Tmprss6 (transmembrane serine protease 6) - Rat Genome Database

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Gene: Tmprss6 (transmembrane serine protease 6) Mus musculus
Analyze
Symbol: Tmprss6
Name: transmembrane serine protease 6
RGD ID: 1316155
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase activity. Involved in intracellular iron ion homeostasis; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within multicellular organismal-level iron ion homeostasis and negative regulation of BMP signaling pathway. Located in plasma membrane. Is expressed in several structures, including cerebral cortex; gut; hemolymphoid system gland; sensory organ; and uterus. Human ortholog(s) of this gene implicated in microcytic anemia. Orthologous to human TMPRSS6 (transmembrane serine protease 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1300008A22Rik; matriptase 2; matriptase-2; transmembrane protease serine 6; transmembrane protease, serine 6; type II transmembrane serine protease 6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391578,323,867 - 78,352,848 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1578,323,867 - 78,352,834 (-)EnsemblGRCm39 Ensembl
GRCm381578,439,667 - 78,468,648 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1578,439,667 - 78,468,634 (-)EnsemblGRCm38mm10GRCm38
MGSCv371578,270,097 - 78,299,064 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361578,266,931 - 78,295,735 (-)NCBIMGSCv36mm8
Celera1579,902,371 - 79,931,350 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (ISO,ISS)
membrane  (ISS)
plasma membrane  (IBA,IDA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal circulating erythropoietin level  (IAGP)
abnormal coat appearance  (IEA)
abnormal coat/ hair morphology  (IEA)
abnormal coat/hair pigmentation  (IEA)
abnormal erythrocyte cell number  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal erythroid progenitor cell morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal hair follicle infundibulum morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hemoglobin content  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal intestinal mineral absorption  (IAGP)
abnormal iron homeostasis  (IAGP)
abnormal iron level  (IAGP)
abnormal liver iron level  (IAGP)
abnormal macrophage morphology  (IAGP)
abnormal ovary development  (IAGP)
abnormal skin morphology  (IEA)
abnormal spleen iron level  (IAGP)
abnormal spleen size  (IAGP)
alopecia  (IAGP)
anemia  (IAGP)
anisopoikilocytosis  (IAGP)
decreased body size  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IEA)
decreased circulating iron level  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased exploration in new environment  (IEA)
decreased heart iron level  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased liver iron level  (IAGP)
decreased locomotor activity  (IEA)
decreased mean corpuscular hemoglobin  (IAGP)
decreased mean corpuscular hemoglobin concentration  (IAGP)
decreased mean corpuscular volume  (IAGP)
decreased NK cell number  (IEA)
decreased pancreas iron level  (IAGP)
decreased prepulse inhibition  (IEA)
decreased spleen iron level  (IAGP)
extramedullary hematopoiesis  (IAGP)
female infertility  (IAGP)
focal hair loss  (IEA)
immune system phenotype  (IEA)
increased CD11b-high dendritic cell number  (IEA)
increased circulating calcium level  (IEA)
increased circulating erythropoietin level  (IAGP)
increased circulating unsaturated transferrin level  (IAGP)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased fasting circulating glucose level  (IEA)
increased heart weight  (IEA)
increased liver iron level  (IAGP)
increased Ly6C-positive mature NK cell number  (IEA)
increased red blood cell distribution width  (IAGP)
increased spleen weight  (IAGP)
maternal effect  (IAGP)
microcytic anemia  (IAGP)
microcytosis  (IAGP)
pallor  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
progressive hair loss  (IAGP)
reduced female fertility  (IEA)
reticulocytopenia  (IAGP)
reticulocytosis  (IAGP)
short tibia  (IEA)
sparse hair  (IAGP)
thin hair follicle outer root sheath  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12744720   PMID:12784999   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16428450  
PMID:16602821   PMID:17981570   PMID:18451267   PMID:18523150   PMID:18799693   PMID:19751239   PMID:20200349   PMID:20562862   PMID:20688966   PMID:20940420   PMID:21115976   PMID:21267068  
PMID:21355094   PMID:21612955   PMID:21628413   PMID:21677750   PMID:21873635   PMID:21907140   PMID:22244935   PMID:22490684   PMID:23223430   PMID:23300183   PMID:23524968   PMID:23590607  
PMID:23922777   PMID:24376517   PMID:24791141   PMID:24904115   PMID:25205713   PMID:25860887   PMID:26755707   PMID:26845567   PMID:28187515   PMID:28462381   PMID:28490634   PMID:28924039  
PMID:29073189   PMID:29441715   PMID:29636509   PMID:30819909   PMID:30888356   PMID:30958854   PMID:31439541   PMID:32325033   PMID:32384154   PMID:32556142   PMID:32857879   PMID:33800732  
PMID:34343368   PMID:34838540   PMID:37417950   PMID:38218852   PMID:38355793  


Genomics

Comparative Map Data
Tmprss6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391578,323,867 - 78,352,848 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1578,323,867 - 78,352,834 (-)EnsemblGRCm39 Ensembl
GRCm381578,439,667 - 78,468,648 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1578,439,667 - 78,468,634 (-)EnsemblGRCm38mm10GRCm38
MGSCv371578,270,097 - 78,299,064 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361578,266,931 - 78,295,735 (-)NCBIMGSCv36mm8
Celera1579,902,371 - 79,931,350 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.49NCBI
TMPRSS6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,065,436 - 37,110,536 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,065,436 - 37,109,713 (-)EnsemblGRCh38hg38GRCh38
GRCh372237,461,476 - 37,505,753 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,791,425 - 35,829,639 (-)NCBINCBI36Build 36hg18NCBI36
Build 342235,785,978 - 35,824,193NCBI
Celera2221,262,809 - 21,300,772 (-)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2220,426,706 - 20,464,791 (-)NCBIHuRef
CHM1_12237,420,983 - 37,458,920 (-)NCBICHM1_1
T2T-CHM13v2.02237,525,034 - 37,570,488 (-)NCBIT2T-CHM13v2.0
Tmprss6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,871,504 - 111,902,127 (-)NCBIGRCr8
mRatBN7.27109,991,008 - 110,021,626 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,985,931 - 110,021,624 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7111,741,252 - 111,771,803 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,964,790 - 113,995,347 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,932,869 - 113,963,426 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,659,323 - 119,689,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,659,324 - 119,689,938 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,649,831 - 119,680,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47116,391,730 - 116,419,671 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17116,425,992 - 116,456,922 (-)NCBI
Celera7106,329,190 - 106,359,893 (-)NCBICelera
Cytogenetic Map7q34NCBI
Tmprss6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541323,580,530 - 23,612,276 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541323,579,946 - 23,615,277 (-)NCBIChiLan1.0ChiLan1.0
TMPRSS6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22346,921,683 - 46,967,316 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12249,610,237 - 49,655,886 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02217,979,094 - 18,032,590 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12235,815,051 - 35,867,818 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2235,815,051 - 35,859,940 (-)Ensemblpanpan1.1panPan2
TMPRSS6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,393,650 - 27,435,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,397,123 - 27,435,908 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1027,353,491 - 27,390,639 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01028,190,798 - 28,228,167 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1028,190,967 - 28,228,124 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,912,441 - 27,949,753 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01028,221,179 - 28,258,351 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01028,399,083 - 28,436,250 (+)NCBIUU_Cfam_GSD_1.0
Tmprss6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,804,553 - 10,838,236 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,819,309 - 3,848,075 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364923,819,347 - 3,848,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMPRSS6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl510,663,635 - 10,705,471 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1510,663,491 - 10,704,583 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.258,263,703 - 8,304,970 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMPRSS6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11919,771,303 - 19,811,751 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1919,771,952 - 19,806,420 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045106,017,797 - 106,057,808 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmprss6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475210,693,634 - 10,727,269 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475210,693,895 - 10,727,269 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmprss6
1060 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:295
Count of miRNA genes:222
Interacting mature miRNAs:239
Transcripts:ENSMUST00000017086
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155356339689584203Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
15092079Igly6_mIgG glycosylation 6, GP6 (mouse)157410054082674156Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined348969478601286Mouse
1357703Vtbt17_mvertebral trabecular bone trait 17 (mouse)Not determined154455331378553437Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155478912988789129Mouse
1558786Msq1_mMAV-1 susceptibility QTL 1 (mouse)Not determined156338964681086436Mouse
15092080Igly7_mIgG glycosylation 7, GP10 (mouse)157779491982674156Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
1301006Hfib1_mhepatic fibrogenesis 1 (mouse)Not determined154730633481306479Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155676339687684201Mouse
10755515Amzn3_manatomical modifier of Zfp423 3 (mouse)154638964680389845Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
1301429Pcir3_mperiosteal circumference 3 (mouse)Not determined154846536282465496Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154216339695497881Mouse
1357756Alaa4_malopecia areata 4 (mouse)Not determined154638964680389845Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927302279474762Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154836339698397881Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
10412067Pain2_mpain 2 (mouse)Not determined155164533985645626Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined348969478601286Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15612948178684200Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155116070885160833Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155711700591117153Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined348969478601286Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15348969478601286Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
1301568Tria2_mT-cell receptor induced activation 2 (mouse)Not determined154485914178859281Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155168583285694449Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155711700591117153Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155141836185418511Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155180651585806651Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156158420095584200Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
1302002Cocia2_mcocaine induced activation 2 (mouse)Not determined157237245979899178Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15348969478601286Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156481182698811946Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
13442492Mecth2_mmechanosensation threshold 2 (mouse)157466284979387201Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156316390397163995Mouse
1301472Pain1_mpain 1 (mouse)Not determined157532084690813185Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800024486684201Mouse
1301860Gct3_mgranulosa cell tumorigenesis 3 (mouse)Not determined154740959681409691Mouse

Markers in Region
UniSTS:225100  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381578,439,963 - 78,440,162UniSTSGRCm38
MGSCv371578,270,393 - 78,270,592UniSTSGRCm37
Celera1579,902,667 - 79,902,866UniSTS
Cytogenetic Map15E2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000017086   ⟹   ENSMUSP00000017086
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1578,323,867 - 78,352,834 (-)Ensembl
GRCm38.p6 Ensembl1578,439,667 - 78,468,634 (-)Ensembl
Ensembl Acc Id: ENSMUST00000229124   ⟹   ENSMUSP00000155414
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1578,329,497 - 78,352,801 (-)Ensembl
GRCm38.p6 Ensembl1578,445,297 - 78,468,601 (-)Ensembl
Ensembl Acc Id: ENSMUST00000229516   ⟹   ENSMUSP00000155355
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1578,326,668 - 78,349,543 (-)Ensembl
GRCm38.p6 Ensembl1578,442,468 - 78,465,343 (-)Ensembl
Ensembl Acc Id: ENSMUST00000230020   ⟹   ENSMUSP00000155435
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1578,324,240 - 78,326,635 (-)Ensembl
GRCm38.p6 Ensembl1578,440,040 - 78,442,435 (-)Ensembl
Ensembl Acc Id: ENSMUST00000230159   ⟹   ENSMUSP00000155549
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1578,327,985 - 78,349,543 (-)Ensembl
GRCm38.p6 Ensembl1578,443,785 - 78,465,343 (-)Ensembl
Ensembl Acc Id: ENSMUST00000230226   ⟹   ENSMUSP00000155401
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1578,323,873 - 78,352,809 (-)Ensembl
GRCm38.p6 Ensembl1578,439,673 - 78,468,609 (-)Ensembl
Ensembl Acc Id: ENSMUST00000230473
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1578,327,983 - 78,328,579 (-)Ensembl
GRCm38.p6 Ensembl1578,443,783 - 78,444,379 (-)Ensembl
RefSeq Acc Id: NM_001355601   ⟹   NP_001342530
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391578,323,867 - 78,352,834 (-)NCBI
GRCm381578,439,667 - 78,468,634 (-)NCBI
Sequence:
RefSeq Acc Id: NM_027902   ⟹   NP_082178
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391578,323,867 - 78,352,834 (-)NCBI
GRCm381578,439,667 - 78,468,634 (-)NCBI
MGSCv371578,270,097 - 78,299,064 (-)RGD
Celera1579,902,371 - 79,931,350 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521417   ⟹   XP_006521480
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391578,323,873 - 78,352,848 (-)NCBI
GRCm381578,439,673 - 78,468,648 (-)NCBI
Sequence:
RefSeq Acc Id: XR_875313
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391578,323,871 - 78,352,848 (-)NCBI
GRCm381578,440,620 - 78,468,648 (-)NCBI
Sequence:
RefSeq Acc Id: NP_082178   ⟸   NM_027902
- Peptide Label: isoform 1
- UniProtKB: Q9DBI0 (UniProtKB/Swiss-Prot),   Q3KN88 (UniProtKB/Swiss-Prot),   A8W479 (UniProtKB/Swiss-Prot),   A8W478 (UniProtKB/Swiss-Prot),   Q6PF94 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006521480   ⟸   XM_006521417
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001342530   ⟸   NM_001355601
- Peptide Label: isoform 2
- UniProtKB: A0A2R8W6T9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000155435   ⟸   ENSMUST00000230020
Ensembl Acc Id: ENSMUSP00000155401   ⟸   ENSMUST00000230226
Ensembl Acc Id: ENSMUSP00000155549   ⟸   ENSMUST00000230159
Ensembl Acc Id: ENSMUSP00000017086   ⟸   ENSMUST00000017086
Ensembl Acc Id: ENSMUSP00000155355   ⟸   ENSMUST00000229516
Ensembl Acc Id: ENSMUSP00000155414   ⟸   ENSMUST00000229124
Protein Domains
CUB   LDL-receptor class A   Peptidase S1   SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9DBI0-F1-model_v2 AlphaFold Q9DBI0 1-811 view protein structure

Promoters
RGD ID:6847274
Promoter ID:MM_ACW:18602
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Liver,   Lung
Transcripts:TMPRSS6.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361578,272,551 - 78,273,051 (-)MPROMDB
RGD ID:6826549
Promoter ID:MM_KWN:18984
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_027902,   UC007WPJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361578,298,831 - 78,299,331 (-)MPROMDB
RGD ID:8684266
Promoter ID:EPDNEW_M20163
Type:multiple initiation site
Name:Tmprss6_1
Description:Mus musculus transmembrane serine protease 6 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381578,468,634 - 78,468,694EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919003 AgrOrtholog
Ensembl Genes ENSMUSG00000016942 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000017086 ENTREZGENE
  ENSMUST00000017086.5 UniProtKB/Swiss-Prot
  ENSMUST00000229124.2 UniProtKB/TrEMBL
  ENSMUST00000229516.2 UniProtKB/Swiss-Prot
  ENSMUST00000230020.2 UniProtKB/TrEMBL
  ENSMUST00000230159.2 UniProtKB/Swiss-Prot
  ENSMUST00000230226 ENTREZGENE
  ENSMUST00000230226.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.10.120 UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.960 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CUB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_S1A_matriptase-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:71753 UniProtKB/Swiss-Prot
MGD MGI:1919003 ENTREZGENE
NCBI Gene 71753 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LOW QUALITY PROTEIN: TRANSMEMBRANE PROTEASE SERINE 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2 UniProtKB/TrEMBL
Pfam Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmprss6 PhenoGen
PIRSF Matriptase-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/Swiss-Prot
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82671 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2R8VHU4_MOUSE UniProtKB/TrEMBL
  A0A2R8W6T9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8W6U1_MOUSE UniProtKB/TrEMBL
  A8W478 ENTREZGENE
  A8W479 ENTREZGENE
  Q3KN88 ENTREZGENE
  Q6PF94 ENTREZGENE
  Q9DBI0 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A8W478 UniProtKB/Swiss-Prot
  A8W479 UniProtKB/Swiss-Prot
  Q3KN88 UniProtKB/Swiss-Prot
  Q6PF94 UniProtKB/Swiss-Prot