Ndst4 (N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4) - Rat Genome Database

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Gene: Ndst4 (N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4) Mus musculus
Analyze
Symbol: Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
RGD ID: 1315202
MGI Page MGI
Description: Exhibits deacetylase activity and sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to localize to Golgi apparatus. Is expressed in several structures, including nervous system. Orthologous to human NDST4 (N-deacetylase and N-sulfotransferase 4); PARTICIPATES IN heparan sulfate biosynthetic pathway; INTERACTS WITH 1,2-dichloroethane; ethanol; 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4930439H17Rik; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferase 4; N-deacetylase/N-sulfotransferase 4; N-heparan sulfate sulfotransferase 4; N-HSST 4; NDST-4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393125,197,678 - 125,522,000 (+)NCBIGRCm39mm39
GRCm39 Ensembl3125,197,725 - 125,522,548 (+)Ensembl
GRCm383125,404,029 - 125,728,351 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3125,404,076 - 125,728,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv373125,107,009 - 125,427,904 (+)NCBIGRCm37mm9NCBIm37
MGSCv363125,429,702 - 125,716,801 (+)NCBImm8
Celera3131,829,352 - 132,166,533 (+)NCBICelera
Cytogenetic Map3G1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11087757   PMID:12070138   PMID:12460940   PMID:14681479   PMID:15944372   PMID:16141072   PMID:16141073   PMID:17107998   PMID:19299468  
PMID:21267068   PMID:21677750   PMID:21858141   PMID:21873635   PMID:22049073   PMID:24457600   PMID:24952961   PMID:26554594   PMID:27793051   PMID:30926747  


Genomics

Comparative Map Data
Ndst4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393125,197,678 - 125,522,000 (+)NCBIGRCm39mm39
GRCm39 Ensembl3125,197,725 - 125,522,548 (+)Ensembl
GRCm383125,404,029 - 125,728,351 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3125,404,076 - 125,728,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv373125,107,009 - 125,427,904 (+)NCBIGRCm37mm9NCBIm37
MGSCv363125,429,702 - 125,716,801 (+)NCBImm8
Celera3131,829,352 - 132,166,533 (+)NCBICelera
Cytogenetic Map3G1NCBI
NDST4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4114,827,763 - 115,113,876 (-)EnsemblGRCh38hg38GRCh38
GRCh384114,824,122 - 115,114,133 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374115,748,919 - 116,034,776 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364115,968,368 - 116,254,481 (-)NCBINCBI36hg18NCBI36
Build 344116,106,534 - 116,392,636NCBI
Celera4113,041,908 - 113,327,826 (-)NCBI
Cytogenetic Map4q26NCBI
HuRef4111,482,596 - 111,769,024 (-)NCBIHuRef
CHM1_14115,724,866 - 116,011,407 (-)NCBICHM1_1
Ndst4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22213,787,010 - 214,116,569 (+)NCBI
Rnor_6.0 Ensembl2229,196,616 - 229,496,516 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02229,170,781 - 229,496,732 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02248,525,754 - 248,852,279 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42222,503,566 - 222,815,293 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12222,464,480 - 222,801,974 (+)NCBI
Celera2206,169,234 - 206,462,526 (+)NCBICelera
Cytogenetic Map2q42NCBI
Ndst4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542824,346,191 - 24,637,737 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542824,376,587 - 24,636,555 (+)NCBIChiLan1.0ChiLan1.0
LOC100986527
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14117,911,985 - 118,198,128 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4117,911,985 - 118,198,128 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04107,345,741 - 107,636,362 (-)NCBIMhudiblu_PPA_v0panPan3
NDST4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13234,347,865 - 34,606,763 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3234,351,162 - 34,631,039 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha327,419,676 - 7,678,620 (+)NCBI
ROS_Cfam_1.03234,574,096 - 34,827,803 (-)NCBI
UMICH_Zoey_3.13234,573,089 - 34,839,569 (-)NCBI
UNSW_CanFamBas_1.03234,320,965 - 34,574,566 (-)NCBI
UU_Cfam_GSD_1.0325,288,077 - 5,540,829 (+)NCBI
Ndst4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053016,216,365 - 6,478,642 (+)NCBI
SpeTri2.0NW_0049365635,434,668 - 5,664,080 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDST4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8107,910,973 - 108,123,325 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18107,882,088 - 108,129,785 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28116,087,271 - 116,176,521 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103236155
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1762,619,344 - 62,911,843 (-)NCBI
ChlSab1.1 Ensembl762,622,455 - 62,874,293 (-)Ensembl
Vero_WHO_p1.0NW_02366603741,400,330 - 41,691,435 (-)NCBI
Ndst4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248671,463,933 - 1,750,490 (-)NCBI

Position Markers
D3Mit370  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383125,522,356 - 125,522,588UniSTSGRCm38
MGSCv373125,225,274 - 125,225,506UniSTSGRCm37
Celera3131,962,060 - 131,962,292UniSTS
Cytogenetic Map3H1UniSTS
cM Map343.8UniSTS
Whitehead Genetic343.7897UniSTS
Whitehead/MRC_RH31452.51UniSTS
Ndst4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv373125,140,814 - 125,141,330UniSTSGRCm37
Cytogenetic Map3H1UniSTS
cM MapUN UniSTS
cM Map3 UniSTS
D3Mit13  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383125,522,368 - 125,522,587UniSTSGRCm38
MGSCv373125,225,286 - 125,225,505UniSTSGRCm37
Celera3131,962,072 - 131,962,291UniSTS
Cytogenetic Map3H1UniSTS
cM Map361.8UniSTS
Whitehead Genetic342.6UniSTS
Whitehead_YAC3 UniSTS
Ndst4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383125,437,896 - 125,438,412UniSTSGRCm38
MGSCv373125,140,814 - 125,141,330UniSTSGRCm37
Cytogenetic Map3H1UniSTS
cM MapUN UniSTS
cM Map3 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)368000000128600000Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387301597125522587Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389232660137747247Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392344217126344334Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396700000148100000Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398830392132830548Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398841635132841734Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398841635132841734Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined399130456133130601Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100465596147339967Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100700000137500000Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101400000150100000Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103689010137689134Mouse
4141220Cia22_mcollagen induced arthritis 22 (mouse)Not determined3107469620125522588Mouse
8655599Cia5c_mcollagen induced arthritis QTL 5c (mouse)Not determined3107469620125522588Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107469620147599053Mouse
1300619Cdcs1_mcytokine deficiency colitis susceptibility 1 (mouse)Not determined3110041233144041356Mouse
12910793Pwbwq7_mpost-weaning body weight QTL 7 (mouse)3110177041136010051Mouse
12910796Pwbwq6_mpost-weaning body weight QTL 6 (mouse)3110177041136010051Mouse
12910815Ogrq1_moverall growth rate QTL 1 (mouse)3110177041136010051Mouse
1301381Bomb1_mbone marrow pre-B 1 (mouse)Not determined3111339594145339768Mouse
1301100Bdt2_mbone density traits 2 (mouse)Not determined3115030856149031023Mouse
1558868Ses9_msalmonella enteritidis susceptibility 9 (mouse)Not determined3119351571153351695Mouse
10043919Afpq8_mabdominal fat percent QTL 8 (mouse)Not determined3119351571153351695Mouse
4141935Tgq15_mtriglyceride QTL 15 (mouse)Not determined119612825153612825Mouse
4142449Tgq14_mtriglyceride QTL 14 (mouse)Not determined119612825153612825Mouse
1302151Lprm2_mlymphoproliferation modifier 2 (mouse)Not determined3120073096154073283Mouse
10412240Alpq6_malcohol preference QTL 6 (mouse)Not determined3121066317155066317Mouse
12903998Cfq3_mconditioned fear QTL 3 (mouse)3122395162127426367Mouse
26884415Bzwq11_mbi-zygomatic width QTL 11, 16 week (mouse)3125200000137500000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1395
Count of miRNA genes:500
Interacting mature miRNAs:604
Transcripts:ENSMUST00000144344, ENSMUST00000147016, ENSMUST00000172632, ENSMUST00000173932, ENSMUST00000174648
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000144344   ⟹   ENSMUSP00000120687
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3125,438,714 - 125,612,408 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147016
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3125,404,090 - 125,686,644 (+)Ensembl
RefSeq Acc Id: ENSMUST00000172632
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3125,680,997 - 125,690,938 (+)Ensembl
RefSeq Acc Id: ENSMUST00000173932   ⟹   ENSMUSP00000133341
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3125,404,076 - 125,728,899 (+)Ensembl
RefSeq Acc Id: ENSMUST00000174648   ⟹   ENSMUSP00000133575
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3125,680,987 - 125,728,339 (+)Ensembl
RefSeq Acc Id: ENSMUST00000198101   ⟹   ENSMUSP00000142414
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3125,710,086 - 125,724,702 (+)Ensembl
RefSeq Acc Id: NM_022565   ⟹   NP_072087
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393125,197,740 - 125,518,635 (+)NCBI
GRCm383125,404,091 - 125,724,986 (+)NCBI
MGSCv373125,107,009 - 125,427,904 (+)RGD
Celera3131,829,352 - 132,166,533 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006501859   ⟹   XP_006501922
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393125,197,678 - 125,491,614 (+)NCBI
GRCm383125,404,029 - 125,697,965 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501860   ⟹   XP_006501923
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393125,197,696 - 125,522,000 (+)NCBI
GRCm383125,404,076 - 125,728,351 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011240189   ⟹   XP_011238491
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393125,197,678 - 125,406,057 (+)NCBI
GRCm383125,404,029 - 125,612,408 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_072087 (Get FASTA)   NCBI Sequence Viewer  
  XP_006501922 (Get FASTA)   NCBI Sequence Viewer  
  XP_006501923 (Get FASTA)   NCBI Sequence Viewer  
  XP_011238491 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB18517 (Get FASTA)   NCBI Sequence Viewer  
  Q9EQW8 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_072087   ⟸   NM_022565
- UniProtKB: Q9EQW8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006501923   ⟸   XM_006501860
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006501922   ⟸   XM_006501859
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011238491   ⟸   XM_011240189
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000142414   ⟸   ENSMUST00000198101
RefSeq Acc Id: ENSMUSP00000120687   ⟸   ENSMUST00000144344
RefSeq Acc Id: ENSMUSP00000133575   ⟸   ENSMUST00000174648
RefSeq Acc Id: ENSMUSP00000133341   ⟸   ENSMUST00000173932
Protein Domains
HSNSD   Sulfotransfer_1

Promoters
RGD ID:6882294
Promoter ID:EPDNEW_M4598
Type:initiation region
Name:Ndst4_1
Description:Mus musculus N-deacetylase/N-sulfotransferase 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4599  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383125,404,120 - 125,404,180EPDNEW
RGD ID:6882296
Promoter ID:EPDNEW_M4599
Type:initiation region
Name:Ndst4_2
Description:Mus musculus N-deacetylase/N-sulfotransferase 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4598  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383125,680,993 - 125,681,053EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1932545 AgrOrtholog
Ensembl Genes ENSMUSG00000027971 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000120687 UniProtKB/TrEMBL
  ENSMUSP00000133341 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000133575 UniProtKB/TrEMBL
  ENSMUSP00000142414 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000144344 UniProtKB/TrEMBL
  ENSMUST00000173932 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000174648 UniProtKB/TrEMBL
  ENSMUST00000198101 UniProtKB/TrEMBL
InterPro Heparan_SO4_deacetylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NST/OST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfotransferase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:64580 UniProtKB/Swiss-Prot
MGD MGI:1932545 ENTREZGENE
NCBI Gene 64580 ENTREZGENE
PANTHER PTHR10605 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSNSD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfotransfer_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ndst4 PhenoGen
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JDL4_MOUSE UniProtKB/TrEMBL
  D3YWZ6_MOUSE UniProtKB/TrEMBL
  G3UX70_MOUSE UniProtKB/TrEMBL
  NDST4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary D3Z1R7 UniProtKB/Swiss-Prot