CD34 (CD34 molecule) - Rat Genome Database
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Gene: CD34 (CD34 molecule) Homo sapiens
Analyze
Symbol: CD34
Name: CD34 molecule
RGD ID: 1315723
HGNC Page HGNC
Description: Exhibits carbohydrate binding activity and transcription factor binding activity. Involved in several processes, including blood vessel development; positive regulation of vasculature development; and regulation of cytokine production. Localizes to external side of plasma membrane; intercellular bridge; and perinuclear region of cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD34 antigen; hematopoietic progenitor cell antigen CD34
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1207,880,972 - 207,911,402 (-)EnsemblGRCh38hg38GRCh38
GRCh381207,880,972 - 207,911,125 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371208,059,883 - 208,084,742 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361206,126,506 - 206,151,306 (-)NCBINCBI36hg18NCBI36
Build 341204,448,278 - 204,472,910NCBI
Celera1181,290,338 - 181,315,139 (-)NCBI
Cytogenetic Map1q32.2NCBI
HuRef1178,734,078 - 178,758,883 (-)NCBIHuRef
CHM1_11209,332,232 - 209,357,037 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
aminoguanidine  (EXP)
antimycin A  (ISO)
antirheumatic drug  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
asbestos  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (ISO)
carbon nanotube  (ISO)
chloroquine  (ISO)
choline  (ISO)
chrysene  (ISO)
clothianidin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
daunorubicin  (ISO)
DDT  (ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
dioxygen  (EXP)
diuron  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
erythromycin A  (EXP)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
isotretinoin  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
maneb  (ISO)
melphalan  (EXP)
nickel atom  (EXP)
paracetamol  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
prednisolone  (EXP)
Quinupristin-dalfopristin  (EXP)
rotenone  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sunitinib  (ISO)
tetraphene  (ISO)
triclosan  (EXP)
valproic acid  (ISO)
valsartan  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell adhesion  (IEA)
cell motility  (IEP)
cell-cell adhesion  (IDA)
cell-matrix adhesion  (IBA)
endothelial cell proliferation  (IDA)
endothelium development  (IEP)
extracellular exosome assembly  (IDA)
glomerular endothelium development  (IEP)
glomerular filtration  (IEP)
hematopoietic stem cell proliferation  (IMP)
hemopoiesis  (IMP)
leukocyte migration  (ISS)
mesangial cell-matrix adhesion  (ISS)
metanephric glomerular mesangial cell differentiation  (IEP)
negative regulation of blood coagulation  (IDA)
negative regulation of cellular response to heat  (IDA)
negative regulation of cellular response to hypoxia  (IDA)
negative regulation of gene expression  (IMP)
negative regulation of interleukin-2 production  (IMP)
negative regulation of neuron death  (IDA)
negative regulation of nitric oxide biosynthetic process  (IDA)
negative regulation of tumor necrosis factor production  (IDA)
paracrine signaling  (IDA)
positive regulation of angiogenesis  (IDA)
positive regulation of gene expression  (IEP)
positive regulation of glial cell-derived neurotrophic factor production  (IDA)
positive regulation of granulocyte colony-stimulating factor production  (IDA,IEP)
positive regulation of interleukin-10 production  (IDA)
positive regulation of odontogenesis  (IDA)
positive regulation of transforming growth factor beta production  (IDA)
positive regulation of vasculogenesis  (IDA)
regulation of blood pressure  (IDA)
regulation of immune response  (TAS)
signal transduction  (IEP)
stem cell proliferation  (IEP)
tissue homeostasis  (IDA)
transdifferentiation  (IEP)
vascular wound healing  (IEP)

Molecular Function

References

Additional References at PubMed
PMID:1370171   PMID:1374051   PMID:1693532   PMID:1694174   PMID:1868864   PMID:2462139   PMID:7525669   PMID:7678811   PMID:8541536   PMID:8547678   PMID:8889549   PMID:9042286  
PMID:9108388   PMID:9780190   PMID:9815891   PMID:10233696   PMID:10330415   PMID:10337918   PMID:10648383   PMID:11389015   PMID:11757722   PMID:11782553   PMID:11798512   PMID:11983914  
PMID:12091359   PMID:12161354   PMID:12215337   PMID:12393582   PMID:12393633   PMID:12393741   PMID:12477932   PMID:12588680   PMID:12827650   PMID:12865405   PMID:12883699   PMID:12939361  
PMID:14702039   PMID:14718574   PMID:14744088   PMID:15063762   PMID:15242879   PMID:15246162   PMID:15249540   PMID:15254762   PMID:15277701   PMID:15489334   PMID:15536192   PMID:15569991  
PMID:15704650   PMID:15735742   PMID:15752760   PMID:15941859   PMID:15969628   PMID:15996935   PMID:16051386   PMID:16133360   PMID:16133456   PMID:16278377   PMID:16286998   PMID:16305332  
PMID:16398042   PMID:16415795   PMID:16439688   PMID:16552335   PMID:16557578   PMID:16698686   PMID:16698689   PMID:16710414   PMID:16830365   PMID:17038503   PMID:17077283   PMID:17090657  
PMID:17095623   PMID:17185613   PMID:17229904   PMID:17253947   PMID:17261663   PMID:17310847   PMID:17429142   PMID:17449014   PMID:17464107   PMID:17474795   PMID:17505307   PMID:17511030  
PMID:17656039   PMID:17786144   PMID:17880611   PMID:17885669   PMID:17923501   PMID:17959862   PMID:18025805   PMID:18048043   PMID:18054528   PMID:18061957   PMID:18085638   PMID:18088553  
PMID:18092954   PMID:18187924   PMID:18190781   PMID:18218912   PMID:18223188   PMID:18231114   PMID:18292296   PMID:18317882   PMID:18371060   PMID:18402976   PMID:18410526   PMID:18436865  
PMID:18511598   PMID:18555590   PMID:18562079   PMID:18604736   PMID:18683236   PMID:18698330   PMID:18757300   PMID:18760838   PMID:18798798   PMID:18813945   PMID:18822690   PMID:18842716  
PMID:18922853   PMID:18985821   PMID:19043799   PMID:19157505   PMID:19194276   PMID:19226222   PMID:19244164   PMID:19245435   PMID:19323831   PMID:19340613   PMID:19372622   PMID:19383239  
PMID:19406403   PMID:19421145   PMID:19437324   PMID:19535348   PMID:19640275   PMID:19644143   PMID:19661015   PMID:19746588   PMID:19746591   PMID:19753521   PMID:19762535   PMID:19817957  
PMID:19855080   PMID:19952356   PMID:20028384   PMID:20038636   PMID:20067819   PMID:20175958   PMID:20181261   PMID:20232575   PMID:20353905   PMID:20354148   PMID:20356686   PMID:20378847  
PMID:20379614   PMID:20388788   PMID:20403242   PMID:20431906   PMID:20479285   PMID:20559119   PMID:20601304   PMID:20639392   PMID:20653822   PMID:20675279   PMID:20702587   PMID:20724541  
PMID:20819778   PMID:20821344   PMID:21054781   PMID:21078695   PMID:21206086   PMID:21238532   PMID:21276080   PMID:21308741   PMID:21318598   PMID:21330325   PMID:21330473   PMID:21333372  
PMID:21364636   PMID:21367453   PMID:21435112   PMID:21440782   PMID:21457155   PMID:21488087   PMID:21527751   PMID:21559522   PMID:21640411   PMID:21651317   PMID:21670473   PMID:21674250  
PMID:21700895   PMID:21710717   PMID:21737787   PMID:21762201   PMID:21808991   PMID:21808992   PMID:21835908   PMID:21873635   PMID:21873977   PMID:21884210   PMID:21933861   PMID:22009965  
PMID:22025365   PMID:22084125   PMID:22118372   PMID:22163120   PMID:22199261   PMID:22233112   PMID:22249946   PMID:22372906   PMID:22395498   PMID:22448926   PMID:22499302   PMID:22547906  
PMID:22574784   PMID:22581926   PMID:22775584   PMID:22862965   PMID:22952296   PMID:22980580   PMID:23171577   PMID:23230080   PMID:23233446   PMID:23301033   PMID:23326517   PMID:23327923  
PMID:23349299   PMID:23473998   PMID:23509738   PMID:23529663   PMID:23554290   PMID:23583979   PMID:23625296   PMID:23640491   PMID:23645504   PMID:23653235   PMID:23656194   PMID:23696920  
PMID:23701943   PMID:23706103   PMID:23772632   PMID:23794425   PMID:23803010   PMID:23838926   PMID:23899963   PMID:23995573   PMID:24030420   PMID:24036614   PMID:24281022   PMID:24335569  
PMID:24364465   PMID:24466138   PMID:24507660   PMID:24664166   PMID:24715164   PMID:24717877   PMID:24826895   PMID:24846193   PMID:24855276   PMID:24884314   PMID:24912771   PMID:24968096  
PMID:25043745   PMID:25136078   PMID:25149387   PMID:25204042   PMID:25344690   PMID:25352641   PMID:25357219   PMID:25436985   PMID:25446160   PMID:25538041   PMID:25542764   PMID:25658015  
PMID:25804236   PMID:25879558   PMID:25921136   PMID:25957287   PMID:26108791   PMID:26109814   PMID:26193208   PMID:26323448   PMID:26394034   PMID:26617768   PMID:26617797   PMID:26625754  
PMID:26626992   PMID:26676225   PMID:26769093   PMID:26861446   PMID:26886640   PMID:26930650   PMID:27043316   PMID:27175552   PMID:27341002   PMID:27344285   PMID:27384731   PMID:27491607  
PMID:27503021   PMID:27745787   PMID:27837456   PMID:27993871   PMID:28062497   PMID:28096094   PMID:28110587   PMID:28282559   PMID:28298297   PMID:28552539   PMID:28669578   PMID:28832078  
PMID:28880435   PMID:28948378   PMID:29063331   PMID:29567882   PMID:29630085   PMID:29745079   PMID:29761851   PMID:29951828   PMID:30197335   PMID:30259659   PMID:30320623   PMID:30587636  
PMID:30695751   PMID:31113468   PMID:31320669   PMID:31395804   PMID:31490235   PMID:31509041   PMID:32007660   PMID:32175898   PMID:32272124   PMID:32293340   PMID:32296183   PMID:32349717  
PMID:32422232   PMID:32435886   PMID:32810787  


Genomics

Comparative Map Data
CD34
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1207,880,972 - 207,911,402 (-)EnsemblGRCh38hg38GRCh38
GRCh381207,880,972 - 207,911,125 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371208,059,883 - 208,084,742 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361206,126,506 - 206,151,306 (-)NCBINCBI36hg18NCBI36
Build 341204,448,278 - 204,472,910NCBI
Celera1181,290,338 - 181,315,139 (-)NCBI
Cytogenetic Map1q32.2NCBI
HuRef1178,734,078 - 178,758,883 (-)NCBIHuRef
CHM1_11209,332,232 - 209,357,037 (-)NCBICHM1_1
Cd34
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,621,129 - 194,643,600 (+)NCBIGRCm39mm39
GRCm381194,938,821 - 194,961,292 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,938,819 - 194,961,279 (+)EnsemblGRCm38mm10GRCm38
MGSCv371196,765,015 - 196,787,486 (+)NCBIGRCm37mm9NCBIm37
MGSCv361196,639,632 - 196,662,003 (+)NCBImm8
Celera1201,838,605 - 201,861,076 (+)NCBICelera
Cytogenetic Map1H6NCBI
cM Map198.38NCBI
Cd34
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.013113,691,842 - 113,711,259 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13113,691,932 - 113,711,647 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013118,531,837 - 118,551,216 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413110,877,594 - 110,896,722 (+)NCBIRGSC3.4rn4RGSC3.4
Celera13105,904,553 - 105,923,681 (+)NCBICelera
Cytogenetic Map13q27NCBI
Cd34
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540643,117,816 - 43,130,463 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540643,116,688 - 43,130,405 (-)NCBIChiLan1.0ChiLan1.0
CD34
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11188,272,551 - 188,297,384 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1188,272,551 - 188,297,384 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01183,459,028 - 183,489,583 (-)NCBIMhudiblu_PPA_v0panPan3
CD34
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl76,734,363 - 6,748,581 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.176,734,363 - 6,747,991 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cd34
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365575,030,788 - 5,051,864 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD34
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9134,913,121 - 134,937,762 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19134,912,793 - 134,937,763 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29148,445,995 - 148,470,638 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD34
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12521,534,969 - 21,559,951 (+)NCBI
ChlSab1.1 Ensembl2521,534,983 - 21,561,215 (+)Ensembl
Cd34
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248073,936,043 - 3,958,274 (+)NCBI

Position Markers
G60378  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371208,060,085 - 208,060,383UniSTSGRCh37
Build 361206,126,708 - 206,127,006RGDNCBI36
Celera1181,290,540 - 181,290,838RGD
Cytogenetic Map1q32.2UniSTS
Cytogenetic Map1q32UniSTS
HuRef1178,734,280 - 178,734,578UniSTS
TNG Radiation Hybrid Map1102501.0UniSTS
SHGC-112283  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371208,073,586 - 208,073,925UniSTSGRCh37
Build 361206,140,209 - 206,140,548RGDNCBI36
Celera1181,304,041 - 181,304,380RGD
Cytogenetic Map1q32UniSTS
HuRef1178,747,785 - 178,748,124UniSTS
TNG Radiation Hybrid MapX14074.0UniSTS
PMC110554P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371208,059,988 - 208,060,879UniSTSGRCh37
Build 361206,126,611 - 206,127,502RGDNCBI36
Celera1181,290,443 - 181,291,334RGD
Cytogenetic Map1q32.2UniSTS
Cytogenetic Map1q32UniSTS
HuRef1178,734,183 - 178,735,074UniSTS
PMC110554P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371208,060,492 - 208,061,260UniSTSGRCh37
Build 361206,127,115 - 206,127,883RGDNCBI36
Celera1181,290,947 - 181,291,715RGD
Cytogenetic Map1q32UniSTS
HuRef1178,734,687 - 178,735,455UniSTS
CD34_304  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371208,059,857 - 208,060,718UniSTSGRCh37
Build 361206,126,480 - 206,127,341RGDNCBI36
Celera1181,290,312 - 181,291,173RGD
HuRef1178,734,052 - 178,734,913UniSTS
RH69685  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371208,059,985 - 208,060,107UniSTSGRCh37
Build 361206,126,608 - 206,126,730RGDNCBI36
Celera1181,290,440 - 181,290,562RGD
Cytogenetic Map1q32.2UniSTS
Cytogenetic Map1q32UniSTS
HuRef1178,734,180 - 178,734,302UniSTS
GeneMap99-GB4 RH Map1689.26UniSTS
NCBI RH Map11868.8UniSTS
RH70214  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371208,059,982 - 208,060,184UniSTSGRCh37
Build 361206,126,605 - 206,126,807RGDNCBI36
Celera1181,290,437 - 181,290,639RGD
Cytogenetic Map1q32.2UniSTS
Cytogenetic Map1q32UniSTS
HuRef1178,734,177 - 178,734,379UniSTS
GeneMap99-GB4 RH Map1689.26UniSTS
NCBI RH Map11868.8UniSTS
D1S3317  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371208,060,078 - 208,060,405UniSTSGRCh37
Build 361206,126,701 - 206,127,028RGDNCBI36
Celera1181,290,533 - 181,290,860RGD
Cytogenetic Map1q32.2UniSTS
Cytogenetic Map1q32UniSTS
HuRef1178,734,273 - 178,734,600UniSTS
TNG Radiation Hybrid Map1102501.0UniSTS
GeneMap99-GB4 RH Map1688.6UniSTS
Whitehead-RH Map1857.0UniSTS
NCBI RH Map11812.4UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR24-2hsa-miR-24-3pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)19748357
MIR125Ahsa-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI18308931
MIR125Ahsa-miR-125a-5pTarbaseexternal_infoReporter GenePOSITIVE
MIR125Ahsa-miR-125a-5pTarbaseexternal_infoWesternblitPOSITIVE
MIR24-1hsa-miR-24-3pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)19748357

Predicted Target Of
Summary Value
Count of predictions:2971
Count of miRNA genes:705
Interacting mature miRNAs:810
Transcripts:ENST00000310833, ENST00000356522, ENST00000367036, ENST00000485761, ENST00000537704
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 1952 2069 1030 231 410 98 3578 1778 949 322 1135 1343 134 1202 2337 1
Low 364 324 630 334 365 305 636 370 2707 63 248 103 28 2 451 2
Below cutoff 106 593 63 57 799 62 140 45 56 31 69 156 9 1 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001025109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA022917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB238231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF202879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF523361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF538601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH000040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK091890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL356275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX538076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX640941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS104354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M81104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S53910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S53911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U36768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000310833   ⟹   ENSP00000310036
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1207,880,972 - 207,911,125 (-)Ensembl
RefSeq Acc Id: ENST00000356522   ⟹   ENSP00000348916
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1207,886,539 - 207,911,402 (-)Ensembl
RefSeq Acc Id: ENST00000367036   ⟹   ENSP00000356003
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1207,886,539 - 207,890,492 (-)Ensembl
RefSeq Acc Id: ENST00000485761
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1207,884,249 - 207,899,134 (-)Ensembl
RefSeq Acc Id: NM_001025109   ⟹   NP_001020280
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381207,880,972 - 207,911,125 (-)NCBI
GRCh371208,059,883 - 208,084,742 (-)NCBI
Build 361206,126,506 - 206,151,306 (-)NCBI Archive
HuRef1178,734,078 - 178,758,883 (-)ENTREZGENE
CHM1_11209,332,232 - 209,357,037 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001773   ⟹   NP_001764
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381207,886,538 - 207,911,125 (-)NCBI
GRCh371208,059,883 - 208,084,742 (-)NCBI
Build 361206,126,506 - 206,151,306 (-)NCBI Archive
HuRef1178,734,078 - 178,758,883 (-)ENTREZGENE
CHM1_11209,332,232 - 209,357,037 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001020280   ⟸   NM_001025109
- Peptide Label: isoform a precursor
- UniProtKB: P28906 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001764   ⟸   NM_001773
- Peptide Label: isoform b precursor
- UniProtKB: P28906 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000310036   ⟸   ENST00000310833
RefSeq Acc Id: ENSP00000356003   ⟸   ENST00000367036
RefSeq Acc Id: ENSP00000348916   ⟸   ENST00000356522

Promoters
RGD ID:6858842
Promoter ID:EPDNEW_H2586
Type:initiation region
Name:CD34_3
Description:CD34 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2587  EPDNEW_H2588  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381207,890,492 - 207,890,552EPDNEW
RGD ID:6858844
Promoter ID:EPDNEW_H2587
Type:initiation region
Name:CD34_1
Description:CD34 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2586  EPDNEW_H2588  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381207,911,115 - 207,911,175EPDNEW
RGD ID:6858846
Promoter ID:EPDNEW_H2588
Type:initiation region
Name:CD34_2
Description:CD34 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2586  EPDNEW_H2587  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381207,911,351 - 207,911,411EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11
pathogenic
GRCh38/hg38 1q32.1-32.2(chr1:204990129-210220258)x3 copy number gain See cases [RCV000051859] Chr1:204990129..210220258 [GRCh38]
Chr1:204959257..210572305 [GRCh37]
Chr1:203225880..208638928 [NCBI36]
Chr1:1q32.1-32.2
pathogenic
NM_001025109.1(CD34):c.1115G>A (p.Gly372Asp) single nucleotide variant Malignant melanoma [RCV000064498] Chr1:207887781 [GRCh38]
Chr1:208061126 [GRCh37]
Chr1:206127749 [NCBI36]
Chr1:1q32.2
not provided
GRCh38/hg38 1q32.2(chr1:207583527-210159181)x1 copy number loss See cases [RCV000139025] Chr1:207583527..210159181 [GRCh38]
Chr1:207756872..210332526 [GRCh37]
Chr1:205823495..208399149 [NCBI36]
Chr1:1q32.2
pathogenic
GRCh38/hg38 1q32.1-42.12(chr1:204764914-225408698)x3 copy number gain See cases [RCV000142054] Chr1:204764914..225408698 [GRCh38]
Chr1:204734042..225596400 [GRCh37]
Chr1:203000665..223663023 [NCBI36]
Chr1:1q32.1-42.12
pathogenic
GRCh38/hg38 1q32.2-44(chr1:207346642-248930485)x3 copy number gain See cases [RCV000143727] Chr1:207346642..248930485 [GRCh38]
Chr1:207519987..249224684 [GRCh37]
Chr1:205586610..247191307 [NCBI36]
Chr1:1q32.2-44
pathogenic
GRCh37/hg19 1q31.3-42.13(chr1:197811907-228997888)x3 copy number gain See cases [RCV000240137] Chr1:197811907..228997888 [GRCh37]
Chr1:1q31.3-42.13
pathogenic
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q32.1-32.3(chr1:204682513-212815646) copy number loss Global developmental delay [RCV000626524] Chr1:204682513..212815646 [GRCh37]
Chr1:1q32.1-32.3
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NC_000001.11:g.(?_204033173)_(208209798_?)del deletion Autistic disorder of childhood onset [RCV000754138] Chr1:204033173..208209798 [GRCh38]
Chr1:1q32.1-32.2
likely pathogenic
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41
pathogenic
GRCh37/hg19 1q32.1-32.3(chr1:206329070-213263817)x3 copy number gain not provided [RCV000848713] Chr1:206329070..213263817 [GRCh37]
Chr1:1q32.1-32.3
uncertain significance
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44
pathogenic
NM_001025109.2(CD34):c.379G>A (p.Val127Ile) single nucleotide variant not provided [RCV000899525] Chr1:207899110 [GRCh38]
Chr1:208072455 [GRCh37]
Chr1:1q32.2
likely benign
GRCh37/hg19 1q31.3-32.2(chr1:194356425-210988710)x3 copy number gain not provided [RCV001249273] Chr1:194356425..210988710 [GRCh37]
Chr1:1q31.3-32.2
not provided
GRCh37/hg19 1q32.1-44(chr1:204045948-249218992)x3 copy number gain See cases [RCV001007407] Chr1:204045948..249218992 [GRCh37]
Chr1:1q32.1-44
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1662 AgrOrtholog
COSMIC CD34 COSMIC
Ensembl Genes ENSG00000174059 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000310036 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000348916 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000356003 UniProtKB/TrEMBL
Ensembl Transcript ENST00000310833 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000356522 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000367036 UniProtKB/TrEMBL
GTEx ENSG00000174059 GTEx
HGNC ID HGNC:1662 ENTREZGENE
Human Proteome Map CD34 Human Proteome Map
InterPro CD34 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CD34/Podocalyxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:947 UniProtKB/Swiss-Prot
NCBI Gene 947 ENTREZGENE
OMIM 142230 OMIM
PANTHER PTHR16677 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CD34_antigen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26211 PharmGKB
PRINTS CD34ANTIGEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.374990 ENTREZGENE
UniProt CD34_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q3C1E7_HUMAN UniProtKB/TrEMBL
  Q5JTA5_HUMAN UniProtKB/TrEMBL
  Q8IUM0_HUMAN UniProtKB/TrEMBL
  Q9UH97_HUMAN UniProtKB/TrEMBL
UniProt Secondary A8K664 UniProtKB/Swiss-Prot
  Q15970 UniProtKB/Swiss-Prot
  Q15971 UniProtKB/Swiss-Prot
  Q5JTA3 UniProtKB/Swiss-Prot
  Q5JTA4 UniProtKB/Swiss-Prot
  Q9UJB1 UniProtKB/Swiss-Prot