CDH5 (cadherin 5) - Rat Genome Database
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Gene: CDH5 (cadherin 5) Homo sapiens
Analyze
Symbol: CDH5
Name: cadherin 5
RGD ID: 1316530
HGNC Page HGNC
Description: Exhibits several functions, including beta-catenin binding activity; enzyme binding activity; and signaling receptor binding activity. Involved in several processes, including cell-cell junction organization; regulation of protein modification process; and regulation of protein-containing complex assembly. Localizes to several cellular components, including adherens junction; cell surface; and nucleus. Biomarker of coronary artery disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 7B4; 7B4 antigen; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); cadherin-5; CD144; cd144 antigen; endothelial-specific cadherin; FLJ17376; vascular endothelial cadherin; VE-cadherin
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1666,366,622 - 66,404,784 (+)EnsemblGRCh38hg38GRCh38
GRCh381666,366,657 - 66,404,784 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371666,400,594 - 66,438,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361664,958,064 - 64,996,190 (+)NCBINCBI36hg18NCBI36
Build 341664,958,063 - 64,996,189NCBI
Celera1650,909,482 - 50,944,587 (+)NCBI
Cytogenetic Map16q21NCBI
HuRef1652,277,104 - 52,314,656 (+)NCBIHuRef
CHM1_11667,807,773 - 67,845,939 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (EXP,ISO)
acetamide  (ISO)
acetic acid  (ISO)
aflatoxin B1  (EXP)
aflatoxin B2  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
aripiprazole  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP,ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cobalt dichloride  (EXP)
columbamine  (EXP)
cortisol  (EXP)
cumene  (ISO)
D-glucose  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
digitonin  (EXP)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
ethanol  (EXP)
flutamide  (ISO)
folic acid  (ISO)
furan  (ISO)
furosemide  (ISO)
glucose  (EXP)
hydrogen peroxide  (EXP)
isotretinoin  (EXP)
jaspamide  (EXP)
lipopolysaccharide  (EXP)
luteolin  (ISO)
lycorine  (EXP)
mercury dichloride  (EXP)
methamphetamine  (ISO)
methyllycaconitine  (EXP)
monocrotaline  (ISO)
oroxylin A  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (ISO)
PCB138  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
procaine  (EXP)
progesterone  (EXP)
resveratrol  (EXP,ISO)
SB 203580  (EXP)
SB 431542  (EXP)
simvastatin  (ISO)
sodium arsenite  (EXP)
sulforaphane  (EXP)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topotecan  (ISO)
triclosan  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
valproic acid  (EXP,ISO)
varenicline  (EXP)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adherens junction organization  (IBA,IDA,TAS)
bicellular tight junction assembly  (IMP)
blood vessel endothelial cell migration  (IMP)
blood vessel maturation  (IEA,ISO)
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  (IBA)
cell morphogenesis  (IBA)
cell-cell adhesion  (IDA,IEA,ISO)
cell-cell adhesion mediated by cadherin  (IDA)
cell-cell adhesion via plasma-membrane adhesion molecules  (IBA)
cell-cell junction assembly  (IBA,IMP)
cellular calcium ion homeostasis  (IDA)
homophilic cell adhesion via plasma membrane adhesion molecules  (IEA)
maintenance of blood-brain barrier  (NAS)
multicellular organism development  (IBA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of endothelial cell apoptotic process  (IMP)
negative regulation of inflammatory response  (IGI)
negative regulation of microtubule polymerization  (IDA)
positive regulation of angiogenesis  (IGI)
positive regulation of BMP signaling pathway  (IMP)
positive regulation of cell migration  (IDA)
positive regulation of establishment of endothelial barrier  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of protein dephosphorylation  (IMP)
positive regulation of protein-containing complex assembly  (IMP)
protein localization to bicellular tight junction  (IMP)
regulation of complement-dependent cytotoxicity  (ISO)
regulation of establishment of cell polarity  (IBA,IMP,ISO)
regulation of protein phosphorylation  (IDA)
regulation of vascular permeability  (IDA)
transforming growth factor beta receptor signaling pathway  (IDA)
vasculature development  (IBA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1522121   PMID:2059658   PMID:7627717   PMID:7806582   PMID:9219219   PMID:9378757   PMID:9434630   PMID:9615235   PMID:9739078   PMID:10063232   PMID:10428027   PMID:10681592  
PMID:10861224   PMID:11490021   PMID:11777950   PMID:11855855   PMID:11900554   PMID:11937138   PMID:11950700   PMID:11950930   PMID:12003790   PMID:12010652   PMID:12088286   PMID:12095140  
PMID:12130501   PMID:12219009   PMID:12234928   PMID:12243749   PMID:12393634   PMID:12413882   PMID:12426320   PMID:12477932   PMID:12584200   PMID:12584244   PMID:12595527   PMID:12626512  
PMID:12658549   PMID:12740216   PMID:14678493   PMID:14699141   PMID:15220112   PMID:15374707   PMID:15572031   PMID:15601837   PMID:15723073   PMID:15731052   PMID:15735710   PMID:15861137  
PMID:15897346   PMID:15980433   PMID:15985432   PMID:16027153   PMID:16115630   PMID:16322481   PMID:16335952   PMID:16481735   PMID:16893970   PMID:16909109   PMID:17057644   PMID:17060906  
PMID:17159998   PMID:17194459   PMID:17638851   PMID:17761936   PMID:18163230   PMID:18180305   PMID:18195090   PMID:18272754   PMID:18287330   PMID:18316602   PMID:18337748   PMID:18402976  
PMID:18420943   PMID:18628953   PMID:18639387   PMID:18641366   PMID:18662404   PMID:18804209   PMID:18979298   PMID:18990449   PMID:19059243   PMID:19212436   PMID:19345098   PMID:19356953  
PMID:19413351   PMID:19420236   PMID:19490893   PMID:19633358   PMID:19735546   PMID:19760520   PMID:19913121   PMID:19915944   PMID:19996314   PMID:20010843   PMID:20032304   PMID:20048167  
PMID:20123964   PMID:20123970   PMID:20167365   PMID:20224040   PMID:20332120   PMID:20386594   PMID:20446815   PMID:20463083   PMID:20470859   PMID:20589320   PMID:20628086   PMID:20693433  
PMID:20711993   PMID:20732872   PMID:20810734   PMID:20926024   PMID:21168935   PMID:21183689   PMID:21190742   PMID:21190990   PMID:21269615   PMID:21439626   PMID:21873635   PMID:22040113  
PMID:22064597   PMID:22133903   PMID:22213015   PMID:22391038   PMID:22391569   PMID:22398721   PMID:22519731   PMID:22562824   PMID:22623531   PMID:22648953   PMID:22720111   PMID:22720799  
PMID:22734943   PMID:22833667   PMID:22865455   PMID:22922959   PMID:22975327   PMID:23074279   PMID:23079531   PMID:23118492   PMID:23159740   PMID:23168683   PMID:23216791   PMID:23243000  
PMID:23288152   PMID:23325790   PMID:23376478   PMID:23465821   PMID:23474739   PMID:23554480   PMID:23635392   PMID:23645533   PMID:23868598   PMID:23887639   PMID:23918034   PMID:24044891  
PMID:24046447   PMID:24061286   PMID:24106276   PMID:24136461   PMID:24227887   PMID:24430214   PMID:24439748   PMID:24469639   PMID:24487320   PMID:24498454   PMID:24603875   PMID:24621569  
PMID:24658140   PMID:24667918   PMID:24820735   PMID:24877096   PMID:24965120   PMID:24965294   PMID:25147336   PMID:25180771   PMID:25275457   PMID:25361430   PMID:25362142   PMID:25402006  
PMID:25422846   PMID:25443888   PMID:25501813   PMID:25542764   PMID:25548487   PMID:25559184   PMID:25633318   PMID:25657827   PMID:25663699   PMID:25746323   PMID:25753039   PMID:25800053  
PMID:25869066   PMID:25893857   PMID:25978380   PMID:26116572   PMID:26574545   PMID:26598555   PMID:26658094   PMID:26663395   PMID:26681130   PMID:26728385   PMID:26905650   PMID:26921435  
PMID:26923917   PMID:26959535   PMID:26980408   PMID:27224670   PMID:27338534   PMID:27362942   PMID:27417273   PMID:27466381   PMID:27693459   PMID:27842057   PMID:27966446   PMID:28056463  
PMID:28112401   PMID:28119542   PMID:28158602   PMID:28347704   PMID:28396577   PMID:28428220   PMID:28485540   PMID:28514442   PMID:28583263   PMID:28599281   PMID:28600292   PMID:28624707  
PMID:28701303   PMID:28712573   PMID:28755278   PMID:28774343   PMID:28842382   PMID:28926625   PMID:29054861   PMID:29143117   PMID:29187459   PMID:29462613   PMID:29504106   PMID:29605606  
PMID:29786069   PMID:30097810   PMID:30280653   PMID:30301260   PMID:30355397   PMID:30368528   PMID:30503342   PMID:30638949   PMID:31342095   PMID:31346222   PMID:31396656   PMID:31566580  
PMID:31934175   PMID:32298238   PMID:32327488  


Genomics

Comparative Map Data
CDH5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1666,366,622 - 66,404,784 (+)EnsemblGRCh38hg38GRCh38
GRCh381666,366,657 - 66,404,784 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371666,400,594 - 66,438,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361664,958,064 - 64,996,190 (+)NCBINCBI36hg18NCBI36
Build 341664,958,063 - 64,996,189NCBI
Celera1650,909,482 - 50,944,587 (+)NCBI
Cytogenetic Map16q21NCBI
HuRef1652,277,104 - 52,314,656 (+)NCBIHuRef
CHM1_11667,807,773 - 67,845,939 (+)NCBICHM1_1
Cdh5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398104,828,247 - 104,871,136 (+)NCBIGRCm39mm39
GRCm39 Ensembl8104,828,257 - 104,871,143 (+)Ensembl
GRCm388104,101,613 - 104,144,504 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8104,101,625 - 104,144,511 (+)EnsemblGRCm38mm10GRCm38
MGSCv378106,625,525 - 106,668,402 (+)NCBIGRCm37mm9NCBIm37
MGSCv368106,990,828 - 107,033,630 (+)NCBImm8
Celera8108,332,486 - 108,375,834 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
Cdh5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.219815,415 - 854,478 (-)NCBI
Rnor_6.0 Ensembl191,023,683 - 1,074,365 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0191,025,122 - 1,074,333 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0191,022,710 - 1,072,784 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.419779,350 - 816,108 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.119779,507 - 1,129,968 (-)NCBI
Celera19805,477 - 843,688 (-)NCBICelera
Cytogenetic Map19p14NCBI
Cdh5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543322,967,960 - 22,992,924 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543322,957,718 - 22,994,515 (+)NCBIChiLan1.0ChiLan1.0
CDH5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11665,787,426 - 65,825,360 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1665,787,370 - 65,825,360 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01646,684,545 - 46,722,740 (+)NCBIMhudiblu_PPA_v0panPan3
CDH5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl582,830,939 - 82,863,882 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1582,830,505 - 82,863,931 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cdh5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647516,738,772 - 16,775,000 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDH5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl627,108,609 - 27,142,180 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1627,108,560 - 27,142,145 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CDH5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1552,059,987 - 52,098,595 (+)NCBI
ChlSab1.1 Ensembl552,060,013 - 52,100,405 (+)Ensembl
Cdh5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474620,028,952 - 20,068,029 (-)NCBI

Position Markers
CDH5_1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371666,436,953 - 66,437,668UniSTSGRCh37
Build 361664,994,454 - 64,995,169RGDNCBI36
Celera1650,942,851 - 50,943,566RGD
HuRef1652,312,920 - 52,313,635UniSTS
SHGC-60813  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371666,437,214 - 66,437,496UniSTSGRCh37
Build 361664,994,715 - 64,994,997RGDNCBI36
Celera1650,943,112 - 50,943,394RGD
Cytogenetic Map16q22.1UniSTS
HuRef1652,313,181 - 52,313,463UniSTS
GeneMap99-GB4 RH Map16401.5UniSTS
Whitehead-RH Map16294.7UniSTS
NCBI RH Map16508.6UniSTS
D16S3319  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371666,438,482 - 66,438,630UniSTSGRCh37
Build 361664,995,983 - 64,996,131RGDNCBI36
Celera1650,944,380 - 50,944,528RGD
Cytogenetic Map16q22.1UniSTS
HuRef1652,314,449 - 52,314,597UniSTS
TNG Radiation Hybrid Map1628594.0UniSTS
Stanford-G3 RH Map162468.0UniSTS
GeneMap99-G3 RH Map162912.0UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR211hsa-miR-211-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22235338

Predicted Target Of
Summary Value
Count of predictions:2656
Count of miRNA genes:1120
Interacting mature miRNAs:1376
Transcripts:ENST00000341529, ENST00000539168, ENST00000562048, ENST00000563425, ENST00000565334, ENST00000568023, ENST00000568155
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1815 1825 1114 232 420 137 3367 1920 1146 246 986 1355 96 1204 2318 5
Low 509 458 580 372 188 306 771 236 2511 135 410 85 73 1 470 1 1
Below cutoff 24 694 11 9 730 11 125 15 32 7 38 61 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011522801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB035304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB209908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC117520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ716387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC381809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC382718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U84722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X79981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000341529   ⟹   ENSP00000344115
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1666,366,691 - 66,404,784 (+)Ensembl
RefSeq Acc Id: ENST00000539168   ⟹   ENSP00000461880
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1666,395,455 - 66,403,335 (+)Ensembl
RefSeq Acc Id: ENST00000562048   ⟹   ENSP00000455302
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1666,376,341 - 66,386,992 (+)Ensembl
RefSeq Acc Id: ENST00000563425   ⟹   ENSP00000458878
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1666,379,225 - 66,392,985 (+)Ensembl
RefSeq Acc Id: ENST00000565334   ⟹   ENSP00000456028
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1666,366,690 - 66,403,408 (+)Ensembl
RefSeq Acc Id: ENST00000568023   ⟹   ENSP00000455655
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1666,377,209 - 66,379,389 (+)Ensembl
RefSeq Acc Id: ENST00000568155   ⟹   ENSP00000456093
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1666,376,390 - 66,386,827 (+)Ensembl
RefSeq Acc Id: ENST00000614547   ⟹   ENSP00000479381
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1666,366,622 - 66,404,782 (+)Ensembl
RefSeq Acc Id: ENST00000649567   ⟹   ENSP00000497290
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1666,366,715 - 66,404,767 (+)Ensembl
RefSeq Acc Id: NM_001795   ⟹   NP_001786
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381666,366,691 - 66,404,784 (+)NCBI
GRCh371666,400,525 - 66,438,689 (+)ENTREZGENE
Build 361664,958,064 - 64,996,190 (+)NCBI Archive
HuRef1652,277,104 - 52,314,656 (+)ENTREZGENE
CHM1_11667,807,773 - 67,845,939 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011522801   ⟹   XP_011521103
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381666,366,657 - 66,404,784 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024450133   ⟹   XP_024305901
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381666,379,317 - 66,404,784 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001786   ⟸   NM_001795
- Peptide Label: preproprotein
- UniProtKB: P33151 (UniProtKB/Swiss-Prot),   Q59EA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011521103   ⟸   XM_011522801
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024305901   ⟸   XM_024450133
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000497290   ⟸   ENST00000649567
RefSeq Acc Id: ENSP00000479381   ⟸   ENST00000614547
RefSeq Acc Id: ENSP00000455302   ⟸   ENST00000562048
RefSeq Acc Id: ENSP00000458878   ⟸   ENST00000563425
RefSeq Acc Id: ENSP00000461880   ⟸   ENST00000539168
RefSeq Acc Id: ENSP00000456028   ⟸   ENST00000565334
RefSeq Acc Id: ENSP00000344115   ⟸   ENST00000341529
RefSeq Acc Id: ENSP00000455655   ⟸   ENST00000568023
RefSeq Acc Id: ENSP00000456093   ⟸   ENST00000568155
Protein Domains
CA   Cadherin   Cadherin_C

Promoters
RGD ID:7232415
Promoter ID:EPDNEW_H21953
Type:initiation region
Name:CDH5_1
Description:cadherin 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381666,366,691 - 66,366,751EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16q13-22.2(chr16:56883592-71279975)x3 copy number gain See cases [RCV000052405] Chr16:56883592..71279975 [GRCh38]
Chr16:56917504..71313878 [GRCh37]
Chr16:55475005..69871379 [NCBI36]
Chr16:16q13-22.2
pathogenic
GRCh38/hg38 16q21-23.1(chr16:58456122-74708723)x3 copy number gain See cases [RCV000052408] Chr16:58456122..74708723 [GRCh38]
Chr16:58490026..74742621 [GRCh37]
Chr16:57047527..73300122 [NCBI36]
Chr16:16q21-23.1
pathogenic
GRCh38/hg38 16q21-24.3(chr16:65313395-90081985)x3 copy number gain See cases [RCV000052421] Chr16:65313395..90081985 [GRCh38]
Chr16:65347298..90148393 [GRCh37]
Chr16:63904799..88675894 [NCBI36]
Chr16:16q21-24.3
pathogenic
GRCh38/hg38 16q21-22.1(chr16:62179331-67770414)x1 copy number loss See cases [RCV000053333] Chr16:62179331..67770414 [GRCh38]
Chr16:62213235..67804317 [GRCh37]
Chr16:60770736..66361818 [NCBI36]
Chr16:16q21-22.1
pathogenic
GRCh38/hg38 16q21-22.1(chr16:63318997-70555249)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053334]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053334]|See cases [RCV000053334] Chr16:63318997..70555249 [GRCh38]
Chr16:63352901..70589152 [GRCh37]
Chr16:61910402..69146653 [NCBI36]
Chr16:16q21-22.1
pathogenic
GRCh38/hg38 16q21-22.1(chr16:64311275-68062011)x1 copy number loss See cases [RCV000053335] Chr16:64311275..68062011 [GRCh38]
Chr16:64345179..68095914 [GRCh37]
Chr16:62902680..66653415 [NCBI36]
Chr16:16q21-22.1
pathogenic
NM_001795.3(CDH5):c.1582G>A (p.Asp528Asn) single nucleotide variant Malignant melanoma [RCV000063074] Chr16:66398552 [GRCh38]
Chr16:66432455 [GRCh37]
Chr16:64989956 [NCBI36]
Chr16:16q21
not provided
GRCh38/hg38 16q21-22.1(chr16:66245888-67473023)x1 copy number loss See cases [RCV000134709] Chr16:66245888..67473023 [GRCh38]
Chr16:66279791..67506926 [GRCh37]
Chr16:64837292..66064427 [NCBI36]
Chr16:16q21-22.1
pathogenic
GRCh38/hg38 16q21-24.1(chr16:62925929-84585795)x3 copy number gain See cases [RCV000135863] Chr16:62925929..84585795 [GRCh38]
Chr16:62959833..84619401 [GRCh37]
Chr16:61517334..83176902 [NCBI36]
Chr16:16q21-24.1
pathogenic
GRCh38/hg38 16q21-24.3(chr16:65511483-90096995)x3 copy number gain See cases [RCV000139426] Chr16:65511483..90096995 [GRCh38]
Chr16:65545386..90163403 [GRCh37]
Chr16:64102887..88690904 [NCBI36]
Chr16:16q21-24.3
pathogenic
GRCh38/hg38 16q21(chr16:66398501-66430566)x3 copy number gain See cases [RCV000140610] Chr16:66398501..66430566 [GRCh38]
Chr16:66432404..66464469 [GRCh37]
Chr16:64989905..65021970 [NCBI36]
Chr16:16q21
likely benign
GRCh38/hg38 16q21-24.3(chr16:64389378-90081985)x3 copy number gain See cases [RCV000142578] Chr16:64389378..90081985 [GRCh38]
Chr16:64423281..90148393 [GRCh37]
Chr16:62980782..88675894 [NCBI36]
Chr16:16q21-24.3
pathogenic|likely pathogenic
GRCh38/hg38 16q12.2-24.3(chr16:52899183-90088654)x3 copy number gain See cases [RCV000143425] Chr16:52899183..90088654 [GRCh38]
Chr16:52933095..90155062 [GRCh37]
Chr16:51490596..88682563 [NCBI36]
Chr16:16q12.2-24.3
pathogenic
GRCh38/hg38 16q12.1-22.1(chr16:49685521-68401712)x3 copy number gain See cases [RCV000143752] Chr16:49685521..68401712 [GRCh38]
Chr16:49719432..68435615 [GRCh37]
Chr16:48276933..66993116 [NCBI36]
Chr16:16q12.1-22.1
pathogenic
GRCh38/hg38 16q21-23.3(chr16:65957829-83611443)x3 copy number gain See cases [RCV000143742] Chr16:65957829..83611443 [GRCh38]
Chr16:65991732..83645048 [GRCh37]
Chr16:64549233..82202549 [NCBI36]
Chr16:16q21-23.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Ductal breast carcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3
uncertain significance
GRCh37/hg19 16q12.2-22.2(chr16:55359026-70884455)x1 copy number loss Ductal breast carcinoma [RCV000207067] Chr16:55359026..70884455 [GRCh37]
Chr16:16q12.2-22.2
likely pathogenic|uncertain significance
Single allele complex Ductal breast carcinoma [RCV000207314] Chr16:56368689..90141355 [GRCh37]
Chr16:16q12.2-24.3
uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3
uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46455960-90354753)x1 copy number loss PARP Inhibitor response [RCV000626435] Chr16:46455960..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q13-24.3(chr16:57051473-89797669)x3 copy number gain See cases [RCV000512511] Chr16:57051473..89797669 [GRCh37]
Chr16:16q13-24.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46497599-90354753)x1 copy number loss PARP Inhibitor response [RCV000626429] Chr16:46497599..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16q12.2-22.2(chr16:54416050-72453266)x3 copy number gain not provided [RCV000683820] Chr16:54416050..72453266 [GRCh37]
Chr16:16q12.2-22.2
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q21-22.1(chr16:65669673-70180183)x1 copy number loss not provided [RCV001006797] Chr16:65669673..70180183 [GRCh37]
Chr16:16q21-22.1
pathogenic
NM_001795.5(CDH5):c.867G>C (p.Gln289His) single nucleotide variant not provided [RCV000919584] Chr16:66390488 [GRCh38]
Chr16:66424391 [GRCh37]
Chr16:16q21
likely benign
NM_001795.5(CDH5):c.265G>A (p.Val89Met) single nucleotide variant Marfanoid habitus and intellectual disability [RCV000850465] Chr16:66386863 [GRCh38]
Chr16:66420766 [GRCh37]
Chr16:16q21
uncertain significance
GRCh37/hg19 16q21-22.1(chr16:64981506-66806661)x3 copy number gain not provided [RCV000996430] Chr16:64981506..66806661 [GRCh37]
Chr16:16q21-22.1
uncertain significance
NM_001795.5(CDH5):c.798C>T (p.Val266=) single nucleotide variant not provided [RCV000966010] Chr16:66390419 [GRCh38]
Chr16:66424322 [GRCh37]
Chr16:16q21
benign
GRCh37/hg19 16q21-24.3(chr16:61524229-90155062)x3 copy number gain not provided [RCV001249359] Chr16:61524229..90155062 [GRCh37]
Chr16:16q21-24.3
not provided

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1764 AgrOrtholog
COSMIC CDH5 COSMIC
Ensembl Genes ENSG00000179776 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000344115 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000455302 UniProtKB/TrEMBL
  ENSP00000455655 UniProtKB/TrEMBL
  ENSP00000456028 UniProtKB/TrEMBL
  ENSP00000456093 UniProtKB/TrEMBL
  ENSP00000458878 UniProtKB/TrEMBL
  ENSP00000461880 UniProtKB/TrEMBL
  ENSP00000479381 UniProtKB/Swiss-Prot
  ENSP00000497290 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000341529 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000539168 UniProtKB/TrEMBL
  ENST00000562048 UniProtKB/TrEMBL
  ENST00000563425 UniProtKB/TrEMBL
  ENST00000565334 UniProtKB/TrEMBL
  ENST00000568023 UniProtKB/TrEMBL
  ENST00000568155 UniProtKB/TrEMBL
  ENST00000614547 UniProtKB/Swiss-Prot
  ENST00000649567 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000179776 GTEx
HGNC ID HGNC:1764 ENTREZGENE
Human Proteome Map CDH5 Human Proteome Map
InterPro Cadherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_cytoplasmic-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Catenin_binding_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CDH5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1003 ENTREZGENE
OMIM 601120 OMIM
PANTHER PTHR24027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24027:SF89 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26301 PharmGKB
PRINTS CADHERIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49313 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B4DTR2_HUMAN UniProtKB/TrEMBL
  CADH5_HUMAN UniProtKB/Swiss-Prot
  H3BPG1_HUMAN UniProtKB/TrEMBL
  H3BQ82_HUMAN UniProtKB/TrEMBL
  H3BR11_HUMAN UniProtKB/TrEMBL
  H3BR64_HUMAN UniProtKB/TrEMBL
  I3L1J2_HUMAN UniProtKB/TrEMBL
  P33151 ENTREZGENE
  Q4VAI4_HUMAN UniProtKB/TrEMBL
  Q59EA3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q4VAI5 UniProtKB/Swiss-Prot
  Q4VAI6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 CDH5  cadherin 5    cadherin 5, type 2 (vascular endothelium)  Symbol and/or name change 5135510 APPROVED
2011-08-16 CDH5  cadherin 5, type 2 (vascular endothelium)  CDH5  cadherin 5, type 2 (vascular endothelium)  Symbol and/or name change 5135510 APPROVED