DUSP11 (dual specificity phosphatase 11) - Rat Genome Database
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Gene: DUSP11 (dual specificity phosphatase 11) Homo sapiens
Analyze
Symbol: DUSP11
Name: dual specificity phosphatase 11
RGD ID: 1315996
HGNC Page HGNC
Description: Exhibits RNA binding activity and phosphatase activity. Involved in RNA metabolic process; polynucleotide 5' dephosphorylation; and protein dephosphorylation. Localizes to fibrillar center; intercellular bridge; and nuclear speck.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dual specificity phosphatase 11 (RNA/RNP complex 1-interacting); dual specificity protein phosphatase 11; phosphatase that interacts with RNA/RNP complex 1; PIR1; RNA/RNP complex 1-interacting; RNA/RNP complex-1-interacting phosphatase; RNA/RNP complex-interacting phosphatase; serine/threonine specific protein phosphatase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl273,762,184 - 73,780,157 (-)EnsemblGRCh38hg38GRCh38
GRCh38273,762,198 - 73,780,157 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37273,989,325 - 74,007,284 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36273,842,837 - 73,860,732 (-)NCBINCBI36hg18NCBI36
Build 34273,900,985 - 73,918,877NCBI
Celera273,840,186 - 73,858,141 (-)NCBI
Cytogenetic Map2p13.1NCBI
HuRef273,723,921 - 73,741,881 (-)NCBIHuRef
CHM1_1273,920,056 - 73,938,015 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

Additional References at PubMed
PMID:9685386   PMID:10347225   PMID:12477932   PMID:15342556   PMID:15489334   PMID:15635413   PMID:16169070   PMID:19120688   PMID:19322201   PMID:19460752   PMID:20383145   PMID:20811636  
PMID:21873635   PMID:21931564   PMID:22658674   PMID:22681889   PMID:24447265   PMID:24457600   PMID:25515538   PMID:26186194   PMID:26496610   PMID:27432908   PMID:27798849   PMID:28296624  
PMID:28514442   PMID:29118270   PMID:29180619   PMID:29672716   PMID:29852174   PMID:30038017   PMID:31091453   PMID:31527615  


Genomics

Comparative Map Data
DUSP11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl273,762,184 - 73,780,157 (-)EnsemblGRCh38hg38GRCh38
GRCh38273,762,198 - 73,780,157 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37273,989,325 - 74,007,284 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36273,842,837 - 73,860,732 (-)NCBINCBI36hg18NCBI36
Build 34273,900,985 - 73,918,877NCBI
Celera273,840,186 - 73,858,141 (-)NCBI
Cytogenetic Map2p13.1NCBI
HuRef273,723,921 - 73,741,881 (-)NCBIHuRef
CHM1_1273,920,056 - 73,938,015 (-)NCBICHM1_1
Dusp11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,919,250 - 85,938,950 (-)NCBIGRCm39mm39
GRCm38685,942,268 - 85,961,732 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,942,268 - 85,961,667 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,892,262 - 85,911,661 (-)NCBIGRCm37mm9NCBIm37
MGSCv36685,907,902 - 85,927,301 (-)NCBImm8
Celera687,876,571 - 87,895,913 (-)NCBICelera
Cytogenetic Map6C3NCBI
Dusp11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04117,617,640 - 117,631,674 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4117,617,533 - 117,631,716 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04182,370,260 - 182,387,183 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44120,094,173 - 120,108,207 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14120,338,653 - 120,352,688 (-)NCBI
Celera4107,344,395 - 107,358,414 (-)NCBICelera
Cytogenetic Map4q34NCBI
Dusp11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,978,469 - 11,990,041 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,978,118 - 11,990,169 (-)NCBIChiLan1.0ChiLan1.0
DUSP11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A75,358,695 - 75,375,785 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A75,358,695 - 75,375,785 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A73,823,262 - 73,841,600 (-)NCBIMhudiblu_PPA_v0panPan3
DUSP11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1749,245,496 - 49,278,767 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11749,245,476 - 49,261,774 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dusp11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649117,512,040 - 17,525,831 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl369,201,239 - 69,226,321 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1369,206,172 - 69,226,004 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2372,407,741 - 72,427,563 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP11
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11433,474,054 - 33,493,629 (+)NCBI
ChlSab1.1 Ensembl1433,474,446 - 33,493,165 (+)Ensembl
Dusp11
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474929,724,792 - 29,734,150 (+)NCBI

Position Markers
RH65653  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37273,994,583 - 73,994,757UniSTSGRCh37
Build 36273,848,091 - 73,848,265RGDNCBI36
Celera273,845,444 - 73,845,618RGD
Cytogenetic Map2p13.1UniSTS
HuRef273,729,178 - 73,729,352UniSTS
GeneMap99-GB4 RH Map2229.04UniSTS
RH65821  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37274,003,972 - 74,004,118UniSTSGRCh37
Build 36273,857,480 - 73,857,626RGDNCBI36
Celera273,854,829 - 73,854,975RGD
Cytogenetic Map2p13.1UniSTS
HuRef273,738,569 - 73,738,715UniSTS
GeneMap99-GB4 RH Map2229.04UniSTS
RH103166  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37273,989,521 - 73,989,671UniSTSGRCh37
Build 36273,843,029 - 73,843,179RGDNCBI36
Celera273,840,382 - 73,840,532RGD
Cytogenetic Map2p13.1UniSTS
HuRef273,724,117 - 73,724,267UniSTS
GeneMap99-GB4 RH Map2231.67UniSTS
RH123002  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37273,989,139 - 73,989,409UniSTSGRCh37
Build 36273,842,647 - 73,842,917RGDNCBI36
Celera273,840,000 - 73,840,270RGD
Cytogenetic Map2p13.1UniSTS
HuRef273,723,735 - 73,724,005UniSTS
TNG Radiation Hybrid Map245985.0UniSTS
DUSP11_1250  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37273,989,146 - 73,989,978UniSTSGRCh37
Build 36273,842,654 - 73,843,486RGDNCBI36
Celera273,840,007 - 73,840,839RGD
HuRef273,723,742 - 73,724,574UniSTS
STS-AA037694  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37273,989,621 - 73,989,829UniSTSGRCh37
Build 36273,843,129 - 73,843,337RGDNCBI36
Celera273,840,482 - 73,840,690RGD
Cytogenetic Map2p13.1UniSTS
HuRef273,724,217 - 73,724,425UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1109
Count of miRNA genes:720
Interacting mature miRNAs:797
Transcripts:ENST00000272444, ENST00000377706, ENST00000443070, ENST00000452812, ENST00000477458, ENST00000480948
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 782 1226 999 184 1078 100 3297 323 1240 265 1368 1333 98 923 1829 3
Low 1650 1754 724 438 867 364 1058 1869 2468 153 80 275 73 281 959 1
Below cutoff 4 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000272444   ⟹   ENSP00000272444
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl273,762,184 - 73,780,157 (-)Ensembl
RefSeq Acc Id: ENST00000443070   ⟹   ENSP00000413444
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl273,767,419 - 73,780,121 (-)Ensembl
RefSeq Acc Id: ENST00000452812   ⟹   ENSP00000394535
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl273,773,253 - 73,779,968 (-)Ensembl
RefSeq Acc Id: ENST00000477458
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl273,766,868 - 73,779,582 (-)Ensembl
RefSeq Acc Id: ENST00000480948
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl273,762,594 - 73,779,878 (-)Ensembl
RefSeq Acc Id: NM_003584   ⟹   NP_003575
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38273,762,198 - 73,780,157 (-)NCBI
GRCh37273,989,325 - 74,007,284 (-)RGD
Build 36273,842,837 - 73,860,732 (-)NCBI Archive
Celera273,840,186 - 73,858,141 (-)RGD
HuRef273,723,921 - 73,741,881 (-)RGD
CHM1_1273,920,056 - 73,938,015 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003575   ⟸   NM_003584
- UniProtKB: O75319 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000394535   ⟸   ENST00000452812
RefSeq Acc Id: ENSP00000413444   ⟸   ENST00000443070
RefSeq Acc Id: ENSP00000272444   ⟸   ENST00000272444
Promoters
RGD ID:6860702
Promoter ID:EPDNEW_H3516
Type:initiation region
Name:DUSP11_1
Description:dual specificity phosphatase 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38273,780,103 - 73,780,163EPDNEW
RGD ID:6797114
Promoter ID:HG_KWN:33275
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000252047,   OTTHUMT00000328024,   OTTHUMT00000328025,   OTTHUMT00000328026,   OTTHUMT00000328027
Position:
Human AssemblyChrPosition (strand)Source
Build 36273,860,376 - 73,860,876 (-)MPROMDB
RGD ID:6850568
Promoter ID:EP73075
Type:multiple initiation site
Name:HS_DUSP11
Description:Dual specificity phosphatase 11 (RNA/RNP complex 1-interacting).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36273,860,738 - 73,860,798EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_003584.2(DUSP11):c.992C>T (p.Pro331Leu) single nucleotide variant Malignant melanoma [RCV000060610] Chr2:73762803 [GRCh38]
Chr2:73989930 [GRCh37]
Chr2:73843438 [NCBI36]
Chr2:2p13.1
not provided
GRCh38/hg38 2p16.1-11.2(chr2:58279519-83586962)x3 copy number gain See cases [RCV000136053] Chr2:58279519..83586962 [GRCh38]
Chr2:58506654..83814086 [GRCh37]
Chr2:58360158..83667597 [NCBI36]
Chr2:2p16.1-11.2
pathogenic
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2
uncertain significance
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2
benign
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p13.2-13.1(chr2:73477212-74065941)x1 copy number loss See cases [RCV000448067] Chr2:73477212..74065941 [GRCh37]
Chr2:2p13.2-13.1
uncertain significance
GRCh37/hg19 2p15-11.2(chr2:62245236-86978895)x3 copy number gain See cases [RCV000448688] Chr2:62245236..86978895 [GRCh37]
Chr2:2p15-11.2
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
Single allele duplication not provided [RCV000677942] Chr2:63671346..85698002 [GRCh37]
Chr2:2p15-11.2
pathogenic
Single allele inversion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NM_003584.2(DUSP11):c.319-7G>C single nucleotide variant not provided [RCV000895976] Chr2:73775051 [GRCh38]
Chr2:74002178 [GRCh37]
Chr2:2p13.1
benign
NM_003584.2(DUSP11):c.24G>A (p.Glu8=) single nucleotide variant not provided [RCV000895977] Chr2:73780092 [GRCh38]
Chr2:74007219 [GRCh37]
Chr2:2p13.1
benign
NM_003584.2(DUSP11):c.935+5C>G single nucleotide variant not provided [RCV000901489] Chr2:73766413 [GRCh38]
Chr2:73993540 [GRCh37]
Chr2:2p13.1
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3066 AgrOrtholog
COSMIC DUSP11 COSMIC
Ensembl Genes ENSG00000144048 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000272444 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000394535 UniProtKB/TrEMBL
  ENSP00000413444 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000272444 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000443070 UniProtKB/Swiss-Prot
  ENST00000452812 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000144048 GTEx
HGNC ID HGNC:3066 ENTREZGENE
Human Proteome Map DUSP11 Human Proteome Map
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot
KEGG Report hsa:8446 UniProtKB/Swiss-Prot
NCBI Gene 8446 ENTREZGENE
OMIM 603092 OMIM
Pfam DSPc UniProtKB/Swiss-Prot
PharmGKB PA27521 PharmGKB
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot
SMART DSPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DUS11_HUMAN UniProtKB/Swiss-Prot
  H7C0E6_HUMAN UniProtKB/TrEMBL
  O75319 ENTREZGENE
UniProt Secondary B2RCT8 UniProtKB/Swiss-Prot
  C9JYA6 UniProtKB/Swiss-Prot
  Q6AI47 UniProtKB/Swiss-Prot
  Q9BWE3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-10 DUSP11  dual specificity phosphatase 11    dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)  Symbol and/or name change 5135510 APPROVED
2011-09-01 DUSP11  dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)  DUSP11  dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)  Symbol and/or name change 5135510 APPROVED