Rybp (RING1 and YY1 binding protein) - Rat Genome Database
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Gene: Rybp (RING1 and YY1 binding protein) Mus musculus
Analyze
Symbol: Rybp
Name: RING1 and YY1 binding protein
RGD ID: 1316055
MGI Page MGI
Description: Exhibits DNA binding activity and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Localizes to nucleoplasm. Predicted to colocalize with PcG protein complex. Is expressed in several structures, including brain; early embryo; extraembryonic component; genitourinary system; and nose. Orthologous to human RYBP (RING1 and YY1 binding protein); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 2410018J24Rik; death effector domain-associated factor; DED-associated factor; DEDA; DEDAF; MGC62213; RING1 and YY1-binding protein; Ring1 interactor Rybp; YEAF1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396100,205,526 - 100,264,319 (-)NCBIGRCm39mm39
GRCm386100,228,565 - 100,287,358 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6100,228,565 - 100,287,485 (-)EnsemblGRCm38mm10GRCm38
MGSCv376100,178,559 - 100,237,352 (-)NCBIGRCm37mm9NCBIm37
MGSCv366100,194,028 - 100,252,821 (-)NCBImm8
Celera6102,093,266 - 102,151,363 (-)NCBICelera
Cytogenetic Map6D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleoplasm  (IDA,ISO)
nucleus  (IBA,IDA,ISO)
PcG protein complex  (ISO)

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10369680   PMID:10919273   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12904583   PMID:14610273   PMID:14765135   PMID:15489334  
PMID:16055728   PMID:16107646   PMID:16141072   PMID:16141073   PMID:17070805   PMID:17093407   PMID:17470285   PMID:17874297   PMID:17967808   PMID:18287559   PMID:18799693   PMID:19170609  
PMID:20059953   PMID:20362541   PMID:20471950   PMID:21267068   PMID:21530438   PMID:21677750   PMID:21873635   PMID:22269950   PMID:22325148   PMID:22496869   PMID:22661705   PMID:22770845  
PMID:23273917   PMID:23395003   PMID:23486062   PMID:23892456   PMID:24457600   PMID:25703348   PMID:26110923   PMID:26711264   PMID:27081692   PMID:27705745   PMID:28111200   PMID:29799838  
PMID:30186101   PMID:30560907   PMID:31940753   PMID:32203418   PMID:32673370  


Genomics

Comparative Map Data
Rybp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396100,205,526 - 100,264,319 (-)NCBIGRCm39mm39
GRCm386100,228,565 - 100,287,358 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6100,228,565 - 100,287,485 (-)EnsemblGRCm38mm10GRCm38
MGSCv376100,178,559 - 100,237,352 (-)NCBIGRCm37mm9NCBIm37
MGSCv366100,194,028 - 100,252,821 (-)NCBImm8
Celera6102,093,266 - 102,151,363 (-)NCBICelera
Cytogenetic Map6D3NCBI
RYBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl372,371,825 - 72,446,621 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl372,371,825 - 72,446,623 (-)EnsemblGRCh38hg38GRCh38
GRCh38372,374,593 - 72,446,623 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37372,423,744 - 72,495,774 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36372,506,438 - 72,578,462 (-)NCBINCBI36hg18NCBI36
Build 34372,508,773 - 72,578,464NCBI
Celera372,354,609 - 72,427,714 (-)NCBI
Cytogenetic Map3p13NCBI
HuRef372,426,405 - 72,499,331 (-)NCBIHuRef
CHM1_1372,375,955 - 72,448,623 (-)NCBICHM1_1
Rybp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24132,876,361 - 132,927,580 (-)NCBI
Rnor_6.0 Ensembl4132,689,531 - 132,740,938 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04132,689,623 - 132,740,823 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04197,177,356 - 197,228,556 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44135,101,700 - 135,153,427 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14135,346,439 - 135,400,411 (-)NCBI
Celera4121,729,359 - 121,780,574 (-)NCBICelera
Cytogenetic Map4q34NCBI
Rybp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542115,728,580 - 15,803,150 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542115,728,778 - 15,803,150 (+)NCBIChiLan1.0ChiLan1.0
RYBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1374,244,030 - 74,319,460 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl374,247,807 - 74,318,398 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0372,315,494 - 72,389,328 (-)NCBIMhudiblu_PPA_v0panPan3
RYBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2019,615,426 - 19,729,474 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12019,650,936 - 19,732,987 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Rybp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366033,618,715 - 3,693,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RYBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1353,724,071 - 53,809,690 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11353,724,062 - 53,809,698 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21359,462,871 - 59,523,645 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103227901
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12233,327,516 - 33,397,463 (-)NCBI
ChlSab1.1 Ensembl2233,331,290 - 33,397,362 (-)Ensembl
Rybp
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247736,899,927 - 6,993,434 (-)NCBI

Position Markers
12.MMHAP29FRD9.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386100,270,324 - 100,270,519UniSTSGRCm38
MGSCv376100,220,318 - 100,220,513UniSTSGRCm37
Celera6102,135,076 - 102,135,271UniSTS
Cytogenetic Map6E1UniSTS
Whitehead_YAC6 UniSTS
G19717  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381366,011,793 - 66,011,953UniSTSGRCm38
MGSCv371366,112,729 - 66,112,889UniSTSGRCm37
Cytogenetic Map6E1UniSTS
Cytogenetic Map13B3UniSTS
A001W26  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381366,011,793 - 66,011,954UniSTSGRCm38
GRCm386100,228,644 - 100,228,805UniSTSGRCm38
MGSCv371366,112,729 - 66,112,890UniSTSGRCm37
MGSCv376100,178,638 - 100,178,799UniSTSGRCm37
Celera6102,093,345 - 102,093,506UniSTS
Celera6102,091,426 - 102,091,587UniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map6E1UniSTS
UniSTS:488703  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381366,007,685 - 66,008,506UniSTSGRCm38
MGSCv371366,108,621 - 66,109,442UniSTSGRCm37
Cytogenetic Map6E1UniSTS
Cytogenetic Map13B3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined689005405123005603Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690795610124795846Mouse
4141578Obrq1_mobesity resistance QTL 1 (mouse)Not determined92607306112004738Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692607306146429238Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined695004651129004738Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696347325130347522Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696347325130347522Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96655951146633626Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96655951146633626Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696655951146633626Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698242853132242977Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698506837145935444Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698717516132717715Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698931748132940036Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699155128133155267Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1167
Count of miRNA genes:608
Interacting mature miRNAs:772
Transcripts:ENSMUST00000101118
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000101118   ⟹   ENSMUSP00000098677
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6100,228,565 - 100,287,485 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203410
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6100,232,011 - 100,233,131 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205164
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6100,233,094 - 100,286,748 (-)Ensembl
RefSeq Acc Id: NM_019743   ⟹   NP_062717
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396100,205,526 - 100,264,319 (-)NCBI
GRCm386100,228,565 - 100,287,358 (-)ENTREZGENE
MGSCv376100,178,559 - 100,237,352 (-)RGD
Celera6102,093,266 - 102,151,363 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062717   ⟸   NM_019743
- UniProtKB: Q8CCI5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000098677   ⟸   ENSMUST00000101118

Promoters
RGD ID:6849209
Promoter ID:MM_XEF:6087
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:NM_001107879
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366100,236,461 - 100,236,961 (-)MPROMDB
RGD ID:6839957
Promoter ID:MM_KWN:47050
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Lung
Transcripts:ENSMUST00000101118
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366100,237,031 - 100,237,917 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929059 AgrOrtholog
Ensembl Genes ENSMUSG00000072872 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000098677 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000101118 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro RYBP/YAF2 UniProtKB/Swiss-Prot
  YAF2_RYBP UniProtKB/Swiss-Prot
  Znf_RanBP2 UniProtKB/Swiss-Prot
  Znf_RanBP2_sf UniProtKB/Swiss-Prot
KEGG Report mmu:56353 UniProtKB/Swiss-Prot
MGD MGI:1929059 ENTREZGENE
NCBI Gene 56353 ENTREZGENE
PANTHER PTHR12920 UniProtKB/Swiss-Prot
Pfam YAF2_RYBP UniProtKB/Swiss-Prot
  zf-RanBP UniProtKB/Swiss-Prot
PhenoGen Rybp PhenoGen
PROSITE ZF_RANBP2_1 UniProtKB/Swiss-Prot
  ZF_RANBP2_2 UniProtKB/Swiss-Prot
SMART ZnF_RBZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF90209 UniProtKB/Swiss-Prot
UniProt Q8CCI5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2RRB6 UniProtKB/Swiss-Prot
  Q9WVK2 UniProtKB/Swiss-Prot