D130043K22Rik (RIKEN cDNA D130043K22 gene) - Rat Genome Database

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Gene: D130043K22Rik (RIKEN cDNA D130043K22 gene) Mus musculus
Analyze
Symbol: D130043K22Rik
Name: RIKEN cDNA D130043K22 gene
RGD ID: 1316638
MGI Page MGI
Description: Acts upstream of or within multicellular organismal response to stress; negative regulation of axon extension involved in regeneration; and response to auditory stimulus. Predicted to be located in early endosome. Predicted to be active in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including brain; esophagus; future spinal cord; male reproductive gland or organ; and olfactory epithelium. Orthologous to human KIAA0319 (KIAA0319).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 4930451E12Rik; dyslexia-associated protein KIAA0319 homolog; hypothetical protein LOC210108; Kiaa0319
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391325,029,114 - 25,085,422 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1325,029,118 - 25,085,253 (+)EnsemblGRCm39 Ensembl
GRCm381324,845,131 - 24,901,439 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1324,845,135 - 24,901,270 (+)EnsemblGRCm38mm10GRCm38
MGSCv371324,937,000 - 24,993,139 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361324,852,596 - 24,908,735 (+)NCBIMGSCv36mm8
Celera1325,075,796 - 25,131,935 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1310.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12693553   PMID:16141072   PMID:16141073   PMID:16600991   PMID:19026994   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:24194600   PMID:27510895   PMID:27721240   PMID:28334068   PMID:28671696   PMID:29045729   PMID:35419947  


Genomics

Comparative Map Data
D130043K22Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391325,029,114 - 25,085,422 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1325,029,118 - 25,085,253 (+)EnsemblGRCm39 Ensembl
GRCm381324,845,131 - 24,901,439 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1324,845,135 - 24,901,270 (+)EnsemblGRCm38mm10GRCm38
MGSCv371324,937,000 - 24,993,139 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361324,852,596 - 24,908,735 (+)NCBIMGSCv36mm8
Celera1325,075,796 - 25,131,935 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1310.72NCBI
KIAA0319
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38624,540,141 - 24,646,191 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl624,544,104 - 24,646,191 (-)EnsemblGRCh38hg38GRCh38
GRCh37624,544,335 - 24,646,419 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36624,652,311 - 24,754,362 (-)NCBINCBI36Build 36hg18NCBI36
Celera625,777,709 - 25,879,725 (-)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef624,493,749 - 24,595,804 (-)NCBIHuRef
CHM1_1624,548,492 - 24,650,521 (-)NCBICHM1_1
T2T-CHM13v2.0624,414,072 - 24,516,155 (-)NCBIT2T-CHM13v2.0
Kiaa0319
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,587,001 - 40,654,525 (-)NCBIGRCr8
mRatBN7.21740,162,512 - 40,226,666 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1740,165,084 - 40,225,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1740,233,213 - 40,293,842 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,837,269 - 41,897,887 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01740,120,468 - 40,181,116 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01742,163,245 - 42,226,725 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1742,165,817 - 42,226,377 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01744,031,044 - 44,094,370 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41747,226,680 - 47,287,240 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11747,230,128 - 47,279,391 (-)NCBI
Celera1739,802,603 - 39,862,958 (-)NCBICelera
Cytogenetic Map17p11NCBI
Kiaa0319
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554832,413,181 - 2,462,735 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554832,404,061 - 2,463,210 (+)NCBIChiLan1.0ChiLan1.0
KIAA0319
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2539,194,856 - 39,296,821 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1635,194,572 - 35,296,284 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0624,377,666 - 24,483,388 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1624,713,922 - 24,815,300 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl624,713,922 - 24,815,300 (-)Ensemblpanpan1.1panPan2
KIAA0319
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13522,589,103 - 22,689,549 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3522,591,353 - 22,652,292 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3522,556,996 - 22,657,004 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03522,711,229 - 22,811,382 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3522,711,238 - 22,810,979 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13522,516,640 - 22,574,230 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03522,564,620 - 22,664,450 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03524,000,847 - 24,100,756 (-)NCBIUU_Cfam_GSD_1.0
Kiaa0319
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049462,708,741 - 2,751,526 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936671870,695 - 912,727 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936671870,107 - 912,727 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIAA0319
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl719,383,196 - 19,486,265 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1719,383,189 - 19,487,669 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2720,533,670 - 20,639,029 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KIAA0319
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11747,603,506 - 47,702,154 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1747,603,705 - 47,696,302 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604424,471,322 - 24,576,965 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kiaa0319
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247562,377,846 - 2,459,936 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247562,377,573 - 2,464,766 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in D130043K22Rik
1469 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1592
Count of miRNA genes:648
Interacting mature miRNAs:781
Transcripts:ENSMUST00000006893, ENSMUST00000141572, ENSMUST00000169411, ENSMUST00000171262
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
1301984Pbd2_mpeak bone density 2 (mouse)Not determined131718950838947406Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse

Markers in Region
D130043K22Rik  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A3.1UniSTS
cM Map13 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000006893   ⟹   ENSMUSP00000006893
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1325,029,118 - 25,085,253 (+)Ensembl
GRCm38.p6 Ensembl1324,845,135 - 24,901,270 (+)Ensembl
RefSeq Acc Id: ENSMUST00000141572   ⟹   ENSMUSP00000116004
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1325,029,118 - 25,085,246 (+)Ensembl
GRCm38.p6 Ensembl1324,845,135 - 24,901,263 (+)Ensembl
RefSeq Acc Id: ENSMUST00000169411
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1325,064,508 - 25,066,642 (+)Ensembl
GRCm38.p6 Ensembl1324,880,525 - 24,882,659 (+)Ensembl
RefSeq Acc Id: ENSMUST00000171262
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1325,077,064 - 25,083,831 (+)Ensembl
GRCm38.p6 Ensembl1324,893,081 - 24,899,848 (+)Ensembl
RefSeq Acc Id: NM_001081051   ⟹   NP_001074520
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391325,029,114 - 25,085,422 (+)NCBI
GRCm381324,845,131 - 24,901,439 (+)NCBI
MGSCv371324,937,000 - 24,993,139 (+)RGD
Celera1325,075,796 - 25,131,935 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_131787
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391325,029,114 - 25,085,422 (+)NCBI
GRCm381324,845,131 - 24,901,439 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001074520   ⟸   NM_001081051
- Peptide Label: precursor
- UniProtKB: Q14BF3 (UniProtKB/Swiss-Prot),   Q80U39 (UniProtKB/Swiss-Prot),   Q5SZV5 (UniProtKB/Swiss-Prot),   Q3UFC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000006893   ⟸   ENSMUST00000006893
RefSeq Acc Id: ENSMUSP00000116004   ⟸   ENSMUST00000141572
Protein Domains
MANSC   PKD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5SZV5-F1-model_v2 AlphaFold Q5SZV5 1-1081 view protein structure

Promoters
RGD ID:8679900
Promoter ID:EPDNEW_M17981
Type:initiation region
Name:D130043K22Rik_1
Description:Mus musculus RIKEN cDNA D130043K22 gene , transcript variant2, non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381324,845,138 - 24,845,198EPDNEW
RGD ID:6823802
Promoter ID:MM_KWN:13592
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   MEF_B6
Transcripts:NM_001081051,   OTTMUST00000062593
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361324,936,491 - 24,937,047 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3036268 AgrOrtholog
Ensembl Genes ENSMUSG00000006711 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000006893 ENTREZGENE
  ENSMUST00000006893.9 UniProtKB/Swiss-Prot
  ENSMUST00000141572 ENTREZGENE
  ENSMUST00000141572.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIAA0319-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MANSC_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MANSC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKD/Chitinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKD_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:210108 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:3036268 ENTREZGENE
NCBI Gene 210108 ENTREZGENE
PANTHER DYSLEXIA-ASSOCIATED PROTEIN KIAA0319 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46182 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen D130043K22Rik PhenoGen
PROSITE MANSC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MANEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49299 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F2Z497_MOUSE UniProtKB/TrEMBL
  K0319_MOUSE UniProtKB/Swiss-Prot
  Q14BF3 ENTREZGENE
  Q3UFC3 ENTREZGENE, UniProtKB/TrEMBL
  Q5SZV5 ENTREZGENE
  Q80U39 ENTREZGENE
UniProt Secondary Q14BF3 UniProtKB/Swiss-Prot
  Q80U39 UniProtKB/Swiss-Prot