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Gene: RNASEH2A (ribonuclease H2 subunit A) Homo sapiens
Symbol: RNASEH2A
Name: ribonuclease H2 subunit A
Description: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AGS4; aicardi-Goutieres syndrome 4 protein; JUNB; ribonuclease H2, large subunit; ribonuclease H2, subunit A; ribonuclease HI large subunit; ribonuclease HI subunit A; ribonuclease HI, large subunit; RNase H(35); RNase H2 subunit A; RNase HI large subunit; RNASEHI; RNHIA; RNHL; THSD8
Mus musculus (house mouse) : Rnaseh2a (ribonuclease H2, large subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rnaseh2a (ribonuclease H2, subunit A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rnaseh2a (ribonuclease H2 subunit A)
Pan paniscus (bonobo/pygmy chimpanzee) : RNASEH2A (ribonuclease H2 subunit A)
Canis lupus familiaris (dog) : RNASEH2A (ribonuclease H2 subunit A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rnaseh2a (ribonuclease H2 subunit A)
Sus scrofa (pig) : RNASEH2A (ribonuclease H2 subunit A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381912,802,054 - 12,813,648 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,912,863 - 12,924,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,778,428 - 12,785,462 (+)NCBINCBI36hg18NCBI36
Build 341912,778,427 - 12,785,462NCBI
Celera1912,807,135 - 12,814,169 (+)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,489,074 - 12,496,108 (+)NCBIHuRef
CHM1_11912,917,906 - 12,924,940 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RNASEH2A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316328
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.