Nat3 (N-acetyltransferase 3) - Rat Genome Database
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Gene: Nat3 (N-acetyltransferase 3) Mus musculus
Analyze
No known orthologs.
Symbol: Nat3
Name: N-acetyltransferase 3
RGD ID: 1316848
MGI Page MGI
Description: Exhibits L-amino acid transmembrane transporter activity. Involved in L-amino acid transport. Localizes to plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); contact dermatitis (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human NAT1 (N-acetyltransferase 1) and NAT2 (N-acetyltransferase 2); INTERACTS WITH dextran sulfate; titanium dioxide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: arylamide acetylase 3; arylamine N-acetyltransferase 3; N-acetyltransferase type 3; NAT-3
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39867,976,506 - 68,001,279 (+)NCBIGRCm39mm39
GRCm38867,523,854 - 67,548,627 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl867,523,854 - 67,548,627 (+)EnsemblGRCm38mm10GRCm38
MGSCv37870,047,753 - 70,072,526 (+)NCBIGRCm37mm9NCBIm37
MGSCv36870,452,843 - 70,477,616 (+)NCBImm8
Celera870,077,424 - 70,102,253 (+)NCBICelera
Cytogenetic Map8B3.2NCBI
cM Map833.39NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:1397516   PMID:7545952   PMID:9070359   PMID:9839355   PMID:10349636   PMID:11042159   PMID:11060463   PMID:11076861   PMID:11217851   PMID:12054539   PMID:12142728   PMID:12477932  
PMID:14681479   PMID:16141072   PMID:16141073   PMID:17403913   PMID:21267068   PMID:21677750   PMID:21873635  


Genomics


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83383736267837502Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:67
Interacting mature miRNAs:68
Transcripts:ENSMUST00000070514
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000070514   ⟹   ENSMUSP00000069359
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl867,523,854 - 67,548,627 (+)Ensembl
RefSeq Acc Id: NM_008674   ⟹   NP_032700
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39867,976,506 - 68,001,279 (+)NCBI
GRCm38867,523,854 - 67,548,627 (+)ENTREZGENE
MGSCv37870,047,753 - 70,072,526 (+)RGD
Celera870,077,424 - 70,102,253 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032700   ⟸   NM_008674
- UniProtKB: P50296 (UniProtKB/Swiss-Prot),   Q546K5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000069359   ⟸   ENSMUST00000070514


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102537 AgrOrtholog
Ensembl Genes ENSMUSG00000056426 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000069359 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000070514 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Arylamine_N-AcTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17962 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:102537 ENTREZGENE
NCBI Gene 17962 ENTREZGENE
PANTHER PTHR11786 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Acetyltransf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nat3 PhenoGen
PRINTS ANATRNSFRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.57193 ENTREZGENE
UniProt ARY3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q546K5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Nat3  N-acetyltransferase 3  Naa20  N(alpha)-acetyltransferase 20, NatB catalytic subunit  Symbol and/or name change 5135510 APPROVED