Fhl5 (four and a half LIM domains 5) - Rat Genome Database

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Gene: Fhl5 (four and a half LIM domains 5) Mus musculus
Analyze
Symbol: Fhl5
Name: four and a half LIM domains 5
RGD ID: 1316023
MGI Page MGI
Description: Enables transcription coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be active in Z disc and nucleus. Is expressed in central nervous system; genitourinary system; heart; and otocyst. Orthologous to human FHL5 (four and a half LIM domains 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700027G07Rik; AC; Act; activator of cAMP-responsive element modulator in testis; activator of CREM in testis; FHL-5; four and a half LIM domains protein 5; LIM-only protein ACT
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39425,199,907 - 25,242,852 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl425,199,908 - 25,242,876 (-)EnsemblGRCm39 Ensembl
GRCm38425,199,907 - 25,242,852 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl425,199,908 - 25,242,876 (-)EnsemblGRCm38mm10GRCm38
MGSCv37425,127,056 - 25,170,023 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36425,290,539 - 25,333,506 (-)NCBIMGSCv36mm8
Celera424,935,116 - 24,977,805 (-)NCBICelera
Cytogenetic Map4A3NCBI
cM Map410.58NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)
Z disc  (IBA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10086359   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11327716   PMID:12062093   PMID:12477932   PMID:12493914   PMID:15247423   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:18287559   PMID:19930692   PMID:20059953   PMID:20488182   PMID:21383078   PMID:21779533   PMID:21873635   PMID:31932482   PMID:32325033  


Genomics

Comparative Map Data
Fhl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39425,199,907 - 25,242,852 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl425,199,908 - 25,242,876 (-)EnsemblGRCm39 Ensembl
GRCm38425,199,907 - 25,242,852 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl425,199,908 - 25,242,876 (-)EnsemblGRCm38mm10GRCm38
MGSCv37425,127,056 - 25,170,023 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36425,290,539 - 25,333,506 (-)NCBIMGSCv36mm8
Celera424,935,116 - 24,977,805 (-)NCBICelera
Cytogenetic Map4A3NCBI
cM Map410.58NCBI
FHL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38696,562,574 - 96,618,626 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl696,562,548 - 96,618,626 (+)EnsemblGRCh38hg38GRCh38
GRCh37697,010,450 - 97,066,502 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36697,117,156 - 97,171,233 (+)NCBINCBI36Build 36hg18NCBI36
Build 34697,117,155 - 97,171,233NCBI
Celera697,652,191 - 97,706,601 (+)NCBICelera
Cytogenetic Map6q16.1NCBI
HuRef694,444,613 - 94,498,689 (+)NCBIHuRef
CHM1_1697,272,425 - 97,326,515 (+)NCBICHM1_1
T2T-CHM13v2.0697,734,473 - 97,790,488 (+)NCBIT2T-CHM13v2.0
Fhl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8543,704,493 - 43,753,356 (-)NCBIGRCr8
mRatBN7.2538,907,941 - 38,956,759 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl538,907,946 - 38,956,552 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx541,005,013 - 41,053,550 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0542,604,019 - 42,652,566 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0542,537,365 - 42,585,904 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0539,564,241 - 39,611,273 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl539,564,242 - 39,611,053 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0544,191,766 - 44,239,094 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4540,253,199 - 40,301,542 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1540,253,378 - 40,301,721 (-)NCBI
Celera537,834,932 - 37,882,495 (-)NCBICelera
Cytogenetic Map5q21NCBI
Fhl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541122,583,292 - 22,619,281 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541122,583,314 - 22,619,281 (+)NCBIChiLan1.0ChiLan1.0
FHL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25116,602,744 - 116,663,641 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16114,480,915 - 114,541,811 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0694,397,172 - 94,450,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1698,283,399 - 98,337,256 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl698,283,399 - 98,337,256 (+)Ensemblpanpan1.1panPan2
FHL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11255,027,765 - 55,074,717 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1255,027,784 - 55,071,570 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1254,841,502 - 54,888,010 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01255,844,813 - 55,891,117 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1255,844,858 - 55,887,960 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11255,180,133 - 55,226,376 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01255,041,040 - 55,087,562 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01255,289,016 - 55,335,600 (+)NCBIUU_Cfam_GSD_1.0
Fhl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494689,602,418 - 89,642,732 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366991,084,550 - 1,124,676 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366991,084,578 - 1,124,783 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FHL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl163,705,936 - 63,754,067 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1163,705,864 - 63,754,079 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2172,074,158 - 72,120,937 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FHL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11377,298,280 - 77,351,797 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1377,298,353 - 77,350,157 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604049,594,298 - 49,645,391 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fhl5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248108,747,613 - 8,792,532 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248108,747,834 - 8,792,527 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fhl5
1710 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:77
Interacting mature miRNAs:78
Transcripts:ENSMUST00000029922, ENSMUST00000108204
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301510Bbaa13_mB.burgdorferi-associated arthritis 13 (mouse)Not determined4126395649Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1302010Wta1_mweight adult 1 (mouse)Not determined4868324042683429Mouse
1558992Ses8_msalmonella enteritidis susceptibility 8 (mouse)Not determined4868324042683429Mouse
1301473Triglq1_mtriglyceride QTL 1 (mouse)Not determined4868324042683429Mouse
1302125Lxw1_mlupus BXSB x NZW 1 (mouse)Not determined4868324042683429Mouse
4141302Ssrq5_mstress response QTL 5 (mouse)Not determined868324042683430Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
25440481Moaq1_mmodifier of alien QTL 1 (mouse)41950000046000000Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1302184Aaom1_mautoimmune aoritis in MRL mice 1 (mouse)Not determined42432229946332776Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000029922   ⟹   ENSMUSP00000029922
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl425,199,908 - 25,242,876 (-)Ensembl
GRCm38.p6 Ensembl425,199,908 - 25,242,876 (-)Ensembl
RefSeq Acc Id: ENSMUST00000108204   ⟹   ENSMUSP00000103839
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl425,199,908 - 25,242,876 (-)Ensembl
GRCm38.p6 Ensembl425,199,908 - 25,242,876 (-)Ensembl
RefSeq Acc Id: NM_001355498   ⟹   NP_001342427
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39425,199,907 - 25,242,266 (-)NCBI
GRCm38425,199,907 - 25,242,266 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001379528   ⟹   NP_001366457
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39425,199,907 - 25,242,852 (-)NCBI
GRCm38425,199,907 - 25,242,852 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021318   ⟹   NP_067293
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39425,199,907 - 25,242,852 (-)NCBI
GRCm38425,199,907 - 25,242,852 (-)NCBI
MGSCv37425,127,056 - 25,170,023 (-)RGD
Celera424,935,116 - 24,977,805 (-)RGD
cM Map4 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_067293   ⟸   NM_021318
- UniProtKB: Q9WTX7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001342427   ⟸   NM_001355498
- UniProtKB: Q9WTX7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001366457   ⟸   NM_001379528
- UniProtKB: Q9WTX7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000029922   ⟸   ENSMUST00000029922
RefSeq Acc Id: ENSMUSP00000103839   ⟸   ENSMUST00000108204
Protein Domains
LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTX7-F1-model_v2 AlphaFold Q9WTX7 1-284 view protein structure

Promoters
RGD ID:6882946
Promoter ID:EPDNEW_M4924
Type:initiation region
Name:Fhl5_1
Description:Mus musculus four and a half LIM domains 5 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38425,242,852 - 25,242,912EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913192 AgrOrtholog
Ensembl Genes ENSMUSG00000028259 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000029922 ENTREZGENE
  ENSMUST00000029922.14 UniProtKB/Swiss-Prot
  ENSMUST00000108204 ENTREZGENE
  ENSMUST00000108204.2 UniProtKB/Swiss-Prot
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot
InterPro FHL5_LIM2 UniProtKB/Swiss-Prot
  Znf_LIM UniProtKB/Swiss-Prot
KEGG Report mmu:57756 UniProtKB/Swiss-Prot
MGD MGI:1913192 ENTREZGENE
NCBI Gene 57756 ENTREZGENE
PANTHER FOUR AND A HALF LIM DOMAINS PROTEIN 5 UniProtKB/Swiss-Prot
  PTHR24205 UniProtKB/Swiss-Prot
Pfam LIM UniProtKB/Swiss-Prot
PhenoGen Fhl5 PhenoGen
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot
SMART LIM UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
UniProt FHL5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE