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Gene: DOCK1 (dedicator of cytokinesis 1) Homo sapiens
Symbol: DOCK1
Name: dedicator of cytokinesis 1
Description: Contributes to guanyl-nucleotide exchange factor activity. Involved in positive regulation of epithelial cell migration and positive regulation of substrate adhesion-dependent cell spreading. Localizes to the cytosol; guanyl-nucleotide exchange factor complex; and nuclear speck.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 180 kDa protein downstream of CRK; ced5; dedicator of cyto-kinesis 1; dedicator of cytokinesis protein 1; DOCK180; DOwnstream of CrK
Mus musculus (house mouse) : Dock1 (dedicator of cytokinesis 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dock1 (dedicator of cyto-kinesis 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dock1 (dedicator of cytokinesis 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DOCK1 (dedicator of cytokinesis 1)
Canis lupus familiaris (dog) : DOCK1 (dedicator of cytokinesis 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dock1 (dedicator of cytokinesis 1)
Sus scrofa (pig) : DOCK1 (dedicator of cytokinesis 1)
Chlorocebus sabaeus (African green monkey) : DOCK1 (dedicator of cytokinesis 1)
Heterocephalus glaber (naked mole-rat) : Dock1 (dedicator of cytokinesis 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10126,905,409 - 127,452,517 (+)Ensembl
GRCh3810126,905,409 - 127,452,517 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710128,768,965 - 129,250,780 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610128,658,955 - 129,140,770 (+)NCBINCBI36hg18NCBI36
Build 3410128,658,954 - 129,140,769NCBI
Celera10122,439,168 - 122,921,173 (+)NCBI
Cytogenetic Map10q26.2NCBI
HuRef10122,340,788 - 122,823,487 (+)NCBIHuRef
CHM1_110128,875,844 - 129,533,069 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on DOCK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315227
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.