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Gene: ADAMTS7 (ADAM metallopeptidase with thrombospondin type 1 motif 7) Homo sapiens
Symbol: ADAMTS7
Name: ADAM metallopeptidase with thrombospondin type 1 motif 7
Description: The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: a disintegrin and metalloprotease with thrombospondin motifs-7 preproprotein; A disintegrin and metalloproteinase with thrombospondin motifs 7; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7; ADAM metallopeptidase with thrombospondin type 1 motif, 7; ADAM-TS 7; ADAM-TS7; ADAMTS-7; COMPase; DKFZp434H204
Related Pseudogenes: ADAMTS7P1   ADAMTS7P3   ADAMTS7P4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381578,759,203 - 78,811,476 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371579,051,545 - 79,103,805 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,838,600 - 76,890,828 (-)NCBINCBI36hg18NCBI36
Build 341576,838,604 - 76,890,828NCBI
Celera1555,988,022 - 56,040,507 (-)NCBI
Cytogenetic Map15q25.1NCBI
HuRef1555,809,947 - 55,863,180 (-)NCBIHuRef
CHM1_11579,169,979 - 79,222,037 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ADAMTS7
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315487
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.