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Gene: Fbxw4 (F-box and WD-40 domain protein 4) Mus musculus
Symbol: Fbxw4
Name: F-box and WD-40 domain protein 4
Description: Involved in cartilage development; embryonic digit morphogenesis; and positive regulation of mesenchymal cell proliferation. Predicted to localize to the SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in split hand-foot malformation 3. Is expressed in brain; diencephalon roof plate; midbrain ventricular layer; and midbrain-hindbrain junction. Orthologous to human FBXW4 (F-box and WD repeat domain containing 4); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Dac; dactylaplasia; dactylin; dactylyn; F-box and WD-40 domain-containing protein 4; F-box protein Fbw4; F-box/WD repeat-containing protein 4; Fbw4; hagoromo; SHFM3; SHSF3
Homo sapiens (human) : FBXW4 (F-box and WD repeat domain containing 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fbxw4 (F-box and WD repeat domain containing 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fbxw4 (F-box and WD repeat domain containing 4)
Pan paniscus (bonobo/pygmy chimpanzee) : FBXW4 (F-box and WD repeat domain containing 4)
Canis lupus familiaris (dog) : FBXW4 (F-box and WD repeat domain containing 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fbxw4 (F-box and WD repeat domain containing 4)
Sus scrofa (pig) : FBXW4 (F-box and WD repeat domain containing 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1945,578,254 - 45,660,312 (-)Ensembl
GRCm381945,578,254 - 45,660,520 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371945,652,747 - 45,734,683 (-)NCBIGRCm37mm9NCBIm37
MGSCv361945,631,568 - 45,713,504 (-)NCBImm8
Celera1946,345,905 - 46,428,364 (-)NCBICelera
Cytogenetic Map19 C3NCBI
cM Map1938.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Fbxw4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1315183
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.