DUSP19 (dual specificity phosphatase 19) - Rat Genome Database

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Gene: DUSP19 (dual specificity phosphatase 19) Homo sapiens
Analyze
Symbol: DUSP19
Name: dual specificity phosphatase 19
RGD ID: 1316661
HGNC Page HGNC:18894
Description: Enables protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in negative regulation of JNK cascade and positive regulation of JNK cascade. Predicted to act upstream of or within JNK cascade and negative regulation of MAPK cascade. Predicted to be active in cytoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity phosphatase TS-DSP1; dual specificity protein phosphatase 19; DUSP17; LMW-DSP3; LMWDSP3; low molecular weight dual specificity phosphatase 3; MGC138210; protein phosphatase SKRP1; SAPK pathway-regulating phosphatase 1; SKRP1; stress-activated protein kinase pathway-regulating phosphatase 1; TS-DSP1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382183,078,747 - 183,100,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2183,078,559 - 183,100,008 (+)EnsemblGRCh38hg38GRCh38
GRCh372183,943,475 - 183,964,736 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362183,651,732 - 183,672,981 (+)NCBINCBI36Build 36hg18NCBI36
Build 342183,768,992 - 183,790,226NCBI
Celera2177,539,400 - 177,560,844 (+)NCBICelera
Cytogenetic Map2q32.1NCBI
HuRef2175,802,186 - 175,823,524 (+)NCBIHuRef
CHM1_12183,949,183 - 183,970,629 (+)NCBICHM1_1
T2T-CHM13v2.02183,567,739 - 183,589,000 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
amenorrhea  (IAGP)
genetic disease  (IAGP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway. Zama T, etal., J Biol Chem. 2002 Jun 28;277(26):23919-26. Epub 2002 Apr 16.
Additional References at PubMed
PMID:11959861   PMID:12477932   PMID:12479873   PMID:14702039   PMID:15489334   PMID:15815621   PMID:19228121   PMID:19322201   PMID:21516116   PMID:21873635   PMID:21989941   PMID:25416956  
PMID:26186194   PMID:26751999   PMID:27432908   PMID:27880917   PMID:28065597   PMID:28330616   PMID:28514442   PMID:28675297   PMID:31586073   PMID:31813339   PMID:32296183   PMID:33770577  
PMID:33961781   PMID:36336681  


Genomics

Comparative Map Data
DUSP19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382183,078,747 - 183,100,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2183,078,559 - 183,100,008 (+)EnsemblGRCh38hg38GRCh38
GRCh372183,943,475 - 183,964,736 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362183,651,732 - 183,672,981 (+)NCBINCBI36Build 36hg18NCBI36
Build 342183,768,992 - 183,790,226NCBI
Celera2177,539,400 - 177,560,844 (+)NCBICelera
Cytogenetic Map2q32.1NCBI
HuRef2175,802,186 - 175,823,524 (+)NCBIHuRef
CHM1_12183,949,183 - 183,970,629 (+)NCBICHM1_1
T2T-CHM13v2.02183,567,739 - 183,589,000 (+)NCBIT2T-CHM13v2.0
Dusp19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39280,447,558 - 80,462,005 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl280,447,389 - 80,462,705 (+)EnsemblGRCm39 Ensembl
GRCm38280,617,214 - 80,631,661 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl280,617,045 - 80,632,361 (+)EnsemblGRCm38mm10GRCm38
MGSCv37280,457,371 - 80,471,818 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36280,418,053 - 80,432,500 (+)NCBIMGSCv36mm8
Celera282,284,005 - 82,298,452 (+)NCBICelera
Cytogenetic Map2C3NCBI
cM Map248.31NCBI
Dusp19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8385,945,289 - 86,081,289 (+)NCBIGRCr8
mRatBN7.2365,538,424 - 65,554,465 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl365,538,420 - 65,553,534 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx368,890,852 - 68,903,336 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0377,474,410 - 77,486,894 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0375,234,840 - 75,250,812 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0367,849,966 - 67,862,475 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl367,849,966 - 67,862,475 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0374,406,311 - 74,418,820 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4363,473,333 - 63,485,843 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1363,369,862 - 63,382,210 (+)NCBI
Celera364,984,512 - 64,997,042 (+)NCBICelera
Cytogenetic Map3q24NCBI
Dusp19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540314,420,243 - 14,440,210 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540314,421,057 - 14,439,829 (-)NCBIChiLan1.0ChiLan1.0
DUSP19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21385,736,631 - 85,763,434 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B85,751,609 - 85,778,412 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B70,347,712 - 70,371,852 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B188,157,061 - 188,178,277 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B188,157,061 - 188,178,266 (+)Ensemblpanpan1.1panPan2
DUSP19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13626,095,436 - 26,111,700 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3626,095,463 - 26,111,774 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3625,992,877 - 26,008,486 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03626,249,353 - 26,265,172 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3626,247,729 - 26,270,212 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13626,375,521 - 26,391,166 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03626,306,406 - 26,322,096 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03626,448,561 - 26,464,353 (+)NCBIUU_Cfam_GSD_1.0
Dusp19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303143,099,366 - 143,118,272 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650911,653,199 - 11,672,476 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650911,653,282 - 11,670,425 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1588,549,275 - 88,571,883 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11588,549,250 - 88,574,978 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21598,104,160 - 98,124,373 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11068,582,797 - 68,607,249 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1068,583,314 - 68,610,537 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040130,937,243 - 130,956,474 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248444,798,455 - 4,818,818 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248444,798,542 - 4,822,739 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DUSP19
12 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q31.1-33.2(chr2:174898848-203941548)x1 copy number loss See cases [RCV000050980] Chr2:174898848..203941548 [GRCh38]
Chr2:175763576..204806271 [GRCh37]
Chr2:175471822..204514516 [NCBI36]
Chr2:2q31.1-33.2		 pathogenic
GRCh38/hg38 2q31.1-33.1(chr2:176304445-202039790)x1 copy number loss See cases [RCV000052558] Chr2:176304445..202039790 [GRCh38]
Chr2:177169173..202904513 [GRCh37]
Chr2:176877419..202612758 [NCBI36]
Chr2:2q31.1-33.1		 pathogenic
GRCh38/hg38 2q31.2-33.1(chr2:177874070-198525492)x1 copy number loss See cases [RCV000052559] Chr2:177874070..198525492 [GRCh38]
Chr2:178738797..199390216 [GRCh37]
Chr2:178447043..199098461 [NCBI36]
Chr2:2q31.2-33.1		 pathogenic
GRCh38/hg38 2q31.2-32.1(chr2:178880151-185352829)x1 copy number loss See cases [RCV000052560] Chr2:178880151..185352829 [GRCh38]
Chr2:179744878..186217556 [GRCh37]
Chr2:179453123..185925801 [NCBI36]
Chr2:2q31.2-32.1		 pathogenic
GRCh38/hg38 2q31.1-32.1(chr2:170407688-186189894)x1 copy number loss See cases [RCV000054127] Chr2:170407688..186189894 [GRCh38]
Chr2:171264198..187054621 [GRCh37]
Chr2:170972444..186762866 [NCBI36]
Chr2:2q31.1-32.1		 pathogenic
GRCh38/hg38 2q31.1-32.2(chr2:171429233-189179568)x1 copy number loss See cases [RCV000136850] Chr2:171429233..189179568 [GRCh38]
Chr2:172285743..190044294 [GRCh37]
Chr2:171993989..189752539 [NCBI36]
Chr2:2q31.1-32.2		 pathogenic
GRCh38/hg38 2q31.1-32.2(chr2:174634502-189000964)x1 copy number loss See cases [RCV000136861] Chr2:174634502..189000964 [GRCh38]
Chr2:175499230..189865690 [GRCh37]
Chr2:175207476..189573935 [NCBI36]
Chr2:2q31.1-32.2		 pathogenic
GRCh38/hg38 2q31.3-32.1(chr2:180942902-187372388)x1 copy number loss See cases [RCV000137116] Chr2:180942902..187372388 [GRCh38]
Chr2:181807629..188237115 [GRCh37]
Chr2:181515874..187945360 [NCBI36]
Chr2:2q31.3-32.1		 pathogenic
GRCh38/hg38 2q31.3-32.3(chr2:181758701-192015392)x1 copy number loss See cases [RCV000138253] Chr2:181758701..192015392 [GRCh38]
Chr2:182623428..192880118 [GRCh37]
Chr2:182331673..192588363 [NCBI36]
Chr2:2q31.3-32.3		 pathogenic
GRCh38/hg38 2q31.3-36.2(chr2:180513793-224302848)x3 copy number gain See cases [RCV000139446] Chr2:180513793..224302848 [GRCh38]
Chr2:181378520..225167565 [GRCh37]
Chr2:181086765..224875809 [NCBI36]
Chr2:2q31.3-36.2		 pathogenic
GRCh38/hg38 2q31.2-32.3(chr2:177827730-195125329)x1 copy number loss See cases [RCV000141735] Chr2:177827730..195125329 [GRCh38]
Chr2:178692457..195990053 [GRCh37]
Chr2:178400703..195698298 [NCBI36]
Chr2:2q31.2-32.3		 pathogenic
GRCh38/hg38 2q31.1-32.3(chr2:176086763-193201970)x1 copy number loss See cases [RCV000143484] Chr2:176086763..193201970 [GRCh38]
Chr2:176951491..194066696 [GRCh37]
Chr2:176659737..193774941 [NCBI36]
Chr2:2q31.1-32.3		 pathogenic
GRCh37/hg19 2q31.1-32.3(chr2:177315153-196375520)x1 copy number loss See cases [RCV000239432] Chr2:177315153..196375520 [GRCh37]
Chr2:2q31.1-32.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2q31.1-35(chr2:169829974-215521436)x3 copy number gain See cases [RCV000448271] Chr2:169829974..215521436 [GRCh37]
Chr2:2q31.1-35		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NM_080876.4(DUSP19):c.563G>T (p.Cys188Phe) single nucleotide variant Inborn genetic diseases [RCV003302585] Chr2:183095567 [GRCh38]
Chr2:183960295 [GRCh37]
Chr2:2q32.1		 uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NC_000002.12:g.183054447_183247902dup duplication Primary amenorrhea [RCV000754405] Chr2:183054447..183247902 [GRCh38]
Chr2:183919175..184112630 [GRCh37]
Chr2:2q32.1		 likely benign
GRCh37/hg19 2q31.2-32.1(chr2:180292467-185489430)x1 copy number loss not provided [RCV000740745] Chr2:180292467..185489430 [GRCh37]
Chr2:2q31.2-32.1		 pathogenic
GRCh37/hg19 2q32.1(chr2:183893404-184110645)x3 copy number gain not provided [RCV000740753] Chr2:183893404..184110645 [GRCh37]
Chr2:2q32.1		 benign
GRCh37/hg19 2q31.1-32.3(chr2:174690039-195521582)x1 copy number loss not provided [RCV001005359] Chr2:174690039..195521582 [GRCh37]
Chr2:2q31.1-32.3		 pathogenic
GRCh37/hg19 2q24.3-32.3(chr2:167329586-192756373)x1 copy number loss not provided [RCV000848216] Chr2:167329586..192756373 [GRCh37]
Chr2:2q24.3-32.3		 pathogenic
GRCh37/hg19 2q24.2-34(chr2:163233162-211927188)x3 copy number gain not provided [RCV001005349] Chr2:163233162..211927188 [GRCh37]
Chr2:2q24.2-34		 pathogenic
GRCh37/hg19 2q31.1-32.1(chr2:173538954-186401606)x1 copy number loss not provided [RCV000846537] Chr2:173538954..186401606 [GRCh37]
Chr2:2q31.1-32.1		 pathogenic
NM_080876.4(DUSP19):c.500A>G (p.Asn167Ser) single nucleotide variant Inborn genetic diseases [RCV003253110] Chr2:183095504 [GRCh38]
Chr2:183960232 [GRCh37]
Chr2:2q32.1		 uncertain significance
GRCh37/hg19 2q32.1(chr2:183764930-187399282)x1 copy number loss not provided [RCV001249408] Chr2:183764930..187399282 [GRCh37]
Chr2:2q32.1		 not provided
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2q31.2-37.3(chr2:178397959-243007457)x3 copy number gain See cases [RCV001263052] Chr2:178397959..243007457 [GRCh37]
Chr2:2q31.2-37.3		 pathogenic
NM_080876.4(DUSP19):c.286C>G (p.Leu96Val) single nucleotide variant Inborn genetic diseases [RCV003293485] Chr2:183087052 [GRCh38]
Chr2:183951780 [GRCh37]
Chr2:2q32.1		 uncertain significance
GRCh37/hg19 2q31.1-35(chr2:169829974-215521436) copy number gain not specified [RCV002053265] Chr2:169829974..215521436 [GRCh37]
Chr2:2q31.1-35		 pathogenic
NC_000002.11:g.(?_183790430)_(184025859_?)del deletion not provided [RCV001951515] Chr2:183790430..184025859 [GRCh37]
Chr2:2q32.1		 pathogenic
NM_080876.4(DUSP19):c.131A>G (p.Glu44Gly) single nucleotide variant Inborn genetic diseases [RCV003284945] Chr2:183079064 [GRCh38]
Chr2:183943792 [GRCh37]
Chr2:2q32.1		 uncertain significance
GRCh37/hg19 2q32.1(chr2:183206179-184174590)x3 copy number gain not provided [RCV002474992] Chr2:183206179..184174590 [GRCh37]
Chr2:2q32.1		 uncertain significance
GRCh37/hg19 2q32.1(chr2:183070475-186717885)x3 copy number gain not provided [RCV002474952] Chr2:183070475..186717885 [GRCh37]
Chr2:2q32.1		 uncertain significance
NM_080876.4(DUSP19):c.79A>T (p.Thr27Ser) single nucleotide variant Inborn genetic diseases [RCV002689463] Chr2:183079012 [GRCh38]
Chr2:183943740 [GRCh37]
Chr2:2q32.1		 uncertain significance
NM_080876.4(DUSP19):c.485T>G (p.Ile162Arg) single nucleotide variant Inborn genetic diseases [RCV002882715] Chr2:183095489 [GRCh38]
Chr2:183960217 [GRCh37]
Chr2:2q32.1		 uncertain significance
NM_080876.4(DUSP19):c.200G>C (p.Gly67Ala) single nucleotide variant Inborn genetic diseases [RCV002728424] Chr2:183079133 [GRCh38]
Chr2:183943861 [GRCh37]
Chr2:2q32.1		 uncertain significance
NM_080876.4(DUSP19):c.481G>A (p.Val161Ile) single nucleotide variant Inborn genetic diseases [RCV002688730] Chr2:183095485 [GRCh38]
Chr2:183960213 [GRCh37]
Chr2:2q32.1		 uncertain significance
NM_080876.4(DUSP19):c.436G>C (p.Val146Leu) single nucleotide variant Inborn genetic diseases [RCV002950187] Chr2:183095440 [GRCh38]
Chr2:183960168 [GRCh37]
Chr2:2q32.1		 uncertain significance
NM_080876.4(DUSP19):c.199G>C (p.Gly67Arg) single nucleotide variant Inborn genetic diseases [RCV002788398] Chr2:183079132 [GRCh38]
Chr2:183943860 [GRCh37]
Chr2:2q32.1		 uncertain significance
NM_080876.4(DUSP19):c.302G>A (p.Gly101Glu) single nucleotide variant Inborn genetic diseases [RCV002680217] Chr2:183087068 [GRCh38]
Chr2:183951796 [GRCh37]
Chr2:2q32.1		 uncertain significance
NM_080876.4(DUSP19):c.244C>A (p.His82Asn) single nucleotide variant Inborn genetic diseases [RCV003180377] Chr2:183083525 [GRCh38]
Chr2:183948253 [GRCh37]
Chr2:2q32.1		 uncertain significance
GRCh37/hg19 2q32.1(chr2:183772883-184373432)x3 copy number gain not provided [RCV003484080] Chr2:183772883..184373432 [GRCh37]
Chr2:2q32.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1927
Count of miRNA genes:893
Interacting mature miRNAs:1036
Transcripts:ENST00000342619, ENST00000354221, ENST00000469344
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH92337  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372183,943,420 - 183,943,549UniSTSGRCh37
Build 362183,651,665 - 183,651,794RGDNCBI36
Celera2177,539,533 - 177,539,662RGD
Cytogenetic Map2q32.1UniSTS
HuRef2175,802,319 - 175,802,448UniSTS
GeneMap99-GB4 RH Map2588.74UniSTS
L17709  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map8q24.11UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map11q12.3UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map3p24.2UniSTS
Cytogenetic Map7q36.1UniSTS
Cytogenetic Map19q13.13UniSTS
Cytogenetic Map4q35.1UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map1p35-p34.3UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map10p14UniSTS
Cytogenetic Map9p12UniSTS
Cytogenetic Map1p36.33UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map1p36.22UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map1p36.12UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map11q22-q23UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic MapXp22.12UniSTS
Cytogenetic Map17q24.1UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map10q11.21UniSTS
Cytogenetic Map4p15.31UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map2p25.1-p24.1UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map10q24.32UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map1p31UniSTS
Cytogenetic MapXp11.4UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map2q32.1UniSTS
Cytogenetic Map2q36.1UniSTS
Cytogenetic Map3p24UniSTS
Cytogenetic Map16q23.2UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map3q27UniSTS
D10S275  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map17q24.2UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map13q12.13UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map10q11.22UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map16q11.2UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map6q22UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map20q11UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map4q32.3UniSTS
Cytogenetic Map3p22.1UniSTS
Cytogenetic Map1p35.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map14q24UniSTS
Cytogenetic Map14q22-q24UniSTS
Cytogenetic Map1p21.2UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map5q35.3UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map4q35.1UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map16q12.1UniSTS
Cytogenetic Map1p36.1UniSTS
Cytogenetic Map22q12.3UniSTS
Cytogenetic Map6p21.33UniSTS
Cytogenetic Map10p11UniSTS
Cytogenetic Map1p13.1UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map7p22.2UniSTS
Cytogenetic MapXq22.1UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic Map1p36.31UniSTS
Cytogenetic Map3q12.3UniSTS
Cytogenetic Map6q24UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map9q13-q21UniSTS
Cytogenetic Map3p25UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map7q22.3UniSTS
Cytogenetic Map9q22UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map1q21-q23UniSTS
Cytogenetic Map5q23.3UniSTS
Cytogenetic Map20q13UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic Map21q22.13UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic MapXp22.2-p22.1UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map20pter-q11.23UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map10p12.3UniSTS
Cytogenetic Map12p13.3UniSTS
Cytogenetic Map3q27UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map2q14.3UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map3q26.3UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map2p16.1UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map22q13UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map9q21.13UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map10q24.31UniSTS
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map17p13.1UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map12p12UniSTS
Cytogenetic Map3q13.31UniSTS
Cytogenetic Map5q23.2UniSTS
Cytogenetic Map22q11.2UniSTS
Cytogenetic Map1q24-q25.3UniSTS
Cytogenetic Map7p11UniSTS
Cytogenetic Map2q32.1UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic MapXq13-q21UniSTS
Cytogenetic Map6p24.3UniSTS
Cytogenetic Map11p15.4UniSTS
Cytogenetic Map1q21.2-q21.3UniSTS
Cytogenetic Map6q25.2-q27UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map12q24.32UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic Map10q11.21UniSTS
Cytogenetic Map14q32.3UniSTS
Cytogenetic Map13q12-q14UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map14q23.1UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map2q24.1UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map14q31UniSTS
Cytogenetic Map15q25.1UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map8p21.1UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map17q23.2UniSTS
Cytogenetic Map11p14.3UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map4q13UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic MapXp11.4UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map2p25.3UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map5q14.1UniSTS
Cytogenetic Map15q15.2UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map5p13.1UniSTS
Cytogenetic Map7q31.3UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map16q23.1UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map1p21UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic Map7p14.2UniSTS
Cytogenetic Map6q24.3UniSTS
Cytogenetic Map22q13.31UniSTS
Cytogenetic Map9p24.3UniSTS
Cytogenetic Map6q12-q13UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map9q31-q33UniSTS
Cytogenetic Map9q34.1UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map3p14.3UniSTS
Cytogenetic Map8p11.21UniSTS
Cytogenetic Map16p12.3UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map9p13.2UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map18q23UniSTS
Cytogenetic Map8p22UniSTS
Cytogenetic Map17p13UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map8p21.2UniSTS
Cytogenetic Map12q13.11UniSTS
Cytogenetic Map1q32.3UniSTS
Cytogenetic Map1p33UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map6p21UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map3p22.2UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic MapXp21.1UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map11p15.1UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map15q21.2UniSTS
Cytogenetic Map9q22.2UniSTS
Cytogenetic MapXp22UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map2p22UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map3p25.2UniSTS
Cytogenetic Map14q22.3UniSTS
Cytogenetic Map2p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 6 12 2 7 6 1 19 6 6
Low 2321 2111 1515 441 1123 298 3409 1632 3354 386 1403 1511 158 1 990 2089 5 2
Below cutoff 111 834 211 183 788 167 940 565 374 32 38 96 16 214 693 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001142314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001321519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_080876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_135688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB038770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB063186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB063187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC064871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF486808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK094800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC112005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000342619   ⟹   ENSP00000343905
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2183,078,559 - 183,095,899 (+)Ensembl
RefSeq Acc Id: ENST00000354221   ⟹   ENSP00000346160
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2183,078,747 - 183,100,008 (+)Ensembl
RefSeq Acc Id: ENST00000469344
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2183,078,989 - 183,095,903 (+)Ensembl
RefSeq Acc Id: NM_001142314   ⟹   NP_001135786
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382183,078,747 - 183,100,008 (+)NCBI
GRCh372183,943,287 - 183,964,736 (+)RGD
Celera2177,539,400 - 177,560,844 (+)RGD
HuRef2175,802,186 - 175,823,524 (+)RGD
CHM1_12183,949,183 - 183,970,629 (+)NCBI
T2T-CHM13v2.02183,567,739 - 183,589,000 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001321519   ⟹   NP_001308448
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382183,078,747 - 183,100,008 (+)NCBI
CHM1_12183,949,183 - 183,970,629 (+)NCBI
T2T-CHM13v2.02183,567,739 - 183,589,000 (+)NCBI
Sequence:
RefSeq Acc Id: NM_080876   ⟹   NP_543152
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382183,078,747 - 183,100,008 (+)NCBI
GRCh372183,943,287 - 183,964,736 (+)RGD
Build 362183,651,732 - 183,672,981 (+)NCBI Archive
Celera2177,539,400 - 177,560,844 (+)RGD
HuRef2175,802,186 - 175,823,524 (+)RGD
CHM1_12183,949,183 - 183,970,629 (+)NCBI
T2T-CHM13v2.02183,567,739 - 183,589,000 (+)NCBI
Sequence:
RefSeq Acc Id: NR_135688
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382183,078,747 - 183,100,008 (+)NCBI
CHM1_12183,949,183 - 183,970,629 (+)NCBI
T2T-CHM13v2.02183,567,739 - 183,589,000 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_543152   ⟸   NM_080876
- Peptide Label: isoform 1
- UniProtKB: Q547H4 (UniProtKB/Swiss-Prot),   B2RA79 (UniProtKB/Swiss-Prot),   Q8WYN4 (UniProtKB/Swiss-Prot),   Q8WTR2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001135786   ⟸   NM_001142314
- Peptide Label: isoform 2
- UniProtKB: Q8WTR2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001308448   ⟸   NM_001321519
- Peptide Label: isoform 3
- UniProtKB: Q8WTR2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000346160   ⟸   ENST00000354221
RefSeq Acc Id: ENSP00000343905   ⟸   ENST00000342619
Protein Domains
Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8WTR2-F1-model_v2 AlphaFold Q8WTR2 1-217 view protein structure

Promoters
RGD ID:6862264
Promoter ID:EPDNEW_H4297
Type:initiation region
Name:DUSP19_1
Description:dual specificity phosphatase 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382183,078,757 - 183,078,817EPDNEW
RGD ID:6797127
Promoter ID:HG_KWN:36251
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000255866,   UC002UPE.1,   UC010FRP.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362183,651,494 - 183,651,994 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:18894 AgrOrtholog
COSMIC DUSP19 COSMIC
Ensembl Genes ENSG00000162999 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000342619 ENTREZGENE
  ENST00000342619.10 UniProtKB/Swiss-Prot
  ENST00000354221 ENTREZGENE
  ENST00000354221.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot
GTEx ENSG00000162999 GTEx
HGNC ID HGNC:18894 ENTREZGENE
Human Proteome Map DUSP19 Human Proteome Map
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot
KEGG Report hsa:142679 UniProtKB/Swiss-Prot
NCBI Gene 142679 ENTREZGENE
OMIM 611437 OMIM
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE 19 UniProtKB/Swiss-Prot
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 19 UniProtKB/Swiss-Prot
Pfam DSPc UniProtKB/Swiss-Prot
PharmGKB PA134895660 PharmGKB
PRINTS ADSPHPHTASE UniProtKB/Swiss-Prot
PROSITE TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot
SMART DSPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot
UniProt B2RA79 ENTREZGENE
  DUS19_HUMAN UniProtKB/Swiss-Prot
  Q547H4 ENTREZGENE
  Q8WTR2 ENTREZGENE
  Q8WYN4 ENTREZGENE
UniProt Secondary B2RA79 UniProtKB/Swiss-Prot
  Q547H4 UniProtKB/Swiss-Prot
  Q8WYN4 UniProtKB/Swiss-Prot