Irx3 (Iroquois related homeobox 3) - Rat Genome Database

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Gene: Irx3 (Iroquois related homeobox 3) Mus musculus
Analyze
Symbol: Irx3
Name: Iroquois related homeobox 3
RGD ID: 1316614
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including His-Purkinje system development; kidney development; and regulation of transcription by RNA polymerase II. Acts upstream of or within mesoderm development; negative regulation of neuron differentiation; and positive regulation of neuron differentiation. Located in axon; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human IRX3 (iroquois homeobox 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI894186; homeodomain protein IRXB1; iroquois homeobox protein 3; iroquois-class homeodomain protein IRX-3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39892,525,139 - 92,528,282 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl892,525,153 - 92,528,695 (-)EnsemblGRCm39 Ensembl
GRCm38891,798,511 - 91,801,654 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl891,798,525 - 91,802,067 (-)EnsemblGRCm38mm10GRCm38
MGSCv37894,322,424 - 94,325,273 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36894,687,653 - 94,690,502 (-)NCBIMGSCv36mm8
Celera896,103,077 - 96,105,918 (-)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP,ISO)
decabromodiphenyl ether  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
formaldehyde  (ISO)
furan  (ISO)
hydralazine  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP)
nicotine  (EXP)
nitrofen  (ISO)
oxaliplatin  (ISO)
panobinostat  (ISO)
perfluorohexanesulfonic acid  (EXP)
pirinixic acid  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
testosterone  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
cytoplasm  (IDA)
nucleus  (IBA,IDA)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Lu QR, etal., Cell 2002 Apr 5;109(1):75-86.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9427753   PMID:9486539   PMID:9817915   PMID:10349636   PMID:10704856   PMID:10822268   PMID:10830170   PMID:10926765   PMID:11042145   PMID:11042159   PMID:11076861   PMID:11118473  
PMID:11124112   PMID:11217851   PMID:11238910   PMID:11245568   PMID:11335133   PMID:11502253   PMID:11520674   PMID:11567614   PMID:11830569   PMID:11956760   PMID:12435629   PMID:12466851  
PMID:12477932   PMID:12595239   PMID:12842915   PMID:12874134   PMID:14534138   PMID:14585979   PMID:14651936   PMID:14660441   PMID:14681479   PMID:15148409   PMID:15342473   PMID:15342729  
PMID:15525990   PMID:15618518   PMID:15789444   PMID:15843409   PMID:15872003   PMID:15963769   PMID:16100003   PMID:16141072   PMID:16141073   PMID:16214126   PMID:16299054   PMID:16357211  
PMID:16407399   PMID:16432183   PMID:16469306   PMID:16602821   PMID:16829211   PMID:16860307   PMID:16919269   PMID:17026983   PMID:17122047   PMID:17336907   PMID:17344230   PMID:17553904  
PMID:17610272   PMID:17875669   PMID:17922007   PMID:18094027   PMID:18159948   PMID:18256198   PMID:18287559   PMID:18697938   PMID:18927154   PMID:18927156   PMID:19258013   PMID:19433083  
PMID:19666821   PMID:19741146   PMID:19766572   PMID:20003319   PMID:20059953   PMID:20106871   PMID:20408909   PMID:20692247   PMID:20969841   PMID:21209331   PMID:21267068   PMID:21293032  
PMID:21338882   PMID:21471156   PMID:21654186   PMID:21734270   PMID:21825130   PMID:21873635   PMID:21943603   PMID:22174793   PMID:22186731   PMID:22396766   PMID:22438573   PMID:22496664  
PMID:22711520   PMID:22844512   PMID:22988430   PMID:22992950   PMID:23300479   PMID:23362348   PMID:23369715   PMID:23616926   PMID:23769843   PMID:24115909   PMID:24146773   PMID:24335256  
PMID:24528677   PMID:24646999   PMID:24726282   PMID:24726283   PMID:24899573   PMID:24952961   PMID:25228773   PMID:25453830   PMID:25848055   PMID:25936505   PMID:26238476   PMID:26329601  
PMID:26429810   PMID:26450968   PMID:26786475   PMID:26956358   PMID:26959361   PMID:27052172   PMID:27151576   PMID:27352137   PMID:27453922   PMID:27581449   PMID:27775552   PMID:28052057  
PMID:28059449   PMID:28467430   PMID:28760814   PMID:29109536   PMID:29459093   PMID:29463648   PMID:30067986   PMID:30071018   PMID:30246301   PMID:30311912   PMID:30581079   PMID:30872278  
PMID:30936836   PMID:30959515   PMID:31112136   PMID:31434798   PMID:31751577   PMID:32108023   PMID:32156750   PMID:32507881   PMID:32662900   PMID:32907847   PMID:33230114   PMID:33787491  
PMID:33859429   PMID:33912929   PMID:34083488   PMID:34095148   PMID:34321664   PMID:34321999   PMID:34556885   PMID:34705510   PMID:35084365   PMID:35138358   PMID:35315772   PMID:35935334  
PMID:36773339   PMID:36877136   PMID:37198424   PMID:37494420   PMID:37524711   PMID:37846569   PMID:38355793   PMID:38794925   PMID:38828908   PMID:39173825   PMID:39366945  


Genomics

Comparative Map Data
Irx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39892,525,139 - 92,528,282 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl892,525,153 - 92,528,695 (-)EnsemblGRCm39 Ensembl
GRCm38891,798,511 - 91,801,654 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl891,798,525 - 91,802,067 (-)EnsemblGRCm38mm10GRCm38
MGSCv37894,322,424 - 94,325,273 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36894,687,653 - 94,690,502 (-)NCBIMGSCv36mm8
Celera896,103,077 - 96,105,918 (-)NCBICelera
Cytogenetic Map8C5NCBI
cM Map844.55NCBI
IRX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381654,283,304 - 54,286,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1654,283,304 - 54,286,787 (-)EnsemblGRCh38hg38GRCh38
GRCh371654,317,216 - 54,320,699 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361652,874,713 - 52,877,879 (-)NCBINCBI36Build 36hg18NCBI36
Build 341652,874,712 - 52,877,879NCBI
Celera1638,831,683 - 38,834,849 (-)NCBICelera
Cytogenetic Map16q12.2NCBI
HuRef1640,203,767 - 40,206,921 (-)NCBIHuRef
CHM1_11655,724,203 - 55,727,369 (-)NCBICHM1_1
T2T-CHM13v2.01660,081,297 - 60,084,780 (-)NCBIT2T-CHM13v2.0
Irx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81931,384,803 - 31,388,241 (+)NCBIGRCr8
mRatBN7.21915,211,882 - 15,215,317 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1915,211,878 - 15,215,317 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1916,902,097 - 16,905,213 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01922,096,906 - 22,100,022 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01925,042,791 - 25,045,908 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01915,838,714 - 15,842,135 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1915,838,714 - 15,840,990 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01926,917,882 - 26,921,326 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41916,345,179 - 16,347,455 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11916,349,206 - 16,352,281 (+)NCBI
Celera1915,124,412 - 15,126,688 (+)NCBICelera
Cytogenetic Map19p11NCBI
Irx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543311,944,890 - 11,948,369 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543311,944,890 - 11,948,372 (-)NCBIChiLan1.0ChiLan1.0
IRX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21863,708,015 - 63,712,146 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11669,626,818 - 69,630,821 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01634,514,107 - 34,517,576 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11653,622,028 - 53,627,033 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1653,622,409 - 53,624,653 (-)Ensemblpanpan1.1panPan2
IRX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1261,555,608 - 61,559,185 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl261,555,492 - 61,558,958 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha258,190,062 - 58,192,778 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0262,094,083 - 62,096,798 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl262,094,083 - 62,096,571 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1258,923,158 - 58,925,876 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0259,949,850 - 59,952,564 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0260,825,325 - 60,828,040 (+)NCBIUU_Cfam_GSD_1.0
Irx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934952,775,883 - 52,778,397 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364756,810,666 - 6,813,192 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364756,810,678 - 6,813,186 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl631,046,146 - 31,049,054 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1631,044,919 - 31,049,067 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2628,167,076 - 28,171,233 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IRX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1540,064,471 - 40,069,630 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl540,066,008 - 40,068,505 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604736,306,655 - 36,310,144 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247572,543,992 - 2,547,464 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247572,543,968 - 2,547,452 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Irx3
260 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:217
Count of miRNA genes:113
Interacting mature miRNAs:115
Transcripts:ENSMUST00000093312, ENSMUST00000175795
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85892810792928107Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85913640493136404Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse

Markers in Region
AI894186  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38891,800,181 - 91,800,324UniSTSGRCm38
MGSCv37894,324,080 - 94,324,223UniSTSGRCm37
Celera896,104,725 - 96,104,868UniSTS
Cytogenetic Map8C5UniSTS
cM Map842.1UniSTS
Whitehead/MRC_RH81083.47UniSTS
Irx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38891,800,437 - 91,800,516UniSTSGRCm38
MGSCv37895,201,191 - 95,201,255UniSTSGRCm37
MGSCv37894,324,463 - 94,324,527UniSTSGRCm37
Celera896,104,981 - 96,105,060UniSTS
Cytogenetic Map8C5UniSTS
cM Map842.1UniSTS
cM Map843.65UniSTS
cM Map842.1UniSTS
PMC310936P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38891,800,771 - 91,801,092UniSTSGRCm38
MGSCv37894,324,670 - 94,324,991UniSTSGRCm37
Celera896,105,315 - 96,105,636UniSTS
Cytogenetic Map8C5UniSTS
cM Map842.1UniSTS
Irx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C5UniSTS
Irx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38891,800,564 - 91,800,628UniSTSGRCm38
GRCm38892,677,292 - 92,677,356UniSTSGRCm38
MGSCv37894,324,463 - 94,324,527UniSTSGRCm37
MGSCv37895,201,191 - 95,201,255UniSTSGRCm37
Celera897,004,047 - 97,004,111UniSTS
Celera896,105,108 - 96,105,172UniSTS
Cytogenetic Map8C5UniSTS
cM Map842.1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000093312   ⟹   ENSMUSP00000091002
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl892,525,153 - 92,528,543 (-)Ensembl
GRCm38.p6 Ensembl891,798,525 - 91,801,915 (-)Ensembl
Ensembl Acc Id: ENSMUST00000175795   ⟹   ENSMUSP00000135488
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl892,525,153 - 92,528,695 (-)Ensembl
GRCm38.p6 Ensembl891,798,525 - 91,802,067 (-)Ensembl
RefSeq Acc Id: NM_001253822   ⟹   NP_001240751
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39892,525,139 - 92,528,282 (-)NCBI
GRCm38891,798,511 - 91,801,654 (-)ENTREZGENE
Celera896,103,063 - 96,106,198 (-)ENTREZGENE
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008393   ⟹   NP_032419
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39892,525,139 - 92,528,282 (-)NCBI
GRCm38891,798,511 - 91,801,654 (-)ENTREZGENE
MGSCv37894,322,424 - 94,325,273 (-)RGD
Celera896,103,063 - 96,106,198 (-)ENTREZGENE
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032419   ⟸   NM_008393
- Peptide Label: isoform 2
- UniProtKB: Q3UPZ3 (UniProtKB/Swiss-Prot),   Q5U3K8 (UniProtKB/Swiss-Prot),   P81067 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001240751   ⟸   NM_001253822
- Peptide Label: isoform 1
- UniProtKB: P81067 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000091002   ⟸   ENSMUST00000093312
Ensembl Acc Id: ENSMUSP00000135488   ⟸   ENSMUST00000175795

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P81067-F1-model_v2 AlphaFold P81067 1-507 view protein structure

Promoters
RGD ID:8667851
Promoter ID:EPDNEW_M11956
Type:initiation region
Name:Irx3_1
Description:Mus musculus Iroquois related homeobox 3 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38891,801,596 - 91,801,656EPDNEW
RGD ID:6843339
Promoter ID:MM_KWN:55258
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   Liver
Transcripts:ENSMUST00000095002,   NM_008393,   UC009MSV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36894,325,414 - 94,325,914 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1197522 AgrOrtholog
Ensembl Genes ENSMUSG00000031734 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000093312 ENTREZGENE
  ENSMUST00000093312.6 UniProtKB/Swiss-Prot
  ENSMUST00000175795 ENTREZGENE
  ENSMUST00000175795.4 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Homeobox_KN_domain UniProtKB/Swiss-Prot
  Iroquois_homeo UniProtKB/Swiss-Prot
KEGG Report mmu:16373 UniProtKB/Swiss-Prot
MGD MGI:1197522 ENTREZGENE
NCBI Gene 16373 ENTREZGENE
PANTHER IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX UniProtKB/Swiss-Prot
  IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-3 UniProtKB/Swiss-Prot
Pfam Homeobox_KN UniProtKB/Swiss-Prot
PhenoGen Irx3 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
  IRO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt IRX3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UPZ3 ENTREZGENE
  Q5U3K8 ENTREZGENE
UniProt Secondary Q3UPZ3 UniProtKB/Swiss-Prot
  Q5U3K8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-26 Irx3  Iroquois related homeobox 3    Iroquois related homeobox 3 (Drosophila)  Symbol and/or name change 5135510 APPROVED