Inka2 (inka box actin regulator 2) - Rat Genome Database

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Gene: Inka2 (inka box actin regulator 2) Mus musculus
Analyze
Symbol: Inka2
Name: inka box actin regulator 2
RGD ID: 1315194
MGI Page MGI
Description: Predicted to enable protein kinase binding activity and protein serine/threonine kinase inhibitor activity. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; dorsal root ganglion; heart; and olfactory epithelium. Orthologous to human INKA2 (inka box actin regulator 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6530418L21Rik; Fam212; Fam212b; family with sequence similarity 212, member B; hypothetical protein LOC109050; In; induced in neural crest by AP2-alpha protein-related homolog; MInca-r; PAK4-inhibitor INKA2; uncharacterized protein C1orf183 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393105,611,915 - 105,628,158 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3105,611,915 - 105,628,158 (+)EnsemblGRCm39 Ensembl
GRCm383105,704,599 - 105,720,842 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3105,704,599 - 105,720,842 (+)EnsemblGRCm38mm10GRCm38
MGSCv373105,507,517 - 105,523,760 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363105,832,733 - 105,847,777 (+)NCBIMGSCv36mm8
Celera3107,893,483 - 107,909,796 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map346.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:25681390   PMID:26292052   PMID:27113764   PMID:30973865   PMID:31975032   PMID:34296073   PMID:36301793   PMID:36586159  


Genomics

Comparative Map Data
Inka2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393105,611,915 - 105,628,158 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3105,611,915 - 105,628,158 (+)EnsemblGRCm39 Ensembl
GRCm383105,704,599 - 105,720,842 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3105,704,599 - 105,720,842 (+)EnsemblGRCm38mm10GRCm38
MGSCv373105,507,517 - 105,523,760 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363105,832,733 - 105,847,777 (+)NCBIMGSCv36mm8
Celera3107,893,483 - 107,909,796 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map346.44NCBI
INKA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,722,064 - 111,755,797 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1111,680,630 - 111,755,824 (-)EnsemblGRCh38hg38GRCh38
GRCh371112,264,686 - 112,298,419 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361112,069,893 - 112,099,942 (-)NCBINCBI36Build 36hg18NCBI36
Celera1110,511,297 - 110,545,039 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1110,136,065 - 110,169,809 (-)NCBIHuRef
CHM1_11112,379,672 - 112,413,403 (-)NCBICHM1_1
T2T-CHM13v2.01111,736,962 - 111,770,699 (-)NCBIT2T-CHM13v2.0
Inka2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82195,873,617 - 195,888,983 (+)NCBIGRCr8
mRatBN7.22193,185,275 - 193,200,643 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2193,185,275 - 193,200,642 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2200,779,694 - 200,795,072 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02198,672,057 - 198,687,421 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02193,489,015 - 193,504,373 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02208,170,652 - 208,187,088 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,170,652 - 208,185,965 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02227,591,605 - 227,606,919 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42200,956,495 - 200,972,339 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12200,919,399 - 200,932,795 (+)NCBI
Celera2185,647,409 - 185,662,872 (+)NCBICelera
Cytogenetic Map2q34NCBI
Inka2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543515,179,558 - 15,195,277 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543515,179,883 - 15,195,457 (-)NCBIChiLan1.0ChiLan1.0
INKA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21115,286,637 - 115,303,534 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11114,434,823 - 114,450,884 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01114,389,334 - 114,402,277 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11125,946,399 - 125,963,744 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1125,929,817 - 125,963,744 (+)Ensemblpanpan1.1panPan2
INKA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1763,216,242 - 63,230,988 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01764,875,866 - 64,890,579 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1764,875,905 - 64,890,454 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11763,608,663 - 63,623,394 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01763,667,112 - 63,680,261 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01764,465,553 - 64,480,305 (+)NCBIUU_Cfam_GSD_1.0
Inka2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505817,077,166 - 17,107,680 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936690369,946 - 386,130 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936690370,051 - 386,094 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INKA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4108,650,661 - 108,667,143 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14108,650,666 - 108,663,756 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24118,798,403 - 118,810,889 (+)NCBISscrofa10.2Sscrofa10.2susScr3
INKA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12021,869,304 - 21,887,246 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2021,869,925 - 21,882,403 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603836,592,395 - 36,609,778 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inka2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247727,434,440 - 7,450,133 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247727,434,816 - 7,451,040 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Inka2
552 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1816
Count of miRNA genes:654
Interacting mature miRNAs:845
Transcripts:ENSMUST00000066610, ENSMUST00000098273
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000066610   ⟹   ENSMUSP00000069212
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3105,611,915 - 105,628,158 (+)Ensembl
GRCm38.p6 Ensembl3105,704,599 - 105,720,842 (+)Ensembl
RefSeq Acc Id: ENSMUST00000098273   ⟹   ENSMUSP00000095874
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3105,612,774 - 105,625,472 (+)Ensembl
GRCm38.p6 Ensembl3105,705,458 - 105,718,156 (+)Ensembl
RefSeq Acc Id: NM_001163356   ⟹   NP_001156828
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393105,612,774 - 105,628,158 (+)NCBI
GRCm383105,705,458 - 105,720,842 (+)NCBI
MGSCv373105,507,517 - 105,523,760 (+)RGD
Celera3107,893,483 - 107,909,796 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_175398   ⟹   NP_780607
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393105,611,915 - 105,628,158 (+)NCBI
GRCm383105,704,599 - 105,720,842 (+)NCBI
MGSCv373105,507,517 - 105,523,760 (+)RGD
Celera3107,893,483 - 107,909,796 (+)RGD
cM Map3 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_780607   ⟸   NM_175398
- Peptide Label: isoform 1
- UniProtKB: Q8C5H0 (UniProtKB/Swiss-Prot),   Q8CCA1 (UniProtKB/Swiss-Prot),   Q80VY2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001156828   ⟸   NM_001163356
- Peptide Label: isoform 2
- UniProtKB: Q80VY2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000069212   ⟸   ENSMUST00000066610
RefSeq Acc Id: ENSMUSP00000095874   ⟸   ENSMUST00000098273
Protein Domains
FAM212

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80VY2-F1-model_v2 AlphaFold Q80VY2 1-300 view protein structure

Promoters
RGD ID:6833220
Promoter ID:MM_KWN:35654
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   Brain,   ES_Cell,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_001163356
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363105,507,756 - 105,508,427 (+)MPROMDB
RGD ID:6881934
Promoter ID:EPDNEW_M4418
Type:multiple initiation site
Name:Fam212b_1
Description:Mus musculus family with sequence similarity 212, member B ,transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4419  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383105,704,668 - 105,704,728EPDNEW
RGD ID:6881936
Promoter ID:EPDNEW_M4419
Type:single initiation site
Name:Fam212b_2
Description:Mus musculus family with sequence similarity 212, member B ,transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4418  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383105,711,825 - 105,711,885EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1923497 AgrOrtholog
Ensembl Genes ENSMUSG00000048458 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000066610 ENTREZGENE
  ENSMUST00000066610.8 UniProtKB/Swiss-Prot
  ENSMUST00000098273 ENTREZGENE
  ENSMUST00000098273.3 UniProtKB/Swiss-Prot
InterPro FAM212 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Inka UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:109050 UniProtKB/Swiss-Prot
MGD MGI:1923497 ENTREZGENE
NCBI Gene 109050 ENTREZGENE
PANTHER PAK4-INHIBITOR INKA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR28615 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FAM212 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Inka2 PhenoGen
UniProt A0A0K2S4W3_MOUSE UniProtKB/TrEMBL
  INKA2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8C5H0 ENTREZGENE
  Q8CCA1 ENTREZGENE
UniProt Secondary Q8C5H0 UniProtKB/Swiss-Prot
  Q8CCA1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-29 Inka2  inka box actin regulator 2  Fam212b  family with sequence similarity 212, member B  Symbol and/or name change 5135510 APPROVED
2012-11-27 Fam212b  family with sequence similarity 212, member B  6530418L21Rik  RIKEN cDNA 6530418L21 gene  Symbol and/or name change 5135510 APPROVED