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Gene: Cyp46a1 (cytochrome P450, family 46, subfamily a, polypeptide 1) Mus musculus
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Symbol: Cyp46a1
Name: cytochrome P450, family 46, subfamily a, polypeptide 1
Description: Exhibits cholesterol 24-hydroxylase activity. Involved in cholesterol catabolic process; protein localization to membrane raft; and regulation of long-term synaptic potentiation. Localizes to several cellular components, including dendrite; endoplasmic reticulum membrane; and postsynapse. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina nuclear layer; and spleen. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CYP46A1 (cytochrome P450 family 46 subfamily A member 1); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CH24H; cholesterol 24-hydroxylase; cholesterol 24-monooxygenase; cholesterol 24S-hydroxylase; cholestrol 24-hydroxylase; Cyp46; cytochrome P450 46A1; cytochrome P450, 46 (cholesterol 24-hydroxylase); cytochrome P450, 46a1 (cholesterol 24-hydroxylase)
Orthologs:
Homo sapiens (human) : CYP46A1 (cytochrome P450 family 46 subfamily A member 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cyp46a1 (cytochrome P450, family 46, subfamily a, polypeptide 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102030124 (cholesterol 24-hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : CYP46A1 (cytochrome P450 family 46 subfamily A member 1)
Canis lupus familiaris (dog) : CYP46A1 (cytochrome P450 family 46 subfamily A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101961079 (cholesterol 24-hydroxylase)
Sus scrofa (pig) : LOC100512793 (cholesterol 24-hydroxylase)
Chlorocebus sabaeus (African green monkey) : CYP46A1 (cytochrome P450 family 46 subfamily A member 1)
Heterocephalus glaber (naked mole-rat) : LOC101708822 (cholesterol 24-hydroxylase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl12108,334,381 - 108,362,234 (+)EnsemblGRCm38mm10GRCm38
GRCm3812108,334,268 - 108,362,234 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3712109,572,591 - 109,600,444 (+)NCBIGRCm37mm9NCBIm37
MGSCv3612108,782,188 - 108,810,041 (+)NCBImm8
Celera12109,576,067 - 109,604,342 (+)NCBICelera
Cytogenetic Map12F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Cyp46a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315315
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.