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Gene: CYP46A1 (cytochrome P450 family 46 subfamily A member 1) Homo sapiens
Symbol: CYP46A1
Name: cytochrome P450 family 46 subfamily A member 1
Description: Exhibits cholesterol 24-hydroxylase activity; heme binding activity; and steroid hydroxylase activity. Involved in cholesterol catabolic process; progesterone metabolic process; and xenobiotic metabolic process. Predicted to localize to dendrite; postsynapse; and presynapse. Implicated in Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CH24H; cholesterol 24-hydroxylase; cholesterol 24-monooxygenase; cholesterol 24S-hydroxylase; CP46; CYP46; cytochrome P450 46A1; cytochrome P450, family 46, subfamily A, polypeptide 1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
Mus musculus (house mouse) : Cyp46a1 (cytochrome P450, family 46, subfamily a, polypeptide 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cyp46a1 (cytochrome P450, family 46, subfamily a, polypeptide 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102030124 (cholesterol 24-hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : CYP46A1 (cytochrome P450 family 46 subfamily A member 1)
Canis lupus familiaris (dog) : CYP46A1 (cytochrome P450 family 46 subfamily A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101961079 (cholesterol 24-hydroxylase)
Sus scrofa (pig) : LOC100512793 (cholesterol 24-hydroxylase)
Chlorocebus sabaeus (African green monkey) : CYP46A1 (cytochrome P450 family 46 subfamily A member 1)
Heterocephalus glaber (naked mole-rat) : LOC101708822 (cholesterol 24-hydroxylase)
more info ...
Related Pseudogenes: CYP46A4P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1499,684,298 - 99,727,301 (+)EnsemblGRCh38hg38GRCh38
GRCh381499,684,262 - 99,727,321 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714100,150,755 - 100,193,638 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,220,508 - 99,263,391 (+)NCBINCBI36hg18NCBI36
Build 341499,220,507 - 99,263,390NCBI
Celera1480,205,602 - 80,248,517 (+)NCBI
Cytogenetic Map14q32.2NCBI
HuRef1480,333,998 - 80,376,909 (+)NCBIHuRef
CHM1_114100,088,519 - 100,131,398 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CYP46A1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315314
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.