Alox12e (arachidonate lipoxygenase, epidermal) - Rat Genome Database

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Gene: Alox12e (arachidonate lipoxygenase, epidermal) Mus musculus
Analyze
No known orthologs.
Symbol: Alox12e
Name: arachidonate lipoxygenase, epidermal
RGD ID: 1316950
MGI Page MGI
Description: Enables arachidonate 12(S)-lipoxygenase activity and linoleate 13S-lipoxygenase activity. Involved in arachidonic acid metabolic process and lipoxygenase pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol and plasma membrane. Is expressed in alimentary system; hemolymphoid system; integumental system; and respiratory system.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 12-LOX; 12-LOX-e; 8-L; 8-LOX; Al; Alox1; Alox12-ps1; Alox12-ps2; Aloxe; arachidonate (12S)-lipoxygenase, epidermal-type; arachidonate 12-lipoxygenase, epidermal; arachidonate 12-lipoxygenase, epidermal-type; AW259591; e(12S)-LOX; e-LO; e-LOX1; linoleate (13S)-lipoxygenase; polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,206,436 - 70,213,545 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,206,436 - 70,213,454 (-)EnsemblGRCm39 Ensembl
GRCm381170,315,610 - 70,322,720 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,315,610 - 70,322,628 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,129,115 - 70,136,020 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,131,808 - 70,138,713 (-)NCBIMGSCv36mm8
Celera1177,860,181 - 77,867,092 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA)
plasma membrane  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Arachidonate 12-lipoxygenases. Yoshimoto T and Takahashi Y, Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:245-62.
Additional References at PubMed
PMID:7492614   PMID:8188678   PMID:8798535   PMID:9037187   PMID:9518531   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11256953  
PMID:11544199   PMID:12477932   PMID:14681479   PMID:14711820   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16254318   PMID:21205794   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:27208706   PMID:27626380   PMID:30855276   PMID:30973865   PMID:31353262   PMID:35158337   PMID:37660780  


Genomics

Variants

.
Variants in Alox12e
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:609
Count of miRNA genes:366
Interacting mature miRNAs:419
Transcripts:ENSMUST00000019051, ENSMUST00000123752, ENSMUST00000139899, ENSMUST00000149060
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116899082672490826Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116899082672490826Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116899082672490826Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116899082672490826Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116899082672490826Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116899082672490826Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116899082672490826Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116899082672490826Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116899082672490826Mouse

Markers in Region
AW259591  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381170,315,652 - 70,315,785UniSTSGRCm38
MGSCv371170,129,154 - 70,129,287UniSTSGRCm37
Celera1177,860,220 - 77,860,353UniSTS
Cytogenetic Map11B3UniSTS
cM Map1140.0UniSTS
Whitehead/MRC_RH11906.67UniSTS
UniSTS:236624  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381170,315,709 - 70,315,924UniSTSGRCm38
MGSCv371170,129,211 - 70,129,426UniSTSGRCm37
Celera1177,860,277 - 77,860,492UniSTS
Cytogenetic Map11B3UniSTS
cM Map1140.0UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000019051   ⟹   ENSMUSP00000019051
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,206,436 - 70,213,454 (-)Ensembl
GRCm38.p6 Ensembl1170,315,610 - 70,322,628 (-)Ensembl
RefSeq Acc Id: ENSMUST00000123752
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,210,797 - 70,212,403 (-)Ensembl
GRCm38.p6 Ensembl1170,319,971 - 70,321,577 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139899
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,211,820 - 70,212,680 (-)Ensembl
GRCm38.p6 Ensembl1170,320,994 - 70,321,854 (-)Ensembl
RefSeq Acc Id: ENSMUST00000149060
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,211,881 - 70,213,274 (-)Ensembl
GRCm38.p6 Ensembl1170,321,055 - 70,322,448 (-)Ensembl
RefSeq Acc Id: NM_145684   ⟹   NP_663717
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,206,436 - 70,213,356 (-)NCBI
GRCm381170,315,610 - 70,322,530 (-)NCBI
MGSCv371170,129,115 - 70,136,020 (-)RGD
Celera1177,860,181 - 77,867,092 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532034   ⟹   XP_006532097
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,206,436 - 70,213,545 (-)NCBI
GRCm381170,315,610 - 70,322,720 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006532035   ⟹   XP_006532098
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,206,436 - 70,213,545 (-)NCBI
GRCm381170,315,610 - 70,322,720 (-)NCBI
Sequence:
RefSeq Acc Id: NP_663717   ⟸   NM_145684
- UniProtKB: Q91YW6 (UniProtKB/Swiss-Prot),   P55249 (UniProtKB/Swiss-Prot),   Q5F2E4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532098   ⟸   XM_006532035
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006532097   ⟸   XM_006532034
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000019051   ⟸   ENSMUST00000019051
Protein Domains
Lipoxygenase   PLAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55249-F1-model_v2 AlphaFold P55249 1-662 view protein structure

Promoters
RGD ID:8675308
Promoter ID:EPDNEW_M15685
Type:initiation region
Name:Alox12e_1
Description:Mus musculus arachidonate lipoxygenase, epidermal , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381170,322,508 - 70,322,568EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1274790 AgrOrtholog
Ensembl Genes ENSMUSG00000018907 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000019051 ENTREZGENE
  ENSMUST00000019051.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.450.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2 domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro LipOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_Fe_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_mml UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT_LOX_verte UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11685 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1274790 ENTREZGENE
NCBI Gene 11685 ENTREZGENE
PANTHER POLYUNSATURATED FATTY ACID (12S)/(13S)-LIPOXYGENASE, EPIDERMAL-TYPE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11771 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipoxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Alox12e PhenoGen
PRINTS LIPOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAMLPOXGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOXYGENASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOXYGENASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48484 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt LX12E_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q5F2E4 ENTREZGENE, UniProtKB/TrEMBL
  Q91YW6 ENTREZGENE
UniProt Secondary Q91YW6 UniProtKB/Swiss-Prot