Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | increases expression | EXP | | 6480464 | ethylene dichloride results in increased expression of TRIM6 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of TRIM6 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | Trim6 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of TRIM6 mRNA and [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TRIM6 mRNA | CTD | PMID:26496021 and PMID:32741896 | 17beta-estradiol 3-benzoate | multiple interactions | ISO | Trim6 (Rattus norvegicus) | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TRIM6 mRNA | CTD | PMID:32741896 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TRIM6 mRNA | CTD | PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Trim6 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TRIM6 mRNA | CTD | PMID:33387578 | 3,4-dichloroaniline | decreases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | 3 and 4-dichloroaniline results in decreased expression of TRIM6 mRNA | CTD | PMID:24172598 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | TRIM6 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TRIM6 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRIM6 mRNA | CTD | PMID:28628672 | acetamide | increases expression | ISO | Trim6 (Rattus norvegicus) | 6480464 | acetamide results in increased expression of TRIM6 mRNA | CTD | PMID:31881176 | acrylamide | decreases expression | ISO | Trim6 (Rattus norvegicus) | 6480464 | Acrylamide results in decreased expression of TRIM6 mRNA | CTD | PMID:28959563 | aflatoxin B1 | affects expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of TRIM6 protein | CTD | PMID:20106945 | aflatoxin B1 | increases methylation | ISO | TRIM6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of TRIM6 intron | CTD | PMID:30157460 | aflatoxin B1 | increases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of TRIM6 mRNA | CTD | PMID:27153756 | all-trans-retinoic acid | increases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of TRIM6 mRNA | CTD | PMID:23830798 | aristolochic acid A | increases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of TRIM6 mRNA | CTD | PMID:33212167 | arsane | affects methylation | ISO | TRIM6 (Homo sapiens) | 6480464 | Arsenic affects the methylation of TRIM6 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | TRIM6 (Homo sapiens) | 6480464 | Arsenic affects the methylation of TRIM6 gene | CTD | PMID:25304211 | benzo[a]pyrene | decreases methylation | ISO | TRIM6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of TRIM6 promoter | CTD | PMID:27901495 | bis(2-ethylhexyl) phthalate | increases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of TRIM6 mRNA | CTD | PMID:31163220 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TRIM6 mRNA | CTD | PMID:26063408 | bisphenol A | multiple interactions | ISO | TRIM6 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TRIM6 mRNA | CTD | PMID:28628672 | bisphenol A | affects expression | ISO | Trim6 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of TRIM6 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | Trim6 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of TRIM6 mRNA | CTD | PMID:26496021 | bisphenol F | multiple interactions | ISO | TRIM6 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRIM6 mRNA | CTD | PMID:28628672 | cadmium dichloride | affects expression | ISO | Trim6 (Rattus norvegicus) | 6480464 | Cadmium Chloride affects the expression of TRIM6 mRNA | CTD | PMID:22110744 | calcitriol | increases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of TRIM6 mRNA | CTD | PMID:16002434 | CGP 52608 | multiple interactions | ISO | TRIM6 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to TRIM6 gene] | CTD | PMID:28238834 | chlordecone | decreases expression | EXP | | 6480464 | Chlordecone results in decreased expression of TRIM6 mRNA | CTD | PMID:33711761 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of TRIM6 mRNA | CTD | PMID:37019170 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRIM6 mRNA | CTD | PMID:20938992 | CU-O LINKAGE | decreases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | cupric oxide results in decreased expression of TRIM6 mRNA | CTD | PMID:22077320 | cyclosporin A | decreases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of TRIM6 mRNA | CTD | PMID:20106945 | cytarabine | decreases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Cytarabine results in decreased expression of TRIM6 mRNA | CTD | PMID:21198554 | decabromodiphenyl ether | decreases expression | ISO | Trim6 (Rattus norvegicus) | 6480464 | decabromobiphenyl ether results in decreased expression of TRIM6 mRNA | CTD | PMID:23640034 | dexamethasone | multiple interactions | ISO | TRIM6 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TRIM6 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRIM6 mRNA | CTD | PMID:28628672 | dichloroacetic acid | increases expression | EXP | | 6480464 | Dichloroacetic Acid results in increased expression of TRIM6 mRNA | CTD | PMID:28962523 | diethyl maleate | decreases expression | ISO | Trim6 (Rattus norvegicus) | 6480464 | diethyl maleate results in decreased expression of TRIM6 mRNA | CTD | PMID:21161181 | dimethylarsinic acid | multiple interactions | EXP | | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of TRIM6 mRNA | CTD | PMID:34876320 | diuron | decreases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Diuron metabolite results in decreased expression of TRIM6 mRNA | CTD | PMID:24172598 | dorsomorphin | multiple interactions | ISO | TRIM6 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | entinostat | increases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | entinostat results in increased expression of TRIM6 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | TRIM6 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM6 mRNA | CTD | PMID:27188386 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRIM6 mRNA | CTD | PMID:20938992 | genistein | decreases expression | EXP | | 6480464 | Genistein results in decreased expression of TRIM6 mRNA | CTD | PMID:32186404 | gentamycin | increases expression | ISO | Trim6 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of TRIM6 mRNA | CTD | PMID:22061828 | gentamycin | decreases expression | ISO | Trim6 (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of TRIM6 mRNA | CTD | PMID:33387578 | glafenine | decreases expression | ISO | Trim6 (Rattus norvegicus) | 6480464 | Glafenine results in decreased expression of TRIM6 mRNA | CTD | PMID:24136188 | indometacin | multiple interactions | ISO | TRIM6 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TRIM6 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TRIM6 mRNA | CTD | PMID:28628672 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRIM6 mRNA | CTD | PMID:20938992 | lithium chloride | increases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Lithium Chloride results in increased expression of TRIM6 mRNA | CTD | PMID:23527032 | methylarsonic acid | multiple interactions | EXP | | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of TRIM6 mRNA | CTD | PMID:34876320 | methylmercury chloride | decreases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of TRIM6 mRNA | CTD | PMID:23179753 | mono(2-ethylhexyl) phthalate | affects expression | EXP | | 6480464 | mono-(2-ethylhexyl)phthalate affects the expression of TRIM6 mRNA | CTD | PMID:21195148 | Monobutylphthalate | affects expression | EXP | | 6480464 | monobutyl phthalate affects the expression of TRIM6 mRNA | CTD | PMID:21195148 | nickel atom | decreases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Nickel results in decreased expression of TRIM6 mRNA | CTD | PMID:24768652 and PMID:25583101 | oxaliplatin | multiple interactions | ISO | Trim6 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of TRIM6 mRNA | CTD | PMID:25729387 | panobinostat | multiple interactions | ISO | TRIM6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM6 mRNA | CTD | PMID:27188386 | panobinostat | increases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | panobinostat results in increased expression of TRIM6 mRNA | CTD | PMID:26272509 | paracetamol | decreases expression | ISO | Trim6 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of TRIM6 mRNA | CTD | PMID:33387578 | phenylmercury acetate | increases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of TRIM6 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | TRIM6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM6 mRNA | CTD | PMID:27188386 | pirinixic acid | multiple interactions | ISO | TRIM6 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TRIM6 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of TRIM6 mRNA | CTD | PMID:18301758 | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TRIM6 mRNA | CTD | PMID:19710929 | potassium dichromate | decreases expression | EXP | | 6480464 | Potassium Dichromate results in decreased expression of TRIM6 mRNA | CTD | PMID:23608068 | propiconazole | increases expression | EXP | | 6480464 | propiconazole results in increased expression of TRIM6 mRNA | CTD | PMID:21278054 | rotenone | increases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Rotenone results in increased expression of TRIM6 mRNA | CTD | PMID:29331484 | SB 431542 | multiple interactions | ISO | TRIM6 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of TRIM6 mRNA | CTD | PMID:25895662 | sodium arsenate | multiple interactions | EXP | | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of TRIM6 mRNA | CTD | PMID:34876320 | sodium arsenite | multiple interactions | EXP | | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of TRIM6 mRNA | CTD | PMID:34876320 | sodium dodecyl sulfate | decreases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Sodium Dodecyl Sulfate results in decreased expression of TRIM6 mRNA | CTD | PMID:31734321 | succimer | multiple interactions | EXP | | 6480464 | [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of TRIM6 mRNA | CTD | PMID:26378955 | temozolomide | decreases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of TRIM6 mRNA | CTD | PMID:31758290 | testosterone | multiple interactions | ISO | Trim6 (Rattus norvegicus) | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of TRIM6 mRNA | CTD | PMID:32741896 | topotecan | multiple interactions | ISO | Trim6 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of TRIM6 mRNA | CTD | PMID:25729387 | trichostatin A | increases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of TRIM6 mRNA | CTD | PMID:24935251 more ... | trichostatin A | multiple interactions | ISO | TRIM6 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM6 mRNA | CTD | PMID:27188386 | Triptolide | increases expression | EXP | | 6480464 | triptolide results in increased expression of TRIM6 mRNA | CTD | PMID:32835833 | valproic acid | affects expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of TRIM6 mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | TRIM6 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of TRIM6 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | TRIM6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRIM6 mRNA | CTD | PMID:27188386 | |