Mouse
1302105	Im1_m	Immunoregulatory 1 (mouse)			Not determined		8	99828531	130127694	Mouse
1301080	Sluc9_m	susceptibility to lung cancer 9 (mouse)			Not determined		8	99828531	130127694	Mouse
4141435	Fbtq3_m	femoral bone trait QTL 3 (mouse)			Not determined		8	100965309	130127694	Mouse
1301316	Dntcs1_m	dental caries susceptibility 1 (mouse)			Not determined		8	103443553	127781786	Mouse
11532691	Sluc38_m	susceptibility to lung cancer 38 (mouse)					8	105033977	130127694	Mouse
11532692	Sluc38a_m	susceptibility to lung cancer 38a (mouse)					8	105033977	130127694	Mouse
14746994	Manh65_m	mandible shape 65 (mouse)					8	106489629	130127694	Mouse
10412273	Fcd1_m	functional capillary density 1 (mouse)			Not determined		8	110415083	130127694	Mouse
10412274	Leci1_m	leukocyte endothelial cell interactions 1 (mouse)			Not determined		8	110415083	130127694	Mouse
12904938	Edlmmq7_m	extensor digitorum longus muscle mass QTL 7 (mouse)					8	111481497	130127694	Mouse
12904960	Gmmq6_m	gastrocnemius muscle mass QTL 6 (mouse)					8	111481497	130127694	Mouse
4141546	Mrdq3_m	modifier of retinal degeneration QTL 3 (mouse)			Not determined			114439420	126055880	Mouse

Markers in Region

Gan

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	8	E1	UniSTS
cM Map	8		UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001081151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC121116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK039455	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC112432	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000064488 ⟹ ENSMUSP00000070168

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	8	117,884,874 - 117,931,925 (+)	Ensembl
GRCm38.p6 Ensembl	8	117,158,135 - 117,205,186 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000162997 ⟹ ENSMUSP00000124904

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	8	117,884,876 - 117,942,736 (+)	Ensembl
GRCm38.p6 Ensembl	8	117,158,137 - 117,215,997 (+)	Ensembl

RefSeq Acc Id:

NM_001081151 ⟹ NP_001074620

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	117,884,720 - 117,932,573 (+)	NCBI
GRCm38	8	117,157,981 - 117,205,834 (+)	NCBI
MGSCv37	8	119,682,035 - 119,729,086 (+)	RGD
Celera	8	121,377,818 - 121,424,875 (+)	RGD
cM Map	8		ENTREZGENE

Sequence:

show sequence

GGCGCAGGCGCGTTGTTGAACTTCCAGCTCTGACTCCAGAGCTTCACTCAGTCCGGGCGGGCGG
GCGAGCGGACGCGAGGAGTGGCCGGCGGGGACGTGCGCGGGACTCGGGCGGGCGGGTCGGGCAG
GTGGCGGCGGAGGAGCGGGAGGCGCGATGGCCGAGGGCAGCGCTGTGTCCGACCCTCAGCACGC
CGCGCGCCTGCTGCGGGCGCTCAGCTCGTTCCGGGAGGAGGCGCGTTTCTGCGACGCGCATCTG
GTCCTCGACGGCGAGGAGATCCCGGTGCAGAAGAACATCCTGGCGGCGGCCAGCCCGTACATCA
GGACAAAGTTAAACTATAATCCTCCAAAAGATGACGGATCCACTTATAAGATTGAACTTGAAGG
GATATCGGTAATGGTGATGAGAGAGATCCTGGATTACATCTTCAGTGGGCAGATCAGGTTAAAT
GAAGATACAATCCAGGATGTTGTGCAGGCAGCCGACCTGCTGCTGCTGACGGACCTGAAAACGC
TGTGCTGTGAGTTCCTGGAGGGCTGCATAGCGGCGGAGAACTGCATTGGCATCCGGGACTTTGC
GCTGCACTACTGCCTGCACCACGTGCATTACCTGGCCACTGAGTACCTGGAGACCCACTTCCGA
GACGTCAGCAGCACAGAGGAGTTCCTGGAGCTGAGTCCACAGAAACTCAAAGAAGTGATCTCTC
TCGAGAAGCTGAACGTTGGCAACGAGAGATACGTGTTCGAGGCAGTGATTCGGTGGATAGCACA
CGATGTAGAGATGAGAAAGGTCCACATGAAGGATGTCATGTCAGCGCTGTGGGTCTCGGGGCTG
GACTCCAGCTACCTGCGCGAGCAGATGCTGAATGAACCCTTGGTGCGAGAAATCGTCAAAGAGT
GCAGCAACATCCCGCTCAGCCAGCCGCAGCAGGGGGAGGCCATGCTGGCCAGCTTCAAGCCCAG
GGGCTACTCAGAGTGCATAGTGACCATCGGAGGGGAGGAGAGAGTGTCACGGAAACCCACAGCG
GCCATGCGATGTATGTGCCCTCTCTACGACCCTAACCGGCAGCTGTGGATTGAACTGGCTCCTC
TGAGCATGCCGAGAATTAACCATGGAGTTCTTTCAGCAGAAGGATTTCTGTTTGTGTTGGGGGG
CCAAGATGAAAACAAGCAGACGCTGAGCTCAGGAGAGAAGTATGACCCAGACGCTAACACGTGG
ACTGCGCTCCCACCCATGCATGAGGCAAGACACAACTTTGGGATCGTGGAGATAGACGGGATGC
TCTACATCCTTGGAGGGGAGGATGGCGATCGAGAGCTCATTTCCATGGAGTGTTATGATATTTA
TTCCAAAACCTGGACGAAGCAGCCCGACTTGACCATGGTTAGGAAGATTGGCTGCTATGCAGCT
ATGAAAAAGAAAATCTATGCCATGGGCGGAGGCTCGTATGGAAAACTGTTTGAGTCTGTGGAGT
GTTACGACCCACGGACCCAGCAATGGACTGCCATATGCCCACTGAAAGAGAGGAGGTTTGGAGC
AGTGGCCTGTGGTGTTGCCATGGAGCTGTATGTGTTTGGAGGCGTCCGAAGTCGAGAGGACATC
CAGGGCAGCGAGATGGTCACCTGCAAGTCCGAGTTCTATCATGACGAGTTTAAGAGGTGGATCT
ACCTTAACGATCAGAACCTATGCATCCCTGCCAGCTCCTCCTTTGTCTACGGAGCGGTCCCCAT
AGGAGCCAGTATTTATGTTATCGGAGACCTGGACACAGGTACCAACTACGACTACGTGCGGGAG
TTTAAGAGAAGCACGGGCACCTGGCACCACACAAAGCCACTCCTGCCATCTGACCTTCGGCGCA
CAGGCTGTGCAGCCCTGCGCATAGCCAACTGCAAGCTCTTCCGCCTGCAGCTGCAACAAGGCTT
GTTCCGCATCCGGGTCCATTCCCCTTGAAGAGGAAGAGGAGCCAAAAGTGAGATCCTGCCCCAA
GCGCATCCCGTGGCTGGCGGCGGCAAGTGCAGTGAAGCAGCCCCATCTCGCTGTGCGCTGGGCT
TGAGTGTGGTTACTCTCTGGTGGTTTTTTTAATGCTTAGGAGCTCAGGCTTCTGCCCTGGTCTG
GAGACCGTGTACTGTTGAAAAACTACCTGCACGGAGTCGGTTCCTCCAGCCTGATGCGTCCGTA
ACCAAGGCTAGTGAATGTCCTAGGAGGAGGGTGTGGGGGTTGGTGTCATGTGAAATATCAAAGT
TAAAACCCTAAGGTGCATTTTCCCAGAAGGGAACTCTTACCTGACTGACTGCGGAGTTCCAGTG
TGTGTGGCTGTGGTCAACAAACAACAGAATCCATATATGCAAGCCAACATAGCCGGCGTACGAG
GTTGTCCTTGTACTGCGTGCGGAGGGGTAGAATGCCTGGCCCCACCGAGTAATTGAGGTTTGCG
CAGTTAGTTCCCACTTATTACTAGTGCTCTGTCTTAAGACTCTTAAAAACTATATTCTGATGAA
CTGAAACTAAGATAAAACTCCTCTCTGGCAACAGTCTACCTTAGTGAAGGTTCAGTCACCCGAG
GAGCTCAGGTCCGAAGCCTGTGTGTGAGCTTAAAGGAATTGTTCACCGGGAAAGATCCTGCGCC
AGGCCGAGAGAGCTCTGGGGTGGTGCTGTGAGATCCGAGGGAGGCATACCGTAATTCCTCCTTC
CCACCTGAGAAGCAGAGCTGTTTTCTAAGCTCCAGGCTGCGAGTGCAAAGGAGACTTTAGACAG
AGTCGGGCAAAGGAGAGTTCCACTGCGACTAAAAACAGTAAGACATATATTTAAAAACAAAAAC
AAAAACTAAAAACACAACTGTCTAGGGATCAAAAGGTCTGCATCTGATCTGTCTTGAAGCACGC
TCGGTCCTGTTTACTGCTGCGTAGAGCTGCAAGCTTGTCTTTGAATGCAGGTGTGTGTGGAATT
GGGTCTTTGGAACAGGCCGCTCCCACAGCATAGGAGTATAGATGAACTTTGCTCCAGGTAACGT
TTGACTGGTAGAATAAACTACCTCAACTTAATTGTATTCTGTTCCCATTAGTACCCACCCCCCA
TTCCCCATCTCTCACCCCCACCTTCACCCTCTGCTCCACTTCCCCTTAGTAAAAAGAATTCCTT
AGTTAGTGGGATTTATTTCGTAAGATATTTTGTTTTCCATTTAGATTATGGCCCCTTGGTGTGA
AATGAGGAGCTTGGCACACTCGGTTATATCATAGTGTGCAATATCAAGTTTCTAGTCGGCTTGA
TAGAGATTTCCTCATTTCTGTTTTCTTTAGATTTCTTTCTCTTAGAGATGAGTGTAAGAGGCAA
CATTGTATCGTAGTGACTGCTAACTGTGTACATGCATCCTCTGGTCATGTTGGAGAACAGGAAT
CTCTTCTCTAAACTTCCTCCCTGCGTGAGATGTTTATATGCAATTAAAGTGCGTGTAAGACA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001074620	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI12433	(Get FASTA)	NCBI Sequence Viewer
	BAC30353	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000070168
	ENSMUSP00000070168.5
	ENSMUSP00000124904.2
GenBank Protein	Q8CA72	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001074620 ⟸ NM_001081151

- UniProtKB:

Q8CA72 (UniProtKB/Swiss-Prot), F6TZU3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEGSAVSDPQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPP
KDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGC
IAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNE
RYVFEAVIRWIAHDVEMRKVHMKDVMSALWVSGLDSSYLREQMLNEPLVREIVKECSNIPLSQP
QQGEAMLASFKPRGYSECIVTIGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHG
VLSAEGFLFVLGGQDENKQTLSSGEKYDPDANTWTALPPMHEARHNFGIVEIDGMLYILGGEDG
DRELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQW
TAICPLKERRFGAVACGVAMELYVFGGVRSREDIQGSEMVTCKSEFYHDEFKRWIYLNDQNLCI
PASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRIA
NCKLFRLQLQQGLFRIRVHSP

hide sequence

RefSeq Acc Id:

ENSMUSP00000124904 ⟸ ENSMUST00000162997

RefSeq Acc Id:

ENSMUSP00000070168 ⟸ ENSMUST00000064488

Protein Domains

BACK BTB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8CA72-F1-model_v2	AlphaFold	Q8CA72	1-597	view protein structure

Promoters

RGD ID:

6843178

Promoter ID:

MM_KWN:55866

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

OTTMUST00000085106

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	8	119,681,621 - 119,682,367 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1890619	AgrOrtholog
Ensembl Genes	ENSMUSG00000052557	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000064488	ENTREZGENE
	ENSMUST00000064488.11	UniProtKB/Swiss-Prot
	ENSMUST00000162997.3	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.420	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.120.10.80	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	BACK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BTB-kelch_protein	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BTB/POZ_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kelch-typ_b-propeller	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kelch_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	KLHL16	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	KLHL16_BTB_POZ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SKP1/BTB/POZ_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:209239	UniProtKB/Swiss-Prot
MGD	MGI:1890619	ENTREZGENE
NCBI Gene	209239	ENTREZGENE
PANTHER	KELCH PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR24412:SF232	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	BACK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BTB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kelch_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Gan	PhenoGen
PIRSF	Kelch-like_protein_gigaxonin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	BTB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	BACK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BTB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kelch	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF117281	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF54695	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	F6TZU3	ENTREZGENE, UniProtKB/TrEMBL
	GAN_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Mammalian Phenotype

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Mammalian Phenotype