Hcar1 (hydrocarboxylic acid receptor 1) - Rat Genome Database

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Gene: Hcar1 (hydrocarboxylic acid receptor 1) Mus musculus
Analyze
Symbol: Hcar1
Name: hydrocarboxylic acid receptor 1
RGD ID: 1316072
MGI Page MGI
Description: Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and negative regulation of lipid catabolic process. Is active in membrane. Is expressed in retina ganglion cell layer and retina layer. Orthologous to human HCAR1 (hydroxycarboxylic acid receptor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 81; G-protein coupled receptor 81; Gpr; Gpr81; hydroxycarboxylic acid receptor 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395124,014,802 - 124,018,066 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5124,014,799 - 124,018,083 (-)EnsemblGRCm39 Ensembl
GRCm385123,876,739 - 123,880,003 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5123,876,736 - 123,880,020 (-)EnsemblGRCm38mm10GRCm38
MGSCv375124,326,745 - 124,330,029 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365124,137,596 - 124,140,621 (-)NCBIMGSCv36mm8
Celera5120,948,767 - 120,952,052 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map563.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18174606   PMID:18952058   PMID:19047060   PMID:19633298  
PMID:20178780   PMID:20374963   PMID:21267068   PMID:21751047   PMID:21873635   PMID:22842580   PMID:24486398   PMID:24657625   PMID:25495836   PMID:27615440   PMID:27846210   PMID:28534495  
PMID:29386257   PMID:30543778   PMID:30926749   PMID:31220454   PMID:31999787   PMID:32071396   PMID:32669546   PMID:34208876   PMID:34737351   PMID:35107038   PMID:35240875   PMID:35830691  
PMID:35902290   PMID:35942676   PMID:36189986   PMID:36799150   PMID:37138018   PMID:37604388   PMID:37940970  


Genomics

Comparative Map Data
Hcar1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395124,014,802 - 124,018,066 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5124,014,799 - 124,018,083 (-)EnsemblGRCm39 Ensembl
GRCm385123,876,739 - 123,880,003 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5123,876,736 - 123,880,020 (-)EnsemblGRCm38mm10GRCm38
MGSCv375124,326,745 - 124,330,029 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365124,137,596 - 124,140,621 (-)NCBIMGSCv36mm8
Celera5120,948,767 - 120,952,052 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map563.24NCBI
HCAR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812122,726,076 - 122,730,844 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12122,726,076 - 122,730,844 (-)EnsemblGRCh38hg38GRCh38
GRCh3712123,210,623 - 123,215,391 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612121,778,106 - 121,781,082 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412121,735,610 - 121,740,009NCBI
Celera12122,804,963 - 122,807,939 (-)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12120,172,181 - 120,175,157 (-)NCBIHuRef
CHM1_112123,180,354 - 123,183,330 (-)NCBICHM1_1
T2T-CHM13v2.012122,721,458 - 122,726,228 (-)NCBIT2T-CHM13v2.0
Hcar1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81238,371,593 - 38,374,847 (+)NCBIGRCr8
mRatBN7.21232,710,680 - 32,713,934 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1232,711,027 - 32,712,082 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1233,889,596 - 33,890,651 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01234,500,949 - 34,502,004 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01233,552,835 - 33,553,890 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,145,177 - 38,146,232 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,144,855 - 38,146,271 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01240,014,637 - 40,015,692 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,847,986 - 33,849,041 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1234,397,576 - 34,398,631 (+)NCBICelera
Cytogenetic Map12q15NCBI
Hcar1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554825,998,796 - 6,002,093 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554825,998,796 - 6,002,093 (+)NCBIChiLan1.0ChiLan1.0
HCAR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210130,819,641 - 130,824,772 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112130,816,017 - 130,821,148 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012120,330,294 - 120,335,425 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112124,566,016 - 124,569,288 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12124,567,699 - 124,568,739 (-)Ensemblpanpan1.1panPan2
HCAR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1266,734,818 - 6,735,906 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl266,734,818 - 6,735,906 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha266,895,785 - 6,896,873 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0266,984,011 - 6,985,099 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl266,983,610 - 6,986,835 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1266,915,982 - 6,917,070 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0267,009,736 - 7,010,824 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0266,963,158 - 6,964,246 (+)NCBIUU_Cfam_GSD_1.0
Hcar1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118157,585,480 - 157,589,414 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365581,890,439 - 1,891,480 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365581,890,027 - 1,893,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCAR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1430,105,285 - 30,106,307 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11430,105,285 - 30,106,307 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21431,795,357 - 31,796,379 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HCAR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111118,055,943 - 118,087,946 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11118,056,603 - 118,057,643 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037127,260,574 - 127,264,069 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hcar1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474722,794,256 - 22,795,452 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474722,792,224 - 22,798,189 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hcar1
101 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:799
Count of miRNA genes:459
Interacting mature miRNAs:553
Transcripts:ENSMUST00000164267
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
1357662Lprq4_mlipoprotein QTL 4 (mouse)Not determined5114021753129632606Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108762509126882944Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse

Markers in Region
BE133641  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385123,876,961 - 123,877,093UniSTSGRCm38
MGSCv375124,326,970 - 124,327,102UniSTSGRCm37
Celera5120,948,992 - 120,949,124UniSTS
Cytogenetic Map5FUniSTS
Whitehead/MRC_RH51501.06UniSTS
D7Mit137  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385123,880,820 - 123,880,953UniSTSGRCm38
MGSCv375124,330,829 - 124,330,962UniSTSGRCm37
Celera5120,952,852 - 120,952,985UniSTS
Cytogenetic Map5FUniSTS
cM Map765.5UniSTS
cM Map5 UniSTS
Whitehead Genetic754.6UniSTS
Gpr81  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385123,878,661 - 123,879,550UniSTSGRCm38
MGSCv375124,328,670 - 124,329,559UniSTSGRCm37
Celera5120,950,693 - 120,951,582UniSTS
Cytogenetic Map5FUniSTS
cM Map5 UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000164267   ⟹   ENSMUSP00000129280
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5124,014,799 - 124,018,083 (-)Ensembl
GRCm38.p6 Ensembl5123,876,736 - 123,880,020 (-)Ensembl
RefSeq Acc Id: NM_175520   ⟹   NP_780729
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395124,014,802 - 124,018,066 (-)NCBI
GRCm385123,876,739 - 123,880,003 (-)NCBI
MGSCv375124,326,745 - 124,330,029 (-)RGD
Celera5120,948,767 - 120,952,052 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_780729   ⟸   NM_175520
- UniProtKB: Q8C131 (UniProtKB/Swiss-Prot),   B9EJ36 (UniProtKB/Swiss-Prot),   A0A4Y1JWM1 (UniProtKB/TrEMBL),   E9PZR8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000129280   ⟸   ENSMUST00000164267
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C131-F1-model_v2 AlphaFold Q8C131 1-343 view protein structure

Promoters
RGD ID:6888056
Promoter ID:EPDNEW_M7477
Type:multiple initiation site
Name:Hcar1_1
Description:Mus musculus hydrocarboxylic acid receptor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385123,880,003 - 123,880,063EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2441671 AgrOrtholog
Ensembl Genes ENSMUSG00000049241 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000164267 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000164267.3 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:243270 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2441671 ENTREZGENE
NCBI Gene 243270 ENTREZGENE
PANTHER HYDROXYCARBOXYLIC ACID RECEPTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46048:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hcar1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4Y1JWM1 ENTREZGENE, UniProtKB/TrEMBL
  B9EJ36 ENTREZGENE
  B9UM22_MOUSE UniProtKB/TrEMBL
  E9PZR8 ENTREZGENE, UniProtKB/TrEMBL
  HCAR1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B9EJ36 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-05-21 Hcar1  hydrocarboxylic acid receptor 1  Gpr81  G protein-coupled receptor 81  Symbol and/or name change 5135510 APPROVED