Mblac1 (metallo-beta-lactamase domain containing 1) - Rat Genome Database

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Gene: Mblac1 (metallo-beta-lactamase domain containing 1) Mus musculus
Analyze
Symbol: Mblac1
Name: metallo-beta-lactamase domain containing 1
RGD ID: 1315827
MGI Page MGI
Description: Predicted to enable RNA endonuclease activity and metal ion binding activity. Predicted to be involved in histone mRNA metabolic process; mRNA 3'-end processing; and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in cytoplasm and nucleus. Orthologous to human MBLAC1 (metallo-beta-lactamase domain containing 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endoribonuclease MBLAC1; metallo-beta-lactamase domain-containing protein 1; MGC49416
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,192,576 - 138,193,883 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5138,192,576 - 138,193,883 (+)EnsemblGRCm39 Ensembl
GRCm385138,194,314 - 138,195,621 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,194,314 - 138,195,621 (+)EnsemblGRCm38mm10GRCm38
MGSCv375138,635,542 - 138,636,628 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365138,424,102 - 138,425,188 (+)NCBIMGSCv36mm8
Celera5135,173,822 - 135,174,908 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO,ISS)
cytosol  (IEA)
nucleus  (ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:18799693   PMID:29868674   PMID:37196079   PMID:38083729  


Genomics

Comparative Map Data
Mblac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,192,576 - 138,193,883 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5138,192,576 - 138,193,883 (+)EnsemblGRCm39 Ensembl
GRCm385138,194,314 - 138,195,621 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,194,314 - 138,195,621 (+)EnsemblGRCm38mm10GRCm38
MGSCv375138,635,542 - 138,636,628 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365138,424,102 - 138,425,188 (+)NCBIMGSCv36mm8
Celera5135,173,822 - 135,174,908 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.98NCBI
MBLAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,126,967 - 100,128,495 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,126,785 - 100,128,495 (+)EnsemblGRCh38hg38GRCh38
GRCh37799,724,590 - 99,726,118 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,562,253 - 99,564,057 (+)NCBINCBI36Build 36hg18NCBI36
Celera794,459,580 - 94,461,384 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,359,423 - 94,361,227 (+)NCBIHuRef
CHM1_1799,654,463 - 99,656,267 (+)NCBICHM1_1
T2T-CHM13v2.07101,366,818 - 101,368,346 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,084,436 - 99,086,240 (+)NCBI
Mblac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81222,185,142 - 22,186,404 (+)NCBIGRCr8
mRatBN7.21217,071,465 - 17,072,736 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1217,071,465 - 17,072,735 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,894,823 - 17,896,085 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,518,568 - 18,519,830 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,571,974 - 17,573,236 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,335,841 - 19,337,103 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,335,841 - 19,337,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,393,471 - 21,394,733 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41217,636,473 - 17,637,735 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11217,625,994 - 17,627,256 (+)NCBI
Celera1219,001,603 - 19,002,865 (+)NCBICelera
Cytogenetic Map12q11NCBI
Mblac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573745,202 - 747,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955573745,202 - 747,402 (-)NCBIChiLan1.0ChiLan1.0
MBLAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26118,045,877 - 118,047,865 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,310,931 - 166,312,516 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0792,162,025 - 92,163,678 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17105,595,134 - 105,596,884 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,595,781 - 105,596,582 (+)Ensemblpanpan1.1panPan2
MBLAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,473,599 - 9,475,162 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,473,135 - 9,474,613 (-)NCBICanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,473,135 - 9,474,613 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.069,410,568 - 9,412,132 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,409,550 - 9,416,597 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.169,259,889 - 9,261,451 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.069,240,209 - 9,241,773 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,419,790 - 9,421,354 (-)NCBIUU_Cfam_GSD_1.0
Mblac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,773,460 - 133,774,737 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543262,033 - 262,848 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936543261,294 - 263,789 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MBLAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,031,835 - 8,033,484 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,029,776 - 8,033,492 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MBLAC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,950,091 - 12,951,859 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,950,389 - 12,951,189 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,321,031 - 3,322,822 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mblac1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,870,789 - 16,871,574 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,870,490 - 16,871,646 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mblac1
71 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:142
Interacting mature miRNAs:148
Transcripts:ENSMUST00000057773
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
13464143Bbaa2b_mB.burgdorferi-associated arthritis 2b (mouse)5133052969140709801Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse

Markers in Region
AI314927  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385138,195,269 - 138,195,350UniSTSGRCm38
MGSCv375138,636,497 - 138,636,578UniSTSGRCm37
Celera5135,174,777 - 135,174,858UniSTS
Cytogenetic Map5G2UniSTS
Whitehead/MRC_RH51670.77UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000057773   ⟹   ENSMUSP00000052869
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5138,192,576 - 138,193,883 (+)Ensembl
GRCm38.p6 Ensembl5138,194,314 - 138,195,621 (+)Ensembl
RefSeq Acc Id: NM_177878   ⟹   NP_808546
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395138,192,576 - 138,193,883 (+)NCBI
GRCm385138,194,314 - 138,195,621 (+)ENTREZGENE
MGSCv375138,635,542 - 138,636,628 (+)RGD
Celera5135,173,822 - 135,175,129 (+)ENTREZGENE
cM Map5 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_808546 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH38925 (Get FASTA)   NCBI Sequence Viewer  
  BAC33723 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000052869
  ENSMUSP00000052869.5
GenBank Protein Q8BWY4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_808546   ⟸   NM_177878
- UniProtKB: Q8CHU7 (UniProtKB/Swiss-Prot),   Q8BWY4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000052869   ⟸   ENSMUST00000057773

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BWY4-F1-model_v2 AlphaFold Q8BWY4 1-260 view protein structure

Promoters
RGD ID:6888508
Promoter ID:EPDNEW_M7705
Type:multiple initiation site
Name:Mblac1_1
Description:Mus musculus metallo-beta-lactamase domain containing 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385138,194,288 - 138,194,348EPDNEW
RGD ID:6837868
Promoter ID:MM_KWN:44546
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_177878
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365138,635,096 - 138,636,247 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2679717 AgrOrtholog
Ensembl Genes ENSMUSG00000049285 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000057773 ENTREZGENE
  ENSMUST00000057773.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.15.10 UniProtKB/Swiss-Prot
InterPro MBLAC1 UniProtKB/Swiss-Prot
  Metallo-B-lactamas UniProtKB/Swiss-Prot
  RibonucZ/Hydroxyglut_hydro UniProtKB/Swiss-Prot
KEGG Report mmu:330216 UniProtKB/Swiss-Prot
MGD MGI:2679717 ENTREZGENE
NCBI Gene 330216 ENTREZGENE
PANTHER METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR23200 UniProtKB/Swiss-Prot
Pfam Lactamase_B UniProtKB/Swiss-Prot
PhenoGen Mblac1 PhenoGen
SMART Lactamase_B UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56281 UniProtKB/Swiss-Prot
UniProt MBLC1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8CHU7 ENTREZGENE
UniProt Secondary Q8CHU7 UniProtKB/Swiss-Prot