Nanos3 (nanos C2HC-type zinc finger 3) - Rat Genome Database
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Gene: Nanos3 (nanos C2HC-type zinc finger 3) Mus musculus
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Symbol: Nanos3
Name: nanos C2HC-type zinc finger 3
RGD ID: 1315422
MGI Page MGI
Description: Exhibits RNA binding activity. Involved in several processes, including gamete generation; negative regulation of apoptotic signaling pathway; and regulation of translation. Localizes to P-body; cytoplasmic stress granule; and nucleus. Is expressed in telencephalon and testis. Orthologous to human NANOS3 (nanos C2HC-type zinc finger 3); INTERACTS WITH 4,4'-diaminodiphenylmethane; busulfan; cypermethrin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC141148; n; nanos homolog 3; nanos homolog 3 (Drosophila); NOS-3; nos3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,900,359 - 84,911,396 (-)NCBIGRCm39mm39
GRCm38884,173,733 - 84,176,552 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,173,731 - 84,185,217 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,697,632 - 86,700,451 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,063,838 - 87,066,657 (-)NCBImm8
Celera888,474,167 - 88,476,986 (-)NCBICelera
Cytogenetic Map8C2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:12947200   PMID:14610273   PMID:14962849   PMID:17062627   PMID:17138666   PMID:17567665   PMID:17967808   PMID:18089289   PMID:18281459   PMID:18436203   PMID:18799693  
PMID:19745153   PMID:19818747   PMID:19861488   PMID:20174582   PMID:20707993   PMID:21115610   PMID:21267068   PMID:21421998   PMID:21775990   PMID:21873635   PMID:22037762   PMID:24091668  
PMID:24850856   PMID:25359900   PMID:25416063   PMID:25810472   PMID:26120033   PMID:26609159   PMID:27353389   PMID:28115634   PMID:28196692   PMID:28585553   PMID:29339164   PMID:32339196  


Genomics

Comparative Map Data
Nanos3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,900,359 - 84,911,396 (-)NCBIGRCm39mm39
GRCm38884,173,733 - 84,176,552 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,173,731 - 84,185,217 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,697,632 - 86,700,451 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,063,838 - 87,066,657 (-)NCBImm8
Celera888,474,167 - 88,476,986 (-)NCBICelera
Cytogenetic Map8C2NCBI
NANOS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1913,862,063 - 13,880,757 (+)EnsemblGRCh38hg38GRCh38
GRCh381913,862,036 - 13,880,757 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,988,063 - 13,991,571 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,848,950 - 13,852,571 (+)NCBINCBI36hg18NCBI36
Celera1913,881,695 - 13,885,316 (+)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1913,559,374 - 13,562,880 (+)NCBIHuRef
CHM1_11913,988,759 - 13,992,267 (+)NCBICHM1_1
Nanos3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01925,284,907 - 25,288,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,284,909 - 25,288,335 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,262,007 - 36,265,766 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,669,353 - 25,672,779 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11925,674,180 - 25,677,606 (+)NCBI
Celera1923,534,011 - 23,537,437 (+)NCBICelera
Cytogenetic Map19q11NCBI
Nanos3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,649,054 - 32,651,936 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,648,455 - 32,651,909 (+)NCBIChiLan1.0ChiLan1.0
NANOS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11914,170,500 - 14,173,267 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,170,699 - 14,173,013 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01913,427,661 - 13,443,218 (+)NCBIMhudiblu_PPA_v0panPan3
Nanos3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366592,590,291 - 2,593,482 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NANOS3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl612,538,133 - 12,541,816 (+)Ensembl
ChlSab1.1612,537,449 - 12,541,660 (+)NCBI
Nanos3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249011,167,052 - 1,171,915 (+)NCBI

Position Markers
Nanos3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C3UniSTS
cM Map8 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:122
Interacting mature miRNAs:129
Transcripts:ENSMUST00000070102
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000070102   ⟹   ENSMUSP00000067385
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,173,733 - 84,176,552 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210202   ⟹   ENSMUSP00000147775
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,173,759 - 84,176,552 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211482
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,173,731 - 84,185,217 (-)Ensembl
RefSeq Acc Id: NM_001357361   ⟹   NP_001344290
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,900,388 - 84,903,181 (-)NCBI
GRCm38884,173,759 - 84,176,552 (-)NCBI
Sequence:
RefSeq Acc Id: NM_194059   ⟹   NP_918948
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,900,362 - 84,903,181 (-)NCBI
GRCm38884,173,733 - 84,176,552 (-)NCBI
MGSCv37886,697,632 - 86,700,451 (-)RGD
Celera888,474,167 - 88,476,986 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036154034   ⟹   XP_036009927
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,900,359 - 84,911,396 (-)NCBI
RefSeq Acc Id: XM_036154035   ⟹   XP_036009928
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,900,359 - 84,911,392 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_918948   ⟸   NM_194059
- Peptide Label: isoform 1
- UniProtKB: P60324 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001344290   ⟸   NM_001357361
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000067385   ⟸   ENSMUST00000070102
RefSeq Acc Id: ENSMUSP00000147775   ⟸   ENSMUST00000210202
RefSeq Acc Id: XP_036009927   ⟸   XM_036154034
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036009928   ⟸   XM_036154035
- Peptide Label: isoform X2
Protein Domains
Nanos-type

Promoters
RGD ID:8667653
Promoter ID:EPDNEW_M11858
Type:initiation region
Name:Nanos3_1
Description:Mus musculus nanos C2HC-type zinc finger 3 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38884,176,554 - 84,176,614EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2675387 AgrOrtholog
Ensembl Genes ENSMUSG00000056155 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000067385 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000147775 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000070102 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000210202 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.680 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Nanos/Xcar2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nanos_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_nanos-typ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:244551 UniProtKB/Swiss-Prot
MGD MGI:2675387 ENTREZGENE
NCBI Gene 244551 ENTREZGENE
PANTHER PTHR12887 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-nanos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nanos3 PhenoGen
PROSITE ZF_NANOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.216740 ENTREZGENE
UniProt NANO3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q0VDU5_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q0VDU6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Nanos3  nanos C2HC-type zinc finger 3    nanos homolog 3 (Drosophila)  Symbol and/or name change 5135510 APPROVED