Tent4a (terminal nucleotidyltransferase 4A) - Rat Genome Database

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Gene: Tent4a (terminal nucleotidyltransferase 4A) Mus musculus
Analyze
Symbol: Tent4a
Name: terminal nucleotidyltransferase 4A
RGD ID: 1316508
MGI Page MGI
Description: Predicted to enable guanylyltransferase activity. Predicted to be involved in RNA 3' uridylation; regulation of mRNA stability; and response to xenobiotic stimulus. Predicted to act upstream of or within mRNA processing. Predicted to be located in Golgi apparatus; nuclear membrane; and nucleoplasm. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human TENT4A (terminal nucleotidyltransferase 4A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA polymerase sigma; LAK; LAK-1; MGC69673; non-canonical poly(A) RNA polymerase PAPD7; Pa; PAP associated domain containing 7; PAP-associated domain-containing protein 7; Papd7; POLK; Pols; polymerase (DNA directed) sigma; terminal guanylyltransferase; TRAMP-like complex polyadenylate polymerase; TRF; TRF4; TRF4-; TRF4-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391369,646,071 - 69,682,710 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1369,646,078 - 69,682,736 (-)EnsemblGRCm39 Ensembl
GRCm381369,497,952 - 69,534,236 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1369,497,959 - 69,534,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv371369,636,837 - 69,672,742 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361369,965,331 - 70,001,211 (-)NCBIMGSCv36mm8
Celera1371,843,268 - 71,879,187 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1335.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15329828   PMID:15489334   PMID:16141072  
PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24194600   PMID:31138677  


Genomics

Comparative Map Data
Tent4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391369,646,071 - 69,682,710 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1369,646,078 - 69,682,736 (-)EnsemblGRCm39 Ensembl
GRCm381369,497,952 - 69,534,236 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1369,497,959 - 69,534,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv371369,636,837 - 69,672,742 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361369,965,331 - 70,001,211 (-)NCBIMGSCv36mm8
Celera1371,843,268 - 71,879,187 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1335.55NCBI
TENT4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3856,713,432 - 6,757,044 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl56,713,432 - 6,757,044 (+)EnsemblGRCh38hg38GRCh38
GRCh3756,713,545 - 6,757,157 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3656,767,718 - 6,810,161 (+)NCBINCBI36Build 36hg18NCBI36
Build 3456,790,619 - 6,810,156NCBI
Celera56,740,937 - 6,785,032 (+)NCBICelera
Cytogenetic Map5p15.31NCBI
HuRef56,688,625 - 6,731,065 (+)NCBIHuRef
CHM1_156,714,585 - 6,757,027 (+)NCBICHM1_1
T2T-CHM13v2.056,644,097 - 6,687,689 (+)NCBIT2T-CHM13v2.0
Tent4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8135,594,380 - 35,627,836 (+)NCBIGRCr8
mRatBN7.2133,765,949 - 33,799,405 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl133,765,672 - 33,799,433 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx133,595,938 - 33,629,277 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0139,594,539 - 39,627,878 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0133,794,205 - 33,827,542 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0136,400,056 - 36,433,238 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl136,400,443 - 36,433,238 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0137,797,077 - 37,830,260 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4173,926,190 - 3,958,985 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1173,898,985 - 3,958,940 (+)NCBI
Celera132,370,578 - 32,403,374 (+)NCBICelera
Cytogenetic Map1p11NCBI
Tent4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555044,443,051 - 4,476,520 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555044,443,051 - 4,476,373 (+)NCBIChiLan1.0ChiLan1.0
TENT4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v246,958,694 - 7,004,254 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan155,112,289 - 5,157,862 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v057,032,809 - 7,077,080 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.156,709,590 - 6,752,159 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl56,724,029 - 6,752,159 (+)Ensemblpanpan1.1panPan2
TENT4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1347,021,743 - 7,063,049 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl347,020,187 - 7,063,129 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3411,528,929 - 11,572,562 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0346,928,417 - 6,972,045 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl346,928,400 - 6,972,045 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1346,975,637 - 7,019,254 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0346,956,407 - 7,000,038 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0347,171,096 - 7,214,777 (-)NCBIUU_Cfam_GSD_1.0
Tent4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213240,075,921 - 240,115,682 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936634667,138 - 706,907 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936634667,170 - 706,901 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TENT4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1675,217,219 - 75,258,556 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11675,217,212 - 75,259,805 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21681,582,545 - 81,598,984 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TENT4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.146,400,248 - 6,442,582 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl46,399,886 - 6,443,002 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606422,276,214 - 22,319,135 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tent4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247514,386,857 - 4,416,719 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247514,387,075 - 4,418,516 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tent4a
1813 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:696
Count of miRNA genes:425
Interacting mature miRNAs:494
Transcripts:ENSMUST00000044081
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4521044283744746Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134521044283744746Mouse
26884396Humsd4_mhumerus midshaft diameter 4, 10 week (mouse)134785347673148119Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5031841184318559Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135031841184318559Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135061682884617027Mouse
14746975Manh74_mmandible shape 74 (mouse)135247726986477269Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135382078387820897Mouse
1357563Bmch6_mbone mechanical trait 6 (mouse)Not determined135538498089385140Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
1558850Sgp3_mserum gp70 production 3 (mouse)Not determined135647045676971314Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135662924996239162Mouse
10412163Wra1_mwheel running activity 1 (mouse)Not determined135913260093132738Mouse
1300941Skl6_mskeletal size (tail length) 6 (mouse)Not determined136425082198250945Mouse
1301949Skull20_mskull morphology 20 (mouse)Not determined136425082198250945Mouse
1301445Listr2_mlisteriosis resistance 2 (mouse)Not determined1366744601100744746Mouse
1301593Heal8_mwound healing/regeneration 8 (mouse)Not determined1368053999102054119Mouse
14696726Kidrq3_mkidney weight, right QTL 3 (mouse)1368217066102217066Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000044081   ⟹   ENSMUSP00000040757
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1369,646,081 - 69,681,983 (-)Ensembl
GRCm38.p6 Ensembl1369,497,962 - 69,533,864 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198607   ⟹   ENSMUSP00000142516
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1369,646,078 - 69,682,736 (-)Ensembl
GRCm38.p6 Ensembl1369,497,959 - 69,534,617 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222497
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1369,677,439 - 69,682,305 (-)Ensembl
GRCm38.p6 Ensembl1369,529,320 - 69,534,186 (-)Ensembl
RefSeq Acc Id: ENSMUST00000223344   ⟹   ENSMUSP00000152244
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1369,647,677 - 69,680,551 (-)Ensembl
GRCm38.p6 Ensembl1369,499,558 - 69,532,432 (-)Ensembl
RefSeq Acc Id: NM_001169131   ⟹   NP_001162602
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391369,646,080 - 69,682,571 (-)NCBI
GRCm381369,497,959 - 69,533,864 (-)NCBI
MGSCv371369,636,837 - 69,672,742 (-)RGD
Celera1371,843,268 - 71,879,187 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_198600   ⟹   NP_941002
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391369,646,080 - 69,682,571 (-)NCBI
GRCm381369,497,959 - 69,533,864 (-)NCBI
MGSCv371369,636,837 - 69,672,742 (-)RGD
Celera1371,843,268 - 71,879,187 (-)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006517187   ⟹   XP_006517250
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391369,646,071 - 69,682,710 (-)NCBI
GRCm381369,497,952 - 69,534,236 (-)NCBI
Sequence:
RefSeq Acc Id: NP_941002   ⟸   NM_198600
- Peptide Label: isoform 1
- UniProtKB: A0A0G2JDV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001162602   ⟸   NM_001169131
- Peptide Label: isoform 2
- Sequence:
RefSeq Acc Id: XP_006517250   ⟸   XM_006517187
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000142516   ⟸   ENSMUST00000198607
RefSeq Acc Id: ENSMUSP00000152244   ⟸   ENSMUST00000223344
RefSeq Acc Id: ENSMUSP00000040757   ⟸   ENSMUST00000044081
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6PB75-F1-model_v2 AlphaFold Q6PB75 1-542 view protein structure

Promoters
RGD ID:8680766
Promoter ID:EPDNEW_M18411
Type:multiple initiation site
Name:Papd7_2
Description:Mus musculus PAP associated domain containing 7 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18412  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381369,525,204 - 69,525,264EPDNEW
RGD ID:8680762
Promoter ID:EPDNEW_M18412
Type:single initiation site
Name:Papd7_1
Description:Mus musculus PAP associated domain containing 7 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18411  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381369,533,780 - 69,533,840EPDNEW
RGD ID:6824269
Promoter ID:MM_KWN:14613
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:NM_001169131,   OTTMUST00000081019
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361369,673,036 - 69,673,536 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2682295 AgrOrtholog
Ensembl Genes ENSMUSG00000034575 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000198607 ENTREZGENE
  ENSMUST00000198607.5 UniProtKB/TrEMBL
  ENSMUST00000223344.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1410.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.460.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NT_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAP_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Polymerase_NTP_transf_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trf4-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:210106 UniProtKB/Swiss-Prot
MGD MGI:2682295 ENTREZGENE
NCBI Gene 210106 ENTREZGENE
PANTHER PTHR23092 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23092:SF24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NTP_transf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAP_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tent4a PhenoGen
Superfamily-SCOP PAP/OAS1 substrate-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81301 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JDV2 ENTREZGENE, UniProtKB/TrEMBL
  PAPD7_MOUSE UniProtKB/Swiss-Prot
  Q3U7R5_MOUSE UniProtKB/TrEMBL
  Q6PB75 ENTREZGENE
UniProt Secondary G3X948 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-06-05 Tent4a  terminal nucleotidyltransferase 4A  Papd7  PAP associated domain containing 7  Symbol and/or name change 5135510 APPROVED