Nedd1 (neural precursor cell expressed, developmentally down-regulated gene 1) - Rat Genome Database

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Gene: Nedd1 (neural precursor cell expressed, developmentally down-regulated gene 1) Mus musculus
Analyze
Symbol: Nedd1
Name: neural precursor cell expressed, developmentally down-regulated gene 1
RGD ID: 1317124
MGI Page MGI
Description: Predicted to enable gamma-tubulin binding activity. Predicted to be involved in microtubule nucleation and mitotic cell cycle. Predicted to act upstream of or within microtubule depolymerization and regulation of establishment of protein localization. Located in apical part of cell; cytoplasm; and microtubule cytoskeleton. Is expressed in several structures, including duodenum epithelium; genitourinary system; lung; nervous system; and sensory organ. Orthologous to human NEDD1 (NEDD1 gamma-tubulin ring complex targeting factor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NEDD-1; neural precursor cell expressed developmentally down-regulated protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391092,520,607 - 92,559,544 (-)NCBIGRCm39mm39
GRCm39 Ensembl1092,520,608 - 92,558,282 (-)Ensembl
GRCm381092,684,745 - 92,722,418 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1092,684,746 - 92,722,420 (-)EnsemblGRCm38mm10GRCm38
MGSCv371092,147,490 - 92,185,163 (-)NCBIGRCm37mm9NCBIm37
MGSCv361092,114,545 - 92,152,159 (-)NCBImm8
Celera1094,676,340 - 94,714,125 (-)NCBICelera
Cytogenetic Map10C2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1378265   PMID:8157664   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12904583   PMID:14610273   PMID:15489334   PMID:16107646   PMID:16141072  
PMID:16141073   PMID:16537572   PMID:16602821   PMID:18207742   PMID:18239929   PMID:20079731   PMID:20224777   PMID:20360068   PMID:20368287   PMID:21267068   PMID:21364642   PMID:21440680  
PMID:21873635   PMID:23106787   PMID:26158450   PMID:26496610   PMID:27298324   PMID:31040226   PMID:32098917   PMID:32325033  


Genomics

Comparative Map Data
Nedd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391092,520,607 - 92,559,544 (-)NCBIGRCm39mm39
GRCm39 Ensembl1092,520,608 - 92,558,282 (-)Ensembl
GRCm381092,684,745 - 92,722,418 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1092,684,746 - 92,722,420 (-)EnsemblGRCm38mm10GRCm38
MGSCv371092,147,490 - 92,185,163 (-)NCBIGRCm37mm9NCBIm37
MGSCv361092,114,545 - 92,152,159 (-)NCBImm8
Celera1094,676,340 - 94,714,125 (-)NCBICelera
Cytogenetic Map10C2NCBI
NEDD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381296,907,257 - 96,953,780 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1296,907,224 - 96,953,780 (+)EnsemblGRCh38hg38GRCh38
GRCh371297,301,035 - 97,347,558 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361295,825,375 - 95,870,172 (+)NCBINCBI36hg18NCBI36
Build 341295,803,711 - 95,848,507NCBI
Celera1296,967,004 - 97,013,462 (+)NCBI
Cytogenetic Map12q23.1NCBI
HuRef1294,363,760 - 94,410,169 (+)NCBIHuRef
CHM1_11297,265,952 - 97,312,431 (+)NCBICHM1_1
Nedd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2727,233,315 - 27,274,486 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl727,233,316 - 27,274,486 (-)Ensembl
Rnor_6.0733,544,097 - 33,584,406 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl733,543,828 - 33,584,564 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0733,615,235 - 33,655,544 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4729,704,249 - 29,745,416 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1729,724,518 - 29,773,468 (-)NCBI
Celera724,340,948 - 24,381,914 (-)NCBICelera
Cytogenetic Map7q13NCBI
Nedd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540533,058,839 - 33,112,358 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540533,066,734 - 33,109,750 (+)NCBIChiLan1.0ChiLan1.0
NEDD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11297,914,112 - 97,959,953 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1297,914,112 - 97,959,945 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01294,497,203 - 94,543,412 (+)NCBIMhudiblu_PPA_v0panPan3
NEDD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11536,542,218 - 36,589,380 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1536,542,152 - 36,587,758 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1536,926,673 - 36,973,707 (+)NCBI
ROS_Cfam_1.01537,206,756 - 37,253,864 (+)NCBI
ROS_Cfam_1.0 Ensembl1537,205,935 - 37,253,850 (+)Ensembl
UMICH_Zoey_3.11536,478,601 - 36,525,635 (+)NCBI
UNSW_CanFamBas_1.01536,572,344 - 36,619,417 (+)NCBI
UU_Cfam_GSD_1.01536,843,539 - 36,890,793 (+)NCBI
LOC101957471
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560252,940,558 - 52,946,286 (+)NCBI
SpeTri2.0NW_0049366772,954,738 - 2,963,072 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEDD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl586,693,815 - 86,737,229 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1586,693,802 - 86,737,259 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2591,290,874 - 91,316,139 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEDD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11192,256,975 - 92,301,430 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1192,259,578 - 92,301,605 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037152,798,574 - 152,843,034 (-)NCBIVero_WHO_p1.0
Nedd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475010,497,362 - 10,542,732 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
1301520Uvbi1_mUVB induced immunosuppression 1 (mouse)Not determined1086909085120909229Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
4141387Lgaq5_mlate growth adjusted QTL 5 (mouse)Not determined84079650122041528Mouse
1302162Ednrbm1_mendothelin receptor type B modifier 1 (mouse)Not determined1092127383103713756Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
4141054mwfh_mmodifier of white forlock hypopigmentation (mouse)Not determined83017003117017136Mouse
1301758Fcsa3_mfemoral cross-sectional area 3 (mouse)Not determined1089927651123927754Mouse
1300797Sluc22_msusceptibility to lung cancer 22 (mouse)Not determined1086713608120713756Mouse
1357594Estoq3_membryo survival total QTL 3 (mouse)Not determined1084079650122041528Mouse
1357622Espq3_membryo survival preimplantation QTL 3 (mouse)Not determined1084079650122041528Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
1357638Cia29_mcollagen induced arthritis 29 (mouse)Not determined1085454982118497353Mouse
4141479W10q8_mweight 10 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1300908Insq4_minsulin QTL 4 (mouse)Not determined1086909085120909229Mouse
1300921Skl4_mskeletal size (tail length) 4 (mouse)Not determined1088088254122088391Mouse
1357779Tesq3_mtestis weight QTL 3 (mouse)Not determined1084079650122041528Mouse
1357831Igf1sl2_mIGF-1 serum levels 2 (mouse)Not determined108769412799936278Mouse
1301165Lith7_mlithogenic gene 7 (mouse)Not determined1082309418116309657Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
4142365Egq9_mearly growth QTL 9 (mouse)Not determined84079650122041528Mouse
4142386Tgq20_mtriglyceride QTL 20 (mouse)Not determined88836456122836456Mouse
10043881Adip24_madiposity 24 (mouse)Not determined1082392803116392952Mouse
4142496W6q8_mweight 6 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
11059551Lmr32b_mleishmaniasis resistance 32b (mouse)1082309418116309657Mouse
13208554Lgth11_mbody length 11 (mouse)1090835862120835905Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
11039516Ltpr5_mLeishmania tropica response 5 (mouse)1090506901125575232Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
13524528Bodwtq9_mbody wweight QTL 9 (mouse)108764311793193117Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
11059550Lmr32a_mleishmaniasis resistance 32a (mouse)1082309418116309657Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
11059555Lmr32f_mleishmaniasis resistance 32f (mouse)1082309418116309657Mouse
11059553Lmr32d_mleishmaniasis resistance 32d (mouse)1082309418116309657Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse
12910821Ogrq4_moverall growth rate QTL 4 (mouse)1092169056107319989Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
14747004Mancz8_mmandible centroid size 8 (mouse)1082078412116078412Mouse
11059554Lmr32e_mleishmaniasis resistance 32e (mouse)1082309418116309657Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:387
Count of miRNA genes:278
Interacting mature miRNAs:315
Transcripts:ENSMUST00000020163
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000020163   ⟹   ENSMUSP00000020163
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1092,520,608 - 92,558,282 (-)Ensembl
GRCm38.p6 Ensembl1092,684,746 - 92,722,420 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214417
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1092,527,376 - 92,558,225 (-)Ensembl
GRCm38.p6 Ensembl1092,691,514 - 92,722,363 (-)Ensembl
RefSeq Acc Id: ENSMUST00000215970
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1092,536,756 - 92,552,340 (-)Ensembl
GRCm38.p6 Ensembl1092,700,894 - 92,716,478 (-)Ensembl
RefSeq Acc Id: ENSMUST00000216086   ⟹   ENSMUSP00000150817
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1092,547,145 - 92,558,266 (-)Ensembl
GRCm38.p6 Ensembl1092,711,283 - 92,722,404 (-)Ensembl
RefSeq Acc Id: NM_008682   ⟹   NP_032708
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391092,520,607 - 92,558,280 (-)NCBI
GRCm381092,684,745 - 92,722,418 (-)NCBI
MGSCv371092,147,490 - 92,185,163 (-)RGD
Celera1094,676,340 - 94,714,125 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036155673   ⟹   XP_036011566
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391092,524,466 - 92,559,544 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032708   ⟸   NM_008682
- UniProtKB: P33215 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000020163   ⟸   ENSMUST00000020163
RefSeq Acc Id: ENSMUSP00000150817   ⟸   ENSMUST00000216086
RefSeq Acc Id: XP_036011566   ⟸   XM_036155673
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33215-F1-model_v2 AlphaFold P33215 1-660 view protein structure

Promoters
RGD ID:6819657
Promoter ID:MM_KWN:5352
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000020163,   UC007GUE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361092,184,941 - 92,185,441 (-)MPROMDB
RGD ID:8673048
Promoter ID:EPDNEW_M14555
Type:initiation region
Name:Nedd1_1
Description:Mus musculus neural precursor cell expressed, developmentallydown-regulated gene 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381092,722,372 - 92,722,432EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97293 AgrOrtholog
Ensembl Genes ENSMUSG00000019988 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000020163 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000150817 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020163 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000216086 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot
InterPro WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WD40_repeat UniProtKB/Swiss-Prot
  WD40_repeat_CS UniProtKB/Swiss-Prot
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17997 UniProtKB/Swiss-Prot
MGD MGI:97293 ENTREZGENE
NCBI Gene 17997 ENTREZGENE
Pfam WD40 UniProtKB/Swiss-Prot
PhenoGen Nedd1 PhenoGen
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot
  WD_REPEATS_2 UniProtKB/Swiss-Prot
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
SMART WD40 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SUM9_MOUSE UniProtKB/TrEMBL
  NEDD1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6NXV3 UniProtKB/Swiss-Prot
  Q8BN12 UniProtKB/Swiss-Prot
  Q8BN86 UniProtKB/Swiss-Prot
  Q8BQL9 UniProtKB/Swiss-Prot
  Q9CWK2 UniProtKB/Swiss-Prot