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Gene: TBX6 (T-box transcription factor 6) Homo sapiens
Symbol: TBX6
Name: T-box transcription factor 6
RGD ID: 1317068
Description: Exhibits sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including cell fate specification; heart development; and regulation of transcription, DNA-templated. Predicted to localize to nuclear chromatin. Implicated in spondylocostal dysostosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DFNB67; SCDO5; T-box 6; T-box protein 6; T-box transcription factor TBX6
Mus musculus (house mouse) : Tbx6 (T-box 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tbx6 (T-box transcription factor 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tbx6 (T-box transcription factor 6)
Pan paniscus (bonobo/pygmy chimpanzee) : TBX6 (T-box transcription factor 6)
Canis lupus familiaris (dog) : TBX6 (T-box transcription factor 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tbx6 (T-box transcription factor 6)
Sus scrofa (pig) : TBX6 (T-box transcription factor 6)
Chlorocebus sabaeus (African green monkey) : TBX6 (T-box transcription factor 6)
Heterocephalus glaber (naked mole-rat) : Tbx6 (T-box transcription factor 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1630,085,793 - 30,091,924 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1630,085,793 - 30,091,887 (-)EnsemblGRCh38hg38GRCh38
GRCh381630,085,793 - 30,091,927 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371630,097,114 - 30,103,258 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,004,583 - 30,010,709 (-)NCBINCBI36hg18NCBI36
Build 341630,004,582 - 30,010,709NCBI
Celera1672,692,515 - 72,698,605 (+)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1627,758,384 - 27,764,471 (-)NCBIHuRef
CHM1_11631,312,871 - 31,318,962 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TBX6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317068
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.