Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Helz (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HELZ mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of HELZ mRNA | CTD | PMID:22574217 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Helz (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of HELZ mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Helz (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HELZ mRNA | CTD | PMID:21215274 and PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Helz (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HELZ mRNA | CTD | PMID:19770486 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | ISO | Helz (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:32109520 | acrolein | multiple interactions | EXP | | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of HELZ mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of HELZ mRNA | CTD | PMID:32699268 | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of HELZ mRNA | CTD | PMID:22100608 | aflatoxin B1 | increases methylation | EXP | | 6480464 | Aflatoxin B1 results in increased methylation of HELZ intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | increases methylation | EXP | | 6480464 | aflatoxin B2 results in increased methylation of HELZ intron | CTD | PMID:30157460 | alpha-pinene | multiple interactions | EXP | | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of HELZ mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of HELZ mRNA | CTD | PMID:32699268 | amphetamine | decreases expression | ISO | Helz (Rattus norvegicus) | 6480464 | Amphetamine results in decreased expression of HELZ mRNA | CTD | PMID:30779732 | antirheumatic drug | increases expression | EXP | | 6480464 | Antirheumatic Agents results in increased expression of HELZ mRNA | CTD | PMID:24449571 | arsane | affects methylation | EXP | | 6480464 | Arsenic affects the methylation of HELZ gene | CTD | PMID:25304211 | arsenic atom | affects methylation | EXP | | 6480464 | Arsenic affects the methylation of HELZ gene | CTD | PMID:25304211 | arsenite(3-) | multiple interactions | EXP | | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to HELZ mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of HELZ promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | EXP | | 6480464 | Benzo(a)pyrene results in decreased methylation of HELZ 5' UTR | CTD | PMID:27901495 | benzo[e]pyrene | increases methylation | EXP | | 6480464 | benzo(e)pyrene results in increased methylation of HELZ intron | CTD | PMID:30157460 | bisphenol A | increases expression | ISO | Helz (Mus musculus) | 6480464 | bisphenol A results in increased expression of HELZ mRNA | CTD | PMID:26063408 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of HELZ gene | CTD | PMID:31601247 | bisphenol A | increases methylation | ISO | Helz (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of HELZ gene | CTD | PMID:28505145 | bisphenol A | increases expression | ISO | Helz (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of HELZ mRNA | CTD | PMID:25181051 more ... | caffeine | affects phosphorylation | EXP | | 6480464 | Caffeine affects the phosphorylation of HELZ protein | CTD | PMID:35688186 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of HELZ mRNA | CTD | PMID:27594783 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of HELZ mRNA | CTD | PMID:19376846 | coumarin | decreases phosphorylation | EXP | | 6480464 | coumarin results in decreased phosphorylation of HELZ protein | CTD | PMID:35688186 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of HELZ mRNA | CTD | PMID:25562108 | diazinon | increases methylation | EXP | | 6480464 | Diazinon results in increased methylation of HELZ gene | CTD | PMID:22964155 | dicrotophos | increases expression | EXP | | 6480464 | dicrotophos results in increased expression of HELZ mRNA | CTD | PMID:28302478 | ethanol | increases expression | ISO | Helz (Mus musculus) | 6480464 | Ethanol results in increased expression of HELZ mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | increases expression | EXP | | 6480464 | Ethyl Methanesulfonate results in increased expression of HELZ mRNA | CTD | PMID:23649840 | fenvalerate | decreases expression | ISO | Helz (Rattus norvegicus) | 6480464 | fenvalerate results in decreased expression of HELZ mRNA | CTD | PMID:30307764 | FR900359 | affects phosphorylation | EXP | | 6480464 | FR900359 affects the phosphorylation of HELZ protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of HELZ gene | CTD | PMID:31601247 | gentamycin | increases expression | ISO | Helz (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of HELZ mRNA | CTD | PMID:33387578 | hydrogen peroxide | multiple interactions | ISO | Helz (Mus musculus) | 6480464 | [Hydrogen Peroxide co-treated with N-(oxo-5 more ... | CTD | PMID:31494107 | inulin | multiple interactions | ISO | Helz (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of HELZ mRNA | CTD | PMID:36331819 | methapyrilene | increases methylation | EXP | | 6480464 | Methapyrilene results in increased methylation of HELZ intron | CTD | PMID:30157460 | methyl methanesulfonate | increases expression | EXP | | 6480464 | Methyl Methanesulfonate results in increased expression of HELZ mRNA | CTD | PMID:23649840 | N(4)-hydroxycytidine | decreases expression | ISO | Helz (Mus musculus) | 6480464 | N(4)-hydroxycytidine results in decreased expression of HELZ mRNA | CTD | PMID:37748715 | ozone | multiple interactions | EXP | | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of HELZ mRNA more ... | CTD | PMID:32699268 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of HELZ mRNA | CTD | PMID:21420995 and PMID:29067470 | paracetamol | decreases expression | ISO | Helz (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of HELZ mRNA | CTD | PMID:33387578 | perfluorohexanesulfonic acid | decreases expression | ISO | Helz (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of HELZ mRNA | CTD | PMID:37995155 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Helz (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of HELZ mRNA | CTD | PMID:36331819 | phenobarbital | affects expression | ISO | Helz (Mus musculus) | 6480464 | Phenobarbital affects the expression of HELZ mRNA | CTD | PMID:23091169 | phenytoin | increases expression | ISO | Helz (Rattus norvegicus) | 6480464 | Phenytoin results in increased expression of HELZ mRNA | CTD | PMID:20345932 | propiconazole | decreases expression | ISO | Helz (Mus musculus) | 6480464 | propiconazole results in decreased expression of HELZ mRNA | CTD | PMID:21278054 | quercetin | decreases expression | EXP | | 6480464 | Quercetin results in decreased expression of HELZ mRNA | CTD | PMID:21632981 | silicon dioxide | decreases expression | ISO | Helz (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of HELZ mRNA | CTD | PMID:19073995 | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of HELZ protein | CTD | PMID:30528433 | succimer | multiple interactions | ISO | Helz (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of HELZ mRNA and [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of HELZ mRNA | CTD | PMID:21641980 and PMID:26378955 | tetrachloromethane | affects expression | ISO | Helz (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of HELZ mRNA | CTD | PMID:17484886 | thioacetamide | increases expression | ISO | Helz (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of HELZ mRNA | CTD | PMID:34492290 | troglitazone | decreases expression | ISO | Helz (Mus musculus) | 6480464 | troglitazone results in decreased expression of HELZ mRNA | CTD | PMID:28973697 | tungsten | decreases expression | ISO | Helz (Mus musculus) | 6480464 | Tungsten results in decreased expression of HELZ mRNA | CTD | PMID:30912803 | valproic acid | increases methylation | EXP | | 6480464 | Valproic Acid results in increased methylation of HELZ gene | CTD | PMID:29154799 | valproic acid | affects splicing | ISO | Helz (Rattus norvegicus) | 6480464 | Valproic Acid affects the splicing of HELZ mRNA | CTD | PMID:29427782 | |