Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pmel | Mouse | 17beta-estradiol | decreases expression | ISO | PMEL (Homo sapiens) | 6480464 | Estradiol results in decreased expression of PMEL mRNA | CTD | PMID:31614463 | Pmel | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Pmel (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PMEL mRNA | CTD | PMID:33387578 | Pmel | Mouse | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | PMEL (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PMEL mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of PMEL mRNA | CTD | PMID:28628672 | Pmel | Mouse | 4,4'-sulfonyldiphenol | multiple interactions | ISO | PMEL (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of PMEL mRNA | CTD | PMID:28628672 | Pmel | Mouse | 5-aza-2'-deoxycytidine | affects expression | ISO | PMEL (Homo sapiens) | 6480464 | Decitabine affects the expression of PMEL mRNA | CTD | PMID:23300844 | Pmel | Mouse | acrylamide | increases expression | ISO | Pmel (Rattus norvegicus) | 6480464 | Acrylamide results in increased expression of PMEL mRNA | CTD | PMID:28959563 | Pmel | Mouse | aflatoxin B1 | decreases expression | ISO | PMEL (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of PMEL mRNA | CTD | PMID:22100608 | Pmel | Mouse | all-trans-retinoic acid | decreases expression | ISO | PMEL (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of PMEL mRNA | CTD | PMID:21934132 and PMID:23724009 | Pmel | Mouse | atrazine | decreases expression | ISO | Pmel (Rattus norvegicus) | 6480464 | Atrazine results in decreased expression of PMEL mRNA | CTD | PMID:36841081 | Pmel | Mouse | benzo[a]pyrene | decreases expression | ISO | PMEL (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of PMEL mRNA | CTD | PMID:32234424 | Pmel | Mouse | bis(2-ethylhexyl) phthalate | increases expression | ISO | PMEL (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of PMEL protein | CTD | PMID:31163220 | Pmel | Mouse | bisphenol A | increases expression | ISO | PMEL (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PMEL mRNA | CTD | PMID:31715268 | Pmel | Mouse | bisphenol A | multiple interactions | EXP | | 6480464 | [Dextran Sulfate co-treated with bisphenol A] results in decreased expression of PMEL protein | CTD | PMID:35999755 | Pmel | Mouse | bisphenol A | decreases expression | ISO | Pmel (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of PMEL mRNA | CTD | PMID:34947998 | Pmel | Mouse | bisphenol A | multiple interactions | ISO | PMEL (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PMEL mRNA | CTD | PMID:28628672 | Pmel | Mouse | bisphenol A | increases expression | ISO | Pmel (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of PMEL mRNA | CTD | PMID:25181051 | Pmel | Mouse | bisphenol F | decreases expression | EXP | | 6480464 | bisphenol F results in decreased expression of PMEL mRNA | CTD | PMID:38685157 | Pmel | Mouse | cadmium dichloride | increases methylation | ISO | Pmel (Rattus norvegicus) | 6480464 | Cadmium Chloride results in increased methylation of PMEL promoter | CTD | PMID:22457795 | Pmel | Mouse | cisplatin | affects expression | ISO | PMEL (Homo sapiens) | 6480464 | Cisplatin affects the expression of PMEL mRNA | CTD | PMID:23300844 | Pmel | Mouse | cisplatin | multiple interactions | ISO | PMEL (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of PMEL mRNA | CTD | PMID:27392435 | Pmel | Mouse | cisplatin | increases expression | ISO | PMEL (Homo sapiens) | 6480464 | Cisplatin results in increased expression of PMEL mRNA | CTD | PMID:27392435 | Pmel | Mouse | copper atom | increases expression | ISO | Pmel (Rattus norvegicus) | 6480464 | Copper results in increased expression of PMEL mRNA | CTD | PMID:30556269 | Pmel | Mouse | copper(0) | increases expression | ISO | Pmel (Rattus norvegicus) | 6480464 | Copper results in increased expression of PMEL mRNA | CTD | PMID:30556269 | Pmel | Mouse | cytarabine | increases expression | ISO | PMEL (Homo sapiens) | 6480464 | Cytarabine results in increased expression of PMEL mRNA | CTD | PMID:21198554 | Pmel | Mouse | dexamethasone | multiple interactions | ISO | PMEL (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PMEL mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of PMEL mRNA | CTD | PMID:28628672 | Pmel | Mouse | dextran sulfate | multiple interactions | EXP | | 6480464 | [Dextran Sulfate co-treated with bisphenol A] results in decreased expression of PMEL protein | CTD | PMID:35999755 | Pmel | Mouse | dorsomorphin | multiple interactions | ISO | PMEL (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Pmel | Mouse | etoposide | affects response to substance | ISO | PMEL (Homo sapiens) | 6480464 | PMEL protein affects the susceptibility to Etoposide | CTD | PMID:16217747 | Pmel | Mouse | fluoxetine | increases expression | ISO | PMEL (Homo sapiens) | 6480464 | Fluoxetine results in increased expression of PMEL mRNA | CTD | PMID:37386098 | Pmel | Mouse | FR900359 | increases phosphorylation | ISO | PMEL (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of PMEL protein | CTD | PMID:37730182 | Pmel | Mouse | indometacin | multiple interactions | ISO | PMEL (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PMEL mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of PMEL mRNA | CTD | PMID:28628672 | Pmel | Mouse | isotretinoin | decreases expression | ISO | PMEL (Homo sapiens) | 6480464 | Isotretinoin results in decreased expression of PMEL mRNA | CTD | PMID:20436886 | Pmel | Mouse | lead diacetate | decreases expression | EXP | | 6480464 | lead acetate results in decreased expression of PMEL mRNA | CTD | PMID:22609695 | Pmel | Mouse | lipopolysaccharide | multiple interactions | ISO | PMEL (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | Pmel | Mouse | lithium chloride | increases expression | ISO | PMEL (Homo sapiens) | 6480464 | Lithium Chloride results in increased expression of PMEL mRNA | CTD | PMID:23527032 | Pmel | Mouse | methylmercury chloride | decreases expression | ISO | PMEL (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of PMEL mRNA | CTD | PMID:34089799 | Pmel | Mouse | mitomycin C | affects response to substance | ISO | PMEL (Homo sapiens) | 6480464 | PMEL protein affects the susceptibility to Mitomycin | CTD | PMID:16217747 | Pmel | Mouse | N-methyl-4-phenylpyridinium | increases expression | ISO | PMEL (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of PMEL mRNA | CTD | PMID:24810058 | Pmel | Mouse | N-methyl-4-phenylpyridinium | increases expression | ISO | Pmel (Rattus norvegicus) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of PMEL mRNA | CTD | PMID:28801915 | Pmel | Mouse | N-Nitrosopyrrolidine | decreases expression | ISO | PMEL (Homo sapiens) | 6480464 | N-Nitrosopyrrolidine results in decreased expression of PMEL mRNA | CTD | PMID:32234424 | Pmel | Mouse | paracetamol | increases expression | ISO | PMEL (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of PMEL mRNA | CTD | PMID:22230336 | Pmel | Mouse | paracetamol | increases expression | ISO | Pmel (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of PMEL mRNA | CTD | PMID:33387578 | Pmel | Mouse | paracetamol | decreases expression | ISO | PMEL (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PMEL mRNA | CTD | PMID:26690555 | Pmel | Mouse | phenylmercury acetate | decreases expression | ISO | PMEL (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of PMEL mRNA | CTD | PMID:26272509 | Pmel | Mouse | phenylmercury acetate | multiple interactions | ISO | PMEL (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PMEL mRNA | CTD | PMID:27188386 | Pmel | Mouse | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | PMEL (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | Pmel | Mouse | S-(1,2-dichlorovinyl)-L-cysteine | increases expression | ISO | PMEL (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine results in increased expression of PMEL mRNA | CTD | PMID:35811015 | Pmel | Mouse | SB 431542 | multiple interactions | ISO | PMEL (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Pmel | Mouse | silicon dioxide | decreases expression | ISO | PMEL (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of PMEL mRNA | CTD | PMID:25895662 | Pmel | Mouse | sunitinib | increases expression | ISO | PMEL (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PMEL mRNA | CTD | PMID:31533062 | Pmel | Mouse | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of PMEL mRNA | CTD | PMID:25549359 | Pmel | Mouse | trichostatin A | decreases expression | ISO | PMEL (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of PMEL mRNA | CTD | PMID:26272509 | Pmel | Mouse | trichostatin A | multiple interactions | ISO | PMEL (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PMEL mRNA | CTD | PMID:27188386 | Pmel | Mouse | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of PMEL mRNA | CTD | PMID:33045310 | Pmel | Mouse | valproic acid | increases expression | ISO | PMEL (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PMEL mRNA | CTD | PMID:19101580 and PMID:23179753 | Pmel | Mouse | valproic acid | affects expression | ISO | PMEL (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PMEL mRNA | CTD | PMID:25979313 | Pmel | Mouse | vemurafenib | increases expression | ISO | PMEL (Homo sapiens) | 6480464 | vemurafenib results in increased expression of PMEL mRNA and vemurafenib results in increased expression of PMEL protein | CTD | PMID:26640592 | Pmel | Mouse | vorinostat | increases expression | ISO | PMEL (Homo sapiens) | 6480464 | vorinostat results in increased expression of PMEL mRNA | CTD | PMID:27188386 | |