GPR15 (G protein-coupled receptor 15) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: GPR15 (G protein-coupled receptor 15) Homo sapiens
Analyze
Symbol: GPR15
Name: G protein-coupled receptor 15
RGD ID: 1315368
HGNC Page HGNC
Description: Enables G protein-coupled receptor activity; coreceptor activity; and virus receptor activity. Involved in G protein-coupled receptor signaling pathway and viral entry into host cell. Located in endosome and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BOB; brother of Bonzo; G-protein coupled receptor 15; MGC126828; MGC126830
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl398,531,978 - 98,534,681 (+)EnsemblGRCh38hg38GRCh38
GRCh38398,531,978 - 98,534,681 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37398,250,822 - 98,253,525 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36399,733,568 - 99,734,650 (+)NCBINCBI36hg18NCBI36
Build 34399,733,567 - 99,734,650NCBI
Celera396,642,535 - 96,643,617 (+)NCBI
Cytogenetic Map3q11.2NCBI
HuRef395,622,878 - 95,624,129 (+)NCBIHuRef
CHM1_1398,213,900 - 98,215,151 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
1. GOA_HUMAN data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8838812   PMID:9230441   PMID:9236192   PMID:10985245   PMID:11696454   PMID:12477932   PMID:12555203   PMID:12566994   PMID:15489334   PMID:15650194   PMID:15992849   PMID:17207965  
PMID:21189250   PMID:21244100   PMID:21835785   PMID:21873635   PMID:22086059   PMID:23430259   PMID:23661644   PMID:23772394   PMID:24558379   PMID:24725539   PMID:24897520   PMID:26246861  
PMID:26348578   PMID:28386128   PMID:28615320   PMID:28900043   PMID:28936214   PMID:29183299   PMID:30387691   PMID:32019074   PMID:32532834   PMID:33310155   PMID:33431697  


Genomics

Comparative Map Data
GPR15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl398,531,978 - 98,534,681 (+)EnsemblGRCh38hg38GRCh38
GRCh38398,531,978 - 98,534,681 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37398,250,822 - 98,253,525 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36399,733,568 - 99,734,650 (+)NCBINCBI36hg18NCBI36
Build 34399,733,567 - 99,734,650NCBI
Celera396,642,535 - 96,643,617 (+)NCBI
Cytogenetic Map3q11.2NCBI
HuRef395,622,878 - 95,624,129 (+)NCBIHuRef
CHM1_1398,213,900 - 98,215,151 (+)NCBICHM1_1
Gpr15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391658,537,006 - 58,539,235 (-)NCBIGRCm39mm39
GRCm39 Ensembl1658,537,796 - 58,539,433 (-)Ensembl
GRCm381658,716,643 - 58,718,872 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1658,717,433 - 58,719,070 (-)EnsemblGRCm38mm10GRCm38
MGSCv371658,717,548 - 58,718,837 (-)NCBIGRCm37mm9NCBIm37
MGSCv361658,659,978 - 58,661,613 (-)NCBImm8
Celera1659,008,102 - 59,009,391 (-)NCBICelera
Cytogenetic Map16C1.2NCBI
Gpr15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21141,898,356 - 41,900,441 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1144,001,579 - 44,003,664 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01143,992,739 - 44,004,189 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01147,191,271 - 47,193,356 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41142,709,928 - 42,712,013 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11142,767,516 - 42,768,599 (+)NCBI
Celera1141,697,724 - 41,699,809 (+)NCBICelera
Cytogenetic Map11q12NCBI
Gpr15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955427115,513 - 119,710 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955427115,513 - 137,557 (+)NCBIChiLan1.0ChiLan1.0
GPR15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13102,311,074 - 102,313,840 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3102,311,203 - 102,312,285 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0395,627,750 - 95,630,518 (+)NCBIMhudiblu_PPA_v0panPan3
GPR15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1335,368,509 - 5,380,024 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl335,396,083 - 5,397,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl335,396,083 - 5,397,165 (+)NCBICanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha335,519,620 - 5,548,538 (+)NCBI
ROS_Cfam_1.0335,507,924 - 5,538,951 (+)NCBI
UMICH_Zoey_3.1335,385,504 - 5,414,699 (+)NCBI
UNSW_CanFamBas_1.0335,448,924 - 5,478,064 (+)NCBI
UU_Cfam_GSD_1.0335,725,631 - 5,754,875 (+)NCBI
Gpr15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602151,562,917 - 151,564,586 (-)NCBI
SpeTri2.0NW_0049366304,459,213 - 4,462,285 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13160,385,646 - 160,391,028 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113160,386,727 - 160,390,965 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213170,557,577 - 170,579,565 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12282,314,259 - 82,317,204 (-)NCBI
ChlSab1.1 Ensembl2282,314,491 - 82,315,573 (-)Ensembl
Vero_WHO_p1.0NW_02366604184,238,542 - 84,241,336 (+)NCBI
Gpr15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478911,401,196 - 11,402,337 (+)NCBI

Position Markers
RH70610  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37398,251,637 - 98,251,869UniSTSGRCh37
Build 36399,734,327 - 99,734,559RGDNCBI36
Celera396,643,294 - 96,643,526RGD
Cytogenetic Map3q11.2-q13.1UniSTS
HuRef395,623,772 - 95,624,004UniSTS
GeneMap99-GB4 RH Map3333.11UniSTS
PMC104479P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37398,250,862 - 98,251,423UniSTSGRCh37
Build 36399,733,552 - 99,734,113RGDNCBI36
Celera396,642,519 - 96,643,080RGD
Cytogenetic Map3q11.2-q13.1UniSTS
HuRef395,622,997 - 95,623,558UniSTS
GPR15_962  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37398,251,150 - 98,252,044UniSTSGRCh37
Build 36399,733,840 - 99,734,734RGDNCBI36
Celera396,642,807 - 96,643,701RGD
HuRef395,623,285 - 95,624,179UniSTS
GPR15  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37398,251,856 - 98,251,956UniSTSGRCh37
Build 36399,734,546 - 99,734,646RGDNCBI36
Celera396,643,513 - 96,643,613RGD
HuRef395,623,991 - 95,624,091UniSTS
UniSTS:481106  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37398,250,878 - 98,251,960UniSTSGRCh37
Celera396,642,535 - 96,643,617UniSTS
HuRef395,623,013 - 95,624,095UniSTS
UniSTS:485610  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37398,250,852 - 98,251,994UniSTSGRCh37
Celera396,642,509 - 96,643,651UniSTS
HuRef395,622,987 - 95,624,129UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:53
Interacting mature miRNAs:53
Transcripts:ENST00000284311
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage pharyngeal arch
High 1 1 1
Medium 285 73 11 34 618 1 4 3 11 22 68 33 10 1
Low 575 643 375 194 799 81 476 51 102 77 282 660 114 322 168
Below cutoff 938 1237 817 254 361 238 2097 966 1700 158 593 547 18 651 1336 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000284311   ⟹   ENSP00000284311
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl398,531,978 - 98,534,681 (+)Ensembl
RefSeq Acc Id: NM_005290   ⟹   NP_005281
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38398,531,978 - 98,534,681 (+)NCBI
GRCh37398,250,743 - 98,251,994 (+)NCBI
Build 36399,733,568 - 99,734,650 (+)NCBI Archive
HuRef395,622,878 - 95,624,129 (+)NCBI
CHM1_1398,213,900 - 98,216,680 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005281   ⟸   NM_005290
- UniProtKB: P49685 (UniProtKB/Swiss-Prot),   B2R8H6 (UniProtKB/TrEMBL),   B6V9G9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000284311   ⟸   ENST00000284311
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:6801100
Promoter ID:HG_KWN:45657
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562,   Lymphoblastoid
Transcripts:ENST00000284311
Position:
Human AssemblyChrPosition (strand)Source
Build 36399,732,546 - 99,734,542 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q11.1-21.1(chr3:93886671-123216683)x1 copy number loss See cases [RCV000051543] Chr3:93886671..123216683 [GRCh38]
Chr3:93605515..122935530 [GRCh37]
Chr3:95088205..124418220 [NCBI36]
Chr3:3q11.1-21.1
pathogenic
GRCh38/hg38 3q11.1-13.31(chr3:93819623-116887056)x1 copy number loss See cases [RCV000135320] Chr3:93819623..116887056 [GRCh38]
Chr3:93538467..116605903 [GRCh37]
Chr3:95021157..118088593 [NCBI36]
Chr3:3q11.1-13.31
pathogenic
GRCh38/hg38 3q11.2-13.31(chr3:97795369-115663349)x1 copy number loss See cases [RCV000138186] Chr3:97795369..115663349 [GRCh38]
Chr3:97514213..115382196 [GRCh37]
Chr3:98996903..116864886 [NCBI36]
Chr3:3q11.2-13.31
pathogenic|uncertain significance
GRCh38/hg38 3q11.1-24(chr3:93800620-145695381)x3 copy number gain See cases [RCV000142340] Chr3:93800620..145695381 [GRCh38]
Chr3:93519464..145413168 [GRCh37]
Chr3:95002154..146895858 [NCBI36]
Chr3:3q11.1-24
pathogenic
GRCh38/hg38 3q11.1-13.11(chr3:93819623-103888749)x3 copy number gain See cases [RCV000143259] Chr3:93819623..103888749 [GRCh38]
Chr3:93538467..103607593 [GRCh37]
Chr3:95021157..105090283 [NCBI36]
Chr3:3q11.1-13.11
likely pathogenic|uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_005290.4(GPR15):c.194G>A (p.Arg65Gln) single nucleotide variant not provided [RCV000660610] Chr3:98532227 [GRCh38]
Chr3:98251071 [GRCh37]
Chr3:3q11.2
uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_005290.4(GPR15):c.738C>T (p.Val246=) single nucleotide variant not provided [RCV000974998] Chr3:98532771 [GRCh38]
Chr3:98251615 [GRCh37]
Chr3:3q11.2
benign
GRCh37/hg19 3q11.2-12.1(chr3:97606054-98499715)x3 copy number gain not provided [RCV001005456] Chr3:97606054..98499715 [GRCh37]
Chr3:3q11.2-12.1
uncertain significance
NM_005290.4(GPR15):c.334A>G (p.Met112Val) single nucleotide variant not provided [RCV000946750] Chr3:98532367 [GRCh38]
Chr3:98251211 [GRCh37]
Chr3:3q11.2
benign
GRCh37/hg19 3q11.2(chr3:97994048-98260542)x3 copy number gain not provided [RCV001005457] Chr3:97994048..98260542 [GRCh37]
Chr3:3q11.2
likely benign
GRCh37/hg19 3q11.2-12.3(chr3:95563096-102371126)x1 copy number loss not provided [RCV001259224] Chr3:95563096..102371126 [GRCh37]
Chr3:3q11.2-12.3
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4469 AgrOrtholog
COSMIC GPR15 COSMIC
Ensembl Genes ENSG00000154165 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000284311 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000284311 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000154165 GTEx
HGNC ID HGNC:4469 ENTREZGENE
Human Proteome Map GPR15 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2838 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2838 ENTREZGENE
OMIM 601166 OMIM
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28858 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2R8H6 ENTREZGENE, UniProtKB/TrEMBL
  B6V9G9 ENTREZGENE, UniProtKB/TrEMBL
  GPR15_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3MIL4 UniProtKB/Swiss-Prot
  Q6ISN6 UniProtKB/Swiss-Prot