Klhl1 (kelch-like 1) - Rat Genome Database

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Gene: Klhl1 (kelch-like 1) Mus musculus
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Symbol: Klhl1
Name: kelch-like 1
RGD ID: 1316653
MGI Page MGI
Description: Predicted to enable actin binding activity. Acts upstream of or within adult walking behavior; cerebellar Purkinje cell layer development; and dendrite development. Located in dendrite and neuronal cell body. Is expressed in central nervous system and extrinsic ocular muscle. Orthologous to human KLHL1 (kelch like family member 1); INTERACTS WITH benzo[a]pyrene; ethanol; folic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: kelch-l like; kelch-like protein 1; KIAA1490; mKIAA1490
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391496,342,701 - 96,756,470 (-)NCBIGRCm39mm39
GRCm39 Ensembl1496,340,172 - 96,756,538 (-)Ensembl
GRCm381496,105,265 - 96,519,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1496,102,736 - 96,519,102 (-)EnsemblGRCm38mm10GRCm38
MGSCv371496,504,484 - 96,918,253 (-)NCBIGRCm37mm9NCBIm37
MGSCv361494,988,399 - 95,402,168 (-)NCBImm8
Celera1494,679,542 - 95,128,348 (-)NCBICelera
Cytogenetic Map14E2.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
cytoskeleton  (IEA)
dendrite  (IBA,IDA)
neuronal cell body  (IBA,IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:10888605   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11919683   PMID:12477932   PMID:15761153   PMID:16141072   PMID:16141073   PMID:16919269   PMID:17005861  
PMID:17289272   PMID:17324934   PMID:18708037   PMID:19515692   PMID:19806008   PMID:20147652   PMID:21267068   PMID:21873635   PMID:25610372   PMID:25802080   PMID:32325033  


Genomics

Comparative Map Data
Klhl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391496,342,701 - 96,756,470 (-)NCBIGRCm39mm39
GRCm39 Ensembl1496,340,172 - 96,756,538 (-)Ensembl
GRCm381496,105,265 - 96,519,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1496,102,736 - 96,519,102 (-)EnsemblGRCm38mm10GRCm38
MGSCv371496,504,484 - 96,918,253 (-)NCBIGRCm37mm9NCBIm37
MGSCv361494,988,399 - 95,402,168 (-)NCBImm8
Celera1494,679,542 - 95,128,348 (-)NCBICelera
Cytogenetic Map14E2.1NCBI
KLHL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1369,700,594 - 70,108,493 (-)EnsemblGRCh38hg38GRCh38
GRCh381369,700,593 - 70,108,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371370,274,729 - 70,682,584 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361369,172,726 - 69,580,460 (-)NCBINCBI36hg18NCBI36
Build 341369,172,726 - 69,580,460NCBI
Celera1351,176,734 - 51,584,696 (-)NCBI
Cytogenetic Map13q21.33NCBI
HuRef1350,976,143 - 51,384,644 (-)NCBIHuRef
CHM1_11370,242,241 - 70,650,179 (-)NCBICHM1_1
Klhl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21572,698,188 - 73,142,707 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1580,271,731 - 80,713,153 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01580,270,846 - 80,714,176 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01583,810,351 - 84,250,513 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41579,306,914 - 79,772,396 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11579,322,860 - 79,787,587 (-)NCBI
Celera1571,996,058 - 72,423,584 (-)NCBICelera
Cytogenetic Map15q21NCBI
Klhl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540436,304,326 - 36,697,236 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540436,304,862 - 36,696,901 (+)NCBIChiLan1.0ChiLan1.0
KLHL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11369,694,185 - 70,119,241 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1369,691,537 - 70,118,448 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01350,906,581 - 51,335,692 (-)NCBIMhudiblu_PPA_v0panPan3
KLHL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12224,190,862 - 24,554,451 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2224,191,778 - 24,555,120 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2224,044,013 - 24,406,868 (-)NCBI
ROS_Cfam_1.02224,501,555 - 24,889,956 (-)NCBI
UMICH_Zoey_3.12224,144,239 - 24,507,168 (-)NCBI
UNSW_CanFamBas_1.02224,230,744 - 24,587,985 (-)NCBI
UU_Cfam_GSD_1.02224,289,783 - 24,660,217 (-)NCBI
Klhl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945135,093,965 - 135,462,773 (+)NCBI
SpeTri2.0NW_00493651110,511,200 - 10,879,121 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1142,033,842 - 42,419,770 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11142,033,842 - 42,420,931 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,253,406 - 46,664,342 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1348,812,816 - 49,237,894 (-)NCBI
ChlSab1.1 Ensembl348,812,845 - 49,086,381 (-)Ensembl
Vero_WHO_p1.0NW_0236660464,765,419 - 5,551,660 (-)NCBI
Klhl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474830,948,092 - 31,387,128 (-)NCBI

Position Markers
D14Mit71  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381496,265,856 - 96,266,027UniSTSGRCm38
MGSCv371496,665,075 - 96,665,246UniSTSGRCm37
Celera1494,863,536 - 94,863,707UniSTS
Cytogenetic Map14E2.1UniSTS
cM Map1444.0UniSTS
Whitehead Genetic1452.5UniSTS
Whitehead/MRC_RH14956.71UniSTS
Whitehead_YAC14 UniSTS
KLHL1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera1494,886,412 - 94,886,569UniSTS
Cytogenetic Map14E2.1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420837405121032392Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1457942183101622037Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146216002096160240Mouse
14747006Mancz12_mmandible centroid size 12 (mouse)1469834541103834541Mouse
10054475Ossc3_mosteosarcoma susceptibility 3 (mouse)Not determined1470626332104626490Mouse
1300551Lprm3_mlymphoproliferation modifier 3 (mouse)Not determined1470983788104983908Mouse
1301844Pgia29_mproteoglycan induced arthritis 29 (mouse)Not determined1474114860108114948Mouse
1558819Ossc2_mosteosarcoma susceptibility 2 (mouse)Not determined1474157540108157657Mouse
14928314Manh77_mmandible shape 77 (mouse)1476530354110530354Mouse
1558823Tbbmd6_mtotal body bone mineral density 6 (mouse)Not determined1476836260110836351Mouse
10043997Bw40_mbody weight QTL 40 (mouse)Not determined1482924828116925025Mouse
4142508Tgq25_mtriglyceride QTL 25 (mouse)Not determined84896632118896632Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:357
Count of miRNA genes:242
Interacting mature miRNAs:289
Transcripts:ENSMUST00000022666
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000022666   ⟹   ENSMUSP00000022666
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1496,102,736 - 96,519,102 (-)Ensembl
RefSeq Acc Id: NM_053105   ⟹   NP_444335
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391496,342,701 - 96,756,470 (-)NCBI
GRCm381496,105,265 - 96,519,034 (-)ENTREZGENE
MGSCv371496,504,484 - 96,918,253 (-)RGD
Celera1494,679,542 - 95,128,348 (-)RGD
cM Map14 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_444335   ⟸   NM_053105
- UniProtKB: Q9JI74 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000022666   ⟸   ENSMUST00000022666
Protein Domains
BTB

Promoters
RGD ID:8683096
Promoter ID:EPDNEW_M19579
Type:multiple initiation site
Name:Klhl1_1
Description:Mus musculus kelch-like 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381496,519,070 - 96,519,130EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2136335 AgrOrtholog
Ensembl Genes ENSMUSG00000022076 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000022666 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022666 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.120.10.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.710.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:93688 UniProtKB/Swiss-Prot
MGD MGI:2136335 ENTREZGENE
NCBI Gene 93688 ENTREZGENE
Pfam BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klhl1 PhenoGen
PROSITE BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt KLHL1_MOUSE UniProtKB/Swiss-Prot
  Q3TQM4_MOUSE UniProtKB/TrEMBL
  Q5DTX3_MOUSE UniProtKB/TrEMBL
  Q8CCY1_MOUSE UniProtKB/TrEMBL
  Q9JI73_MOUSE UniProtKB/TrEMBL
  Q9JI74 ENTREZGENE
UniProt Secondary Q505E9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-12 Klhl1  kelch-like 1    kelch-l like  Symbol and/or name change 5135510 APPROVED
2013-01-22 Klhl1  kelch-l like    kelch-like 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED