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Gene: KDM4C (lysine demethylase 4C) Homo sapiens
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Symbol: KDM4C
Name: lysine demethylase 4C
Description: Exhibits several functions, including androgen receptor binding activity; histone demethylase activity; and zinc ion binding activity. Involved in histone lysine demethylation; positive regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Localizes to the nuclear chromatin. Implicated in several diseases, including autistic disorder; esophagus squamous cell carcinoma; head and neck cancer; renal cell carcinoma; and withdrawal disorder. Biomarker of alopecia areata; esophagus squamous cell carcinoma; medulloblastoma; prostate cancer; and stomach carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bA146B14.1; FLJ25949; GASC-1 protein; GASC1; gene amplified in squamous cell carcinoma 1 protein; JHDM3C; JmjC domain-containing histone demethylation protein 3C; JMJD2C; jumonji domain containing 2C; jumonji domain-containing protein 2C; KIAA0780; lysine (K)-specific demethylase 4C; lysine-specific demethylase 4C; TDRD14C; tudor domain containing 14C
Orthologs:
Mus musculus (house mouse) : Kdm4c (lysine (K)-specific demethylase 4C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kdm4c (lysine demethylase 4C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm4c (lysine demethylase 4C)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM4C (lysine demethylase 4C)
Canis lupus familiaris (dog) : KDM4C (lysine demethylase 4C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm4c (lysine demethylase 4C)
Sus scrofa (pig) : KDM4C (lysine demethylase 4C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3896,720,863 - 7,175,648 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3796,720,863 - 7,175,648 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3696,747,654 - 7,165,648 (+)NCBINCBI36hg18NCBI36
Build 3496,748,082 - 7,165,647NCBI
Celera96,649,815 - 7,106,122 (+)NCBI
Cytogenetic Map9p24.1NCBI
HuRef96,675,237 - 7,130,973 (+)NCBIHuRef
CHM1_196,721,531 - 7,175,696 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on KDM4C
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316776
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.