FCSK (fucose kinase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: FCSK (fucose kinase) Homo sapiens
Analyze
Symbol: FCSK
Name: fucose kinase
RGD ID: 1315934
HGNC Page HGNC
Description: Enables fucokinase activity. Involved in GDP-L-fucose salvage. Predicted to be located in cytosol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1110046B12Rik; CDGF2; FLJ39408; fucokinase; FUK; L-fucose kinase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1670,454,595 - 70,480,274 (+)EnsemblGRCh38hg38GRCh38
GRCh381670,454,590 - 70,480,274 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371670,488,498 - 70,514,177 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361669,045,999 - 69,071,678 (+)NCBINCBI36hg18NCBI36
Build 341669,045,998 - 69,071,677NCBI
Celera1655,014,116 - 55,039,795 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1656,320,614 - 56,346,293 (+)NCBIHuRef
CHM1_11671,895,869 - 71,921,551 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (TAS)

Molecular Function

References

Additional References at PubMed
PMID:12056818   PMID:12975309   PMID:14702039   PMID:15489334   PMID:21873635   PMID:23251661   PMID:26186194   PMID:28514442   PMID:29924834   PMID:30503518   PMID:31753913   PMID:32235678  
PMID:32296183  


Genomics

Comparative Map Data
FCSK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1670,454,595 - 70,480,274 (+)EnsemblGRCh38hg38GRCh38
GRCh381670,454,590 - 70,480,274 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371670,488,498 - 70,514,177 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361669,045,999 - 69,071,678 (+)NCBINCBI36hg18NCBI36
Build 341669,045,998 - 69,071,677NCBI
Celera1655,014,116 - 55,039,795 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1656,320,614 - 56,346,293 (+)NCBIHuRef
CHM1_11671,895,869 - 71,921,551 (+)NCBICHM1_1
Fcsk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398111,609,088 - 111,629,120 (-)NCBIGRCm39mm39
GRCm39 Ensembl8111,609,088 - 111,629,120 (-)Ensembl
GRCm388110,882,456 - 110,902,488 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8110,882,456 - 110,902,488 (-)EnsemblGRCm38mm10GRCm38
MGSCv378113,406,363 - 113,426,359 (-)NCBIGRCm37mm9NCBIm37
MGSCv368113,769,140 - 113,789,136 (-)NCBImm8
Celera8115,106,085 - 115,126,168 (-)NCBICelera
Cytogenetic Map8E1NCBI
Fcsk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21938,849,130 - 38,874,497 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1943,338,166 - 43,357,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01943,338,146 - 43,357,826 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01954,149,422 - 54,190,885 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41940,803,644 - 40,823,587 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11940,808,531 - 40,863,816 (-)NCBI
Celera1938,247,827 - 38,267,268 (-)NCBICelera
Cytogenetic Map19q12NCBI
Fcsk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554843,263,795 - 3,278,078 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554843,259,165 - 3,278,621 (+)NCBIChiLan1.0ChiLan1.0
FCSK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11670,294,061 - 70,318,493 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1670,294,061 - 70,318,493 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01654,534,064 - 54,559,894 (-)NCBIMhudiblu_PPA_v0panPan3
FCSK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1576,442,597 - 76,463,165 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl576,443,411 - 76,462,771 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha576,403,883 - 76,424,449 (+)NCBI
ROS_Cfam_1.0576,879,027 - 76,899,580 (+)NCBI
UMICH_Zoey_3.1576,705,672 - 76,721,573 (+)NCBI
UNSW_CanFamBas_1.0576,524,033 - 76,544,592 (+)NCBI
UU_Cfam_GSD_1.0577,016,091 - 77,036,654 (+)NCBI
Fcsk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934936,452,464 - 36,472,476 (+)NCBI
SpeTri2.0NW_00493647523,116,638 - 23,136,635 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCSK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl613,471,833 - 13,506,444 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1613,471,771 - 13,492,581 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FCSK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1553,606,693 - 53,634,749 (+)NCBI
ChlSab1.1 Ensembl553,615,958 - 53,637,550 (+)Ensembl
Vero_WHO_p1.0NW_02366604716,402,617 - 16,430,934 (+)NCBI
Fcsk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474612,695,007 - 12,715,173 (+)NCBI

Position Markers
D16S2587E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371670,514,511 - 70,514,624UniSTSGRCh37
Build 361669,072,012 - 69,072,125RGDNCBI36
Celera1655,013,669 - 55,013,782RGD
Cytogenetic Map16q22.1UniSTS
HuRef1656,346,627 - 56,346,740UniSTS
RH44544  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371670,513,843 - 70,513,964UniSTSGRCh37
Build 361669,071,344 - 69,071,465RGDNCBI36
Celera1655,014,329 - 55,014,450RGD
Cytogenetic Map16q22.1UniSTS
HuRef1656,345,959 - 56,346,080UniSTS
GeneMap99-GB4 RH Map16411.5UniSTS
NCBI RH Map16508.6UniSTS
D16S2583E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371670,514,027 - 70,514,139UniSTSGRCh37
Build 361669,071,528 - 69,071,640RGDNCBI36
Celera1655,014,154 - 55,014,266RGD
Cytogenetic Map16q22.1UniSTS
HuRef1656,346,143 - 56,346,255UniSTS
GeneMap99-GB4 RH Map16425.4UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR618hsa-miR-618Mirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Target Of
Summary Value
Count of predictions:4510
Count of miRNA genes:1046
Interacting mature miRNAs:1328
Transcripts:ENST00000288078, ENST00000378912, ENST00000428974, ENST00000464499, ENST00000485034, ENST00000498702, ENST00000571487, ENST00000571514, ENST00000572784, ENST00000573352, ENST00000573832, ENST00000574784, ENST00000576107, ENST00000576453
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1447 631 1219 139 640 46 2280 471 1548 184 1170 1284 95 277 1519 1
Low 992 2356 507 485 1305 419 2077 1726 2186 235 290 329 80 1 927 1269 5 2
Below cutoff 4 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_145059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006721162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011522928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011522929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011522931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001751854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001751856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001751857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002957788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002957789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002957790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC012184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC106804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ441184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK056456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK123470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK128387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY829643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000288078   ⟹   ENSP00000288078
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1670,454,595 - 70,480,274 (+)Ensembl
RefSeq Acc Id: ENST00000378912   ⟹   ENSP00000368192
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1670,454,595 - 70,480,274 (+)Ensembl
RefSeq Acc Id: ENST00000464499
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1670,454,595 - 70,480,274 (+)Ensembl
RefSeq Acc Id: ENST00000485034
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1670,477,358 - 70,480,274 (+)Ensembl
RefSeq Acc Id: ENST00000498702   ⟹   ENSP00000463088
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1670,474,625 - 70,479,681 (+)Ensembl
RefSeq Acc Id: ENST00000571487
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1670,454,595 - 70,468,974 (+)Ensembl
RefSeq Acc Id: ENST00000571514   ⟹   ENSP00000462584
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1670,454,595 - 70,480,273 (+)Ensembl
RefSeq Acc Id: ENST00000572784   ⟹   ENSP00000458483
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1670,454,595 - 70,466,206 (+)Ensembl
RefSeq Acc Id: ENST00000573352   ⟹   ENSP00000460484
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1670,454,727 - 70,466,174 (+)Ensembl
RefSeq Acc Id: ENST00000573832
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1670,474,789 - 70,475,853 (+)Ensembl
RefSeq Acc Id: ENST00000574784   ⟹   ENSP00000459168
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1670,454,595 - 70,466,939 (+)Ensembl
RefSeq Acc Id: ENST00000576107
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1670,454,595 - 70,466,544 (+)Ensembl
RefSeq Acc Id: ENST00000576453   ⟹   ENSP00000458622
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1670,454,727 - 70,466,908 (+)Ensembl
RefSeq Acc Id: NM_145059   ⟹   NP_659496
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,454,595 - 70,480,274 (+)NCBI
GRCh371670,488,498 - 70,514,177 (+)RGD
Build 361669,045,999 - 69,071,678 (+)NCBI Archive
Celera1655,014,116 - 55,039,795 (-)RGD
HuRef1656,320,614 - 56,346,293 (+)ENTREZGENE
CHM1_11671,895,869 - 71,921,551 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006721162   ⟹   XP_006721225
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,454,595 - 70,480,274 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011522928   ⟹   XP_011521230
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,454,727 - 70,480,274 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011522929   ⟹   XP_011521231
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,454,727 - 70,480,274 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011522931   ⟹   XP_011521233
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,454,595 - 70,479,237 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017023012   ⟹   XP_016878501
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,457,838 - 70,480,274 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017023013   ⟹   XP_016878502
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,454,590 - 70,480,274 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024450180   ⟹   XP_024305948
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,454,595 - 70,477,331 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024450181   ⟹   XP_024305949
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,467,059 - 70,480,274 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001751854
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,454,595 - 70,480,274 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001751856
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,454,595 - 70,479,617 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001751857
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,454,595 - 70,480,274 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002957788
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,454,595 - 70,480,274 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002957789
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,454,595 - 70,480,274 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002957790
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,454,595 - 70,478,357 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_659496   ⟸   NM_145059
- UniProtKB: Q8N0W3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006721225   ⟸   XM_006721162
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011521233   ⟸   XM_011522931
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011521230   ⟸   XM_011522928
- Peptide Label: isoform X1
- UniProtKB: Q8N0W3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011521231   ⟸   XM_011522929
- Peptide Label: isoform X1
- UniProtKB: Q8N0W3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016878502   ⟸   XM_017023013
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016878501   ⟸   XM_017023012
- Peptide Label: isoform X1
- UniProtKB: Q8N0W3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_024305948   ⟸   XM_024450180
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_024305949   ⟸   XM_024450181
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSP00000462584   ⟸   ENST00000571514
RefSeq Acc Id: ENSP00000458483   ⟸   ENST00000572784
RefSeq Acc Id: ENSP00000460484   ⟸   ENST00000573352
RefSeq Acc Id: ENSP00000459168   ⟸   ENST00000574784
RefSeq Acc Id: ENSP00000368192   ⟸   ENST00000378912
RefSeq Acc Id: ENSP00000458622   ⟸   ENST00000576453
RefSeq Acc Id: ENSP00000288078   ⟸   ENST00000288078
RefSeq Acc Id: ENSP00000463088   ⟸   ENST00000498702
Protein Domains
Fucokinase   GHMP_kinases_C   GHMP_kinases_N

Promoters
RGD ID:6793141
Promoter ID:HG_KWN:24158
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_145059,   OTTHUMT00000157292,   OTTHUMT00000157293,   UC002EYZ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361669,045,546 - 69,046,152 (+)MPROMDB
RGD ID:6793143
Promoter ID:HG_KWN:24160
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000157294
Position:
Human AssemblyChrPosition (strand)Source
Build 361669,067,981 - 69,069,847 (+)MPROMDB
RGD ID:7232737
Promoter ID:EPDNEW_H22114
Type:multiple initiation site
Name:FUK_1
Description:fucokinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381670,454,595 - 70,454,655EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16q13-22.2(chr16:56883592-71279975)x3 copy number gain See cases [RCV000052405] Chr16:56883592..71279975 [GRCh38]
Chr16:56917504..71313878 [GRCh37]
Chr16:55475005..69871379 [NCBI36]
Chr16:16q13-22.2
pathogenic
GRCh38/hg38 16q21-23.1(chr16:58456122-74708723)x3 copy number gain See cases [RCV000052408] Chr16:58456122..74708723 [GRCh38]
Chr16:58490026..74742621 [GRCh37]
Chr16:57047527..73300122 [NCBI36]
Chr16:16q21-23.1
pathogenic
GRCh38/hg38 16q21-24.3(chr16:65313395-90081985)x3 copy number gain See cases [RCV000052421] Chr16:65313395..90081985 [GRCh38]
Chr16:65347298..90148393 [GRCh37]
Chr16:63904799..88675894 [NCBI36]
Chr16:16q21-24.3
pathogenic
GRCh38/hg38 16q22.1-23.1(chr16:69918076-76723348)x1 copy number loss See cases [RCV000053356] Chr16:69918076..76723348 [GRCh38]
Chr16:69951979..76757245 [GRCh37]
Chr16:68509480..75314746 [NCBI36]
Chr16:16q22.1-23.1
pathogenic
GRCh38/hg38 16q21-22.1(chr16:63318997-70555249)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053334]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053334]|See cases [RCV000053334] Chr16:63318997..70555249 [GRCh38]
Chr16:63352901..70589152 [GRCh37]
Chr16:61910402..69146653 [NCBI36]
Chr16:16q21-22.1
pathogenic
GRCh38/hg38 16q22.1-23.1(chr16:68698941-74353205)x1 copy number loss See cases [RCV000053337] Chr16:68698941..74353205 [GRCh38]
Chr16:68732844..74387103 [GRCh37]
Chr16:67290345..72944604 [NCBI36]
Chr16:16q22.1-23.1
pathogenic
NM_145059.3(FCSK):c.2221C>T (p.Arg741Ter) single nucleotide variant Congenital disorder of glycosylation with defective fucosylation 2 [RCV001332946] Chr16:70474855 [GRCh38]
Chr16:70508758 [GRCh37]
Chr16:16q22.1
likely pathogenic
GRCh38/hg38 16q22.1-24.1(chr16:70414573-84908120)x1 copy number loss See cases [RCV000133814] Chr16:70414573..84908120 [GRCh38]
Chr16:70448476..84941726 [GRCh37]
Chr16:69005977..83499227 [NCBI36]
Chr16:16q22.1-24.1
pathogenic
GRCh38/hg38 16q21-24.1(chr16:62925929-84585795)x3 copy number gain See cases [RCV000135863] Chr16:62925929..84585795 [GRCh38]
Chr16:62959833..84619401 [GRCh37]
Chr16:61517334..83176902 [NCBI36]
Chr16:16q21-24.1
pathogenic
GRCh38/hg38 16q22.1-22.2(chr16:69918076-71541872)x3 copy number gain See cases [RCV000137875] Chr16:69918076..71541872 [GRCh38]
Chr16:69951979..71575775 [GRCh37]
Chr16:68509480..70133276 [NCBI36]
Chr16:16q22.1-22.2
uncertain significance
GRCh38/hg38 16q21-24.3(chr16:65511483-90096995)x3 copy number gain See cases [RCV000139426] Chr16:65511483..90096995 [GRCh38]
Chr16:65545386..90163403 [GRCh37]
Chr16:64102887..88690904 [NCBI36]
Chr16:16q21-24.3
pathogenic
GRCh38/hg38 16q22.1-23.3(chr16:69053457-83274681)x3 copy number gain See cases [RCV000142038] Chr16:69053457..83274681 [GRCh38]
Chr16:69087360..83308286 [GRCh37]
Chr16:67644861..81865787 [NCBI36]
Chr16:16q22.1-23.3
pathogenic
GRCh38/hg38 16q21-24.3(chr16:64389378-90081985)x3 copy number gain See cases [RCV000142578] Chr16:64389378..90081985 [GRCh38]
Chr16:64423281..90148393 [GRCh37]
Chr16:62980782..88675894 [NCBI36]
Chr16:16q21-24.3
pathogenic|likely pathogenic
GRCh38/hg38 16q12.2-24.3(chr16:52899183-90088654)x3 copy number gain See cases [RCV000143425] Chr16:52899183..90088654 [GRCh38]
Chr16:52933095..90155062 [GRCh37]
Chr16:51490596..88682563 [NCBI36]
Chr16:16q12.2-24.3
pathogenic
GRCh38/hg38 16q21-23.3(chr16:65957829-83611443)x3 copy number gain See cases [RCV000143742] Chr16:65957829..83611443 [GRCh38]
Chr16:65991732..83645048 [GRCh37]
Chr16:64549233..82202549 [NCBI36]
Chr16:16q21-23.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Ductal breast carcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3
uncertain significance
NM_145059.3(FCSK):c.2980A>C (p.Lys994Gln) single nucleotide variant Congenital disorder of glycosylation with defective fucosylation 2 [RCV000757950] Chr16:70479230 [GRCh38]
Chr16:70513133 [GRCh37]
Chr16:16q22.1
pathogenic
GRCh37/hg19 16q12.2-22.2(chr16:55359026-70884455)x1 copy number loss Ductal breast carcinoma [RCV000207067] Chr16:55359026..70884455 [GRCh37]
Chr16:16q12.2-22.2
likely pathogenic|uncertain significance
Single allele complex Ductal breast carcinoma [RCV000207314] Chr16:56368689..90141355 [GRCh37]
Chr16:16q12.2-24.3
uncertain significance
NM_145059.3(FCSK):c.667T>C (p.Ser223Pro) single nucleotide variant Congenital disorder of glycosylation with defective fucosylation 2 [RCV000757948] Chr16:70468852 [GRCh38]
Chr16:70502755 [GRCh37]
Chr16:16q22.1
pathogenic|uncertain significance
NM_145059.3(FCSK):c.2047C>T (p.Arg683Cys) single nucleotide variant Congenital disorder of glycosylation with defective fucosylation 2 [RCV000757949] Chr16:70474586 [GRCh38]
Chr16:70508489 [GRCh37]
Chr16:16q22.1
pathogenic|uncertain significance
GRCh37/hg19 16q22.1(chr16:70024576-70673886)x3 copy number gain See cases [RCV000449413] Chr16:70024576..70673886 [GRCh37]
Chr16:16q22.1
uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3
pathogenic
GRCh37/hg19 16q22.1-22.2(chr16:70273406-70960990)x3 copy number gain See cases [RCV000446624] Chr16:70273406..70960990 [GRCh37]
Chr16:16q22.1-22.2
uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3
uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46455960-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626435] Chr16:46455960..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16q13-24.3(chr16:57051473-89797669)x3 copy number gain See cases [RCV000512511] Chr16:57051473..89797669 [GRCh37]
Chr16:16q13-24.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46497599-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626429] Chr16:46497599..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16q12.2-22.2(chr16:54416050-72453266)x3 copy number gain not provided [RCV000683820] Chr16:54416050..72453266 [GRCh37]
Chr16:16q12.2-22.2
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q22.1(chr16:70471827-70515915)x1 copy number loss not provided [RCV000751731] Chr16:70471827..70515915 [GRCh37]
Chr16:16q22.1
benign
NM_145059.3(FCSK):c.2314A>G (p.Thr772Ala) single nucleotide variant not provided [RCV000970018] Chr16:70474948 [GRCh38]
Chr16:70508851 [GRCh37]
Chr16:16q22.1
likely benign
NM_145059.3(FCSK):c.759G>A (p.Leu253=) single nucleotide variant not provided [RCV000967419] Chr16:70468944 [GRCh38]
Chr16:70502847 [GRCh37]
Chr16:16q22.1
benign
NM_145059.3(FCSK):c.12G>A (p.Pro4=) single nucleotide variant not provided [RCV000967418] Chr16:70463202 [GRCh38]
Chr16:70497105 [GRCh37]
Chr16:16q22.1
benign
NC_000016.9:g.(?_70286614)_(70669268_?)dup duplication Charcot-Marie-Tooth disease, type 2 [RCV000813323] Chr16:70252711..70635365 [GRCh38]
Chr16:70286614..70669268 [GRCh37]
Chr16:16q22.1
uncertain significance
GRCh37/hg19 16q22.1-22.2(chr16:70467293-71560136)x3 copy number gain not provided [RCV000848000] Chr16:70467293..71560136 [GRCh37]
Chr16:16q22.1-22.2
uncertain significance
NM_145059.3(FCSK):c.2581G>A (p.Val861Met) single nucleotide variant not provided [RCV000965332] Chr16:70475707 [GRCh38]
Chr16:70509610 [GRCh37]
Chr16:16q22.1
benign
GRCh37/hg19 16q22.1-22.2(chr16:70277618-70917102)x4 copy number gain not provided [RCV000845716] Chr16:70277618..70917102 [GRCh37]
Chr16:16q22.1-22.2
uncertain significance
GRCh37/hg19 16q22.1(chr16:70493170-70531886)x1 copy number loss not provided [RCV000849308] Chr16:70493170..70531886 [GRCh37]
Chr16:16q22.1
uncertain significance
GRCh37/hg19 16q22.1(chr16:70393149-70798654)x3 copy number gain not provided [RCV000847423] Chr16:70393149..70798654 [GRCh37]
Chr16:16q22.1
uncertain significance
NM_145059.3(FCSK):c.2572G>T (p.Ala858Ser) single nucleotide variant not specified [RCV001175524] Chr16:70475698 [GRCh38]
Chr16:70509601 [GRCh37]
Chr16:16q22.1
uncertain significance
NM_145059.3(FCSK):c.1579C>T (p.Arg527Cys) single nucleotide variant not specified [RCV001175523] Chr16:70473155 [GRCh38]
Chr16:70507058 [GRCh37]
Chr16:16q22.1
uncertain significance
NM_145059.3(FCSK):c.1071G>A (p.Glu357=) single nucleotide variant not provided [RCV000912912] Chr16:70470973 [GRCh38]
Chr16:70504876 [GRCh37]
Chr16:16q22.1
benign
GRCh37/hg19 16q22.1(chr16:70381448-70627356)x3 copy number gain not provided [RCV001006799] Chr16:70381448..70627356 [GRCh37]
Chr16:16q22.1
uncertain significance
GRCh37/hg19 16q21-24.3(chr16:61524229-90155062)x3 copy number gain not provided [RCV001249359] Chr16:61524229..90155062 [GRCh37]
Chr16:16q21-24.3
not provided
NC_000016.9:g.(?_70286614)_(70669268_?)dup duplication Charcot-Marie-Tooth disease, type 2 [RCV001304386] Chr16:70286614..70669268 [GRCh37]
Chr16:16q22.1
uncertain significance
NM_145059.3(FCSK):c.394G>C (p.Asp132His) single nucleotide variant Congenital disorder of glycosylation with defective fucosylation 2 [RCV001358679] Chr16:70466240 [GRCh38]
Chr16:70500143 [GRCh37]
Chr16:16q22.1
uncertain significance
NM_145059.3(FCSK):c.379C>A (p.Leu127Met) single nucleotide variant Congenital disorder of glycosylation with defective fucosylation 2 [RCV001358680] Chr16:70466225 [GRCh38]
Chr16:70500128 [GRCh37]
Chr16:16q22.1
uncertain significance
NM_145059.3(FCSK):c.1955C>T (p.Ala652Val) single nucleotide variant Congenital disorder of glycosylation with defective fucosylation 2 [RCV001332944] Chr16:70474306 [GRCh38]
Chr16:70508209 [GRCh37]
Chr16:16q22.1
uncertain significance
NM_145059.3(FCSK):c.2186A>G (p.Tyr729Cys) single nucleotide variant Congenital disorder of glycosylation with defective fucosylation 2 [RCV001332945] Chr16:70474820 [GRCh38]
Chr16:70508723 [GRCh37]
Chr16:16q22.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:29500 AgrOrtholog
COSMIC FCSK COSMIC
Ensembl Genes ENSG00000157353 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000288078 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000368192 UniProtKB/Swiss-Prot
  ENSP00000458483 UniProtKB/TrEMBL
  ENSP00000458622 UniProtKB/TrEMBL
  ENSP00000459168 UniProtKB/TrEMBL
  ENSP00000460484 UniProtKB/TrEMBL
  ENSP00000462584 UniProtKB/TrEMBL
  ENSP00000463088 UniProtKB/TrEMBL
Ensembl Transcript ENST00000288078 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000378912 UniProtKB/Swiss-Prot
  ENST00000464499 ENTREZGENE
  ENST00000498702 UniProtKB/TrEMBL
  ENST00000571514 UniProtKB/TrEMBL
  ENST00000572784 UniProtKB/TrEMBL
  ENST00000573352 UniProtKB/TrEMBL
  ENST00000574784 UniProtKB/TrEMBL
  ENST00000576453 UniProtKB/TrEMBL
Gene3D-CATH 3.30.230.10 UniProtKB/TrEMBL
GTEx ENSG00000157353 GTEx
HGNC ID HGNC:29500 ENTREZGENE
Human Proteome Map FCSK Human Proteome Map
InterPro Fucokinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GHMP_kinase_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GHMP_kinase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GHMP_kinase_N_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
KEGG Report hsa:197258 UniProtKB/Swiss-Prot
NCBI Gene 197258 ENTREZGENE
OMIM 608675 OMIM
  618324 OMIM
Pfam Fucokinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GHMP_kinases_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GHMP_kinases_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134863646 PharmGKB
Superfamily-SCOP SSF54211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55060 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt FCSK_HUMAN UniProtKB/Swiss-Prot
  I3L106_HUMAN UniProtKB/TrEMBL
  I3L171_HUMAN UniProtKB/TrEMBL
  I3L1X0_HUMAN UniProtKB/TrEMBL
  I3L3J1_HUMAN UniProtKB/TrEMBL
  J3KSP6_HUMAN UniProtKB/TrEMBL
  J3KTP6_HUMAN UniProtKB/TrEMBL
  Q8N0W3 ENTREZGENE
UniProt Secondary Q5PSM3 UniProtKB/Swiss-Prot
  Q5XKL6 UniProtKB/Swiss-Prot
  Q6ZRA0 UniProtKB/Swiss-Prot
  Q96MT9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 FCSK  fucose kinase  FUK  fucokinase  Symbol and/or name change 5135510 APPROVED