Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1,1-trichloroethane | increases expression | EXP | | 6480464 | 1 more ... | CTD | PMID:25270620 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of TMC5 mRNA | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | Tmc5 (Rattus norvegicus) | 6480464 | Estradiol results in increased expression of TMC5 mRNA | CTD | PMID:26945725 | 17beta-estradiol | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of TMC5 mRNA | CTD | PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TMC5 mRNA | CTD | PMID:21570461 | 2-hydroxypropanoic acid | decreases expression | ISO | TMC5 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of TMC5 mRNA | CTD | PMID:30851411 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TMC5 mRNA | CTD | PMID:16997883 | 4,4'-sulfonyldiphenol | increases expression | EXP | | 6480464 | bisphenol S results in increased expression of TMC5 mRNA | CTD | PMID:30951980 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | Tmc5 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of TMC5 mRNA | CTD | PMID:36041667 | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of TMC5 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | ISO | Tmc5 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of TMC5 mRNA | CTD | PMID:30047161 | 8-Br-cAMP | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TMC5 mRNA | CTD | PMID:16997883 | aflatoxin B1 | increases methylation | ISO | TMC5 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of TMC5 gene | CTD | PMID:27153756 | Aflatoxin B2 alpha | increases methylation | ISO | TMC5 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of TMC5 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | TMC5 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of TMC5 mRNA | CTD | PMID:21934132 more ... | amitrole | decreases expression | ISO | Tmc5 (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of TMC5 mRNA | CTD | PMID:30047161 | Aroclor 1254 | decreases expression | EXP | | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of TMC5 mRNA | CTD | PMID:23650126 | arsenous acid | decreases response to substance | ISO | TMC5 (Homo sapiens) | 6480464 | TMC5 protein results in decreased susceptibility to Arsenic Trioxide | CTD | PMID:20707922 | benzo[a]pyrene | decreases methylation | ISO | TMC5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of TMC5 5' UTR and Benzo(a)pyrene results in decreased methylation of TMC5 promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | TMC5 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20018196 | bisphenol A | decreases expression | ISO | Tmc5 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of TMC5 mRNA | CTD | PMID:25181051 more ... | bisphenol A | multiple interactions | ISO | Tmc5 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of TMC5 mRNA | CTD | PMID:36041667 | bisphenol A | increases methylation | ISO | TMC5 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of TMC5 gene | CTD | PMID:31601247 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TMC5 mRNA | CTD | PMID:30951980 and PMID:32156529 | bisphenol A | increases methylation | ISO | Tmc5 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of TMC5 gene | CTD | PMID:28505145 | bisphenol F | increases expression | EXP | | 6480464 | bisphenol F results in increased expression of TMC5 mRNA | CTD | PMID:30951980 | bisphenol F | multiple interactions | ISO | Tmc5 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of TMC5 mRNA | CTD | PMID:36041667 | buta-1,3-diene | decreases expression | EXP | | 6480464 | 1 and 3-butadiene results in decreased expression of TMC5 mRNA | CTD | PMID:29038090 | C60 fullerene | decreases expression | ISO | Tmc5 (Rattus norvegicus) | 6480464 | fullerene C60 results in decreased expression of TMC5 mRNA | CTD | PMID:19167457 | cadmium atom | increases expression | ISO | TMC5 (Homo sapiens) | 6480464 | Cadmium results in increased expression of TMC5 mRNA | CTD | PMID:23369406 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMC5 mRNA | CTD | PMID:20938992 | chromium(6+) | affects expression | EXP | | 6480464 | chromium hexavalent ion affects the expression of TMC5 mRNA | CTD | PMID:28472532 | copper atom | increases expression | ISO | Tmc5 (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of TMC5 mRNA | CTD | PMID:26033743 | copper atom | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of TMC5 mRNA | CTD | PMID:20971185 | copper(0) | increases expression | ISO | Tmc5 (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of TMC5 mRNA | CTD | PMID:26033743 | copper(0) | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of TMC5 mRNA | CTD | PMID:20971185 | copper(II) sulfate | increases expression | ISO | TMC5 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of TMC5 mRNA | CTD | PMID:19549813 | dexamethasone | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of TMC5 mRNA | CTD | PMID:16997883 | diarsenic trioxide | decreases response to substance | ISO | TMC5 (Homo sapiens) | 6480464 | TMC5 protein results in decreased susceptibility to Arsenic Trioxide | CTD | PMID:20707922 | dorsomorphin | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | elemental selenium | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of TMC5 mRNA | CTD | PMID:19244175 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMC5 mRNA | CTD | PMID:20938992 | genistein | increases expression | EXP | | 6480464 | Genistein results in increased expression of TMC5 mRNA | CTD | PMID:32186404 | hydrogen peroxide | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TMC5 protein | CTD | PMID:18951874 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TMC5 mRNA | CTD | PMID:20938992 | methimazole | decreases expression | ISO | Tmc5 (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of TMC5 mRNA | CTD | PMID:30047161 | methylmercury chloride | decreases expression | ISO | TMC5 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of TMC5 mRNA | CTD | PMID:28001369 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of TMC5 mRNA | CTD | PMID:24535843 | panobinostat | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMC5 mRNA | CTD | PMID:27188386 | panobinostat | increases expression | ISO | TMC5 (Homo sapiens) | 6480464 | panobinostat results in increased expression of TMC5 mRNA | CTD | PMID:26272509 | paraquat | increases expression | ISO | Tmc5 (Rattus norvegicus) | 6480464 | Paraquat results in increased expression of TMC5 mRNA | CTD | PMID:32680482 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of TMC5 mRNA | CTD | PMID:19482888 | phenobarbital | multiple interactions | EXP | | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TMC5 mRNA] | CTD | PMID:19482888 | phenylmercury acetate | increases expression | ISO | TMC5 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of TMC5 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMC5 mRNA | CTD | PMID:27188386 | rac-lactic acid | decreases expression | ISO | TMC5 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of TMC5 mRNA | CTD | PMID:30851411 | SB 431542 | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | selenium atom | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of TMC5 mRNA | CTD | PMID:19244175 | silicon dioxide | increases expression | ISO | TMC5 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of TMC5 mRNA | CTD | PMID:25895662 | sodium arsenite | increases expression | ISO | TMC5 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of TMC5 mRNA | CTD | PMID:35954277 | sulforaphane | decreases expression | ISO | TMC5 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of TMC5 mRNA | CTD | PMID:31838189 | theophylline | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of TMC5 protein | CTD | PMID:18951874 | thimerosal | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Thimerosal co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMC5 mRNA | CTD | PMID:27188386 | titanium dioxide | affects expression | EXP | | 6480464 | titanium dioxide affects the expression of TMC5 mRNA | CTD | PMID:23557971 | titanium dioxide | increases expression | ISO | Tmc5 (Rattus norvegicus) | 6480464 | titanium dioxide results in increased expression of TMC5 mRNA | CTD | PMID:30012374 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of TMC5 mRNA | CTD | PMID:25549359 | trichostatin A | increases expression | ISO | TMC5 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of TMC5 mRNA | CTD | PMID:24935251 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of TMC5 mRNA | CTD | PMID:33045310 | valproic acid | increases expression | ISO | TMC5 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of TMC5 mRNA | CTD | PMID:24383497 | vitamin E | decreases expression | ISO | TMC5 (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of TMC5 mRNA | CTD | PMID:19244175 | vitamin E | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of TMC5 mRNA | CTD | PMID:19244175 | vorinostat | multiple interactions | ISO | TMC5 (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMC5 mRNA | CTD | PMID:27188386 | vorinostat | increases expression | ISO | TMC5 (Homo sapiens) | 6480464 | vorinostat results in increased expression of TMC5 mRNA | CTD | PMID:26272509 | zoledronic acid | increases expression | ISO | TMC5 (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of TMC5 mRNA | CTD | PMID:24714768 | |