Isy1 (ISY1 splicing factor homolog) - Rat Genome Database
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Gene: Isy1 (ISY1 splicing factor homolog) Mus musculus
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Symbol: Isy1
Name: ISY1 splicing factor homolog
RGD ID: 1317021
MGI Page MGI
Description: Orthologous to several human genes including ISY1-RAB43 (ISY1-RAB43 readthrough); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5830446M03Rik; AI181014; AU020769; pre-mRNA-splicing factor ISY1 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39687,795,429 - 87,815,883 (-)NCBIGRCm39mm39
GRCm39 Ensembl687,791,251 - 87,815,780 (-)Ensembl
GRCm38687,818,447 - 87,838,923 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl687,814,269 - 87,838,798 (-)EnsemblGRCm38mm10GRCm38
MGSCv37687,768,441 - 87,788,753 (-)NCBIGRCm37mm9NCBIm37
MGSCv36687,784,088 - 87,804,400 (-)NCBImm8
Celera689,755,774 - 89,776,088 (-)NCBICelera
Cytogenetic Map6D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15368895   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17967808   PMID:18799693  
PMID:21873635   PMID:26496610   PMID:30196744  


Genomics

Comparative Map Data
Isy1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39687,795,429 - 87,815,883 (-)NCBIGRCm39mm39
GRCm39 Ensembl687,791,251 - 87,815,780 (-)Ensembl
GRCm38687,818,447 - 87,838,923 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl687,814,269 - 87,838,798 (-)EnsemblGRCm38mm10GRCm38
MGSCv37687,768,441 - 87,788,753 (-)NCBIGRCm37mm9NCBIm37
MGSCv36687,784,088 - 87,804,400 (-)NCBImm8
Celera689,755,774 - 89,776,088 (-)NCBICelera
Cytogenetic Map6D1NCBI
ISY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3129,127,415 - 129,161,063 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl3129,127,415 - 129,161,293 (-)EnsemblGRCh38hg38GRCh38
GRCh383129,127,415 - 129,161,063 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373128,846,258 - 128,879,906 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363130,330,925 - 130,362,719 (-)NCBINCBI36hg18NCBI36
Celera3127,279,847 - 127,296,403 (-)NCBI
Cytogenetic Map3q21.3NCBI
HuRef3126,232,620 - 126,266,455 (-)NCBIHuRef
CHM1_13128,809,709 - 128,843,507 (-)NCBICHM1_1
Isy1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24120,276,535 - 120,297,227 (-)NCBI
Rnor_6.0 Ensembl4119,721,660 - 119,742,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04119,721,659 - 119,742,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04184,972,994 - 184,993,684 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44122,006,785 - 122,027,475 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14122,251,266 - 122,271,956 (-)NCBI
Celera4109,237,067 - 109,257,757 (-)NCBICelera
Cytogenetic Map4q34NCBI
Isy1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542913,513,191 - 13,527,516 (-)NCBIChiLan1.0ChiLan1.0
ISY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13133,545,726 - 133,575,974 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3133,545,726 - 133,575,974 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03126,187,354 - 126,219,355 (-)NCBIMhudiblu_PPA_v0panPan3
ISY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl202,945,720 - 2,972,245 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1202,945,636 - 2,972,245 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ISY1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12251,905,564 - 51,940,705 (+)NCBI
Isy1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624943968,193 - 984,683 (+)NCBI

Position Markers
RH136565  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38687,818,639 - 87,818,841UniSTSGRCm38
MGSCv37687,768,633 - 87,768,835UniSTSGRCm37
Celera689,755,966 - 89,756,168UniSTS
Cytogenetic Map6D2UniSTS
AI181014  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38687,818,633 - 87,818,856UniSTSGRCm38
MGSCv37687,768,627 - 87,768,850UniSTSGRCm37
Celera689,755,960 - 89,756,183UniSTS
Cytogenetic Map6D2UniSTS
Whitehead/MRC_RH6909.59UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:171
Interacting mature miRNAs:188
Transcripts:ENSMUST00000089497
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000089497   ⟹   ENSMUSP00000086923
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl687,814,269 - 87,838,798 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203429
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl687,821,578 - 87,822,554 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204310
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl687,825,256 - 87,838,756 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204421
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl687,827,035 - 87,838,713 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204431   ⟹   ENSMUSP00000145001
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl687,827,640 - 87,838,747 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204881   ⟹   ENSMUSP00000144710
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl687,821,508 - 87,838,738 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204892
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl687,833,545 - 87,838,756 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205070   ⟹   ENSMUSP00000144956
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl687,822,392 - 87,838,700 (-)Ensembl
RefSeq Acc Id: NM_133934   ⟹   NP_598695
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39687,795,429 - 87,815,741 (-)NCBI
GRCm38687,818,447 - 87,838,759 (-)ENTREZGENE
MGSCv37687,768,441 - 87,788,753 (-)RGD
Celera689,755,774 - 89,776,088 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030255520   ⟹   XP_030111380
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39687,795,429 - 87,815,883 (-)NCBI
GRCm38687,818,447 - 87,838,923 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598695   ⟸   NM_133934
- UniProtKB: Q69ZQ2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030111380   ⟸   XM_030255520
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000144956   ⟸   ENSMUST00000205070
RefSeq Acc Id: ENSMUSP00000144710   ⟸   ENSMUST00000204881
RefSeq Acc Id: ENSMUSP00000145001   ⟸   ENSMUST00000204431
RefSeq Acc Id: ENSMUSP00000086923   ⟸   ENSMUST00000089497

Promoters
RGD ID:6839512
Promoter ID:MM_KWN:46787
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_133934
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36687,788,564 - 87,789,064 (-)MPROMDB
RGD ID:6890348
Promoter ID:EPDNEW_M8625
Type:initiation region
Name:Isy1_1
Description:Mus musculus ISY1 splicing factor homolog , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38687,838,741 - 87,838,801EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1923310 AgrOrtholog
Ensembl Genes ENSMUSG00000030056 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000086923 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000144710 UniProtKB/TrEMBL
  ENSMUSP00000144956 UniProtKB/TrEMBL
  ENSMUSP00000145001 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000089497 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000204431 UniProtKB/TrEMBL
  ENSMUST00000204881 UniProtKB/TrEMBL
  ENSMUST00000205070 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Helix_hairpin_bin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Isy1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Isy1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:57905 UniProtKB/Swiss-Prot
MGD MGI:1923310 ENTREZGENE
NCBI Gene 57905 ENTREZGENE
PANTHER PTHR13021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Isy1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Isy1 PhenoGen
Superfamily-SCOP SSF140102 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SUJ7_MOUSE UniProtKB/TrEMBL
  A0A0N4SV52_MOUSE UniProtKB/TrEMBL
  A0A0N4SV90_MOUSE UniProtKB/TrEMBL
  ISY1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8R241_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q8VDX4 UniProtKB/Swiss-Prot
  Q9D3E2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-29 Isy1  ISY1 splicing factor homolog    ISY1 splicing factor homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED