Il36a (interleukin 36A) - Rat Genome Database

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Gene: Il36a (interleukin 36A) Mus musculus
Analyze
Symbol: Il36a
Name: interleukin 36A
RGD ID: 1315733
MGI Page MGI
Description: Enables cytokine activity. Acts upstream of or within positive regulation of interleukin-6 production and signal transduction. Located in extracellular space. Orthologous to human IL36A (interleukin 36 alpha).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fi; Fil; Fil1; FIL1 epsilon; Fil1epsilon; If36a; IL-1; IL-1 epsilon; IL-1F6; IL-1H1; Il1f6; Il1f9; IL1RP2; interleukin 1 family, member 6 (epsilon); interleukin 1 family, member 9; interleukin-1 epsilon; interleukin-1 family member 6; interleukin-1 homolog 1; interleukin-36 alpha; MGC151479; MGC151481
RGD Orthologs
Human
Rat
Bonobo
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,105,429 - 24,115,713 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,105,430 - 24,115,714 (+)EnsemblGRCm39 Ensembl
GRCm38224,215,417 - 24,225,701 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,215,418 - 24,225,702 (+)EnsemblGRCm38mm10GRCm38
MGSCv37224,070,937 - 24,081,221 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36224,037,426 - 24,047,710 (+)NCBIMGSCv36mm8
Celera223,934,862 - 23,945,148 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10625660   PMID:10744718   PMID:11042159   PMID:11076861   PMID:11466363   PMID:11991723   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16896013   PMID:19571816  
PMID:19717513   PMID:20101239   PMID:20833839   PMID:21242515   PMID:21860022   PMID:21873635   PMID:21965679   PMID:23029241   PMID:24829417   PMID:26066982   PMID:26203636   PMID:26438362  
PMID:26813344   PMID:28057979   PMID:28724920   PMID:29109726   PMID:29279353   PMID:29794016   PMID:30352688   PMID:31068441   PMID:31884525   PMID:31982702   PMID:32488871   PMID:33645549  
PMID:34555640   PMID:34686582   PMID:34697411   PMID:38412100  


Genomics

Comparative Map Data
Il36a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,105,429 - 24,115,713 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,105,430 - 24,115,714 (+)EnsemblGRCm39 Ensembl
GRCm38224,215,417 - 24,225,701 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,215,418 - 24,225,702 (+)EnsemblGRCm38mm10GRCm38
MGSCv37224,070,937 - 24,081,221 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36224,037,426 - 24,047,710 (+)NCBIMGSCv36mm8
Celera223,934,862 - 23,945,148 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.26NCBI
IL36A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,005,459 - 113,011,072 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2113,005,459 - 113,008,044 (+)EnsemblGRCh38hg38GRCh38
GRCh372113,763,036 - 113,765,621 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,479,920 - 113,482,092 (+)NCBINCBI36Build 36hg18NCBI36
Build 342113,479,679 - 113,481,852NCBI
Celera2107,148,610 - 107,150,782 (+)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2106,218,002 - 106,220,174 (+)NCBIHuRef
CHM1_12113,767,604 - 113,769,776 (+)NCBICHM1_1
T2T-CHM13v2.02113,431,988 - 113,437,599 (+)NCBIT2T-CHM13v2.0
Il36a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8327,395,146 - 27,399,695 (+)NCBIGRCr8
mRatBN7.236,996,851 - 7,001,400 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl36,996,851 - 7,001,400 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx310,091,850 - 10,096,462 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0318,678,075 - 18,682,687 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0316,867,882 - 16,872,494 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.031,330,790 - 1,335,811 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,331,226 - 1,335,775 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.031,323,993 - 1,328,542 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.432,482,480 - 2,487,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.132,473,610 - 2,485,996 (+)NCBI
Celera31,834,196 - 1,838,742 (+)NCBICelera
Cytogenetic Map3p13NCBI
IL36A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21215,143,627 - 15,157,101 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A15,146,393 - 15,151,862 (-)NCBINHGRI_mPanPan1
Il36a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,474,970 - 82,476,974 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367831,369,537 - 1,371,458 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367831,369,454 - 1,371,458 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL36A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11416,017,847 - 16,030,680 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1416,028,002 - 16,030,097 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660803,651,138 - 3,653,829 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Il36a
244 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:238
Count of miRNA genes:143
Interacting mature miRNAs:154
Transcripts:ENSMUST00000028361, ENSMUST00000144442
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141836Tgq11_mtriglyceride QTL 11 (mouse)Not determined125324559Mouse
4142333Tgq10_mtriglyceride QTL 10 (mouse)Not determined125324559Mouse
1301838Sluc16_msusceptibility to lung cancer 16 (mouse)Not determined2126529589Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323494028179150Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
12903993Opfaq1_mopen field activity QTL 1 (mouse)2967669127022642Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000028361   ⟹   ENSMUSP00000028361
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,105,430 - 24,115,714 (+)Ensembl
GRCm38.p6 Ensembl224,215,418 - 24,225,702 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144442
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl224,105,517 - 24,115,537 (+)Ensembl
GRCm38.p6 Ensembl224,215,505 - 24,225,525 (+)Ensembl
RefSeq Acc Id: NM_019450   ⟹   NP_062323
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39224,105,429 - 24,115,713 (+)NCBI
GRCm38224,215,417 - 24,225,701 (+)ENTREZGENE
MGSCv37224,070,937 - 24,081,221 (+)RGD
Celera223,934,862 - 23,945,148 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_062323   ⟸   NM_019450
- UniProtKB: Q9JLA2 (UniProtKB/Swiss-Prot),   Q149U6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000028361   ⟸   ENSMUST00000028361

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLA2-F1-model_v2 AlphaFold Q9JLA2 1-160 view protein structure

Promoters
RGD ID:6876510
Promoter ID:EPDNEW_M1705
Type:single initiation site
Name:Il1f6_1
Description:Mus musculus interleukin 1 family, member 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38224,215,472 - 24,215,532EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1859324 AgrOrtholog
Ensembl Genes ENSMUSG00000026984 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028361 ENTREZGENE
  ENSMUST00000028361.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IL-1_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-1RA/IL-36 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:54448 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1859324 ENTREZGENE
NCBI Gene 54448 ENTREZGENE
PANTHER PTHR10078 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10078:SF25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il36a PhenoGen
PRINTS INTRLEUKIN1X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2SSZ4_MOUSE UniProtKB/TrEMBL
  IL36A_MOUSE UniProtKB/Swiss-Prot
  Q149U6 ENTREZGENE, UniProtKB/TrEMBL
  Q9JLA2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-28 Il36a  interleukin 36A  Il1f6  interleukin 1 family, member 6  Symbol and/or name updated 27372883 PROVISIONAL