Klhl6 (kelch-like 6) - Rat Genome Database

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Gene: Klhl6 (kelch-like 6) Mus musculus
Analyze
Symbol: Klhl6
Name: kelch-like 6
RGD ID: 1316765
MGI Page MGI
Description: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in B cell receptor signaling pathway and germinal center formation. Acts upstream of or within response to bacterium. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in blood vessel; notochord; and thymus primordium. Orthologous to human KLHL6 (kelch like family member 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kelch-like protein 6; MGC118659
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391619,765,242 - 19,801,766 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1619,765,246 - 19,801,787 (-)EnsemblGRCm39 Ensembl
GRCm381619,946,492 - 19,983,049 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1619,946,496 - 19,983,037 (-)EnsemblGRCm38mm10GRCm38
MGSCv371619,946,586 - 19,983,122 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361619,860,060 - 19,896,520 (-)NCBIMGSCv36mm8
Celera1620,509,929 - 20,546,858 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11544199   PMID:12477932   PMID:12617994   PMID:16166635   PMID:21267068   PMID:21677750   PMID:21822279   PMID:21873635   PMID:22008794   PMID:23012479   PMID:26018251   PMID:28807996  
PMID:29459677  


Genomics

Comparative Map Data
Klhl6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391619,765,242 - 19,801,766 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1619,765,246 - 19,801,787 (-)EnsemblGRCm39 Ensembl
GRCm381619,946,492 - 19,983,049 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1619,946,496 - 19,983,037 (-)EnsemblGRCm38mm10GRCm38
MGSCv371619,946,586 - 19,983,122 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361619,860,060 - 19,896,520 (-)NCBIMGSCv36mm8
Celera1620,509,929 - 20,546,858 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.32NCBI
KLHL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383183,487,551 - 183,555,706 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3183,487,551 - 183,555,706 (-)EnsemblGRCh38hg38GRCh38
GRCh373183,205,339 - 183,273,494 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363184,688,013 - 184,756,193 (-)NCBINCBI36Build 36hg18NCBI36
Build 343184,688,040 - 184,756,110NCBI
Celera3181,641,698 - 181,709,843 (-)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3180,611,770 - 180,679,998 (-)NCBIHuRef
CHM1_13183,168,972 - 183,237,150 (-)NCBICHM1_1
T2T-CHM13v2.03186,295,709 - 186,363,954 (-)NCBIT2T-CHM13v2.0
Klhl6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81194,475,262 - 94,514,653 (+)NCBIGRCr8
mRatBN7.21180,970,917 - 81,010,593 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,970,917 - 81,009,677 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,698,651 - 89,745,379 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01182,352,005 - 82,398,737 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01181,413,148 - 81,459,874 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,745,958 - 84,785,315 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,745,904 - 84,785,893 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,808,385 - 87,847,742 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41183,221,776 - 83,260,528 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11183,279,726 - 83,318,448 (+)NCBI
Celera1179,806,183 - 79,844,910 (+)NCBICelera
Cytogenetic Map11q23NCBI
Klhl6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542023,813,482 - 23,877,886 (+)NCBIChiLan1.0ChiLan1.0
KLHL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22181,362,659 - 181,427,297 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13181,367,374 - 181,432,015 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03180,523,141 - 180,591,218 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13188,692,193 - 188,760,244 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3188,692,200 - 188,760,926 (-)Ensemblpanpan1.1panPan2
KLHL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13416,443,282 - 16,556,991 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3416,446,944 - 16,504,549 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3420,531,581 - 20,645,243 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03416,351,275 - 16,464,989 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3416,351,275 - 16,472,437 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13416,390,376 - 16,503,817 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03416,376,664 - 16,438,114 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03416,614,814 - 16,728,495 (-)NCBIUU_Cfam_GSD_1.0
Klhl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602120,134,597 - 120,194,353 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365786,226,495 - 6,284,293 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365786,226,533 - 6,284,343 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113121,426,618 - 121,487,260 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213130,829,174 - 130,850,400 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,844,728 - 5,912,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,845,721 - 5,913,734 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606314,630,818 - 14,705,887 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473072,916,601 - 72,972,204 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klhl6
943 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:522
Count of miRNA genes:366
Interacting mature miRNAs:413
Transcripts:ENSMUST00000058839, ENSMUST00000165530, ENSMUST00000166801, ENSMUST00000171910
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
11565820Vasr1_mvariability in acoustic startle response 1 (mouse)161969865726368664Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
15092082Igly9_mIgG glycosylation 9, GP17b (mouse)161477522320103513Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000058839   ⟹   ENSMUSP00000053023
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1619,765,246 - 19,801,787 (-)Ensembl
GRCm38.p6 Ensembl1619,946,496 - 19,983,037 (-)Ensembl
Ensembl Acc Id: ENSMUST00000165530
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1619,784,794 - 19,801,680 (-)Ensembl
GRCm38.p6 Ensembl1619,966,044 - 19,982,930 (-)Ensembl
Ensembl Acc Id: ENSMUST00000166801
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1619,775,720 - 19,801,757 (-)Ensembl
GRCm38.p6 Ensembl1619,956,970 - 19,983,007 (-)Ensembl
Ensembl Acc Id: ENSMUST00000171910
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1619,775,700 - 19,785,069 (-)Ensembl
GRCm38.p6 Ensembl1619,956,950 - 19,966,319 (-)Ensembl
RefSeq Acc Id: NM_001417212   ⟹   NP_001404141
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391619,765,242 - 19,801,766 (-)NCBI
RefSeq Acc Id: NM_001417213   ⟹   NP_001404142
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391619,765,242 - 19,801,766 (-)NCBI
RefSeq Acc Id: NM_001417214   ⟹   NP_001404143
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391619,765,242 - 19,801,766 (-)NCBI
RefSeq Acc Id: NM_001417215   ⟹   NP_001404144
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391619,765,242 - 19,801,766 (-)NCBI
RefSeq Acc Id: NM_001417216   ⟹   NP_001404145
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391619,765,242 - 19,801,766 (-)NCBI
RefSeq Acc Id: NM_183390   ⟹   NP_899246
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391619,765,242 - 19,801,766 (-)NCBI
GRCm381619,946,492 - 19,983,049 (-)ENTREZGENE
MGSCv371619,946,586 - 19,983,122 (-)RGD
Celera1620,509,929 - 20,546,858 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_184432
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391619,765,242 - 19,801,766 (-)NCBI
RefSeq Acc Id: XM_036159920   ⟹   XP_036015813
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391619,765,242 - 19,801,729 (-)NCBI
Sequence:
RefSeq Acc Id: NP_899246   ⟸   NM_183390
- Peptide Label: isoform 1
- UniProtKB: Q497G3 (UniProtKB/Swiss-Prot),   Q6V595 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000053023   ⟸   ENSMUST00000058839
RefSeq Acc Id: XP_036015813   ⟸   XM_036159920
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001404145   ⟸   NM_001417216
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001404143   ⟸   NM_001417214
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001404144   ⟸   NM_001417215
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001404142   ⟸   NM_001417213
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001404141   ⟸   NM_001417212
- Peptide Label: isoform 2
Protein Domains
BACK   BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6V595-F1-model_v2 AlphaFold Q6V595 1-619 view protein structure

Promoters
RGD ID:6827194
Promoter ID:MM_KWN:20445
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Spleen
Transcripts:NM_183390
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361619,982,839 - 19,983,339 (-)MPROMDB
RGD ID:8685720
Promoter ID:EPDNEW_M20890
Type:initiation region
Name:Klhl6_1
Description:Mus musculus kelch-like 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381619,983,016 - 19,983,076EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2686922 AgrOrtholog
Ensembl Genes ENSMUSG00000043008 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000058839 ENTREZGENE
  ENSMUST00000058839.10 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.420 UniProtKB/Swiss-Prot
  2.120.10.80 UniProtKB/Swiss-Prot
InterPro BACK UniProtKB/Swiss-Prot
  BTB-kelch_protein UniProtKB/Swiss-Prot
  BTB/POZ_dom UniProtKB/Swiss-Prot
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot
  Kelch_1 UniProtKB/Swiss-Prot
  KLHL6 UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
KEGG Report mmu:239743 UniProtKB/Swiss-Prot
MGD MGI:2686922 ENTREZGENE
NCBI Gene 239743 ENTREZGENE
PANTHER KELCH PROTEIN UniProtKB/Swiss-Prot
  PTHR24412:SF428 UniProtKB/Swiss-Prot
Pfam BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot
  Kelch_1 UniProtKB/Swiss-Prot
PhenoGen Klhl6 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot
PROSITE BTB UniProtKB/Swiss-Prot
SMART BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot
  Kelch UniProtKB/Swiss-Prot
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot
  SSF54695 UniProtKB/Swiss-Prot
UniProt KLHL6_MOUSE UniProtKB/Swiss-Prot
  Q497G3 ENTREZGENE
  Q6V595 ENTREZGENE
UniProt Secondary Q497G3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-29 Klhl6  kelch-like 6    kelch-like 6 (Drosophila)  Symbol and/or name change 5135510 APPROVED