Grap (GRB2-related adaptor protein) - Rat Genome Database
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Gene: Grap (GRB2-related adaptor protein) Mus musculus
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Symbol: Grap
Name: GRB2-related adaptor protein
RGD ID: 1315754
MGI Page MGI
Description: Predicted to be involved in sensory perception of sound. Predicted to localize to membrane and synapse. Is expressed in cochlea; liver; lung; metanephros; and nervous system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 114. Orthologous to several human genes including GRAP (GRB2 related adaptor protein); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 8430435N19Rik; BB233594; GRB2-related adapter protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,544,081 - 61,563,610 (+)NCBIGRCm39mm39
GRCm381161,653,321 - 61,672,777 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,653,265 - 61,672,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv371161,466,823 - 61,486,279 (+)NCBIGRCm37mm9NCBIm37
MGSCv361162,082,523 - 62,101,842 (+)NCBImm8
MGSCv361161,469,516 - 61,488,972 (+)NCBImm8
Cytogenetic Map11B2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell junction  (IEA)
membrane  (IEA)
synapse  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11971956   PMID:12477932   PMID:15174222   PMID:15456754   PMID:16141072   PMID:16141073   PMID:19836472   PMID:21267068   PMID:21677750  
PMID:30610177  


Genomics

Comparative Map Data
Grap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,544,081 - 61,563,610 (+)NCBIGRCm39mm39
GRCm381161,653,321 - 61,672,777 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,653,265 - 61,672,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv371161,466,823 - 61,486,279 (+)NCBIGRCm37mm9NCBIm37
MGSCv361162,082,523 - 62,101,842 (+)NCBImm8
MGSCv361161,469,516 - 61,488,972 (+)NCBImm8
Cytogenetic Map11B2NCBI
GRAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1719,020,656 - 19,047,011 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1719,020,673 - 19,047,637 (-)EnsemblGRCh38hg38GRCh38
GRCh381719,020,656 - 19,046,957 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371718,923,969 - 18,950,270 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371718,923,969 - 18,950,336 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361718,864,715 - 18,891,061 (-)NCBINCBI36hg18NCBI36
Build 341718,864,714 - 18,891,061NCBI
Cytogenetic Map17p11.2NCBI
HuRef1718,491,292 - 18,506,704 (-)NCBIHuRef
CHM1_11718,932,781 - 18,959,175 (-)NCBICHM1_1
Grap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21046,298,965 - 46,352,057 (+)NCBI
Rnor_6.0 Ensembl1047,930,633 - 47,949,773 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01047,930,633 - 47,949,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01047,723,737 - 47,742,916 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,812,362 - 47,831,473 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11047,825,984 - 47,845,096 (+)NCBI
Celera1045,584,426 - 45,600,140 (+)NCBICelera
Cytogenetic Map10q22NCBI
Grap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955467559,397 - 581,098 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955467559,411 - 581,098 (+)NCBIChiLan1.0ChiLan1.0
LOC100983443
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11737,038,113 - 37,152,052 (+)NCBIpanpan1.1PanPan1.1panPan2
LOC489534
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,014,193 - 41,038,965 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC101971396
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936881580,713 - 607,553 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,260,981 - 60,281,884 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,261,560 - 60,281,886 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21262,817,467 - 62,974,589 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103242505
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11617,721,294 - 17,747,366 (-)NCBI
ChlSab1.1 Ensembl1617,720,269 - 17,747,319 (-)Ensembl
Grap
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248495,441,806 - 5,468,300 (-)NCBI

Position Markers
BB247706  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381161,672,631 - 61,672,717UniSTSGRCm38
MGSCv371161,486,133 - 61,486,219UniSTSGRCm37
Cytogenetic Map11B2UniSTS
Whitehead/MRC_RH11825.15UniSTS
BB233594  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381161,672,624 - 61,672,717UniSTSGRCm38
MGSCv371161,486,126 - 61,486,219UniSTSGRCm37
Cytogenetic Map11B2UniSTS
Whitehead/MRC_RH11825.15UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11330000063000000Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111160000068600000Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111180000066100000Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1231863768609504Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111231863768609504Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111231863768609504Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1231863768609504Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1231863768609504Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111231863768609504Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1231863768609504Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1231863768609504Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1231863768609504Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111231863768609504Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111231863768609504Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111231863769794121Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111710617567187585Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111783196668609504Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112827504662275149Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112867832062678320Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112881775462817873Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113111738265117382Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113220975066209867Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113568778969794161Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5417484463428696Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115417484467187585Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115419011565213015Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115936579169591873Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:531
Count of miRNA genes:358
Interacting mature miRNAs:431
Transcripts:ENSMUST00000004959, ENSMUST00000155380
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000004959   ⟹   ENSMUSP00000004959
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1161,653,265 - 61,672,784 (+)Ensembl
RefSeq Acc Id: ENSMUST00000155380
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1161,669,046 - 61,669,880 (+)Ensembl
RefSeq Acc Id: NM_027817   ⟹   NP_082093
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391161,544,147 - 61,563,603 (+)NCBI
GRCm381161,653,321 - 61,672,777 (+)ENTREZGENE
MGSCv371161,466,823 - 61,486,279 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036156992   ⟹   XP_036012885
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391161,544,081 - 61,563,610 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_082093   ⟸   NM_027817
- UniProtKB: Q9CX99 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000004959   ⟸   ENSMUST00000004959
RefSeq Acc Id: XP_036012885   ⟸   XM_036156992
- Peptide Label: isoform X1
Protein Domains
SH2   SH3

Promoters
RGD ID:6821015
Promoter ID:MM_KWN:7786
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:OTTMUST00000012997
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361161,466,569 - 61,467,069 (+)MPROMDB
RGD ID:6821014
Promoter ID:MM_KWN:7787
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000012998
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361161,482,436 - 61,482,936 (+)MPROMDB
RGD ID:8674942
Promoter ID:EPDNEW_M15501
Type:initiation region
Name:Grap_1
Description:Mus musculus GRB2-related adaptor protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381161,653,307 - 61,653,367EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1918770 AgrOrtholog
Ensembl Genes ENSMUSG00000004837 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000004959 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000004959 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
InterPro GRAP_N_SH3 UniProtKB/Swiss-Prot
  Grb2-like UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report mmu:71520 UniProtKB/Swiss-Prot
MGD MGI:1918770 ENTREZGENE
NCBI Gene 71520 ENTREZGENE
PANTHER PTHR46037 UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
  SH3_2 UniProtKB/Swiss-Prot
PhenoGen Grap PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
SMART SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt GRAP_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q0VBE3 UniProtKB/Swiss-Prot
  Q3U545 UniProtKB/Swiss-Prot