Piwil2 (piwi-like RNA-mediated gene silencing 2) - Rat Genome Database

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Gene: Piwil2 (piwi-like RNA-mediated gene silencing 2) Mus musculus
Analyze
Symbol: Piwil2
Name: piwi-like RNA-mediated gene silencing 2
RGD ID: 1315878
MGI Page MGI
Description: Enables RNA binding activity; RNA endonuclease activity; and polysome binding activity. Involved in several processes, including germ-line stem cell population maintenance; regulation of gene expression; and retrotransposon silencing. Acts upstream of with a positive effect on piRNA-mediated retrotransposon silencing by heterochromatin formation. Acts upstream of or within positive regulation of meiosis I. Located in several cellular components, including cytoplasmic ribonucleoprotein granule; dense body; and perinucleolar chromocenter. Part of PET complex. Is expressed in central nervous system; genitourinary system; and sensory organ. Orthologous to human PIWIL2 (piwi like RNA-mediated gene silencing 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: m; mili; Miwi like; Miwi likw; piwi like homolog 2; piwi-like homolog 2; piwi-like protein 2; Piwil1l
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,609,926 - 70,674,338 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,609,926 - 70,666,832 (-)EnsemblGRCm39 Ensembl
GRCm381470,372,477 - 70,436,898 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,372,477 - 70,429,383 (-)EnsemblGRCm38mm10GRCm38
MGSCv371470,772,287 - 70,828,901 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361469,107,560 - 69,164,174 (-)NCBIMGSCv36mm8
Celera1467,913,743 - 67,970,583 (-)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11279525   PMID:11578866   PMID:12466851   PMID:12477932   PMID:12906857   PMID:14516689   PMID:14736746  
PMID:16033648   PMID:16141072   PMID:16141073   PMID:16261612   PMID:16751777   PMID:16787967   PMID:17395546   PMID:17446352   PMID:18287559   PMID:18381894   PMID:18404146   PMID:18799693  
PMID:18922463   PMID:19114715   PMID:19345099   PMID:19345100   PMID:19465913   PMID:19584108   PMID:19730684   PMID:19735482   PMID:19735653   PMID:19898466   PMID:20011505   PMID:20014101  
PMID:20059948   PMID:20439430   PMID:20460113   PMID:20534472   PMID:20547853   PMID:21056461   PMID:21267068   PMID:21383078   PMID:21397847   PMID:21539824   PMID:21566194   PMID:21674058  
PMID:21677750   PMID:21873635   PMID:22020280   PMID:22110608   PMID:22360967   PMID:22628161   PMID:22842725   PMID:22902560   PMID:23132912   PMID:23364048   PMID:23401851   PMID:23611983  
PMID:23706823   PMID:23714778   PMID:23924633   PMID:24058407   PMID:24067652   PMID:24850856   PMID:25238487   PMID:25276231   PMID:25453759   PMID:25582775   PMID:25762440   PMID:26279574  
PMID:26669262   PMID:27655786   PMID:27856912   PMID:28115634   PMID:28254886   PMID:28378742   PMID:28461596   PMID:28530707   PMID:28633017   PMID:28903391   PMID:29437694   PMID:30193099  
PMID:30590800   PMID:30617251   PMID:30951587   PMID:31860668   PMID:31949138   PMID:32166374   PMID:32325033   PMID:32381626   PMID:32674113   PMID:34083437   PMID:34650118   PMID:34880491  
PMID:34912016   PMID:35679863   PMID:36472244   PMID:36473462   PMID:37641092  


Genomics

Comparative Map Data
Piwil2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,609,926 - 70,674,338 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,609,926 - 70,666,832 (-)EnsemblGRCm39 Ensembl
GRCm381470,372,477 - 70,436,898 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,372,477 - 70,429,383 (-)EnsemblGRCm38mm10GRCm38
MGSCv371470,772,287 - 70,828,901 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361469,107,560 - 69,164,174 (-)NCBIMGSCv36mm8
Celera1467,913,743 - 67,970,583 (-)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.32NCBI
PIWIL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38822,275,316 - 22,357,568 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl822,275,316 - 22,357,568 (+)EnsemblGRCh38hg38GRCh38
GRCh37822,132,829 - 22,215,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,188,796 - 22,269,545 (+)NCBINCBI36Build 36hg18NCBI36
Build 34822,188,800 - 22,269,529NCBI
Celera821,095,224 - 21,174,910 (+)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef820,675,010 - 20,755,706 (+)NCBIHuRef
CHM1_1822,334,485 - 22,415,561 (+)NCBICHM1_1
T2T-CHM13v2.0822,549,271 - 22,631,533 (+)NCBIT2T-CHM13v2.0
Piwil2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,841,104 - 51,907,729 (-)NCBIGRCr8
mRatBN7.21545,431,402 - 45,498,034 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,431,703 - 45,497,702 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,549,570 - 49,615,564 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,661,059 - 50,727,061 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,520,373 - 47,586,368 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01552,037,693 - 52,116,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,037,693 - 52,116,001 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,760,496 - 55,839,763 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,757,820 - 50,823,943 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,775,399 - 50,839,987 (-)NCBI
Celera1545,111,291 - 45,176,770 (-)NCBICelera
Cytogenetic Map15p11NCBI
Piwil2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540345,737,674 - 45,819,873 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540345,737,674 - 45,819,478 (+)NCBIChiLan1.0ChiLan1.0
PIWIL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2740,777,023 - 40,865,972 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1816,502,223 - 16,591,180 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0821,520,166 - 21,608,374 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1818,459,052 - 18,546,688 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,463,173 - 18,544,186 (+)Ensemblpanpan1.1panPan2
PIWIL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12534,911,120 - 34,987,287 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2534,912,358 - 34,987,339 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2535,501,009 - 35,577,016 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02535,122,157 - 35,198,747 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2535,123,395 - 35,198,755 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12535,068,198 - 35,144,239 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02534,922,162 - 34,998,398 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02535,077,336 - 35,153,884 (-)NCBIUU_Cfam_GSD_1.0
Piwil2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494312,435,718 - 12,493,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365556,078,681 - 6,133,020 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365556,078,681 - 6,133,184 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIWIL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl146,560,565 - 6,632,523 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1146,560,402 - 6,632,524 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2146,994,765 - 7,064,683 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIWIL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,347,998 - 20,436,016 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl820,352,771 - 20,433,947 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605221,799,635 - 21,889,513 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Piwil2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475817,834,191 - 17,902,575 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475817,834,268 - 17,911,886 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Piwil2
1743 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:659
Count of miRNA genes:432
Interacting mature miRNAs:507
Transcripts:ENSMUST00000048129
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse
14747006Mancz12_mmandible centroid size 12 (mouse)1470071977104071977Mouse

Markers in Region
Piwil2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14D2UniSTS
G65205  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14D2UniSTS
cM Map14 UniSTS
G65781  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381470,372,582 - 70,372,822UniSTSGRCm38
MGSCv371470,772,389 - 70,772,629UniSTSGRCm37
Celera1467,913,845 - 67,914,085UniSTS
Cytogenetic Map14D2UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000048129   ⟹   ENSMUSP00000047385
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,609,926 - 70,666,543 (-)Ensembl
GRCm38.p6 Ensembl1470,372,477 - 70,429,094 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226229   ⟹   ENSMUSP00000154615
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,648,583 - 70,666,832 (-)Ensembl
GRCm38.p6 Ensembl1470,411,134 - 70,429,383 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226426   ⟹   ENSMUSP00000154541
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,663,958 - 70,666,513 (-)Ensembl
GRCm38.p6 Ensembl1470,426,509 - 70,429,064 (-)Ensembl
RefSeq Acc Id: NM_001364321   ⟹   NP_001351250
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,609,926 - 70,674,338 (-)NCBI
GRCm381470,372,477 - 70,436,898 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021308   ⟹   NP_067283
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,609,926 - 70,666,557 (-)NCBI
GRCm381470,372,477 - 70,429,108 (-)NCBI
MGSCv371470,772,287 - 70,828,901 (-)RGD
Celera1467,913,743 - 67,970,583 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006519329   ⟹   XP_006519392
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,609,926 - 70,667,000 (-)NCBI
GRCm381470,372,477 - 70,429,528 (-)NCBI
Sequence:
RefSeq Acc Id: NP_067283   ⟸   NM_021308
- Peptide Label: isoform 1
- UniProtKB: Q99MV6 (UniProtKB/Swiss-Prot),   Q3TQE8 (UniProtKB/Swiss-Prot),   A6H617 (UniProtKB/Swiss-Prot),   Q9JMB6 (UniProtKB/Swiss-Prot),   Q8CDG1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006519392   ⟸   XM_006519329
- Peptide Label: isoform X1
- UniProtKB: Q99MV6 (UniProtKB/Swiss-Prot),   Q3TQE8 (UniProtKB/Swiss-Prot),   A6H617 (UniProtKB/Swiss-Prot),   Q9JMB6 (UniProtKB/Swiss-Prot),   Q8CDG1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001351250   ⟸   NM_001364321
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000047385   ⟸   ENSMUST00000048129
RefSeq Acc Id: ENSMUSP00000154615   ⟸   ENSMUST00000226229
RefSeq Acc Id: ENSMUSP00000154541   ⟸   ENSMUST00000226426
Protein Domains
PAZ   Piwi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CDG1-F1-model_v2 AlphaFold Q8CDG1 1-971 view protein structure

Promoters
RGD ID:8682904
Promoter ID:EPDNEW_M19483
Type:multiple initiation site
Name:Piwil2_1
Description:Mus musculus piwi-like RNA-mediated gene silencing 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381470,429,105 - 70,429,165EPDNEW
RGD ID:6824895
Promoter ID:MM_KWN:17380
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:ENSMUST00000104389,   NM_021308
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361470,828,626 - 70,829,126 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1930036 AgrOrtholog
Ensembl Genes ENSMUSG00000033644 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000048129 ENTREZGENE
  ENSMUST00000048129.6 UniProtKB/Swiss-Prot
  ENSMUST00000226229.2 UniProtKB/TrEMBL
  ENSMUST00000226426.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.10 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
  paz domain UniProtKB/Swiss-Prot
InterPro ArgoL1 UniProtKB/Swiss-Prot
  PAZ_dom UniProtKB/Swiss-Prot
  PAZ_dom_sf UniProtKB/Swiss-Prot
  Piwi UniProtKB/Swiss-Prot
  RNaseH-like_sf UniProtKB/Swiss-Prot
  RNaseH_sf UniProtKB/Swiss-Prot
KEGG Report mmu:57746 UniProtKB/Swiss-Prot
MGD MGI:1930036 ENTREZGENE
NCBI Gene 57746 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2C UniProtKB/Swiss-Prot
  PIWI-LIKE PROTEIN 2 UniProtKB/Swiss-Prot
Pfam ArgoL1 UniProtKB/Swiss-Prot
  PAZ UniProtKB/Swiss-Prot
  Piwi UniProtKB/Swiss-Prot
PhenoGen Piwil2 PhenoGen
PROSITE PAZ UniProtKB/Swiss-Prot
  PIWI UniProtKB/Swiss-Prot
SMART DUF1785 UniProtKB/Swiss-Prot
  PAZ UniProtKB/Swiss-Prot
  Piwi UniProtKB/Swiss-Prot
Superfamily-SCOP SSF101690 UniProtKB/Swiss-Prot
  SSF53098 UniProtKB/Swiss-Prot
UniProt A0A2I3BRD3_MOUSE UniProtKB/TrEMBL
  A0A2I3BRK1_MOUSE UniProtKB/TrEMBL
  A6H617 ENTREZGENE
  PIWL2_MOUSE UniProtKB/Swiss-Prot
  Q3TQE8 ENTREZGENE
  Q8CDG1 ENTREZGENE
  Q99MV6 ENTREZGENE
  Q9JMB6 ENTREZGENE
UniProt Secondary A6H617 UniProtKB/Swiss-Prot
  Q3TQE8 UniProtKB/Swiss-Prot
  Q99MV6 UniProtKB/Swiss-Prot
  Q9JMB6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-27 Piwil2  piwi-like RNA-mediated gene silencing 2    piwi-like homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED