Nat3 (N-acetyltransferase 3) - Rat Genome Database

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Gene: Nat3 (N-acetyltransferase 3) Mus musculus
Analyze
No known orthologs.
Symbol: Nat3
Name: N-acetyltransferase 3
RGD ID: 1316848
MGI Page MGI
Description: Enables L-amino acid transmembrane transporter activity. Acts upstream of or within L-amino acid transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); contact dermatitis (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human NAT1 (N-acetyltransferase 1) and NAT2 (N-acetyltransferase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arylamide acetylase 3; arylamine N-acetyltransferase 3; N-acetyltransferase type 3; NAT-3
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39867,976,506 - 68,001,279 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl867,976,506 - 68,001,279 (+)EnsemblGRCm39 Ensembl
GRCm38867,523,854 - 67,548,627 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl867,523,854 - 67,548,627 (+)EnsemblGRCm38mm10GRCm38
MGSCv37870,047,753 - 70,072,526 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36870,452,843 - 70,477,616 (+)NCBIMGSCv36mm8
Celera870,077,424 - 70,102,253 (+)NCBICelera
Cytogenetic Map8B3.2NCBI
cM Map833.39NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1397516   PMID:7545952   PMID:9070359   PMID:9839355   PMID:10349636   PMID:11042159   PMID:11060463   PMID:11076861   PMID:11217851   PMID:12054539   PMID:12142728   PMID:12477932  
PMID:14681479   PMID:16141072   PMID:16141073   PMID:17403913   PMID:21267068   PMID:21677750   PMID:21873635  


Genomics

Variants

.
Variants in Nat3
1152 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:67
Interacting mature miRNAs:68
Transcripts:ENSMUST00000070514
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83250657271740637Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3250657271740637Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3250657271740637Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3250657271740637Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83429039768290537Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84474791478748059Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84809006482090180Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84809006482090180Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84819016882190288Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84924559183245673Mouse
14746987Manh64_mmandible shape 64 (mouse)85050595884505958Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85050595884505958Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85233484386334843Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85474046188740637Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85515925889159407Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85629887290298872Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
11039503Ccc4_mcolitis susceptibility in the Collaborative Cross 4 (mouse)86517423778002730Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000070514   ⟹   ENSMUSP00000069359
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl867,976,506 - 68,001,279 (+)Ensembl
GRCm38.p6 Ensembl867,523,854 - 67,548,627 (+)Ensembl
RefSeq Acc Id: NM_008674   ⟹   NP_032700
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39867,976,506 - 68,001,279 (+)NCBI
GRCm38867,523,854 - 67,548,627 (+)ENTREZGENE
MGSCv37870,047,753 - 70,072,526 (+)RGD
Celera870,077,424 - 70,102,253 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032700   ⟸   NM_008674
- UniProtKB: P50296 (UniProtKB/Swiss-Prot),   Q546K5 (UniProtKB/TrEMBL),   Q8VDD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000069359   ⟸   ENSMUST00000070514

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50296-F1-model_v2 AlphaFold P50296 1-290 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102537 AgrOrtholog
Ensembl Genes ENSMUSG00000056426 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000070514 ENTREZGENE
  ENSMUST00000070514.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.2140.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Arylamine_N-AcTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17962 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:102537 ENTREZGENE
NCBI Gene 17962 ENTREZGENE
PANTHER ARYLAMINE N-ACETYLTRANSFERASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11786 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Acetyltransf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nat3 PhenoGen
PRINTS ANATRNSFRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ARY3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q546K5 ENTREZGENE, UniProtKB/TrEMBL
  Q8VDD3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Nat3  N-acetyltransferase 3  Naa20  N(alpha)-acetyltransferase 20, NatB catalytic subunit  Symbol and/or name change 5135510 APPROVED