Spink8 (serine peptidase inhibitor, Kazal type 8) - Rat Genome Database
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Gene: Spink8 (serine peptidase inhibitor, Kazal type 8) Mus musculus
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Symbol: Spink8
Name: serine peptidase inhibitor, Kazal type 8
RGD ID: 1316173
MGI Page MGI
Description: Predicted to have serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to localize to extracellular region. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; hemolymphoid system; and liver. Orthologous to human SPINK8 (serine peptidase inhibitor Kazal type 8 (putative)); INTERACTS WITH 4-hydroxyphenyl retinamide; progesterone; valproic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C630041L24Rik; serine protease inhibitor Kazal type 8; serine protease inhibitor Kazal-type 8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399109,641,271 - 109,655,696 (+)NCBIGRCm39mm39
GRCm389109,812,203 - 109,826,628 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,812,280 - 109,826,633 (+)EnsemblGRCm38mm10GRCm38
MGSCv379109,719,141 - 109,729,142 (+)NCBIGRCm37mm9NCBIm37
MGSCv369109,674,051 - 109,684,029 (+)NCBImm8
Celera9109,536,212 - 109,546,212 (+)NCBICelera
Cytogenetic Map9F2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16930550   PMID:19164599   PMID:21267068  
PMID:21677750   PMID:27357688  


Genomics

Comparative Map Data
Spink8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399109,641,271 - 109,655,696 (+)NCBIGRCm39mm39
GRCm389109,812,203 - 109,826,628 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9109,812,280 - 109,826,633 (+)EnsemblGRCm38mm10GRCm38
MGSCv379109,719,141 - 109,729,142 (+)NCBIGRCm37mm9NCBIm37
MGSCv369109,674,051 - 109,684,029 (+)NCBImm8
Celera9109,536,212 - 109,546,212 (+)NCBICelera
Cytogenetic Map9F2NCBI
SPINK8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl348,306,842 - 48,328,341 (-)EnsemblGRCh38hg38GRCh38
GRCh38348,306,842 - 48,333,909 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37348,348,336 - 48,369,831 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,323,340 - 48,344,835 (-)NCBINCBI36hg18NCBI36
Celera348,298,735 - 48,320,292 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef348,402,368 - 48,423,818 (-)NCBIHuRef
CHM1_1348,300,661 - 48,322,136 (-)NCBICHM1_1
Spink8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08117,903,088 - 117,917,821 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,906,014 - 117,917,842 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08117,255,606 - 117,270,334 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48114,190,549 - 114,202,178 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18114,210,003 - 114,221,633 (+)NCBI
Celera8109,107,161 - 109,118,789 (+)NCBICelera
Cytogenetic Map8q32NCBI
Spink8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542024,283,223 - 24,298,948 (+)NCBIChiLan1.0ChiLan1.0
SPINK8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1349,304,505 - 49,327,605 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,304,505 - 49,327,704 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0348,219,663 - 48,249,064 (-)NCBIMhudiblu_PPA_v0panPan3
SPINK8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2040,737,264 - 40,753,712 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12040,737,192 - 40,753,887 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC100739218
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.12149,400,864 - 149,406,484 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22155,929,219 - 155,934,832 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPINK8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1229,702,931 - 9,734,555 (-)NCBI
ChlSab1.1 Ensembl229,703,065 - 9,726,287 (-)Ensembl
Spink8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473073,399,530 - 73,409,788 (+)NCBI

Position Markers
Spink8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F2UniSTS
cM Map9 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13515058Adip20d_madiposity 20d (mouse)9108915010118915010Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:541
Count of miRNA genes:321
Interacting mature miRNAs:344
Transcripts:ENSMUST00000055821, ENSMUST00000118732, ENSMUST00000154663
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000118732   ⟹   ENSMUSP00000112990
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9109,816,627 - 109,826,628 (+)Ensembl
RefSeq Acc Id: ENSMUST00000198988   ⟹   ENSMUSP00000142586
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9109,816,544 - 109,826,633 (+)Ensembl
RefSeq Acc Id: ENSMUST00000200555   ⟹   ENSMUSP00000142856
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9109,812,280 - 109,820,600 (+)Ensembl
RefSeq Acc Id: NM_183136   ⟹   NP_898959
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399109,645,695 - 109,655,696 (+)NCBI
GRCm389109,816,627 - 109,826,628 (+)NCBI
MGSCv379109,719,141 - 109,729,142 (+)RGD
Celera9109,536,212 - 109,546,212 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006512398   ⟹   XP_006512461
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399109,641,271 - 109,655,696 (+)NCBI
GRCm389109,812,203 - 109,826,612 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_898959   ⟸   NM_183136
- Peptide Label: precursor
- UniProtKB: Q09TK9 (UniProtKB/Swiss-Prot),   Q8C1F8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512461   ⟸   XM_006512398
- Peptide Label: isoform X1
- UniProtKB: Q09TK9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000142586   ⟸   ENSMUST00000198988
RefSeq Acc Id: ENSMUSP00000112990   ⟸   ENSMUST00000118732
RefSeq Acc Id: ENSMUSP00000142856   ⟸   ENSMUST00000200555
Protein Domains
Kazal-like

Promoters
RGD ID:8670966
Promoter ID:EPDNEW_M13514
Type:initiation region
Name:Spink8_1
Description:Mus musculus serine peptidase inhibitor, Kazal type 8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389109,816,662 - 109,816,722EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1925959 AgrOrtholog
Ensembl Genes ENSMUSG00000050074 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000112990 UniProtKB/TrEMBL
  ENSMUSP00000142586 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000142856 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000118732 UniProtKB/TrEMBL
  ENSMUST00000198988 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000200555 UniProtKB/TrEMBL
InterPro Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:78709 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1925959 ENTREZGENE
NCBI Gene 78709 ENTREZGENE
Pfam Kazal_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spink8 PhenoGen
PROSITE KAZAL_2 UniProtKB/Swiss-Prot
SMART KAZAL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.99613 ENTREZGENE
UniProt A0A0G2JEP9_MOUSE UniProtKB/TrEMBL
  ISK8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8C1F8 ENTREZGENE, UniProtKB/TrEMBL